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Drug Repurposing Opportunities in Pancreatic Ductal Adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is considered one of the deadliest tumors worldwide. The diagnosis is often possible only in the latter stages of the disease, with patients already presenting an advanced or metastatic tumor. It is also one of the cancers with poorest prognosis, presenting a five-year survival rate of around 5%. Treatment of PDAC is still a major challenge, with cytotoxic chemotherapy remaining the basis of systemic therapy. However, no major advances have been made recently, and therapeutic options are limited and highly toxic. Thus, novel therapeutic options are urgen

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… In fact, the tetracycline and chloramphenicol families may inhibit mitochondrial and bacterial translation and affect some complexes of the mitochondrial respiratory chain [ 120 ]. …

Lost in Translation (LiT): IUPHAR Review 6.

Translational medicine is a roller coaster with occasional brilliant successes and a large majority of failures. Lost in Translation 1 ('LiT1'), beginning in the 1950s, was a golden era built upon earlier advances in experimental physiology, biochemistry and pharmacology, with a dash of serendipity, that led to the discovery of many new drugs for serious illnesses. LiT2 saw the large-scale industrialization of drug discovery using high-throughput screens and assays based on affinity for the target molecule. The links between drug development and university sciences and medicine weakened, but t

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… Aplastic anaemia with chloramphenicol, phenylbutazone and oxyphenbutazone led to their withdrawal or severe limitations on their use in the mid‐1970s. …

Neutrophil extracellular traps in homeostasis and disease.

Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are renowned for their propensity to expel decondensed chromatin embedded with inflammatory proteins. Our comprehension of NETs in pathogen clearance, immune regulation and disease pathogenesis, has grown significantly in recent years. NETs are not only pivotal in the context of infections but also exhibit significant involvement in sterile inflammation. Evidence suggests that excessive accumulation of NETs can result in vessel occlusion, tissue damage, and prolonged inflammatory responses, thereby contributing to the

9th Trends in Medical Mycology Held on 11-14 October 2019, Nice, France, Organized under the Auspices of EORTC-IDG and ECMM.

Dear Friends and Colleagues,It is a great honor and pleasure for us to invite you cordially to participate in the 9th Congress on Trends in Medical Mycology (TIMM-9) [...].

Drug Repurposing for Cancer Treatment: A Comprehensive Review.

Cancer ranks among the primary contributors to global mortality. In 2022, the global incidence of new cancer cases reached about 20 million, while the number of cancer-related fatalities reached 9.7 million. In Saudi Arabia, there were 13,399 deaths caused by cancer and 28,113 newly diagnosed cases of cancer. Drug repurposing is a drug discovery strategy that has gained special attention and implementation to enhance the process of drug development due to its time- and money-saving effect. It involves repositioning existing medications to new clinical applications. Cancer treatment is a therap

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… Members of the tetracycline and chloramphenicol families of frequently used antibiotics block both mitochondrial and bacterial translation. …

Therapeutic Uses and Pharmacological Properties of Shallot (Allium ascalonicum): A Systematic Review.

BackgroundShallot (Allium ascalonicum L.) is a traditional plant species used throughout the world both for culinary purposes and as a folk remedy. To date (i.e., April 2022), there is no report on the main pharmacological activities exerted by shallot preparations and/or extracts.Scope and approachThe aim of this study was to comprehensively review the pharmacological activities exerted by shallot, with rigorous inclusion and exclusion criteria based on the scientific rigor of studies. Prisma guidelines were followed to perform the literature search.Key findings and conclusionsThe literature

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… NA | Shallot; A. ascalonicum; bulb | ( 17 ) Bacillus cereus | | E : MIC = 5,000–10,000; MBC = 5,000 | | E (Water; SLR 2:1, 5 h) >> F | Zagros mountains, Iran | Shallot/red onion; A. ascalonicum; bulb | ( 26 ) | ATCC25923 | PC: 32 mm; J: 9 mm; Soxtec : 13 mm; dd = 6 mm; | # | J (20 g); Soxtec PC : chloramphenicol …

Infectious Diseases

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… Treat with doxycycline or chloramphenicol ehrlichia — E. chaffeensis (human monocytic ehrlichiosis) transmitted by lone star tick. Peaks in May to July. Infects lymphocytes, monocytes, and neutrophils intracellularly. …

Organelle-oriented nanomedicines in tumor therapy: Targeting, escaping, or collaborating?

Precise tumor therapy is essential for improving treatment specificity, enhancing efficacy, and minimizing side effects. Targeting organelles is a key strategy for achieving this goal and is a frontier research area attracting a considerable amount of attention. The concept of organelle targeting has a significant effect on the structural design of the nanodrugs employed. Most notably, the intricate interactions among different organelles in a tumor cell essentially create a unified system. Unfortunately, this aspect might have been somewhat overlooked when existing organelle-targeting nanodru

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… Similarly, He et al. constructed nanoparticles of a peptide-lipid conjugate, Flag-(C16) 2 , to serve as a substrate for enterokinase and encapsulate chloramphenicol, a clinically-used antibiotic [ 111 ]. … Peri-mitochondrial enterokinase cleaved the Flag-tag on the conjugate to exclusively deliver chloramphenicol into the mitochondria of tumor cells, thus inhibiting the synthesis of mitochondrial proteins, inducing the release of cytochrome C into the cytosol, and ultimately leading to the demise of the …

Mitochondrial Genetic and Epigenetic Regulations in Cancer: Therapeutic Potential.

Mitochondria are dynamic organelles managing crucial processes of cellular metabolism and bioenergetics. Enabling rapid cellular adaptation to altered endogenous and exogenous environments, mitochondria play an important role in many pathophysiological states, including cancer. Being under the control of mitochondrial and nuclear DNA (mtDNA and nDNA), mitochondria adjust their activity and biogenesis to cell demands. In cancer, numerous mutations in mtDNA have been detected, which do not inactivate mitochondrial functions but rather alter energy metabolism to support cancer cell growth. Increa

Infectious Diseases

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Совпадение в полном тексте источника
… Treat with doxycycline or chloramphenicol ehrlichia — E. chaffeensis (human monocytic ehrlichiosis) transmitted by lone star tick. Peaks in May to July. Infects lymphocytes, monocytes, and neutrophils intracellularly. …

Hematology

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… medical alert bracelet Neutropenia Differential Diagnosis ★ PANIC ★ P ost-infectious —sepsis A utoimmune —drug induced, SLE N eoplastic —lymphoproliferative disorders, myelodysplasia, leukemias, myelophthisis I nfections —sepsis, HIV I nsufficiency —folate, vitamin B12 I atrogenic —chemotherapy, chloramphenicol …

Hematology

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… medical alert bracelet Neutropenia Differential Diagnosis ★PANIC★ P ost-infectious —sepsis A utoimmune —drug induced, SLE N eoplastic —lymphoproliferative disorders, myelodysplasia, leukemias, myelophthisis I nfections —sepsis, HIV I nsufficiency —folate, vitamin B12 I atrogenic —chemotherapy, chloramphenicol …

Respiratory and Thoracic Medicine

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… Pharmacologic Treatment of Upper Respiratory Tract Disease Class Drug Dosage Antibiotics Amoxicillin 10-22 mg/kg, PO, every 12 hours Amoxicillin-clavulanate 13.75 mg/kg, PO, every 12 hours Azithromycin 15 mg/kg, PO, every 24 hours Cefadroxil 22 mg/kg, PO, every 12 hours Cephalexin 22 mg/kg, PO, every 8 hours Chloramphenicol … Class | Drug | Dosage Antibiotics | Amoxicillin | 10-22 mg/kg, PO, every 12 hours Amoxicillin-clavulanate | 13.75 mg/kg, PO, every 12 hours Azithromycin | 15 mg/kg, PO, every 24 hours Cefadroxil | 22 mg/kg, PO, every 12 hours Cephalexin | 22 mg/kg, PO, every 8 hours Chloramphenicol | 10-15 mg/kg, PO, …

Emergency Care

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DNA Damaging Drugs

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The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity.

Glucocorticoids exert pleiotropic effects on all tissues to regulate cellular and metabolic homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their anti-inflammatory benefits, at the cost of dose and duration-dependent side effects. Significant variability occurs between tissues, disease states, and individuals with regard to both the beneficial and deleterious effects. The glucocorticoid receptor (GR) is the site of action for these hormones and a vast body of work has been conducted understanding its function. Traditionally, it was thought that the anti-

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… Transfection studies have demonstrated that GR-P alone does not activate a known glucocorticoid-responsive reporter (mouse mammary tumor virus-chloramphenicol acetyltransferase; MMTV-CAT) ( 241 ). However, GR-P modulates GRα activity in a cell type–specific manner. …

Repurposed Drugs in Gastric Cancer.

Gastric cancer (GC) is one of the major causes of death worldwide, ranking as the fifth most incident cancer in 2020 and the fourth leading cause of cancer mortality. The majority of GC patients are in an advanced stage at the time of diagnosis, presenting a poor prognosis and outcome. Current GC treatment approaches involve endoscopic detection, gastrectomy and chemotherapy or chemoradiotherapy in an adjuvant or neoadjuvant setting. Drug development approaches demand extreme effort to identify molecular mechanisms of action of new drug candidates. Drug repurposing is based on the research of

C

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Engineering with Biomedical Sciences Changing the Horizon of Healthcare-A Review.

In the dynamic realm of healthcare, the convergence of engineering and biomedical sciences has emerged as a pivotal frontier. In this review we go into specific areas of innovation, including medical imaging and diagnosis, developments in biomedical sensors, and drug delivery systems. Wearable biosensors, non-wearable biosensors, and biochips, which include gene chips, protein chips, and cell chips, are all included in the scope of the topic that pertains to biomedical sensors. Extensive research is conducted on drug delivery systems, spanning topics such as the integration of computer modelin

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… Gold nanoparticles (AuNPs) contribute to biosensing by facilitating the detection of various antibiotics through calorimetry, including amoxicillin, chloramphenicol, kanamycin, tetracycline, oxytetracycline, and streptomycin [ 66 ]. …

TB AND OTHER CHEST INFECTIONS

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