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Integrated Network Pharmacology Approach for Drug Combination Discovery: A Multi-Cancer Case Study.

Despite remarkable efforts of computational and predictive pharmacology to improve therapeutic strategies for complex diseases, only in a few cases have the predictions been eventually employed in the clinics. One of the reasons behind this drawback is that current predictive approaches are based only on the integration of molecular perturbation of a certain disease with drug sensitivity signatures, neglecting intrinsic properties of the drugs. Here we integrate mechanistic and chemocentric approaches to drug repositioning by developing an innovative network pharmacology strategy. We developed

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… Three combinations for PRAD suggest both paclitaxel and vinblastine together with drugs for the treatment of hyperthyroidism, such as methimazole and carbimazole. … For instance, in breast cancer, clomethiazole, gaboxadol, fomepizole, methimazole and tranylcypromine appear in combination with both of the drugs, while betahistine, carbimazole and amantadine are suggested to be suitable in combination only with paclitaxel. 3.3. …

Hirata Syndrome Clinical Presentation and Management: A Single-Centre Experience.

BackgroundHirata syndrome, or Insulin Autoimmune Syndrome (IAS), is a rare condition characterized by hyperinsulinemic hypoglycemia due to autoantibodies targeting endogenous insulin. Its rarity and unique presentation make diagnosis and management challenging.ObjectiveTo analyze the clinical presentation, diagnostic methods, and management of IAS based on a single-center experience.MethodologyThis was a case series, conducted at a tertiary care center in northeast India, involving six cases diagnosed between January 2022 and April 2024. Clinical histories, including drug use and comorbidities

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… 1000 | 23.96 | 188.0 | Prednisolone 3 | 42 | F | Fasting | α lipoic acid | >600 | 5.5 | 78.7 | Acarbose and Prednisolone 4 | 60 | F | Fasting | α lipoic acid | >1000 | 23.02 | 98.0 | Acarbose 5 | 64 | M | Fasting | α lipoic acid | >1000 | 23.27 | 93.0 | Acarbose 6 | 42 | F | Fasting and postprandial | Carbimazole …

Клиническое лечение заболеваний щитовидной железы, вызванных аутоиммунной алемтузумабской болезнью: обзор повествования.

Alemtuzumab — это мощное лекарство против CD52, которое является общепринятым средством лечения у пациентов с множественным склерозом в силу его доказанной эффективности. Вместе с тем около 50% пациентов пользуются алемтузумабами в результате развития вторичных аутоиммунных заболеваний щитовидной железы, представляющих собой целый ряд заболеваний щитовидной железы, вызванных аутоиммунной алемтузумой. Болезнь грейвеса (GD) является наиболее распространенным заболеванием AIATD с частотой заболевания около 60% и отличается от традиционной формы. Действительно, GD с изменяющимися курсами гораздо б

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… A relapse of mild hyperthyroidism at gestational week 18 necessitated low-dose carbimazole, which was subsequently discontinued at week 25 as TRAb further declined. The pregnancy resulted in a healthy, euthyroid neonate. …

Non-diabetic hypoglycemia: bridging gaps in diagnosis and treatment: a position statement report by the Arabic Association for the Study of Diabetes and Metabolism (AASD).

BACKGROUND: Non-diabetic hypoglycemia presents a substantial diagnostic challenge due to its diverse and often nonspecific symptomatology. The resultant delay in diagnosis can lead to a myriad of misdiagnoses. This misidentification not only prolongs patient suffering but also elevates the risk of severe complications, such as permanent neurologic damage and mortality. Recognizing the clinical nuances of non-diabetic hypoglycemia is paramount for timely and accurate diagnosis, which ultimately enhances patient outcomes and safety. MAIN BODY: A position statement has been formulated by the Ara

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… Other causes include carbimazole, propylthiouracil, captopril and some autoimmune diseases. …

Secondary Neutropenias.

Neutrophils are a critical component of immunity, particularly against bacteria and other pathogens, but also in inflammation and tissue repair. As a consequence, individuals with neutropenia, defined by a reduction in absolute neutrophil counts, exhibit a strong propensity to severe infections that typically present with muted symptoms. Neutropenias encompass a heterogeneous set of disorders, comprising primary neutropenias, in which specific genes are mutated, and the more common secondary neutropenias, which have diverse non-genetic causes. These include hematological and other cancers, inv

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… , tenoxicam anticonvulsants | carbamazepine, phenytoin, valproate antimicrobials | acyclovir, chloroquine, levamisole, penicillins, tetracycline, trimethoprim-sulfamethoxazol antipsychotics | amoxapine, clozapine, diazepam, olanzapine, phenothiazines antirheumatics | gold, levamisole antithyroids | carbimazole …

Irish Endocrine Society 44th Annual Meeting.

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… He was commenced on carbimazole 15 mg BD and propranolol 20 mg BD. Two weeks post discharge his carbimazole dose was increased to 20 mg BD. He initially required oral potassium supplementation which was ceased with resolution of the hyperthyroidism. He had full recovery of his lower limb paralysis. … He is currently euthyroid on 10 mg carbimazole OD 15 months post presentation and definitive treatment is being considered. This case highlights the importance of prompt recognition of this rare life-threatening complication of Graves’ disease, especially in Asian patients. P2. …

RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS.

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61st Annual Conference of Indian Society of Gastroenterology, Virtual Diamond Jubilee ISGCON 2020, 19-20th December 2020.

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Research Communications of the 26th ECVIM‐CA Congress

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Proceedings of the RAMI Intern Section Meeting.

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