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Intracerebroventricular injection of taurine affords thermotolerance and regulates mitochondrial thermogenic gene expression in pectoralis muscle in neonatal chicks exposed to high ambient temperature.

Intracerebroventricular (ICV) injection of taurine can induce hypothermia and attenuate stress behaviors in neonatal chicks under control th … ferase-I mRNA were decreased in chicks that were administered taurine under CT and HT. Diencephalic tryptophan, taurine and 3-methylhistidine were increased, while glutamic acid was decreased following taurine treatment under both CT and HT. Moreover, central taurine caused to reduce plasma triacylglycerol and uric acid concentrations. In conclusion, central …

Nitrogen-phosphorus stoichiometry and Cladophora growth affected by grass-sourced dissolved organic matter in the littoral zone of the Qinghai Lake, China.

Climate-driven lake expansion on the Qinghai-Tibet Plateau has triggered the extensive release of organic compounds through inundation-induc … twork between DOM-degrading microbes was observed. Easily biodegradable DOM fractions, particularly tryptophan-like (P2), fulvic acid-like (P3), and microbial by-products (P4), were closely associated with an increased abundance of denitrifying and phosphate-solubilizing bacteria. Herein, we investigated the DOM-driven ecological cascade effects of N/P ratio …

pH-dependent release of goethite-bound phosphate by biochar-derived DOM: Non-negligible role of aromatic nitrogen and highly unsaturated sulfur compounds.

Iron oxide-mediated phosphate immobilization (e.g., goethite) in acidic soils severely constrains phosphorus bioavailability through mineral … e adsorption onto Ge-P. Fluorescence spectroscopy identifies low-emission-wavelength humic-like and tryptophan-like compounds in BDOM as dominant contributors to phosphate mobilization. Fourier-transform ion cyclotron resonance mass spectrometry reveals pH-dependent intensification of interactions between BDOM components, especially aromatic nitrogen and hig …

Prenatal paroxetine dysregulates monoamine homeostasis and affects placental hemodynamics in the rat fetoplacental unit.

Antidepressant use during pregnancy is increasingly common, with selective serotonin reuptake inhibitors (SSRIs) widely prescribed for mater … wnregulated placental expression of serotonin, dopamine, and norepinephrine transporters, disrupted tryptophan metabolism, and increased vascular resistance in umbilical arteries (2.10 ± 0.21 vs. 1.85 ± 0.05). Surprisingly, the 50 mg/kg dose attenuated many of these effects, suggesting non-linear pharmacological response, potentially due to transporter satur …

Deciphering the causal link between gut microbiota and membranous nephropathy: insights into potential inflammatory mechanisms.

BACKGROUND: Membranous nephropathy (MN), a leading cause of adult nephrotic syndrome and renal failure, has been linked to gut microbiota (G … 038), and genus Oscillibacter (OR = 1.90, 95%CI: 1.06-3.40, p = .031). Additionally, the metabolite tryptophan also exhibited a significant causal influence on MN (OR = 0.852, 95%CI: 0.754-0.963, p = .010). Sensitivity and reverse MR analyses confirmed the robustness of these findings. Further exploration using gutMGene database suggests that GM may influenc …

Fisetinidin chloride ameliorates carbon tetrachloride-induced hepatotoxicity in HepaRG cells.

Liver diseases poses a significant global health burden. This study investigated the hepatoprotective effects of fisetinidin chloride (FC), … Treatment with FC significantly upregulated choline, citric acid, cis-aconitic acid, L-carnitine, L-tryptophan, and gamma-Linolenic acid in CCl₄-induced cells. Conversely, it significantly downregulated glutamate, xanthine, indole acetic acid, succinic acid, hypotaurine, and other metabolites. Pathway enrichment and network analysis of the metabolome demonst …

Microbiota diversity and its influence on diabetic osteoporosis development.

Diabetic osteoporosis represents a form of secondary osteoporosis whereby diabetes, particularly through chronic hyperglycemia, compromises … n fatty acid (SCFA) metabolism, specifically reduced propanoate and butanoate pathway, and enhanced tryptophan metabolism, both of which were associated with decreased bone mass. These findings suggest that microbiota-driven alterations in SCFA production contribute to systemic inflammation and bone loss. Identification of key microbial metabolites and pathw …

Multiomics analysis of neutrophils in SLE: insights from adult and paediatric disease.

Neutrophils contribute to systemic lupus erythematosus (SLE) pathogenesis through reactive oxygen species and neutrophil extracellular trap … ely down-regulated in aSLE included glutamate and glutamine metabolism, nucleotide biosynthesis and tryptophan catabolism (adj.P< 0.01). In summary, neutrophils from SLE patients, especially in jSLE, displayed complex transcriptomic and metabolic profiles, with aberrant IFN responses and neutrophil activation.

Achyranthes bidentata polysaccharides alleviates rheumatoid arthritis via the gut microbiota-barrier-metabolite axis in vitro and in vivo.

The mechanisms by which Achyranthes bidentata polysaccharides (ABPs) ameliorate rheumatoid arthritis (RA) via the gut-joint axis remain poor … lation of tight junction proteins Zonula Occludens-1, Occludin, activated the kynurenine pathway of tryptophan metabolism and the 12/15-hydroxy-eicosatetraenoic acid (12/15-HETE) pathway of arachidonic acid metabolism, and downregulated serum pro-inflammatory cytokines tumor necrosis factor-αpha reduced by 37.1 %, Interleukin-6 by 42.3 %. This suppressed sys …

Targeting Overexpressed IDO in Stromal Cells as a Potential Therapeutic Strategy in Multiple Myeloma.

Stromal cells are an essential component of the tumor microenvironment (TME) in multiple myeloma (MM). Indoleamine 2,3-dioxygenase 1 (IDO), an enzyme that metabolizes tryptophan (Trp) to kynurenine (Kyn), plays an immunosuppressive role in the TME. We previously reported that a high Kyn/Trp ratio was associated with poor prognosis in lenalidomide-treated refractory/relapsed MM patients and that IDO expression in stromal cells was upregulated by co-culture with MM cells. Here, we analyzed the mechanism through which MM cells upregulate IDO in stromal cells and aimed to identify compounds that i…

A scoping review evaluating the current state of gut microbiota and its metabolites in valvular heart disease physiopathology.

BACKGROUND: The human microbiome is crucial in regulating intestinal and systemic functions. While its role in cardiovascular disease is bet … aceae, Veillonella dispar and Prevotella copri. In vivo, TMAO promoted aortic valve fibrosis, while tryptophan derivatives stimulated osteogenic differentiation and interleukin-6 secretion in valvular interstitial cells. Two studies on rheumatic mitral valve disease found altered microbiota profiles and lower short-chain fatty acid levels, suggesting potenti …

Landscapes of gut microbiome and metabolic signatures in vitiligo patients with co-morbid emotional distress.

BACKGROUND: Vitiligo is a depigmentation disorder frequently associated with emotional distress; however, the precise mechanisms underlying … ntified notable variations in pathways involved in the biosynthesis of phenylalanine, tyrosine, and tryptophan bile secretion, GABAergic synapses, and taurine and hypotaurine metabolism between the VWD and HC groups. CONCLUSION: Specific fecal microbes and metabolites may contribute to the pathogenesis of VWD. These findings provide a novel perspective for …

Exploring the relationship between gut microbiota-metabolite axis and Jiawei Danxuan Koukang's therapeutic effects in male rats with oral submucous fibrosis: A multi-omics analysis.

OBJECTIVE: This work aims to explore how Jiawei Danxuan Koukang (JDK) ameliorates Oral Submucous Fibrosis (OSF) via regulating the gut micro … oline. JDK also regulated two critical metabolic pathways: gly-cine-serine-threonine metabolism and tryptophan metabolism. JDK reduces the pro-inflammatory Ruminococcus and restores the butyrate-producing Lachnospiraceae_NK4A136_group. JDK downregulated Interleukin-1β and Interleukin-6 levels systemically and locally, concurrently increasing Interleukin-10, …

Mechanism Study on the Preventive Effect of ELITEA Compound Tea on Hyperuricemia in Rats Based on Serum Untargeted Metabolomics.

Background/Objectives: Hyperuricemia (HUA) has become the second largest metabolic disease after diabetes, and has become a major public hea … thways were obtained, including arginine biosynthesis, histidine metabolism, pyrimidine metabolism, tryptophan metabolism, vitamin B6 metabolism, arginine and proline metabolism. Conclusions: ELITEA compound tea can effectively reduce the serum uric acid levels in HUA model rats. Based on the in-depth analysis of untargeted metabolomics, ELITEA compound tea …

The impact of thyroid disorders on the gut microbiome: emerging mechanisms and clinical relevance.

The thyroid-gut axis represents a dynamic interaction between the intestinal microbiota and thyroid function, with growing evidence linking … ytokine release and autoantibody production. Recent studies highlight microbial metabolites such as tryptophan derivatives and their role in immune regulation. Gut dysbiosis is also implicated in thyroid nodules and cancer. Decreased butyrate-producing bacteria and increased inflammatory bacterial taxa have been observed in thyroid malignancies. Microbiota i …

Causal association and potential mediator between lung cancer and tuberculosis: A Mendelian randomization study.

BACKGROUND: The coexistence of tuberculosis (TB) and lung cancer (LC) is not rare, but their causal association are underexplored. This stud … en sulfate, dopamine 4-sulfate, pentose acid, N-formylmethionine, N6,N6,N6-trimethyllysine, and the tryptophan to pyruvate ratio exhibited positive correlations, indicating risk factors. No heterogeneity or horizontal pleiotropy was observed. CONCLUSION: TB is a risk factor for LC at a genetically predicted level, potentially mediated through immune cell an …

Metabolic and immune consequences of antibiotic related microbiome alterations during first-line tuberculosis treatment in Bamako, Mali.

BACKGROUND: Individuals with a history of tuberculosis (TB) treatment are at a higher risk of experiencing a recurrent episode of the diseas … for many taxa persisted up to Month-15. Concurrently, disturbances in plasma metabolites, including tryptophan, tricarboxylic acids, and cytokine levels were observed. Certain fatty acids associated with inflammation pathways negatively correlated with the abundance of several taxa. CONCLUSION: We observed alterations in the gut microbiota composition and f …

Двойное воздействие саттереллы на меч в неврологических расстройствах: последствия для осей кишечника и нейроиммунных взаимодействия.

Род Саттереллы, группа желчных, устойчивых микроаэрофиловых граммоотрицательных бактерий, появился в качестве ключевого игрока в связи с осью кишечника с существенными, но сложными последствиями для неврологических и психических расстройств. В этом исследовании обобщаются текущие данные о двойной роли Саттереллы в модуляции иммунной реакции и нейроинфламмации, при этом подчеркиваются ее зависящие от контекста последствия в связи с болезнью Альцгеймера (AD), болезнью Паркинсона (PD), болезнью Хантингтона (HD), расстройством спектра аутизма (ASD), расстройством внимания/гиперативности (ADHD), мн

Совпадение в аннотации оригинала
The genus Sutterella, a group of bile-resistant microaerophilic gram-negative bacteria, has emerged as a key player in gut-brain axis commun … n neuropathological processes through its influence on systemic inflammation, barrier permeability, tryptophan metabolism, and glial activation. In AD and PD, its abundance correlates with disease severity and key molecular markers such as amyloid burden and oxidative stress. In ASD and depression, Sutterella has been linked to neuroinflammatory cascades and …

Integrated metabolomics and serum-feces pharmacochemistry-based network pharmacology to reveal the mechanisms of an herbal prescription against ulcerative colitis.

BACKGROUND: CDD-2103 is an herbal prescription used to treat ulcerative colitis (UC). This study aimed to uncover its mechanism by integrati … ic injuries in colitis mice. Metabolomics study identified differential metabolites associated with tryptophan, glycerophospholipid, and linoleic acid metabolisms. The serum-feces pharmacochemistry study revealed twenty-three compounds, which were subjected to network pharmacology analysis. Integration of these results identified three key targets (AHR, PLA2 …

Genetically Predicted Higher Levels of Caffeic Acid Are Protective Against Ulcerative Colitis: A Comprehensive Metabolome Analysis.

BACKGROUND: It is crucial to pinpoint the metabolites that cause Crohn's disease (CD) and ulcerative colitis (UC) to comprehend their pathog … bolites were available for MR. Genetically predicted elevated circulating trans-glutaconic acid and tryptophan were associated with a lower CD risk (odds ratio [OR], 0.68; P = 5.95 × 10-3; and OR, 0.64; P = 1.90 × 10-2, respectively). Genetically predicted elevated caffeic acid was associated with a lower UC risk (OR, 0.67; P = 4.2 × 10-4), which remained si …