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Preliminary results: Effect of whole-body cooling in patients with myasthenia gravis.

INTRODUCTION: Local muscle cooling has been shown to reduce symptoms in some neuromuscular diseases. PURPOSE: To determine whether lowering body temperature using a cooling vest would result in improvement in muscle strength, subjective perceptions of weakness and fatigue, and pulmonary function in patients with generalized myasthenia gravis (MG). METHODS: Patients (five female, one male) with generalized MG, aged 29-58 yr, were studied when mean body temperature was lowered (34.9 +/- 0.62 degrees C) using a cooling vest (CT) and at normal body temperature (35.8 +/- 0.58 degrees C) (NT). Iso…

Physiological mechanisms underlying enhanced performance with blood flow restriction training: neuromuscular, vascular and metabolic adaptations.

We investigated how blood flow restriction (BFR) training enhances performance and neuromuscular function during dynamic exercise through ad … k power output (Wmax) and constant workload trials at 90% pre-training Wmax to assess neuromuscular fatigue [maximal voluntary contraction (MVC) and evoked contractile force (QT)]. Blood flow responsiveness was evaluated using Doppler ultrasound during reactive hyperaemia (RH), passive leg movement (PLM) and rapid-onset vasodilatation (ROV). Mitochondrial …

Evaluating nurse-led self-regulation in multiple sclerosis management with an interactive web-based program: a randomized controlled trial.

This study aimed to evaluate the effect of the 'I Can Manage' an interactive web-based program that supports self-regulation under the leadership of nurses, application on self-management, fatigue and anxiety levels in individuals with Multiple Sclerosis (MS). This study is a parallel-group randomized controlled trial. Individuals with MS were randomly assigned to an intervention group (N = 38) and a control group (N = 38). The intervention group used 'I Can Manage' for eight weeks, while the control group did not receive any intervention. Data were collected using the Participant Identificati…

Correlates of depression and anxiety among family caregivers of pediatric patients with cancer in Lebanon.

BACKGROUND: Cancer diagnosis in the child is stressful for the family caregiver and could have a major impact on his/her mental health, including depression and anxiety, especially during the harsh current Lebanese economic crisis. This study aims at evaluating the correlates of depression and anxiety among family caregivers of pediatric cancer patients in Lebanon. METHODS: It is a cross-sectional study, using a convenience sample of 193 caregivers of pediatric patients with cancer. Depression, anxiety, and work fatigue were assessed using the Patient Health Questionnaire-9, Lebanese Anxiety …

Incidence and Factors Influencing Locomotive Syndrome in Cancer Patients Living in the Community.

Background Investigating locomotive syndrome (LS) of cancer survivors in the community will help clarify the importance of rehabilitation for cancer survivors in the community and provide a basis for exploring effective interventions. The primary purpose of this study was to conduct a comparison of LS, fatigue, psychological problems, and physical activity in cancer survivors and those without cancer in the community. The secondary purpose was to analyze factors influencing LS in cancer patients. Methods The study involved 59 cancer patients undergoing chemotherapy at home and 59 people withou…

Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis.

PurposeTo evaluate the effects of physical exercise on key clinical outcomes (such as quality of life (QoL), aerobic capacity, fatigue, and muscle strength) in patients undergoing haematopoietic stem cell transplantation.MethodsPRISMA systematic review and meta-analysis from inception to April 2025. PubMed, Embase, Cochrane Library, Web of Science and Scopus databases were searched for eligible studies. Methodological quality and risk of bias were evaluated with the Pedro scale and the Risk-Of-Bias Tool for randomized trials (ROB2.0) respectively.ResultsAn initial search retrieved 5217 article…

The Impact of Sleep on the Lives of Women Who Have Breast Cancer-Related Lymphedema: A Qualitative Exploration.

Background: Breast cancer survivors (BCSs) have many lifelong symptoms of anxiety, depression, lymphedema, and fatigue that can be exacerbated by sleep disturbance. However, little is known about unique factors contributing to sleep disturbance among BCSs with lymphedema; this requires further investigation to offer appropriate support and treatment to these individuals. Therefore, the objective of this study was to capture perceptions and experiences of lymphedema and sleep among BCSs with lymphedema. Methods and Results: Qualitative description guided data collection and analysis as part of …

Prospective multicentre study of experience in real-world clinical practice in monitoring reported outcome measures (PROMs) of patient with a diagnosis of psoriatic and/or spondyloarthritis and initiating treatment with secukinumab.

OBJECTIVE: To analyse the effect of secukinumab on self-reported variables of patients diagnosed with psoriatic arthritis and/or ankylosing spondylitis in relation to their health status, pain, fatigue, sleep and quality of life. METHODS: A six-month, observational, longitudinal, prospective, multicentre study was conducted with 39 patients who initiated treatment with secukinumab as therapy for psoriatic arthritis and/or spondylitis. The main variables were changes in patient-reported measures and they were evaluated by means of the questionnaires: FACIT-fatigue, Insomnia Severity Index, Eur…

Neuropsychological effects of long-term occupational exposure to mercury among chloralkali workers.

BACKGROUND: Mercury is one of the most well-known toxic metals for humans. Chloralkali workers are exposed to mercury vapours extensively, w … exposed group. All subjects were assessed using the Hamilton Depression Rating Scale, Piper Chronic Fatigue Scale and Essential Tremor Rating Scale. Mercury concentration was measured in blood and air samples using cold vapour atomic absorption spectrometry. RESULTS: There was significantly more severe fatigue, depression and tremor in the exposed group …

Prospective multicentre study of experience in real-world clinical practice in monitoring reported outcome measures (PROMs) of patient with a diagnosis of psoriatic and/or spondyloarthritis and initiating treatment with secukinumab.

OBJECTIVE: To analyse the effect of secukinumab on self-reported variables of patients diagnosed with psoriatic arthritis and/or ankylosing spondylitis in relation to their health status, pain, fatigue, sleep and quality of life. METHODS: A six-month, observational, longitudinal, prospective, multicentre study was conducted with 39 patients who initiated treatment with secukinumab as therapy for psoriatic arthritis and/or spondylitis. The main variables were changes in patient-reported measures and they were evaluated by means of the questionnaires: FACIT-fatigue, Insomnia Severity Index, Eur…

Carotid body tumors are not associated with an increased risk for sleep-disordered breathing.

PURPOSE: Tumors in the carotid bodies may interfere with their function as peripheral chemoreceptors. An altered control of ventilation may … oreflex drive was assessed using euoxic and hyperoxic CO2 rebreathing tests. Daytime sleepiness and fatigue were assessed with the Epworth Sleepiness Scale and the Multidimensional Fatigue Index. RESULTS: All patient groups reported significant fatigue-related complaints, but no differences in excessive daytime sleepiness (EDS) were found. The apnea/hypo …

Developmental changes in diaphragm muscle function in the preterm and postnatal lamb.

RATIONALE: The preterm diaphragm is structurally and functionally immature, potentially contributing to an increased risk of respiratory distress and failure. We investigated developmental changes in contractile function and susceptibility to fatigue of the costal diaphragm in the fetal lamb to understand factors contributing to the risk of developing diaphragm dysfunction and respiratory disorders. We hypothesized that the functional capacity of the diaphragm will vary with maturational stage as will its susceptibility to fatigue. METHODS: Lambs were studied at 75, 100, 125, 145, 154, 168, a…

Comorbidity of fibromyalgia with medical and psychiatric disorders.

PURPOSE: Patients with fibromyalgia have been reported to display high rates of several concomitant medical and psychiatric disorders, including migraine, irritable bowel syndrome, chronic fatigue syndrome, major depression, and panic disorder. To test further these and other possible associations, we assessed the personal and family histories of a broad range of medical and psychiatric disorders in patients with fibromyalgia. PATIENTS AND METHODS: Subjects were 33 women (mean age 42.1 years) who each met American College of Rheumatology criteria for fibromyalgia and presented to a rheumatolo…

Performance fatigability on a constant-load dynamic task is greater in females with moderate-severity Parkinson's disease than healthy-aging controls.

Parkinson's disease (PD) is a neurodegenerative disorder associated with self-reported fatigue. While fatigue is a disabling symptom, performance fatigability, a decline in strength or power during sustained tasks, remains poorly understood, particularly during isotonic (constant-load) contractions, which are encountered in everyday activities. We assessed performance fatigability and recovery in people with PD compared to healthy-aging controls. Fifteen females with PD and 14 healthy-aging controls underwent neuromuscular testing of knee extensors using dynamometry. Participants then performe…

Numerical Simulation of Thermal Cycling and Vibration Effects on Solder Layer Reliability in High-Power Diode Lasers for Space Applications.

High-power laser diodes (HPLDs) are increasingly used in space applications, yet solder layer (SL) reliability critically limits their perfo … values remained far below their yield strengths, indicating that only elastic strain and high-cycle fatigue occurred in the SLs. The calculated thermal fatigue lives of the two SLs were 2851 cycles and 5730 cycles, respectively. Their random vibration fatigue lives were determined as 5.75 × 107 h and 8.31 × 107 h. Using damage superposition under combined …

Повреждённая временная обработка в множестве склерозов.

Множественный склероз (MS) — хроническое аутоиммунное заболевание центральной нервной системы, которое повреждает серую и белую материю и снижает эффективность нейронной передачи. По данным исследований МРТ, ранние нейродегенерации в субкортических структурах, включая базальную ганглию (БГ), с микроструктурными повреждениями и изменчивой анизотропией тканей, о которых сообщается по всем подтипам MS, влияют на функциональную связь BG, а также связаны с усталостью. Учитывая центральную роль BG во временной обработке, мы предположили, что у людей с MS (PwMS) будет нарушено восприятие и двигательн

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that damages grey and white matter and reduces neural … py reported across all MS subtypes, affecting BG functional connectivity while also being linked to fatigue. Given the BG's central role in temporal processing, we hypothesized that people with MS (pwMS) would show impaired perceptual and motor timing. Twenty-two pwMS (14 females) with relapsing-remitting MS completed the Battery for the Assessment of Aud …

Driving Behaviour in Depression Based on Subjective Evaluation and Data from a Driving Simulator.

Road traffic collisions are a major issue for public health. Depression is characterized by mental, emotional and executive dysfunction, which may have an impact on driving behaviour. Patients with depression (N = 39) and healthy controls (N = 30) were asked to complete questionnaires and to drive on a driving simulator in different scenarios. Driving simulator data included speed, safety distance from the preceding vehicle and lateral position. Demographic and medical information, insomnia (Athens Insomnia Scale, AIS), sleepiness (Epworth Sleepiness Scale, ESS), fatigue (Fatigue Severity Scal…

Evaluating the perspectives of those with severe physical impairments while learning BCI control of a commercial augmentative and alternative communication paradigm.

Augmentative and alternative communication (AAC) techniques can provide access to communication for individuals with severe physical impairm … training session to evaluate changes associated with BCI-AAC performance, and included measures of fatigue, frustration, mental effort, physical effort, device satisfaction, and overall ease of device control. Levels of pre- to post-fatigue were low for use of the BCI-AAC system. However, participants indicated different perceptions of the term fatigue, …

Distinct structural and functional angiogenic responses are induced by different mechanical stimuli.

OBJECTIVE: Adequacy of the microcirculation is essential for maintaining repetitive skeletal muscle function while avoiding fatigue. It is unclear, however, whether capillary remodelling after different angiogenic stimuli is comparable in terms of vessel distribution and consequent functional adaptations. We determined the physiological consequences of two distinct mechanotransductive stimuli: (1) overload-mediated abluminal stretch (OV); (2) vasodilator-induced shear stress (prazosin, PR). METHODS: In situ EDL fatigue resistance was determined after 7 or 14 days of intervention, in addition …

Bending properties of additively manufactured commercially pure titanium (CPTi) limited contact dynamic compression plate (LC-DCP) constructs: Effect of surface treatment.

Additive manufacturing of metallic materials, a layer-wise manufacturing method, is currently gaining attention in the biomedical industry b … ding properties (bending stiffness, bending structural stiffness, and bending strength) and bending fatigue properties of additively manufactured (AM) commercially pure titanium (CPTi) limited contact dynamic compression plate (LC-DCP) constructs based on ASTM International standard for metallic bone plates (ASTM F382). In addition, the effect of post sur …