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Оценка стабильности урожая генотипов пшеницы пальца методом анализа AMMI и GGE биоплота в различных условиях среды.

Производительность пшеницы пальца сильно зависит от взаимодействия генотипа × среды (GEI), что усложняет идентификацию высокопродуктивных и стабильных генотипов. В данном исследовании оценены 35 генетически разнообразных генотипов пшеницы пальца в трех агро-эко-зоне: Одиша (E1), ДжхаркHAND (E2) и Бихар (E3) в течение двух рахи сезонов (2023-24 и 2024-25). Использовался блочный дизайн с тремя повторами, и были зафиксированы ключевые количественные признаки, такие как урожайность на растение, вес 1000 зерен и количество пальцев на основной узле. Применены анализы AMMI и GGE биоплотов для оценки

New players in the landscape of renal cell carcinoma bone metastasis and therapeutic opportunities.

Approximately one-third of advanced renal cell carcinoma (RCC) patients develop osteolytic bone metastases, leading to skeletal complications. In this review, we first provide a comprehensive perspective of seminal studies on bone metastasis of RCC describing the main molecular modulators and growth factor signaling pathways most important for the RCC-stimulated osteoclast-mediated bone destruction. We next focus on newer developments revealing with in-depth details, the bidirectional interplay between renal cancer cells and the immune and stromal microenvironment that can through epigenetic r

"It's very important that you measure throughout that journey…": patient perspectives towards quality-of-life data collection following haematopoietic cell transplant.

BackgroundThere is increasing interest in using Patient Reported Outcome Measures (PROMs) to provide evidence of how a haematopoietic stem cell transplant (HCT) affects blood cancer patients' long-term quality-of-life (QoL). The purpose of this qualitative study was to explore patients' opinions on what QoL data should be collected post-transplant, when this data should be collected, the use of this data beyond research, and how this data should be captured.MethodsTwenty-one HCT patients with median age of 45 years (range: 26-71 years) took part in a semi-structured interview. Two commonly use

Мы игнорируем сексуальные различия в гематологии? Призыв к совершенствованию отчетности.

Существуют явные различия по признаку пола в частотности, факторах риска и смертности от большинства гематологов (ГМ). Несмотря на известные различия в физиологии, гематопоисеях, молекулярных профилях, фармакокинетике наркотиков, токсичности, связанной с лечением, и опыте лечения, мужчины и женщины получают стандартизованное и одинаковое лечение большинства ТМ. Предыдущая опубликованная работа продемонстрировала различия в представленности женщин в клинических испытаниях на рак и выявила недостаток информации о результатах дифференцированного лечения и токсичности в разбивке по полу. Мы проана

Kidney Disease and Hematopoietic Stem Cell Transplantation.

Hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for patients with hematologic malignancies and certain solid tumors and nonmalignant hematologic conditions. Both AKI and CKD occur commonly after HSCT and are associated with significant morbidity and mortality. AKI and CKD in this setting may result from direct effects of the transplant or be caused by pretransplant bone marrow conditioning regimens and/or nephrotoxic agents administered in the post-transplant period. In this article, we review the epidemiology, risk factors, etiologies, pathophysiology, diagnos

Systemic mastocytosis: current status and challenges in 2024.

AbstractSystemic mastocytosis (SM) is a rare disease and has had significant discoveries in its biology, prognostication, and management in the past 2 decades. The latest update of the World Health Organization classification and the new International Consensus Classification are current standards in the diagnosis and prognostication of SM. In clinical practice, SM can be divided into 2 main categories: nonadvanced SM (nonAdvSM) and advanced SM (AdvSM). The integration of clinical signs and symptoms as well as bone marrow morphologic, immunophenotypic, and molecular results is required to diag

UFMTrack, "Недоходный миграционный трекер", позволяющий проанализировать весь многоэтапный каскад экстравазии иммунных клеток через барьер кровеносного мозга в микрофлюидовых устройствах.

Эндотелиальный барьер кровеносного мозга (БДБ) строго контролирует оборот иммунных клеток в центральную нервную систему (КНС). В таких нейро-воспалительных заболеваниях, как множественный склероз, этот жесткий контроль, однако, нарушается, что приводит к инфильтрации иммунных клеток в CNS. Разработка моделей BBB in vitro в сочетании с микрофлюидовыми устройствами способствовала более глубокому пониманию клеточных и молекулярных механизмов посредничества многоэтапной экстравазии Т-клеток по всему BBB. Одним из основных узких мест в этих исследованиях in vitro является отсутствие надежного и авт

Обоснование 4-month, параллельные, выборочно контролируемые испытания для оценки осуществимости и эффективности дистанционного обучения испаноязычных/латиноязычных лиц с множественным склерозом (FERLA MS).

ИСТОРИЯ ВОПРОСА: Испаноязычные/латиноязычные лица с множественным склерозом (МС) сталкиваются с бóльшим бременем болезней и коморбидностью из-за ограниченного доступа к медицинскому обслуживанию, недостаточной представленности в научных исследованиях и социальных факторов, определяющих состояние здоровья (SDOH). Профессиональная подготовка могла бы способствовать достижению результатов в области здравоохранения, однако в существующих исследованиях, посвященных мерам вмешательства, не представлены испаноязычные/латиноязычные страны. МЕТОДЫ: Мы предлагаем провести технико-экономическое обоснован

Структура и состав микробных сообществ в водной толще Южного залива Мексики и обнаружение предполагаемых микроорганизмов, деградирующих углеводороды.

В ходе этого исследования была проведена оценка сообщества бактериопланктонов и его связи с экологическими переменными, включая общую концентрацию нефтяных углеводородов (ТПГ), в районе шельфа Юкатан в Южном заливе Мексики. Анализ разнообразия бета на основе последовательности 16S rRNA показал различия в структуре общины бактериопланктона между участками отбора проб. ПЕРМАНОВА указала, что эти изменения могут быть связаны главным образом с глубокими изменениями (см.5 в адрес 180 m), концентрация растворенного кислорода (2.06 в адрес 5.93 мг L-1), и концентрация хлорофилла (0.184 в адрес 7.65 м

Biopsy Techniques for Musculoskeletal Tumors: Basic Principles and Specialized Techniques.

Biopsy is a pivotal component in the diagnostic process of bone and soft tissue tumors. The objective is to obtain adequate tissue without compromising local tumor dissemination and the patient's survival. This review explores contemporary principles and practices in musculoskeletal biopsies, emphasizing the critical role of diagnostic accuracy while also delving into the evolving landscape of liquid biopsies as a promising alternative in the field. A thorough literature search was done in PubMed and Google Scholar as well as in physical books in libraries to summarize the available biopsy tec

Gene and cell therapy of human genetic diseases: Recent advances and future directions.

Disruptions in normal development and the emergence of health conditions often result from the malfunction of vital genes in the human body. Decades of scientific research have focused on techniques to modify or substitute defective genes with healthy alternatives, marking a new era in disease treatment, prevention and cure. Recent strides in science and technology have reshaped our understanding of disorders, medication development and treatment recommendations, with human gene and cell therapy at the forefront of this transformative shift. Its primary objective is the modification of genes o

Multi-ancestry genome-wide association study of cannabis use disorder yields insight into disease biology and public health implications.

As recreational use of cannabis is being decriminalized in many places and medical use widely sanctioned, there are growing concerns about increases in cannabis use disorder (CanUD), which is associated with numerous medical comorbidities. Here we performed a genome-wide association study of CanUD in the Million Veteran Program (MVP), followed by meta-analysis in 1,054,365 individuals (ncases = 64,314) from four broad ancestries designated by the reference panel used for assignment (European n = 886,025, African n = 123,208, admixed American n = 38,289 and East Asian n = 6,843). Population-spe

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… Considering the gradually increasing permissiveness surrounding its use, understanding various sources of risk that influence CanUD is both necessary and timely. …

Immunotherapeutic approaches for systemic lupus erythematosus: early overview and future potential.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Current SLE therapies include immunosuppressants, antimalarial drugs, non-steroidal anti-inflammatory drugs (NSAIDs), and corticosteroids, but these treatments can cause substantial toxicities to organs and may not be effective for all patients. In recent years, significant progress has been made in the treatment of SLE using immunotherapy, including Benlysta and Saphnelo. These advances in immunotherapy hold promise for SLE patients, providing new therapeutic options that may offer better clinical benefit and effectiveness. S

Chemotherapy-Associated Thrombotic Microangiopathy.

Thrombotic microangiopathy (TMA) is a syndrome of microangiopathic hemolytic anemia and thrombocytopenia with end-organ dysfunction. Although the advent of plasma exchange, immunosuppression, and complement inhibition has improved morbidity and mortality for primary TMAs, the management of secondary TMAs, particularly drug-induced TMA, remains less clear. TMA related to cancer drugs disrupts the antineoplastic treatment course, increasing the risk of cancer progression. Chemotherapeutic agents such as mitomycin-C, gemcitabine, and platinum-based drugs as well as targeted therapies such as anti

Molecular imaging in oncology: Common PET/CT radiopharmaceuticals and applications.

PET/CT is a commonly used modality in cancer imaging, as it can help in diagnosis, staging and assessment of treatment response in many cancer types. A better understanding of the tumor microenvironment and identification of multiple selective targets are promoting further investigation into different radiotracers for diagnosis and therapy. In the past few decades many radiopharmaceuticals have emerged for specific oncologic indications providing superior detection rate than some morphologic modalities. The purpose of this review is to provide an update on the most current radiopharmaceuticals

Judicialization of health: profile of demands for oncological medicines in a state in the central region of Brazil.

BACKGROUND: The significant increase in access to oncological medicines through court cases suggests that constitutional guarantees of integral and universal care in the Brazilian public health system are uncertain. METHODS: A retrospective observational study was conducted to analyze data from lawsuits requesting oncological medicines from 2014 to 2020 in the State of Goiás, Brazil, in state and federal courts. Sociodemographic, medical, and legal variables were statistically examined using descriptive, association, and correlation methods. RESULTS: Women brought more than half (54%) of the

Системный склероз-ассоциированная легочная гипертензия: спектр и воздействие

Систематическая склерозная гипертония легких (SSc-PAH) является катастрофическим осложнением one из наиболее распространенных и разрушительных аутоиммунных заболеваний. После диагностирования он становится главной причиной смертности среди этой пациентки. Различные организации и общества разработали и подтвердили методы обследования и оценки рисков, с тем чтобы выявить пациентов на раннем этапе их курса лечения и незамедлительно направить их в экспертные центры для гемодинамической оценки и официальной диагностики. Кроме того, в настоящее время в ряде крупных многоцентровых клинических испытан

Hematological Diseases and Osteoporosis.

Secondary osteoporosis is a common clinical problem faced by bone specialists, with a higher frequency in men than in women. One of several causes of secondary osteoporosis is hematological disease. There are numerous hematological diseases that can have a deleterious impact on bone health. In the literature, there is an abundance of evidence of bone involvement in patients affected by multiple myeloma, systemic mastocytosis, thalassemia, and hemophilia; some skeletal disorders are also reported in sickle cell disease. Recently, monoclonal gammopathy of undetermined significance appears to inc

Development and Applications of Prognostic Risk Models in the Management of Invasive Mold Disease.

Prognostic models or risk scores are frequently used to aid individualize risk assessment for diseases with multiple, complex risk factors and diagnostic challenges. However, relatively little attention has been paid to the development of risk models for invasive mold diseases encountered in patients with hematological malignancies, despite a large body of epidemiological research. Herein we review recent studies that have described the development of prognostic models for mold disease, summarize our experience with the development and clinical use of one such model (BOSCORE), and discuss the

PD-1 Pathway Inhibitors: Immuno-Oncology Agents for Restoring Antitumor Immune Responses.

Immune checkpoint inhibitors are designed to restore a patient's own antitumor immune response that has been suppressed during tumor development. The first monoclonal antibodies against the immune checkpoint programmed death 1 (PD-1) receptor, nivolumab and pembrolizumab, are now approved for clinical use. Both agents are indicated for the treatment of advanced melanoma, as well as for the treatment of metastatic non-small cell lung cancer (NSCLC). Nivolumab is also approved for the treatment of advanced renal cell carcinoma. In patients with melanoma, these agents result in objective response