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Use of azathioprine for graft-vs-host disease is the major risk for development of secondary malignancies after haematopoietic stem cell transplantation: a nationwide population-based study.

BackgroundAs more patients are treated by haematopoietic stem cell transplantation (HSCT), development of secondary malignancy (SM) becomes an increasingly common issue in long-term survivors.MethodsWe conducted a nationwide population-based study of the Taiwanese population to analyse patients who received HSCT between January 1997 and December 2010. Standardised incidence ratios (SIRs) were used to compare the risk of SM in HSCT patients and the general population. Multivariate analysis was performed to identify independent predictors of SM.ResultsPatients receiving HSCT had a significantly

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… The NHI has implemented an extremely strict verification process before issuing certification for treatment and requires pathological proof of malignancy or a clinical diagnosis based on laboratory and imaging evidence. …

To what degree is palliative care integrated in guidelines and pathways for adult cancer patients in Europe: a systematic literature review.

BackgroundPalliative Care (PC) aims to improve the quality of life for patients with cancer and their families and its benefits have been demonstrated by several studies. The objective of this systematic review is to assess the integration of PC in the content of guidelines/pathways of adult cancer patients in Europe.MethodsWe included studies of adult patients with cancer published from 01/01/1995 and 31/12/2013 in Europe in six languages. We searched nine electronic databases, hand-searched six journals and also performed citation tracking. Studies were ranked using Emanuel's Integrated Pall

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… Timely verification and certification of death. Practical and emotional bereavement support for carer or family. Immediate and ongoing, emotional, bereavement & spiritual support as appropriate to the needs and preferences of the carer/family. … according to the nature of the grief, with professionals trained to deal with these issues. | Methods, aims and outcomes of bereavement counselling are described in the guideline. | Consultation after death, differentiation between depression, normal and complicated grief. | Timely verification and certification …

Validation of the Medicare-Enhanced Laboratory and Demographics (MELD™) Dataset: A Comprehensive Psychometric, Epidemiologic, and Predictive-Utility Assessment of a 60-Million-Patient Real-World Evidence Resource.

BackgroundReal-world evidence studies increasingly rely on integrated data resources that combine Medicare fee-for-service claims with electronic medical records (EMRs), laboratory results, and patient-reported outcomes. The Medicare-Enhanced Laboratory and Demographics (MELD™) dataset, developed by Columbia Data Analytics, spans 2020 through 2024 and contains 60 million unique patients, roughly 1 billion visits, and more than 241 000 clinicians. Its data-quality properties must be characterized before regulatory-grade use.ObjectiveTo provide a preregistered, multidomain validation of MELD, qu

A prospective study of physical activity and cardiometabolic diseases in association with cancer risk.

BackgroundMost physical activity research focuses on general populations, and its cancer-preventive benefits in adults with cardiometabolic diseases remain poorly understood. This study investigated associations between non-occupational physical activity and cancer risk in adults with and without cardiometabolic diseases (cardiovascular disease and/or type 2 diabetes).MethodsWe conducted a meta-analysis of individual participant data of 598,890 men and women, aged 35-70 years at recruitment, across six European countries from the European Prospective Investigation into Cancer and Nutrition (EP

Ретроспективное когортное исследование по вопросу о смертности от щелочной фосфаты и СИС при множественной миеломе.

Алькалин фосфатаза имеет другое клиническое значение в миеломе, чем в других новообразованиях. Изменения уровней щелочного фосфатаза могут служить хорошим прогнозом для пациентов с множественным миэломой в отделении интенсивной терапии. Однако данных о взаимосвязи между щелочной фосфатазой и смертностью у пациентов с множественной миеломой в СИС не имеется. Было проведено ретроспективное когортное исследование с участием 161 Участники получили доступ к базе данных " Medical Information Mart for Inтенциальный уход " ( " Медицинская информация для интенсивной терапии " ). Коэ

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… Access to the database was granted to certified researchers 17 (Qian-hui Wang’s certification number is 52,968,321), and ethical approval was waived due to the anonymized nature of the data 18 . Patients who meet the criteria are screened in the MIMIC-IV database. …

Incidence and survival of lymphoid neoplasms in Spain, 2002-2013: A population-based study from the Spanish Network of Cancer Registries (REDECAN).

IntroductionThe aim of this study was to describe incidence, incidence trends and survival patterns of lymphoid neoplasms (LNs) and its subtypes in Spain in the period 2002-2013 using data from the Spanish Network of Cancer Registries (REDECAN).Materials and methodsData were extracted from 13 Spanish population-based cancer registries. LNs incident cases were codified using the International Classification of Diseases for Oncology, third edition (ICD-O-3) and grouped according to the WHO 2008 classification. Age-standardized incidence rates to the 2013 European standard population (ASIRe) were

Australian Utility Weights for the EORTC QLU-C10D, a Multi-Attribute Utility Instrument Derived from the Cancer-Specific Quality of Life Questionnaire, EORTC QLQ-C30.

BackgroundThe EORTC QLU-C10D is a new multi-attribute utility instrument derived from the widely used cancer-specific quality-of-life (QOL) questionnaire, EORTC QLQ-C30. The QLU-C10D contains ten dimensions (Physical, Role, Social and Emotional Functioning; Pain, Fatigue, Sleep, Appetite, Nausea, Bowel Problems), each with four levels. To be used in cost-utility analysis, country-specific valuation sets are required.ObjectiveThe aim of this study was to provide Australian utility weights for the QLU-C10D.MethodsAn Australian online panel was quota-sampled to ensure population representativenes

Use of Complementary Traditional Chinese Medicines by Adult Cancer Patients in Taiwan: A Nationwide Population-Based Study.

BACKGROUND: Many patients with cancer seek complementary and alternative medicine treatments. We investigated the use of traditional Chinese medicine (TCM) by adult cancer patients in Taiwan. METHODS: We reviewed the Registry for Catastrophic Illness Patients Database of Taiwan, and included all adult patients diagnosed cancer, based on the International Classification of Diseases (ninth revision), from 2001 to 2009 and followed until 2011. This database allowed categorization of patients as TCM users (n = 74 620) or non-TCM users (n = 508 179). All demographic and clinical claims data were a

Hypercalcaemia and hypocalcaemia: finding the balance.

Calcium metabolism in cancer and hypercalcaemia of malignancyThe balance between bone formation and resorption may be disrupted in patients with cancer, leading either to increased bone resorption, calcium release, and possibly hypercalcaemia, or to increased bone formation, sequestration of calcium, and possibly hypocalcaemia. In adults, hypercalcaemia of malignancy is most common in patients with tumours that produce factors that induce osteoclast activation and enhance bone resorption. Impaired renal function and increased renal tubular calcium resorption may further affect calcium levels.T

Diagnostic Trends and Geographic Health Care Disparities Among Patients With Transthyretin Amyloid Cardiomyopathy.

BACKGROUND: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a rare, life-threatening form of restrictive cardiomyopathy. Access to cardiology providers and specialized amyloid centers may impact ATTR-CM diagnosis. We sought to elucidate diagnostic disparities of ATTR-CM through assessment of diagnostic trends and the geographic distribution of amyloid centers and cardiology providers in the United States. METHODS: This was a cross-sectional geospatial analysis of amyloid centers and cardiology providers and a retrospective cohort analysis of patients with ATTR-CM from the Komodo Healthcare

The Effect of Laughter Yoga on Chemotherapy-Induced Symptoms and Sleep Quality in Patients with Haematologic Cancer.

There are international studies that examine the effects of laughter yoga on the symptoms and quality of life of cancer patients as a complementary therapeutic method.AimThis study aims to examine the effect of laughter yoga on chemotherapy-induced symptoms and sleep quality in patients with haematologic cancer.Materials and methodsThis study was conducted as a randomised controlled trial with two parallel treatment arms. The study was between November 2020 and December 2021. The sample was calculated with 60 patients including in the study. A total of 4 sessions of laughter yoga were applied

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… In this context, it is recommended that nurses attend certification programs on complementary practices. Courses on the subject can be added to the curriculum of undergraduate education programs. It may be recommended that future studies be conducted with a larger sample group. …

The efficacy of lavender oil on fatigue and sleep quality in patients with hematological malignancy receiving chemotherapy: a single-blind randomized controlled trial.

PurposeThe aim of this study is to evaluate how aromatherapy with the inhalation of lavender oil affects fatigue and sleep quality in patients with hematological malignancies undergoing chemotherapy.MethodsThis randomized, parallel-group study was carried out in the Adult Bone Marrow Transplant unit and Hematology-Oncology clinics between January 2022 and April 2023. A total of 120 patients were assigned to experimental and control groups by randomization. The study was completed with 100 patients including 50 in the experimental group and 50 in the control group. Lavender essential oil was ap

Сопоставление эффективности различных вакцин у людей с аутоиммунными заболеваниями и без них: протокол исследования для пробной эмуляции цели.

АИМ: Эта статья представляет собой протокол исследования ретроспективного когортного исследования, предназначенного для сопоставления эффективности герпеса-зостера и вакцин против гриппа у лиц с множественным склерозом (МС), хроническими воспалительными кишечными заболеваниями (ИБД) или хроническими воспалительными ревматическими заболеваниями (КВРД) с лицами, не имеющими этих заболеваний, с использованием данных, касающихся одной из крупнейших систем медицинского страхования населения Германии. КОЛИЧЕСТВО: Лица, страдающие аутоиммунными заболеваниями, такими, как MS, IBD и CIRD, в большей сте

Cancer burden across the South Asian Association for Regional Cooperation in 2022.

ObjectiveThe objective of this study is to present a cross-sectional analysis of cancer burden in the South Asian Association for Regional Cooperation (SAARC) region and explain unique characteristics of its cancer burden as compared with the rest of the world.Methods and analysisUsing publicly available data from the Global Cancer Observatory (GCO) and the World Bank, we collected cancer statistics and population statistics for Afghanistan, Bangladesh, Bhutan, India, the Maldives, Nepal, Pakistan, and Sri Lanka from 2017 to 2022.ResultsThe number of newly diagnosed cases in the region was 1 8

Survival in hematological malignancies in the Nordic countries through a half century with correlation to treatment.

Studies of survival in hematological malignancies (HMs) have generally shown an improvement over time, although most of these studies are limited by a short follow-up period. Using the NORDCAN database with data from Denmark, Finland, Norway and Sweden, we follow periodic increases in relative survival in seven HMs through half a century up to 2015-2019. Five-year survival improved in all seven HMs, reaching 90% for Hodgkin lymphoma (HL), myeloproliferative neoplasias and chronic lymphocytic leukemia (CLL), 60% for multiple myeloma (MM) and chronic myeloid leukemias (CMLs), 50% for the myelody

Associations of Education Level With Survival Outcomes and Treatment Receipt in Patients With Gastric Adenocarcinoma.

BackgroundIt remains largely unclear how education level, an important socioeconomic factor, affects prognoses for patients with gastric adenocarcinoma (GAC). We aimed to demonstrate the associations between education level and clinical outcomes in patients with GAC.MethodsWe included a total of 30,409 patients diagnosed with GAC from the Surveillance, Epidemiology, and End Results 18 registry database. Education level, household income, unemployment rate, poverty rate, insurance status, and marital status were selected as sociodemographic variables for the comprehensive analysis. Cox and logi

Symptom Prevalence in Spanish and Colombian Oncology Patients Measured with the MSAS.

Cancer patients experience several symptoms throughout their illness and the treatments they receive. While this pathology represents a worldwide health problem, knowing the symptom prevalence in oncology patients remains a challenge; validated tools to obtain this information are essential. Furthermore, this prevalence information would help health professionals to establish appropriate treatments. The objective of this study was to ascertain the symptom prevalence in cancer patients from Spain and Colombia to improve future approaches. The frequency, severity, and distress of 32 symptoms fro

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… Quality of death certification in Colombia. Colomb. Med. 2018;49:121–127. doi: 10.25100/cm.v49i1.3155. 38. Pardo C., de Vries E. Breast and cervical cancer survival in Instituto Nacional de Cancerología, Colombia. Colomb. Med. 2018;49:102–108. doi: 10.25100/cm.v49i1.2840. 39. Bravo L.E., Muñoz N. …

Patient Perceived Financial Burden in Haematological Malignancies: A Systematic Review.

UNLABELLED: Advances in scientific understanding have led to novel therapies and improved supportive care for many patients with haematological malignancies. However, these new drugs are often costly, only available at centralised health care facilities, require regular specialist reviews and lengthy treatment regimens. This leads to a significant financial burden. Understanding the impact of financial burden on haematological patients is important to appreciate the urgency of alleviating this systemic issue. METHOD: Eligible studies were identified by systematically searching Medline, PsycIN

Efficacy and safety of modified Bushen Yiqi formulas (MBYF) as an add-on to formoterol and budesonide in the management of COPD: study protocol for a multicentre, double-blind, placebo-controlled, parallel-group, randomized clinical trial: FB-MBYF Trial.

BackgroundInhaled glucocorticoid corticosteroid (ICS), long-acting β2-adrenoceptor agonist (LABA), and other drugs have limited therapeutic effects on COPD with significant individual differences. Traditional Chinese medicine (TCM)-modified Bushen Yiqi formula (MBYF) demonstrates advantages in COPD management in China. This study aims to evaluate the efficacy and safety of MBYF as an add-on to budesonide/formoterol in COPD patients and confirm the related genes affecting the therapeutic effect in the treatment of COPD.MethodsIn this multicentre, randomised, double-blind, placebo-controlled, pa

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… Granule production was certified to the standard certification of the National medical Products Administration in China ( https://www.nmpa.gov.cn/directory/web/nmpa/xxgk/ggtg/qtggtg/20210210145453181.html ). …

Clinical Posters From JADPRO Live 2025

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… The structure and curriculum for a twelve-month fellowship was developed using current literature and Advanced Practice Provider Fellowship Accreditation (APPFA) guidelines for certification. This structure included classroom and self-guided didactic experiences aligned with 11 clinical rotations. … All Advanced Practice Providers (APPs) were required to maintain ACLS certification as of September 2020. Internal ACLS courses were implemented starting in June 2021, with crash carts being placed at each clinic site as of April 2022. …