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The role of miR-320a and IL-1β in human chondrocyte degradation.

ObjectivesThis study aimed to explore the role of miR-320a in the pathogenesis of osteoarthritis (OA).MethodsHuman cartilage cells (C28/I2) were transfected with miR-320a or antisense oligonucleotides (ASO)-miR-320a, and treated with IL-1β. Subsequently the expression of collagen type II alpha 1 (Col2α1) and aggrecan (ACAN), and the concentrations of sulfated glycosaminoglycans (sGAG) and matrix metallopeptidase 13 (MMP-13), were assessed. Luciferase reporter assay, qRT-PCR, and Western blot were performed to explore whether pre-B-cell leukemia Homeobox 3 (PBX3) was a target of miR-320a. Furth

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… Arthritis Rheum 2010 ; 62 : 1361 - 1371 . 20131257 10.1002/art.27329 PMC3139404 22 Park SJ Cheon EJ Kim HA MicroRNA-558 regulates the expression of cyclooxygenase-2 and IL-1beta-induced catabolic effects in human articular chondrocytes . …

Rare Diseases of the Orbit.

This article provides an overview of rare orbital diseases. Congenital malformations, inflammatory diseases, benign and malignant neoplasias are described. Although it represents a relatively small area of the body the orbit contains multiple different tissues. Therefore, a great variety of diseases can be found within the orbital space. That is the reason, why both the completeness and the level of detail in the description of particular diseases must be somewhat limited. Nevertheless, clinical manifestations, important aspects of diagnosis, treatment strategies, and, when specific data are a

UK clinical guideline for the prevention and treatment of osteoporosis.

UNLABELLED: The National Osteoporosis Guideline Group (NOGG) has revised the UK guideline for the assessment and management of osteoporosis and the prevention of fragility fractures in postmenopausal women, and men age 50 years and older. Accredited by NICE, this guideline is relevant for all healthcare professionals involved in osteoporosis management. INTRODUCTION: The UK National Osteoporosis Guideline Group (NOGG) first produced a guideline on the prevention and treatment of osteoporosis in 2008, with updates in 2013 and 2017. This paper presents a major update of the guideline, the scope

Новое развитие аутоиммунного расстройства после лечения иммунной реконституции при множественном склерозе.

Иммунная реконституционная терапия (IRT) является относительно новым и высокоэффективным средством лечения множественного склероза (MS). Неопределенность в отношении развития аутоиммунных расстройств (АД) после сохранения некоторых методов лечения. Цель этого исследования состояла в том, чтобы провести оценку новых разработок в области АД после IRT у пациентов с РС и описать характер этих АД и время их начала. В исследование было включено в общей сложности 179 пациентов с множественным склерозом (37 после аналоговой трансплантации гематопоэтических стволовых клеток (АХСТ), 19 пациентов после а

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… Arthritis Rheum. 52 (5), 1555–1563 (2005). 50. Mammen, J. S. R. & Cappola, A. R. Autoimmune thyroid disease in women. JAMA. 325 (23), 2392–2393 (2021). …

European guidance for the diagnosis and management of osteoporosis in postmenopausal women.

UnlabelledGuidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk of fractures due to osteoporosis.IntroductionThe International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis published guidance for the diagnosis and management of osteoporosis in 2008. This manuscript updates these in a European setting.MethodsSystematic literature reviews.ResultsThe following areas are reviewed: the role of bone mineral density measurement for the diagnosis of osteoporosis and assessment of fr

Поздняя нейтропения после Ритуксимаба в множестве склерозов: несчастные случаи, прогнозы и результаты в ретроспективной мультицентральной коорте.

ЗАДАЧИ И ЗАДАЧИ: Поздняя нейтропенсия (LON) представляет собой редкое, переходное сокращение абсолютного количества нейтрофильов (ANC), связанное с anti-CD20 Лечение. В множестве склерозов (МС) данные о степени тяжести, инфекционных результатах и прогнозах остаются ограниченными. Мы поставили перед собой цель определить частотность, характеристики и предсказатели LON у людей с ритуксимабом, обработанных с помощью MS (PwMS). МЕТОДЫ: Мы провели ретроспективное многоцентральное исследование PSMS в Швеции, подвергшееся воздействию ritoximab в период между 2008 и 2024. Любой LON определяется как AN

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… Arthritis Rheum. 2011;63(8):2209-2214. doi: 10.1002/art.30427 22. Parodis I, Soder F, Faustini F, et al. Rituximab-mediated late-onset neutropenia in systemic lupus erythematosus - distinct roles of BAFF and APRIL. Lupus. 2018;27(9):1470-1478. doi: 10.1177/0961203318777116 23. …

Biologics and Non-Biologics Immunosuppressive Treatments for IgA Nephropathy in Both Adults and Children.

Immunoglobulin A nephropathy represents the most prevalent cause of glomerulonephritis worldwide and may lead to renal failure in a relevant number of cases in both paediatric and adult subjects. Although their pathogenesis is still largely unclear, evidence of immune abnormalities provides the background for the use of immunosuppressive drugs, such as corticosteroids, calcineurin inhibitors, and antiproliferative and alkylating agents. Unfortunately, these treatments fail to achieve a sustained remission in a significant percentage of affected patients and are burdened by significant toxiciti

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… Rheum. Dis. 2000;59:841–849. doi: 10.1136/ard.59.11.841. 49. Cheung C.K., Barratt J., Carroll K., Lafayette R.A., Liew A., Suzuki Y., Tesař V., Trimarchi H., Wong M.G., Zhang H., et al. Targeting APRIL in the Treatment of IgA Nephropathy. Clin. J. Am. Soc. …

Analyzing the factors associated with efficacy among teriparatide treatment in postmenopausal women with osteoporosis.

BACKGROUND: Teriparatide (TPTD) is a widely used anabolic agent for the treatment of osteoporosis. Several factors have been identified to be related to bone mineral density (BMD) increase in anti-osteoporosis treatment with other agents; however, there has been no systematic analysis to summarize the associated determinants of BMD reaction to daily teriparatide treatment. METHODS: In this retrospective study, we performed a comprehensive investigation involving not only clinical data but also several relevant lifestyle factors to be examined for their potential contribution to BMD response.

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… Arthritis Rheum. 2009;60(11):3346–3355. doi: 10.1002/art.24879. 49. Devogelaer JP, Adler RA, Recknor C, See K, Warner MR, Wong M, Krohn K. Baseline glucocorticoid dose and bone mineral density response with teriparatide or alendronate therapy in patients with glucocorticoid-induced osteoporosis. …

Exploring the association and causal effect between white blood cells and psoriasis using large-scale population data.

IntroductionPsoriasis is a chronic inflammatory disease of the skin. A few studies have shown that psoriasis is an immune-mediated disease in which multiple immune cells play crucial roles. However, the association between circulating immune cells and psoriasis remains elusive.MethodsTo explore the role of circulating immune cells in psoriasis, 361,322 individuals from the UK Biobank (UKB) and 3,971 patients with psoriasis from China were included to investigate the association between white blood cells and psoriasis via an observational study. Genome-wide association studies (GWAS) and Mendel

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… Ann Rheum Dis (2018) 77:175–87. doi: 10.1136/annrheumdis-2017-211555 73. Langewouters AM, van Erp PE, de Jong EM, van de Kerkhof PC. Lymphocyte subsets in peripheral blood of patients with moderate-to-severe versus mild plaque psoriasis. …

MicroRNA-17-92a-1 Host Gene (MIR17HG) Expression Signature and rs4284505 Variant Association with Alopecia Areata: A Case-Control Study.

Accumulating evidence indicates the implication of microRNAs (miRs) in cutaneous and hair follicle immunobiology. We evaluated, for the first time, the miR-17-92a-1 cluster host gene (MIR17HG) expression in peripheral blood of 248 unrelated alopecia areata (AA) patients compared to 244 matched controls using Real-Time qPCR. We also tested its association with different rs4284505A>G genotypes (based on TaqMan allelic discrimination PCR) and the available clinical data. The adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated for each genetic association model. The upregulat

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… Arthritis Rheum. 2013;65:1324–1334. doi: 10.1002/art.37890. 52. Cox M.B., Cairns M.J., Gandhi K.S., Carroll A.P., Moscovis S., Stewart G.J., Broadley S., Scott R.J., Booth D.R., Lechner-Scott J., et al. …

Anemia and Iron Deficiency in Cancer Patients: Role of Iron Replacement Therapy.

Anemia in cancer patients is quite common, with remarkable negative impacts on quality of life and overall prognosis. The pathogenesis is complex and typically multifactorial, with iron deficiency (ID) often being a major and potentially treatable contributor. In turn, ID in cancer patients can be due to multiple concurring mechanisms, including bleeding (e.g., in gastrointestinal cancers or after surgery), malnutrition, medications, and hepcidin-driven iron sequestration into macrophages with subsequent iron-restricted erythropoiesis. Indeed, either absolute or functional iron deficiency (AID

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… Arthritis Rheum. 2011;63:3672–3680. doi: 10.1002/art.30623. 63. Bergamaschi G., Di Sabatino A., Albertini R., Costanzo F., Guerci M., Masotti M., Pasini A., Massari A., Campostrini N., Corbella M., et al. Serum hepcidin in inflammatory bowel diseases: Biological and clinical significance. Inflamm. …

Yellow nail syndrome: a review.

Yellow nail syndrome (YNS; OMIM 153300, ORPHA662) is a very rare disorder that almost always occurs after 50 years of age but a juvenile or familial form has also been observed. YNS is diagnosed based on a triad associating yellow nail discoloration, pulmonary manifestations (chronic cough, bronchiectasia, pleural effusion) and lower limb lymphedema. Chronic sinusitis is frequently associated with the triad. YNS etiology remains unknown but a role of lymphatic impairment is usually evoked. YNS is more frequently isolated but may be associated in rare cases with autoimmune diseases, other clini

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… Mattingly PC Bossingham DH Yellow nail syndrome in rheumatoid arthritis: report of three cases Ann Rheum Dis 1979 38 475 8 10.1136/ard.38.5.475 518148 PMC1000397 84. …

Modulation of angiogenesis with siRNA inhibitors for novel therapeutics.

Cancer and many other serious diseases are characterized by the uncontrolled growth of new blood vessels. Recently, RNA interference (RNAi) has reinvigorated the therapeutic prospects for inhibiting gene expression and promises many advantages over binding inhibitors, including high specificity, which is essential for targeted therapeutics. This article describes the latest developments using small-interfering RNA (siRNA) inhibitors to downregulate various angiogenic and tumor-associated factors, both in cell-culture assays and in animal disease models. The majority of research efforts are cur

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… Arthritis Rheum. 2004;50:420–431. doi: 10.1002/art.20037. 60. Miyashita T. Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells. Biochem. Biophys. Res. …

KIAA1429-mediated M6A methylation inhibits osteoclast differentiation via stabilizing Lrp4 mRNA and protects against osteoporosis.

N6-methyladenosine (m6A) is a novel epigenetic modification that has been reported to be involved in the progression of osteoporosis (OP), providing new insights into the pathogenesis of OP. The methyltransferases KIAA1429 [also known as virus-like m6A methyltransferase-associated protein (VIRMA)] participates in various essential biological processes by regulating target gene expression levels. However, the function of KIAA1429-mediated m6A modification in OP progression remains unclear. This study aimed to investigate the biological roles and potential underlying mechanisms of KIAA1429 in OP

Oroxylin A: A Promising Flavonoid for Prevention and Treatment of Chronic Diseases.

There have been magnificent advancements in the understanding of molecular mechanisms of chronic diseases over the past several years, but t … sing potential of OA against cancer, cardiovascular diseases, inflammation, neurological disorders, rheumatoid arthritis, osteoarthritis, etc. Therefore, the current review focuses on delineating the role of OA in combating different chronic diseases and highlighting the intrinsic molecular mechanisms of its action.

Dynamics of Patient-Based Benefit-Risk Assessment of Medicines in Chronic Diseases: A Systematic Review.

BackgroundA critical gap exits in understanding the dynamics of patient-based benefit-risk assessment (BRA) of medicines in chronic diseases during the disease journey.PurposeTo systematically review and synthesize current evidence on the changes of patients' preferences about the benefits and risks of medicines during their disease journey including the influence of disease duration and severity, and previous treatment experience.MethodsA systematic review of studies identified in PubMed and Embase, from inception to November 2020, was conducted in accordance with the PRISMA (Preferred Report

IFN-γ-driven skewing towards Th1 over Th17 differentiation underlies CRS and neutropenia in CAR-T therapy.

Chimeric antigen receptor T cell (CAR-T) therapy has led to significant improvements in patient survival. However, a subset of patients experience high-grade toxicities, including cytokine release syndrome (CRS) and immune cell-associated hematological toxicity (ICAHT). We utilized IL-2Ra knockout mice to model toxicities with elevated levels of IL-6, IFN-γ, and TNF-α and increased M1-like macrophages. Onset of CRS was accompanied by a reduction in peripheral blood neutrophils due to disruption of bone marrow neutrophil homeostasis characterized by an increase in apoptotic neutrophils and a de

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… Ann Rheum Dis. 2014;73(5):945–947. doi: 10.1136/annrheumdis-2013-204137. 24. Bracaglia C, et al. Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis. … Ann Rheum Dis. 2017;76(1):166–172. doi: 10.1136/annrheumdis-2015-209020. 25. Buatois V, et al. Use of a mouse model to identify a blood biomarker for IFN-gamma activity in pediatric secondary hemophagocytic lymphohistiocytosis. Transl Res. 2017;180:37–52.e2. doi: 10.1016/j.trsl.2016.07.023. 26. …

Unraveled role of TLR7-mediated interferon signaling activation in COVID-19.

Emerging evidence underscores the critical role of Toll-like receptor 7 (TLR7)-mediated interferon (IFN) signaling in host defense against viral infections including SARS-CoV-2, through the modulation of both innate and adaptive immunity. However, the specific mechanisms by which TLR7 activation shapes SARS-CoV-2-specific immune responses, particularly via IRF-IFN pathways, remain incompletely elucidated. This review synthesizes current findings on how intrinsic TLR7-driven IFN signaling influences viral clearance, modulates adaptive immunity, and contributes to autoantibody production in COVI

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… Rheum. Dis. 81 , 1136 – 1142 . doi: 10.1136/annrheumdis-2022-222212 , PMID: 35477518 PMC9279852 Maiti A. K. ( 2024 ). MDA5 is a major determinant of developing symptoms in critically ill COVID-19 patients . Clin. Rev. … Rheum. Dis. 81 , 575 – 583 . doi: 10.1136/annrheumdis-2021-221097 , PMID: 34607791 PMC8494536 Naqvi I. Giroux N. Olson L. Morrison S. A. Llanga T. Akinade T. O. . ( 2022 ). …

Molecular Mechanisms Leading from Periodontal Disease to Cancer.

Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigati

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… RANK and RANKL Expression as markers of dendritic cell-T cell interactions in paired samples of rheumatoid synovium and lymph nodes Arthritis Rheum. 2005 52 2307 2312 10.1002/art.21211 16052586 95. Ono T. Hayashi M. Sasaki F. Nakashima T. … Expression and function of RANK in human monocyte chemotaxis Arthritis Rheum. 2004 50 2309 2316 10.1002/art.20352 15248232 103. Henriksen K. Karsdal M. Delaissé J.M. Engsig M.T. …

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