Результаты поиска

Resilience of the Urogenital Microbiota Following Urogynecologic Surgery.

IMPORTANCE: Little is known about the resilience of the urogenital microbiota in response to urogynecologic surgery. OBJECTIVES: The aim of this study was to determine if the urogenital microbiota are disrupted after surgery and if the postoperative composition returns to a preoperative baseline. We also sought to determine if the process of recovery differs in premenopausal women versus postmenopausal women. STUDY DESIGN: Women undergoing surgery for pelvic floor disorders were invited to participate in this longitudinal descriptive study. Catheterized urine specimens and vaginal swabs were…

Microbiota-based therapies in oral health and disorders.

The human oral microbiome is a complex, dynamic ecosystem critically involved in maintaining oral health and contributing to systemic well-b … ther precision tool for targeting oral pathogens by lysing bacteria upon replication. Finally, oral microbiota transplantation aimed at treating periodontal disease by restoring a balanced microbial community in the oral cavity. These innovative strategies, combined with a nuanced understanding of biofilm dynamics and host-microbe interactions, pave the way …

Dynamics of gut microbiota in qualified female boxers.

OBJECTIVE: Aim: To analyze changes in the gut microbiota of qualified female boxers at different stages of the training cycle, influenced by physical activity of different intensity. PATIENTS AND METHODS: Materials and Methods: The study involved nine qualified female boxers, who performed high-intensity training sessions. The study of changes in the state of the microbiota, namely its diversity, was carried out in two phases of the training cycle. A microbiological quantitative method was used, in-depth with species identification and detection of anaerobes, the unit of measurement of which …

Precision microbiota therapy for IBD: premise and promise.

Inflammatory Bowel Disease (IBD) is a spectrum of chronic inflammatory diseases of the intestine that includes subtypes of ulcerative colitis (UC) and Crohn's Disease (CD) and currently has no cure. While IBD results from a complex interplay between genetic, environmental, and immunological factors, sequencing advances over the last 10-15 years revealed signature changes in gut microbiota that contribute to the pathogenesis of IBD. These findings highlight IBD as a disease target for microbiome-based therapies, with the potential to treat the underlying microbial pathogenesis and provide adjuv…

Alteration of gut microbiota associated with hypertension in children.

BACKGROUND: The association of disturbance in gut microbiota with hypertension (HTN) defined on three separate occasions among children and adolescents remains unclear. In this study, we aimed to compare the differences in gut microbiota composition and diversity between children with HTN and those with normal blood pressure (BP). METHODS: Data and stool samples were collected from the second follow-up of a childhood cardiovascular health cohort study in 2021. 16 S ribosomal RNA gene sequencing was conducted to determine the relative abundance of microbial taxa in 51 children aged 10-14 years…

The emerging role of the gut microbiota in vaccination responses.

The gut microbiota has emerged as a key modulator of host immune responses, and growing evidence suggests it plays a role in shaping vaccine-induced immunity. While immunization remains vital for preventing infectious diseases, inter-individual variability in vaccine responses poses a persistent challenge. Traditional factors such as age, sex, genetics, and immune status do not fully account for this variability. Recent studies highlight the gut microbiome as a potential contributor. This review examines current evidence linking the gut microbiota to vaccine responses, with a focus on vaccines…

The Impact of the Oral and Esophageal Microbiota in EoE and Achalasia.

Background/Objectives: Eosinophilic esophagitis (EoE) and achalasia are two chronic esophageal disorders, characterized by inflammatory and neuromotor dysfunction, respectively, that share overlapping immune-inflammatory features. Emerging evidence suggests that dysbiosis of the oral and esophageal microbiota may represent a common determinant in their pathophysiology. This review aims to provide a comparative and integrated overview of microbial and immune alterations in EoE and Achalasia, with potential diagnostic and therapeutic implications. Methods: A bibliographic search was conducted on…

Gut Microbiota in the Treatment of Migraine with Acupuncture: A Review.

Migraine is one of the most common nervous system diseases in the world, which is characterized by recurrent severe headache, accompanied by gut microbiota imbalance and gut-brain axis dysfunction, seriously affecting the quality of life of patients. The existing treatment methods have some limitations, such as low diagnostic rate and drug dependence, so we should pay attention to the potential value of acupuncture, a traditional Chinese medicine therapy. This paper systematically reviews the mechanisms underlying the association between gut microbiota and migraine, and the pathways by which a…

Research progress on the correlation between microbiota and endometriosis.

The microbiota constitutes a vital component of the human microenvironment, dynamically responding to physiological changes and playing crucial roles in maintaining normal bodily functions. Endometriosis (EMs), defined as a chronic, hormone-dependent inflammatory disorder, involves the ectopic implantation of endometrium-like tissue beyond the uterine cavity (e.g., ovaries, peritoneum). This pathology initiates local and systemic inflammatory cascades, leading to characteristic clinical manifestations such as dysmenorrhea (occurring in ∼ 84.9 % of patients), chronic pelvic pain, infertility, a…

Evaluation of ocular surface microbiota in children with blepharoconjunctivitis.

PURPOSE: To investigate the conjunctival and eyelid margin bacterial microbiota in children with blepharoconjunctivitis by using 16S rDNA amplicon sequencing. METHODS: In this prospective cross-sectional study, 20 children aged between 3-15 years with blepharoconjunctivitis or blepharokeratokonjunctivitis formed Blepharitis Group and 21 children aged between 3-15 years without any ocular and sysemic diseases except mild refractive errors formed Control Group. Swap samples from all children were taken. The alpha diversity of the ocular surface microbiota within each group were evaluated by usi…

Human microbiota in dengue infection: A narrative review.

Dengue fever, a widespread mosquito-borne viral infection in tropical regions, typically manifests fever and gastrointestinal symptoms, including nausea, vomiting, and diarrhea. However, the human gut microbiota's role in dengue pathogenesis remains incompletely understood. Studies have demonstrated dysbiosis during dengue virus infection, characterized by increased abundance of potentially pathogenic bacteria like Bacteroidaceae and Proteobacteria, particularly during the critical phase. Furthermore, microbial translocation and leaky gut syndrome, characterized by the translocation of intesti…

Перестройка носовой и пероральной микробиоты в множестве склероза.

Несмотря на то, что изменения в кишечной микробиоте были зафиксированы в множестве склерозов (MS), мало что известно о носовой и пероральной микробиоте, которые являются важными модуляторами мукосальной иммунной системы. Гринивальная микробиота может приводить к системному воспалению, фламматическая микробиота может приводить к аутоиммунным неврологическим болезням, а изменённые носовые бактериальные токсигенные гены регистрируются в активных MS. Мы изучили микробиоту носовой, ингивальной и оргарсингеальной сериал с 69 до 40 здоровых контрольных объектов по секвенированию 16S rRNA и выявили ос

Совпадение в аннотации оригинала
BACKGROUND: While changes in the gut microbiota have been reported in multiple sclerosis (MS), little is known about the nasal and oral microbiota, which are important modulators of the mucosal immune system. The gingival microbiota can drive systemic inflammation, the pharyngeal microbiota can lead to autoimmune-mediated neurologic diseases, and altered nas…

Неизлечимое возмущение изилиальной микробиотой в множестве склерозов.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… They compared the microbiota from faeces, ileum, and colon—regions with distinct immune characteristics—and transferred ileum microbiota to a germ-free transgenic mouse model predisposed to spontaneous experimental autoimmune encephalomyelitis (EAE). … In Parkinson’s disease, preclinical evidence indicates that microbiota manipulation—through antibiotics, probiotics, or fecal microbiota transplantation (FMT)—can influence motor symptoms, neuroinflammation, and α-synuclein pathology ( 4 ). …

Functional Abdominal Bloating and Gut Microbiota: An Update.

(1) Background: Functional abdominal bloating and distension (FAB/FAD) are common disorders of the gut-brain interaction. Their physiopathology is complex and not completely clarified, although gut microbiota imbalances play a central role. The treatment of FAB/FAD still represents a clinical challenge for both patients and healthcare providers. Gut microbiota modulation strategies might play a crucial role in their management. The aim of this narrative review was to update the current evidence on FAB/FAD, with a focus on gut microbiota. (2) Methods: In October 2023, a review was conducted thr…

Lower airway microbiota in COPD and healthy controls.

BACKGROUND: The lower airway microbiota in patients with chronic obstructive pulmonary disease (COPD) are likely altered compared with the microbiota in healthy individuals. Information on how the microbiota is affected by smoking, use of inhaled corticosteroids (ICS) and COPD severity is still scarce. METHODS: In the MicroCOPD Study, participant characteristics were obtained through standardised questionnaires and clinical measurements at a single centre from 2012 to 2015. Protected bronchoalveolar lavage samples from 97 patients with COPD and 97 controls were paired-end sequenced with the I…

The role of the fecal microbiota in inflammatory bowel disease.

The understanding of the potential role of the microbiota in the pathogenesis of inflammatory bowel disease (IBD) is ever-evolving. Traditionally, the management of IBD has involved medical therapy and/or surgical intervention. IBD can be characterized by gut microbiome alterations through various pathological processes. Various studies delve into nontraditional methods such as probiotics and fecal microbiota transplant and their potential therapeutic effects. Fecal microbiota transplant involves the delivery of a balanced composition of gut microorganisms into an affected patient via multiple…

Impacts of pancreatic exocrine insufficiency on gut microbiota.

Pancreatic exocrine insufficiency (PEI) can be induced by various kinds of diseases, including chronic pancreatitis, acute pancreatitis, and … therapy. Clinical studies have also confirmed the association between PEI and the dysbiosis of gut microbiota. Pancreatic exocrine secretions and changes in duodenal pH as well as bile salt malabsorption brought about by PEI may affect and shape the abundance and composition of gut microbiota. In turn, the gut microbiota may impact the pancreatic exocrine a …

The Impact of Probiotic Bifidobacterium on Liver Diseases and the Microbiota.

Recent studies have shown the promising potential of probiotics, especially the bacterial genus Bifidobacterium, in the treatment of liver diseases. In this work, a systematic review was conducted, with a focus on studies that employed advanced Next Generation Sequencing (NGS) technologies to explore the potential of Bifidobacterium as a probiotic for treating liver pathologies such as Non-Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH), Alcoholic Liver Disease (ALD), Cirrhosis, and Hepatocelullar Carcinoma (HCC) and its impact on the microbiota. Our results indicat…

The Role of Diet and Gut Microbiota in Alzheimer's Disease.

Alzheimer's disease (AD), the most prevalent form of dementia, is characterized by the accumulation of amyloid-beta (Aβ) plaques and hyperphosphorylated tau tangles. Currently, Alzheimer's disease (AD) impacts 50 million individuals, with projections anticipating an increase to 152 million by the year 2050. Despite the increasing global prevalence of AD, its underlying pathology remains poorly understood, posing challenges for early diagnosis and treatment. Recent research suggests a link between gut dysbiosis and the aggregation of Aβ, the development of tau proteins, and the occurrence of ne

The impact of gut microbiota on morbidities in preterm infants.

The gut microbiota undergoes substantial development from birth, and its development in the initial years of life has a potentially lifelong effect on the health of the individual. However, various factors can disrupt the development of the gut microbiota, leading to a condition known as dysbiosis, particularly in preterm infants. Current studies involving adults have suggested that the gut microbiota not only influences the gut but also has multidimensional effects on remote organs; these pathways are often referred to as the gut-organ axis. Imbalance of the gut microbiota may lead to the dev…