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Editorial: Towards continued and affordable accessibility of innovative drugs: sustainable development and efficient use of medicines.

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… In the absence of such guidance, oncologists should aim to prescribe just enough medication for patients to use at home, minimising the risk of wasting unused surplus when therapy changes are necessary ( Dane et al. ) while being mindful not to increase the burden of care for patients. 4 Combination …

Profile of Malignant Spinal Cord Compression: One Year Study at Regional Cancer Center.

BACKGROUND AND OBJECTIVES: Malignant spinal cord compression is an oncologic emergency, unless diagnosed early and treated appropriately, can lead to permanent neurological impairment and compromised quality of life of patients. We analyzed the epidemiology and the effect of common interventions on the outcome in these patients. PATIENTS AND METHODS: We conducted a prospective study of 77 patients in the year 2014 and recorded relevant patient and disease characteristics. All patients received corticosteroids. Eight patients were operated upon, and radiotherapy was delivered in 62 patients.

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… All patients were assessed jointly by oncologists and neurosurgeons in the hospital for feasibility of surgery for rapid decompression. …

Mixed-Methods to Define Meaningful Change using Exit Interviewand Clinical Trial Data in Patients with Tenosynovial Giant Cell Tumor (TGCT).

BACKGROUND: Tenosynovial giant cell tumor (TGCT) is a locally aggressive neoplasm associated with limited range of motion (ROM), stiffness, joint damage, pain, and reduced physical functioning (PF). The MOTION Phase 3 trial (NCT05059262) was a randomized, placebo-controlled, double-blind study of vimseltinib among patients with TGCT. The objective of the current study was to define meaningful changes in clinical outcome assessments (COAs) measuring active ROM, PF, and stiffness using qualitative and quantitative data from patients in the MOTION trial. METHODS: Embedded exit interviews with pa

Мы игнорируем сексуальные различия в гематологии? Призыв к совершенствованию отчетности.

Существуют явные различия по признаку пола в частотности, факторах риска и смертности от большинства гематологов (ГМ). Несмотря на известные различия в физиологии, гематопоисеях, молекулярных профилях, фармакокинетике наркотиков, токсичности, связанной с лечением, и опыте лечения, мужчины и женщины получают стандартизованное и одинаковое лечение большинства ТМ. Предыдущая опубликованная работа продемонстрировала различия в представленности женщин в клинических испытаниях на рак и выявила недостаток информации о результатах дифференцированного лечения и токсичности в разбивке по полу. Мы проана

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… Attitudes toward and use of cancer management guidelines in a national sample of medical oncologists and surgeons. J Natl Compr Cancer Netw. 2014;12(2):204–212. 11. IARC . Cancer today. [Internet]. [cited 2024 Dec 13]. Available from: https://gco.iarc.fr/today/en/dataviz/bars‐compare‐populations? … Oncologist. 2021;26(9):779–786. 72. Khaliq A, Wesson W, Logan E, Tabak C, Mushtaq MU, Lin T, et al. The Glass Wall: gendered authorship disparities in CD 19 and BCMA CAR‐T clinical trials for lymphoma and myeloma. Clin Lymphoma Myeloma Leuk. 2024;24(10):e344–e349. 73. …

Comprehensive Review of Prevention and Management Strategies for Medication-related Osteonecrosis of the Jaw (MRONJ).

PURPOSE: To assess and classify the strategies employed in various dental specialities for the prevention and management of medication-related osteonecrosis of the jaw (MRONJ). MATERIALS AND METHODS: A comprehensive literature review was conducted, acquiring studies sourced from Google Scholar and PubMed. The emphasis was on studies published in recent years, focusing on successful MRONJ prevention techniques across various dental specialties. RESULTS: Four types of prevention were identified. Primary prevention strategies include optimizing oral hygiene, managing dental caries, and extracti

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… , and reduced quality of life. 46 , 50 However, while these therapies are effective in controlling skeletal-related events, they may carry the risk of severe adverse effects, such as unusual femur fractures and osteonecrosis of the jaw. 72 Hence, due to the increasing prevalence of MRONJ, dentists, oncologists … Multidisciplinary Approach A comprehensive approach involving dentists, primary care physicians, oncologists, oral and maxillofacial surgeons, and nurses is crucial for managing MRONJ effectively and improving patient symptoms and quality of life. 7 , 22 , 53 This approach ensures continuous monitoring …

ЦАРТ клетки в качестве новой терапевтической стратегии для множественных склерозов и других нейроиммунных расстройств.

В качестве трансформационного подхода к лечению множественных склерозов (MS) и других нейроиммунных расстройств, таких, как расстройства спектра нейромиелита (NMOSD), миелин олигодендроцита гликпротеина, связанных с антителами (MOGAD), и миастения гравис (MG), наряду с рядом других редких нейроиммунологических заболеваний, которые в настоящее время оцениваются в исследованиях, посвященных сочувствию или ранней фазе. Отчасти эти условия обусловлены автоматически реактивными клетками B, вызывающими хроническое воспаление и прогрессивное повреждение тканей. Несмотря на то, что нынешняя иммунодуля

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… Chimeric antigen receptor T-Cell therapy for the community oncologist. Oncologist. 2016;21(5):608–17. 39. Dotti G, Gottschalk S, Savoldo B, Brenner MK. Design and development of therapies using chimeric antigen receptor-expressing T cells. Immunol Rev. 2014;257(1):107–26. 40. … CAR T-cell therapy: A collaboration between authorized treatment centers and community oncologists. Semin Oncol. 2024;51(3–4):87–94. 119. Qin C, Zhang M, Mou DP, Zhou LQ, Dong MH, Huang L, et al. …

All-cause and immune checkpoint inhibitor-associated acute kidney injury in immune checkpoint inhibitor users: a meta-analysis of occurrence rate, risk factors and mortality.

BackgroundImmune checkpoint inhibitors (ICIs) have been associated with acute kidney injury (AKI). However, the occurrence rate of ICI-related AKI has not been systematically examined. Additionally, exposure to proton pump inhibitors (PPIs) and non-steroidal anti-inflammatory drugs (NSAIDs) were considered as risk factors for AKI, but with inconclusive results in ICI-related AKI. Our aim was to analyse the occurrence rate of all-cause AKI and ICI-related AKI and the occurrence rates of severe AKI and dialysis-requiring AKI, and to determine whether exposure to PPIs and NSAIDs poses a risk for

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… Renal irAEs have become a topic of interest among nephrologists and oncologists due to the growing prescription of ICIs in recent years [ 3 , 4 ]. … For ICI-related AKI, 14 of 29 relevant studies were determined by nephrologists or oncologists ( Supplementary Tables S3 and S4 ). …

The Effects of Patient-Centered Communication on Patient Engagement, Health-Related Quality of Life, Service Quality Perception and Patient Satisfaction in Patients with Cancer: A Cross-Sectional Study in Türkiye.

IntroductionPatient-centered communication is a type of communication that takes place between the provider and the patient.ObjectivesIt is aimed to reveal the effects of patient-centered communication on patient engagement, health-related quality of life, perception of service quality and patient satisfaction.MethodThe study was conducted by applying multiple regression analysis to the data obtained from 312 patients with cancer treated in a training and research hospital affiliated to the Ministry of Health in Diyarbakır, Türkiye.ResultsMore than half of the patients were female and had stag

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… communication was found to significantly affect patient satisfaction with care. 94 According to the results of a meta-analysis study examining the impact of patients with cancer’ level of communication with oncologists on patient outcomes and satisfaction, patient-centered communication was found to … Oncologists’ communication about uncertain ınformation in second opinion consultations: a focused qualitative analysis . Front Psychol . 2021 ; 12 : 635422 . 34135806 10.3389/fpsyg.2021.635422 PMC8201772 89 Agha Z Schapira RM Laud PW McNutt G Roter DL . …

Cardiovascular toxicities associated with novel cellular immune therapies.

AbstractOver the past decade, T-cell-directed therapies, including chimeric antigen receptor T-cell (CAR-T) and bispecific T-cell engager (BTE) therapies, have reshaped the treatment of an expanding number of hematologic malignancies, whereas tumor-infiltrating lymphocytes, a recently approved cellular therapy, targets solid tumor malignancies. Emerging data suggest that these therapies may be associated with a high incidence of serious cardiovascular toxicities, including atrial fibrillation, heart failure, ventricular arrhythmias, and other cardiovascular toxicities. The development of these

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… Multidisciplinary collaboration between cardiologists and oncologists and the strengthening of pharmacovigilance reporting are essential to fully evaluate cardiovascular outcomes. … Multidisciplinary strategies inclusive of cardio-oncologic assessments and shared decision-making with patients, cardiologists, and oncologists are needed to facilitate increased applications of these impactful therapies. …

Drug Repurposing in Oncology: A Systematic Review of Randomized Controlled Clinical Trials.

Quality pharmacological treatment can improve survival in many types of cancer. Drug repurposing offers advantages in comparison with traditional drug development procedures, reducing time and risk. This systematic review identified the most recent randomized controlled clinical trials that focus on drug repurposing in oncology. We found that only a few clinical trials were placebo-controlled or standard-of-care-alone-controlled. Metformin has been studied for potential use in various types of cancer, including prostate, lung, and pancreatic cancer. Other studies assessed the possible use of t

Management of patients with multiple myeloma beyond the clinical-trial setting: understanding the balance between efficacy, safety and tolerability, and quality of life.

Treatment options in multiple myeloma (MM) are increasing with the introduction of complex multi-novel-agent-based regimens investigated in randomized clinical trials. However, application in the real-world setting, including feasibility of and adherence to these regimens, may be limited due to varying patient-, treatment-, and disease-related factors. Furthermore, approximately 40% of real-world MM patients do not meet the criteria for phase 3 studies on which approvals are based, resulting in a lack of representative phase 3 data for these patients. Therefore, treatment decisions must be tai

Lifestyle Factors in Cancer Survivorship: Where We Are and Where We Are Headed.

Advances in early detection and curative therapies have led to an increased number of cancer survivors over the last twenty years. With this population comes the need to evaluate the late and long term effects of cancer treatment and develop recommendations about how to optimally care for these survivors. Lifestyle factors (diet, body weight, physical activity, and smoking) have been linked to a higher risk of many medical comorbidities (cardiovascular, metabolic, etc.). There is increasing evidence linking these factors to the risk of developing cancer and likely cancer-related outcomes. This

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… Results from our own work suggest that despite educating oncologists on the importance of healthy diet for survivors, only 14% of colorectal cancer and 22% of lung cancer survivors had documentation of healthy diet counseling from their providers. … Oncologists’ opinions towards recommending exercise to patients with cancer: A Canadian national survey Support Care Cancer 2005 13 929 937 10.1007/s00520-005-0805-8 15809835 112. Peeters C. Stewart A. Segal R. Wouterloot E. Scott C.G. Aubry T. …

Financial Toxicity of Hematologic Malignancy Therapies, Including Cellular Therapy and Its Impact on Access to Care: Prospective Pilot Study.

BackgroundPatients with cancer often face significant financial challenges, known as financial toxicity (FT), which is associated with reduced quality of life. Patients with hematologic malignancies (HMs) are especially vulnerable due to intensive and prolonged treatments, frequent hospital visits, and a high risk of complications. While FT affects many in the general population, it is particularly severe among racial and ethnic minorities, especially those below the poverty line. To our knowledge, no studies have specifically examined FT in this vulnerable group in the United States.Objective

Advancing access to CAR T-cell therapy: insights and real-world experience from a community oncology practice.

IntroductionChimeric antigen receptor (CAR) T-cell therapy has transformed the treatment of hematologic malignancies, offering durable remissions for patients with otherwise refractory disease. However, access to these therapies remains limited and primarily restricted to academic medical centers, contributing to significant geographic and demographic disparities in care delivery.MethodsWe conducted a retrospective review of a community practice-based outpatient CAR T-cell therapy program, independent of academic or hospital affiliation, treating patients with relapsed hematologic malignancies

Pentoxifylline and Tocopherol for the Management of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Retrospective Clinical Audit.

Background/Objectives: Medication-related osteonecrosis of the jaw (MRONJ) is a challenging complication in patients receiving antiresorptive therapy. Management strategies range from conservative pharmacological approaches to extensive surgical resection of necrotic bone. This clinical audit retrospectively evaluated the clinical outcomes of patients undergoing sequestrectomy for MRONJ, comparing those treated with antibiotics alone with those receiving antibiotics in combination with the pentoxifylline-tocopherol (PENTO) protocol. The PENTO protocol was introduced at our institution in 2021

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… A multidisciplinary approach is essential, and collaboration between oncologists, rheumatologists, dentists, and oral and maxillofacial surgeons is essential for a comprehensive evaluation of the patient [ 11 ]. … systematically prescribed to all eligible patients, although it was adopted in most cases; its use was guided by clinical judgment and additional clinical criteria, the latter including the presence of active anticancer treatment, which required confirmation of protocol safety evaluation by the treating oncologist …

Posterior minimally invasive percutaneous short-segment fixation combined with mini-open anterior L5 corpectomy for metastatic tumor: a case report and literature review.

BACKGROUND: Metastatic tumors of the lumbar spine are a common complication of advanced malignancies. They often present with severe pain, neurological deficits, and spinal instability. Surgical removal of L5 vertebral body metastases is challenging due to the complex anatomy and biomechanical characteristics of the lumbosacral junction. Corpectomy using a combined approach is a common surgical strategy for achieving pain relief, adequate tumor resection, spinal cord and root decompression, and spinal stabilization. However, this approach may be associated with significant surgical trauma and

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… Date | Clinical event / Patient management 30.09.2025 | Outpatient visit of the patient for persistent lumbar pain. 12.10.2025 | MRI examination was performed. 30.10.2025 | CT examination was performed. 02.11.2025 | Multidisciplinary tumor board (neurosurgeons, oncologists, and radiologists): a consensus … Oncologist. (2016) 21(4):508–13. 10.1634/theoncologist.2015-0377 6. Guo Q, Zhang C, Guo X, Tao F, Xu Y, Feng G, et al. Incidence of bone metastasis and factors contributing to its development and prognosis in newly diagnosed renal cell carcinoma: a population-based study. …

The Role of Transcranial Magnetic Stimulation and Peripheral Magnetic Field Therapy in Chemotherapy-Induced Peripheral Neuropathy: A Narrative Review.

Chemotherapy-induced peripheral neuropathy (CIPN) impairs quality of life and may result in discontinuation of anti-neoplastic therapy. In older patients, CIPN is associated with reduced executive function, more severe pain, comorbidities and polypharmacy. The use of magnetic fields to modulate central and peripheral neurons may offer some benefit for relieving neuropathic pain, with few adverse effects. The evidence of the benefits of using transcranial magnetic stimulation (TMS) or peripheral magnetic stimulation (PMS) in patients with CIPN is evaluated in this narrative review. Improved pat

Influence of PSMB6 and PSMB9 Genetic Polymorphisms on Bortezomib-Based Therapy Response in Newly Diagnosed Multiple Myeloma.

BACKGROUND: Bortezomib (BTZ)-based regimens play a crucial role in the treatment of multiple myeloma (MM), significantly improving patient outcomes. BTZ, a proteasome inhibitor, interferes with cellular processes essential for cancer cell growth and survival, resulting in high response rates. Its use in initial and recurrent treatment strategies has been associated with extended disease control and improved long-term outcomes, contributing to overall survival. This study aimed to delineate the clinical characteristics of newly diagnosed MM patients and investigate the influence of single nucle

AI predictive modeling of survival outcomes for renal cancer patients undergoing targeted therapy.

Renal clear cell cancer (RCC) is a complex disease that is challenging to predict patient outcomes. Despite improvements with targeted therapy, personalized treatment planning is still needed. Artificial intelligence (AI) can help address this challenge by developing predictive models that accurately forecast patient survival periods. With AI-powered decision support, clinicians can provide patients with tailored treatment plans, enhancing treatment efficacy and quality of life. The study analyzed 267 patients with renal clear cell carcinoma, focusing on 26 who received targeted drug therapy.

Chordoma combined with Trousseau syndrome: a case report and literature review.

BackgroundTrousseau syndrome (TS) refers to spontaneous, recurrent, and wandering arterial and venous thromboembolic events in patients with tumors. It results from abnormalities in coagulation and fibrinolytic mechanisms of varying degrees throughout the course of the disease. It has a high fatality rate, and it is commonly seen in patients with highly invasive tumors, such as lung, pancreatic, gastrointestinal, and breast cancers; however, to date, there has been no report of TS combined with chordoma.Case descriptionA 56-year-old male with a diagnosis of chordoma underwent surgery, immunoth