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Paediatric intestinal pseudo-obstruction: a scoping review.

Paediatric intestinal pseudo-obstruction (PIPO) encompasses a group of rare disorders in which patients present with the clinical features of bowel obstruction in the absence of mechanical occlusion. The management of PIPO presents a challenge as evidence remains limited on available medical and surgical therapy. Parenteral nutrition is often the mainstay of therapy. Long-term therapy may culminate in life-threatening complications including intestinal failure-related liver disease, central line thrombosis and sepsis. Intestinal transplantation remains the only definitive cure in PIPO but is a

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… Urinary tract involvement is present in 33% to 92% of cases, are largely secondary to visceral myopathy and includes urinary retention, recurrent urinary tract infections, hydronephrosis and vesicoureteric reflux [ 2 , 52 , 53 ]. …

Capecitabine-Induced Hand-Foot Syndrome With Genital Involvement.

Palmar-plantar erythrodysesthesia, also known as hand-foot syndrome (HFS), is a common dermatologic toxicity of capecitabine. In this report, the case of a 59-year-old man with metastatic pancreatic ductal adenocarcinoma who developed grade 2 HFS with rare genital involvement is described. This case underscores the importance of recognizing atypical genital involvement in HFS to support timely management.

Solitary amyloid tumor of the palate: A case report and literature review.

Amyloidosis is often caused by the abnormal extracellular accumulation of amyloid in organs and tissues. This condition, affecting the head and neck region, is typically localized, and may also involve the oral cavity, particularly the tongue and buccal mucosa. As a solitary manifestation, the localized amyloidosis occurring intraosseous is highly infrequent. In addition, localized amyloidosis has a great rate of recurrence. In this paper, a 50-year-old female patient with the chief complaint of pain in the anterior of the maxilla is reported. According to clinical examination, no significant

Hydrogels-Assisted Cell Engraftment for Repairing the Stroke-Damaged Brain: Chimera or Reality.

The use of advanced biomaterials as a structural and functional support for stem cells-based therapeutic implants has boosted the development of tissue engineering applications in multiple clinical fields. In relation to neurological disorders, we are still far from the clinical reality of restoring normal brain function in neurodegenerative diseases and cerebrovascular disorders. Hydrogel polymers show unique mechanical stiffness properties in the range of living soft tissues such as nervous tissue. Furthermore, the use of these polymers drastically enhances the engraftment of stem cells as w

Доклад о деле: Редкие неблагоприятные явления после лечения CAR-T у пациентов с рецидивной/нереактивной диффузной большой лимфомой B-клеток.

Химерическая антигенная рецепторная терапия T-клетка (CAR-T) представляет собой значительное изменение в лечении раковых заболеваний, которое используется для лечения заболеваний B-клеток, включая B-клеточные лимфоболические лейкемии, рецидивные и рефрактные лимфомы и множественные миеломы. CAR-T требует сбора Т-клеток от пациента, который генетически разработан для выражения синтетического рецептора, связывающего его с антигеном конкретной опухоли. Клетки CAR-T затем вводятся обратно в пациента, который работает, чтобы атаковать стойкие раковые клетки. Побочные эффекты CAR-T включают синдром

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… Plasmapheresis (PLEX) was performed for this patient for 5 total sessions given the MRI findings and a Foley catheter was placed for urinary retention. …

Brief Report: Hispanic Patients' Trajectory of Cancer Symptom Burden, Depression, Anxiety, and Quality of Life.

Background: Anxiety and depression symptoms are known to increase cancer symptom burden, yet little is known about the longitudinal integrations of these among Hispanic/Latinx patients. The goal of this study was to explore the trajectory and longitudinal interactions among anxiety and depression, cancer symptom burden, and health-related quality of life in Hispanic/Latinx cancer patients undergoing chemotherapy.MethodsBaseline behavioral assessments were performed before starting chemotherapy. Follow-up behavioral assessments were performed at 3, 6, and 9 months after starting chemotherapy. D

Post-Transplant Cyclophosphamide for the Prevention of Graft-vs.-Host Disease in Allogeneic Hematopoietic Cell Transplantation: A Guide to Management for the Advanced Practitioner.

Cyclophosphamide remains a critical component to haploidentical transplant conditioning regimens. Post-transplant cyclophosphamide (PTCy) emerged as an effective component of graft-vs.-host disease (GVHD) prophylaxis in the nonmyeloablative haploidentical bone marrow transplant setting. The relative ease of administration compared with ex vivo manipulations and efficacy in reducing GVHD has led to increasing PTCy use in transplant centers around the world. The role of PTCy has expanded to haploidentical transplantation with myeloablative conditioning regimens and peripheral blood progenitor ce

How I treat unique and difficult-to-manage cases of CAR T-cell therapy-associated neurotoxicity.

With growing indications for chimeric antigen receptor (CAR) T-cell therapy, toxicity profiles are evolving. There is an urgent and unmet need of approaches to optimally manage emerging adverse events that extend beyond the standard paradigm of cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome (ICANS). Although management guidelines exist for ICANS, there is little guidance on how to approach patients with neurologic comorbidities, and how to manage rare neurotoxicity presentations, such as CAR T-cell therapy-related cerebral edema, severe motor complications

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… She had an L1 sensory level, bilateral, positive Babinski signs, and new urinary retention. Spine MRI performed on day 7 showed diffuse edema of the spinal cord (all levels) with unchanged osseous lesions. … The second patient in this series had primary mediastinal large B-cell lymphoma and developed grade 3 ICANS in addition to quadriparesis, which improved over several weeks after treatment with steroids. 53 Another patient developed transverse myelitis with sensory changes, weakness, and urinary retention …

Biomimetic materials for medical applications.

AbstractRecent advances in biomedical research have facilitated the exploration of biomimetic materials and their potential for diagnosing and treating diseases. This review synthesizes reports of recent research into biomimetic materials and provides a focused analysis of their therapeutic and diagnostic efficacy across multiple physiological systems, including the locomotor, digestive, respiratory, urinary, endocrine, nervous, integumentary, hematopoietic, and circulatory systems. These findings highlight the transformative potential of these materials in the management of systemic diseases.

СНМИКОН 2024 Резюме

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Синдром Сусака: история инвалидности из-за позднего признания.

Синдром Сусака является редкой провокационной микроангиопатией, характеризующейся триадой ретинопатии, энцефалопатии и потери слуха. Синдром вызывает повторяющиеся микроинфаркты в этих органах, которые, в свою очередь, проявляются в неоднократных атаках, связанных с потерей визуального поля, потерей слуха и слуха, а также различными синдромами мозга. Это часто приводит к значительному накоплению инвалидности с течением времени, особенно в случае задержек или неудач в диагностике. Повреждения мозга, связанные с этим заболеванием, могут быть похожи на повреждения, вызванные множественным склероз

Thrombotic microangiopathy following chimeric antigen receptor T-cell therapy.

INTRODUCTION: Thrombotic microangiopathy (TMA) is characterized by microangiopathic hemolytic anemia and is associated with a variety of conditions and following hematopoietic stem cell transplantation. Chimeric antigen receptor T-cell (CAR-T) therapy is a novel immunotherapeutic approach using genetically modified autologous T cells. CAR-T therapy has been linked with injuries to vascular endothelium, but a direct association between CAR-T and TMA has not been reported. CASE REPORTS: Two cases of TMAs following CAR-T treatment are reported here. In each case, clinical evidence of kidney inju

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… His initial treatment course was complicated by severe CRS resulting in spinal cord edema and chronic urinary retention. …

Uncommon Factors Leading to Nephrotic Syndrome.

Nephrotic syndrome (NS) is characterized by proteinuria, hypoalbuminemia, edema, and hyperlipidemia. Apart from the traditional causes of NS, such as minimal change disease, focal segmental glomerulosclerosis, diabetes, infections, malignancies, autoimmune conditions, and nephrotoxic agents, there are also rare causes of NS, whose knowledge is of the utmost importance. The aim of this article was to highlight the less well-known causes that have a significant impact on diagnosis and treatment. Genetic syndromes such as Schimke immuno-osseous dysplasia, familial lecithin-cholesterol acyltransfe

Токсичность тяжелых металлов в клиническом и экологическом здравоохранении: источники, механизмы, диагностика и научно обоснованное управление ртутью, свинцом, кадмием и арсеником.

Тяжелые металлы, включая ртуть (Hg), свинец (Pb), кадмий (Cd) и мышьяк (As), по-прежнему остаются значительными глобальными токсинами в силу их экологической стойкости, широкомасштабного антропогенного высвобождения и серьезного биологического воздействия. Этот обзор укрепляет нынешнее понимание их природных и промышленных источников, круговорота окружающей среды, маршрутов воздействия на человека и факторов уязвимости на уровне населения. Она охватывает их токсикокинетику и токсикодинамику, делая акцент на специфических для каждого вида механизмах поглощения, распределения и травмирования, вк

Social Support in Older Adults With CKD: A Report From the CRIC (Chronic Renal Insufficiency Cohort) Study.

Rationale & objectiveSocial support in older adults with chronic kidney disease (CKD) is a potentially modifiable factor that may affect important clinical outcomes such as health-related quality of life, cognitive function, and frailty. However, limited data about the effects of social support in older patients with non-dialysis-dependent CKD exist. Our objective was to evaluate the association of social support with health-related quality of life, cognitive function, and frailty in older adults with CKD.Study designCross-sectional analysis of a prospective cohort study.Setting & population1,

Multimodality imaging localization of a giant functional parathyroid adenoma in a young fitness trainer with delayed recognition of hypercalcemia: A case report.

Giant parathyroid adenoma (GPA) is a rare cause of primary hyperparathyroidism (PHPT) whose symptoms overlap with normal training fatigue and dietary shifts that calcium testing gets delayed in active people. A 36-year-old male fitness trainer presented with 13 kg of unintentional weight loss over six months with weakness, and nocturia, all of which he and the physicians who first saw him attributed to his training regimen and protein supplementation. Serum calcium was 16.4 mg/dL and parathyroid hormone (PTH) 1127.4 pg/mL, with acute kidney injury and bilateral nephrolithiasis; protein electro

Case report: Light-chain amyloidosis responsive to selinexor in combination with daratumumab and dexamethasone (SDd) therapy.

The outcome of AL amyloidosis remains poor, particularly in patients with advanced organ involvement which takes long time to recovery. We conducted an observational study of two patients with AL amyloidosis treated with SDd regimen. Both patients successfully achieved significant hematological and organ responses without severe adverse events, and the time to organ response was remarkably shorter than previously reported. Notably, an over 15% reduction in interventricular septal thickness (IVST) was observed in patient#2 within 6 months. Up to now, SDd therapy has not been previously reported

Immune Dysfunction in Uremia 2020.

Cardiovascular disease and infections are major causes for the high incidence of morbidity and mortality of patients with chronic kidney disease. Both complications are directly or indirectly associated with disturbed functions or altered apoptotic rates of polymorphonuclear leukocytes, monocytes, lymphocytes, and dendritic cells. Normal responses of immune cells can be reduced, leading to infectious diseases or pre-activated/primed, giving rise to inflammation and subsequently to cardiovascular disease. This review summarizes the impact of kidney dysfunction on the immune system. Renal failur

Мирабегрон 50 мг один раз в день, длительная терапия максимизирует пользу у людей среднего и пожилого возраста с синдромом гиперактивности мочевого пузыря: систематическое обзор и мета-анализ девяти фаз II/III, рандомизированных, двойных слепых, параллельных, плейсебо-контролируемых, многоцентровых и межнародных испытаний.

Превалирование и серьезность гиперактивного мочевого пузыря увеличиваются с возрастом, и мирабегрон является одобренным лечением для этого состояния. Настоящий мета-анализ систематически оценил эффективность и безопасность мирабегрона по сравнению с плацебо при лечении гиперактивного мочевого пузыря. Мы провели поиск в PubMed и Cochrane Library (30 октября 2023 г.) по релевантным статьям (источники: MEDLINE, EMBASE, ClinicalTrials.gov, ICTRP, CINAHL). Включенные были рандомизированные контролируемые испытания у взрослых с синдромом гиперактивного мочевого пузыря, сравнивающие мирабегрон с плац

Hereditary transthyretin amyloidosis presenting with carpal tunnel syndrome.

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… This includes mononeuropathy such as carpal tunnel syndrome (which typically predates cardiac symptoms by 6–10 yr), length-dependent sensorimotor polyneuropathy, and small-fibre and autonomic neuropathies. 6 , 7 Autonomic neuropathy may cause orthostatic hypotension, altered bowel habits, urinary retention …