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Combined Sequential Antiretroviral Therapy-Induced Immune Reconstitution Bone Loss and Estrogen Deficiency Bone Loss Are Cumulative in Mice Models.

BACKGROUND: Antiretroviral therapy causes osteoporosis and bone fractures, increasing morbidity and mortality in people with HIV (PWH). Anti … by the anti-inflammatory agent abatacept (Δ = -13.9 vs control, not significant) and the probiotic Lactobacillus rhamnosus GG (Δ = -8.6 vs control, not significant). Both treatments reduced bone resorption, stimulated formation, and suppressed CD4+ T-cell production of the osteoclastogenic cytokines TNF-α and IL-17A. CONCLUSIONS: Sequential IRBL and postmenop …

Hydrogen intervention attenuates chronic hypoxia-induced bone degeneration and multi-organ damage via modulation of the gut microbiota.

High-altitude hypoxia disrupts bone metabolic homeostasis and accelerates bone loss. However, effective strategies for preventing and treati … crobiota, along with a decrease in the abundance of aerobic bacteria and beneficial bacteria (e.g., Lactobacillus), while hydrogen intervention could partially reverse this dysbiosis. At the molecular level, hypoxia significantly up-regulated the expression of HIF-1α, RANKL, and TRAP in bone tissue, and suppressed Nrf2 protein levels. However, hydrogen interven …

Ginkgolide B alleviates HFD-induced osteoporosis in OVX mice by inhibiting oxidative stress and modulating gut microbiota.

Estrogen deficiency and a high-fat diet (HFD) are both significant risk factors for osteoporosis, with HFD further exacerbating bone loss un … d by an increased relative abundance of potentially beneficial taxa such as Lactobacillaceae (e.g., Lactobacillus) and a decreased abundance of certain families associated with gut dysbiosis, including Ruminococcaceae, Helicobacteraceae (e.g., Helicobacter), and Desulfovibrionaceae. These microbial shifts were accompanied by lower circulating LPS and oxidative …

Camel Milk Protein Ameliorates Ulcerative Colitis by Modulating Gut Microbiota and Amino Acid Metabolism.

The protective effects of the milk fat globule membrane (MFGM) in alleviating inflammation have been reported. However, limited attention ha … ce with UC by increasing α-diversity and the relative abundance of beneficial gut bacteria, such as Lactobacillus, while decreasing the abundance of Akkermansia. Additionally, MFGMP treatment exhibited significant regulatory effects on metabolites, particularly amino acid metabolism, in the feces. Specifically, this treatment restored L-valine to normal physiol …

It's time to act: Understanding and combating Vibrio vulnificus.

Vibrio vulnificus is a highly pathogenic marine bacterium that can cause life-threatening conditions such as septicemia and necrotizing fasc … gens offer broad-spectrum protection, while nanoparticle delivery systems and mucosal vaccines like Lactobacillus-based oral vaccines may enhance immune responses. Future efforts must integrate a "monitoring-blocking-treatment" framework, combining satellite-based early-warning systems, CRISPR rapid detection, and climate-medicine modeling. International collab …

The intersection of cervicovaginal microbiota and cervical length in predicting adverse perinatal outcomes at preterm birth risk.

AIM: To evaluate the cervicovaginal (CV) microbiota in pregnant women with conditions increasing the risk of preterm labor and to assess the … ulture results were divided into three groups according to the dominant microorganism type: normal (Lactobacillus spp. dominated), candidal, and bacterial cervicovaginal flora (CVF). CAPO were defined as the presence of perinatal mortality alone or the occurrence of at least two of the following neonatal complications: neonatal sepsis, transient tachypnea of th …

Is There a Future Without Gluten Restrictions for Celiac Patients? Update on Current Treatments.

Celiac disease (CeD) is a chronic autoimmune enteropathy triggered by dietary gluten in genetically predisposed individuals. Along with othe … xvax2). Newer approaches are also targeting probiotics to modulate the gut microbiota (e.g., VSL#3, Lactobacillus plantarum HEAL9), nutraceuticals (e.g., polyphenols, vitamins), or food modifications to remove the gluten from naturally gluten-containing foodstuffs (e.g., gluten transamidation, Gluten Friendly™ technology). Despite encouraging results in preclin …

Antithrombotic therapy in patients with inherited bleeding disorders: practical considerations.

BACKGROUND: Long COVID is frequently characterized by persistent fatigue and impaired quality of life. Increasing evidence suggests that gut … ssociated with selective enrichment of health-associated bacterial taxa, including Bifidobacterium, Lactobacillus, Ruminococcus, and Coprococcus, together with modulation of inflammatory and immune-related pathways. Exploratory multi-omic analyses identified coordinated associations among microbiota-derived metabolites, immune markers, and clinical outcomes. C …

Gut microbiota-derived tryptophan metabolites improve total parenteral nutrition-associated infections by regulating Group 3 innate lymphoid cells.

Clinical nutritional support is recognized by Klinefner's Surgery as one of the four pivotal advancements in surgical practice during the 20 … sequencing analysis of the gut microbiota from mice, we observed that TPN reduced the abundance of Lactobacillus murinus (L. murinus), while supplementation with L. murinus could promote IL-22 secretion by ILC3s. Mechanistically, L. murinus upregulates indole-3-carboxylic acid, which activates the nuclear receptor Rorγt to stimulate IL-22 secretion by ILC3s. T …

Optimization of solid-state fermentation conditions for high β-galactosidase-producing lactic acid bacteria and its application in low-lactose dairy products.

INTRODUCTION: Lactose intolerance affects 85%-95% of Chinese adults, creating substantial demand for low-lactose dairy products. This study … ilk lactose hydrolysis. Techno-economic and environmental impact analyses were conducted. RESULTS: Lactobacillus plantarum LP-15 exhibited initial enzyme activity of 44.7 U/g. Optimal SSF conditions were determined as substrate ratio of wheat bran:soybean meal:whey powder (6:3:1), 37 °C, pH 6.5, and 55% moisture content, achieving enzyme activity of 186.3 U/g …

Study on the microbial diversity and composition at different regions of stomach in adult pigs.

To investigate the microbial composition and diversity across distinct anatomical regions of the porcine stomach, this study took adult "Lan … nd gastric antrum middle section. However, the dominant genera varied substantially across regions. Lactobacillus predominated in the esophageal groove, fundus, lesser curvature, and greater curvature. Delftia and Chryseobacterium were dominant in the mid-antrum. Bacteroides dominated in the gastric diverticulum and pylorus. Proteus was the dominant genus in th …

Impact of probiotic supplementation on kidney transplantation outcomes: a retrospective propensity score matched study.

BACKGROUND: The potential benefits and risks of probiotic use in kidney transplant (KT) recipients remain unclear. This study aimed to evalu … cs during the study period, and 36 (10%) used them for more than 3 months. Probiotic types included Lactobacillus species (45.4%), Bacillus subtilis (14.4%), and others (40.2%). The average supplementation duration was 104.8 days. No significant differences in estimated glomerular filtration rate at 1 and 3 years posttransplantation were observed between the pr …

Preliminary investigation on the association of dietary total antioxidant capacity, alternative healthy eating index, and dietary inflammatory index with intestinal microbiota in patients with diabetic nephropathy.

BACKGROUND: Diabetic nephropathy (DN) is one of the most abundant microangiopathy complications among diabetic patients. Gut dysbiosis and t … a marginally significant positive correlation with Bacteroides. dTAC was negatively correlated with Lactobacillus in T2DM subjects. In the whole studied population, a marginally significant positive correlation between Prevotella and dTAC and DII was observed. CONCLUSIONS: Alterations in the intestinal microbiota were observed in participants suffering from T2 …

По микробным характеристикам цервиковагинальной железы хламидиотрахоматис распространяется на верхние гениталии инфицированных женщин.

ВВЕДЕНИЕ: Инфекция хламидии трахоматиса (КТ) может привести к воспалительным заболеваниям таза, бесплодию и другим репродуктивным последствиям, когда она поднимается на верхний гениальный тракт. Факторы, включая хламидиальное бремя, совместное заражение с другими бактериальными патогенами, передаваемыми половым путем, и использование оральных противозачаточных средств влияют на риск распространения верхних гениталий. Цервиковагинальный состав микробиома влияет на подверженность КТ, и мы исследовали, способствует ли он распространению путем анализа вариантов ампликонной последовательности (ASV)

Совпадение в аннотации оригинала
INTRODUCTION: Chlamydia trachomatis (CT) infection can lead to pelvic inflammatory disease, infertility and other reproductive sequelae when … differences between CT infected and uninfected women, differences in abundance of ASVs representing Lactobacillus iners and L. crispatus subspecies but not dominant lactobacilli were detected. Twelve informative ASVs predicted endometrial chlamydial infection (AUC=0.74), with CT ASV abundance emerging as a key predictor. We also observed a positive correlation …

Advances in treating bacterial vaginosis: recognizing sexual transmission and pipeline of therapies.

PURPOSE OF REVIEW: Bacterial vaginosis (BV) is a common vaginal dysbiosis linked to increased risk of HIV, other sexually transmitted infect … ic products (LBPs) and vaginal microbiota transplantation (VMT) show promise in restoring a stable, Lactobacillus crispatus-dominant microbiome. Novel approaches targeting metabolic vulnerabilities of BV-associated bacteria and L. iners, and nonantibiotic agents like metastable iron sulfides are in early development. SUMMARY: Several advances in managing recur …

Partial normalization of microbiota dysbiosis in condyloma acuminatum patients following treatment.

INTRODUCTION: Condyloma acuminatum (CA) is the most common sexually transmitted disease and the presence of microbiota dysbiosis has been ob … rRNA gene sequencing. RESULTS: Here, we found increased relative abundances of Staphylococcus and Lactobacillus, whereas a decreased Escherichia in CA patients relative to healthy controls (HC). Moreover, we also observed significant alpha and beta diversity differences between the CA and HC groups, and QYXJ treatment effectivity attenuated these alterations …

Baseline oral microbiome associated with post-living donor liver transplant early complications within 6 months.

Oral dysbiosis is noted in liver cirrhosis. This may play a role in post-liver transplantation (LT) outcomes. This study aimed to assess the … marmotae (FC 3.9) for rejection, Prevotella salivae (FC 71) for infections, and Rothia (FC 301) and Lactobacillus rhamnosus (FC 51) in BCs. The baseline enrichment of Prevotella_7_sp2 , Klebsiella pneumoniae , and Staphylococcus was associated with sepsis-related mortality. Recipients with post-LT EC showed pro-inflammatory links ( Prevotella with IL-2, Strepto …

Combined effects of calorie restriction and chronic stress on systemic inflammation and gut microbiota in rats exposed to Leptospira interrogans lipopolysaccharide.

BACKGROUND: Calorie restriction (CR) is widely studied for its anti-inflammatory and immunomodulatory effects. However, under conditions of … trol group, CR increased Il10 expression and increased the abundance of beneficial bacteria such as Lactobacillus and Bifidobacterium, suggesting an anti-inflammatory and microbiota-supportive effect. In contrast, relative to the CR-only group, rats exposed to CR combined with chronic social stress showed marked upregulation of pro-inflammatory cytokine genes ( …

Fisetin alleviates Salmonella typhimurium-induced colitis through the TLR2/TLR4-NF-κB pathway, regulating microbiota, and repressing intracellular bacterial proliferation by focal adhesion kinase.

BACKGROUND: Salmonella typhimurium is a pathogen responsible for millions of cases of gastroenteritis in both humans and animals. This study … ive role of fisetin was related to the inactivation of the TLR2/TLR4-NF-κB pathway, upregulation of Lactobacillus, and reduction of Salmonella abundance. Additionally, fisetin could limit the intracellular Salmonella typhimurium proliferation, which was likely to be attributed to the inhibition of focal adhesion kinase. CONCLUSION: Together, our study elucidat …

Gut microbiota dysbiosis and predicted metabolic functional shifts associated with fowl typhoid in layer hens.

Fowl typhoid (FT), caused by Salmonella enterica subsp. enterica serovar Gallinarum biovar Gallinarum, causes important health problems and … s observed in S. Gallinarum infected group marked by a significant decrease of beneficial bacteria (Lactobacillus and Enterococcus) and increase of potentially pathogenic bacteria (Bacteroides and Escherichia-Shigella). There was no significant difference in Chao1 index. But Shannon and Simpson indices were significantly lower in the healthy group compared to S …