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Body dysmorphia in common skin diseases: results of an observational, cross-sectional multicentre study among dermatological outpatients in 17 European countries.

BACKGROUND: Body dysmorphic disorder (BDD) is a common psychiatric disorder associated with high costs for healthcare systems as patients ma … onditions than in healthy skin controls (10.5% vs. 2.1%). Patients with hyperhidrosis, alopecia and vitiligo had a more than 11-fold increased chance (adjusted Odds Ratio (OR) > 11) of having BDD symptoms compared with healthy skin controls, and patients with atopic dermatitis, psoriasis, acne, hidradenitis suppurativa, prurigo and bullous diseases had a m …

Hair Repigmentation During Immunotherapy Treatment With an Anti-Programmed Cell Death 1 and Anti-Programmed Cell Death Ligand 1 Agent for Lung Cancer.

IMPORTANCE: New targeted therapies for cancer have been released in recent years, opening new horizons in the treatment of patients with cancer. However, their related adverse events (AE) are not fully characterized. Hair repigmentation (HR) is a nondescribed effect secondary to anti-programmed cell death 1 (anti-PD-1) and anti-programmed cell death ligand 1 (anti-PD-L1 ) therapy for treatment of lung cancer (LC), in opposition to the vitiligo reactions that develop during melanoma treatment. OBJECTIVE: To describe a new adverse event occurring during anti-PD-1/anti-PD-L1 therapy for LC. DES…

A survey of herbal weeds for treating skin disorders from Southern Thailand: Songkhla and Krabi Province.

ETHNOPHARMACOLOGICAL RELEVANCE: Skin diseases are common health problems which affecting to all ages. In Thailand, the number of patients di … The highest UV was recorded for Commelina benghalensis (0.65). The highest ICF values were found in vitiligo, ringworm, tinea versicolor and burns (1.00 each). The highest FL values were recorded for Cleome gynandra, Cleome viscosa, Sphenoclea zeylanica, Acmella oleracea, Leersia hexandra, Cyperus involucratus, Phyllanthus urinaria and Iresine herbstii (10 …

The mechanisms of action of phototherapy in the treatment of the most common dermatoses.

Phototherapy denotes the use of ultraviolet (UV) light in the management of several dermatoses. Most phototherapy regimens utilize ultraviol … approach are numerous, with psoriasis, atopic dermatitis, cutaneous T-cell lymphomas, morphea, and vitiligo as main indications. The immunomodulatory effects of UVB radiation primarily affect the epidermis and superficial dermis, while UVA radiation affects mid and deep dermal components, especially blood vessels. UVB radiation is absorbed by endogenous c …

Prevalence of Clinical Manifestations Known to Be Associated With Insulin Resistance Among Female Medical Students of a Private College in Saudi Arabia.

Background Insulin resistance has a significant relationship with a lot of chronic diseases. This is an alarm for the future high prevalence … of all the dermatological manifestations, acne, psoriasis, hidradenitis suppurativa, hirsutism, and vitiligo were not associated with waist circumference. Also, polycystic ovary syndrome (PCOS) was statistically significant. Regards cognitive changes, carbohydrate craving, and day sleep were all proportionally higher in the high waist circumference categor …

Immune related adverse events associated with anti-CTLA-4 antibodies: systematic review and meta-analysis.

BACKGROUND: Targeting CTLA-4 is a recent strategic approach in cancer control: blocking CTLA-4 enhances an antitumor immunity by promoting T … rials included in the meta-analysis. Described irAEs consisted of skin lesions (rash, pruritus, and vitiligo), colitis, and less frequently hepatitis, hypophysitis, thyroiditis, and some rare events such as sarcoidosis, uveitis, Guillain-Barré syndrome, immune-mediated cytopenia and polymyalgia rheumatic/Horton. The overall incidence of all-grade irAEs was …

[Examination of animal RBC, Hb and human skin surface blood stream in oxygenation-deoxidization conditions using different spectrum techniques].

UNLABELLED: The authors examined and analyzed animal blood RBC (RBC. O2, RBC. CO2), Hb (HbO2, HbCO2) and the human body's skin surface flowing blood in oxygenation-deoxidization conditions and revealed the characteristic of OD value in the imaginable and unimaginable visible spectrum domain and this gave a foundation for the technology to be applied in the vitiligo sickness epidermis melanin pellet examination. METHODS: Using different spectrum and in vitro and in vivo methods, the authors did statistics for the information of OD value under different state and wavelength. RESULTS: Examinati…

Role of PSO genes in repair of DNA damage of Saccharomyces cerevisiae.

Photoactivated psoralens used in treatment of skin diseases like Psoriasis and Vitiligo cause DNA damage, the repair of which may lead to mutations and thus to higher risk to have skin cancer. The simple eukaryote Saccharomyces cerevisiae was chosen to investigate the cells' genetic endowment with repair mechanisms for this type of DNA damage and to study the genetic consequences of such repair. Genetic studies on yeast mutants sensitive to photoactivated psoralens, named pso mutants, showed their allocation to 10 distinct loci. Cloning and molecular characterization allowed their grouping int…

Обычные педиатрические и подростковые кожные заболевания.

Повреждения кожи встречаются во всех областях медицины, и поэтому важно, чтобы врачи понимали основы объяснения и диагностики общих кожных условий. Эта статья начинается с описания и документирования повреждений кожи на основе цвета, размера, морфологии и распределения. Изображаются такие пигментационные расстройства, как витилиго. В педиатрическом и подростковом возрасте наблюдается резкий рост акрохордонов, дерматофибром, келоид, килиа, нейрофибромы и пиогенные грануломы. Лечение этих ростков, как правило, включает наблюдение или излечение электродессессией. Псориаз, атомный дерматит, ядовит

Совпадение в аннотации оригинала
Skin lesions are encountered in all areas of medicine, and it is therefore important for physicians to understand the fundamentals of explai … of skin lesions based on color, size, morphology, and distribution. Pigmentation disorders such as vitiligo are depicted. Cutaneous growths that are found in the pediatric and adolescent population include acrochordons, dermatofibromas, keloids, milia, neurofibromas, and pyogenic granulomas. Treatment of these growths usually involves observation or curet …

Molecular basis of congenital hypopigmentary disorders in humans: a review.

Many specific gene products are sequentially made and utilized by the melanocyte as it emigrates from its embryonic origin, migrates into sp … absence of melanocytes repopulating the germinative hair follicle during subsequent anagen stages. Vitiligo, in contrast, results from the destruction and removal of the melanocyte in the epidermis and mucous membranes.

Prevalence of skin disorders and associated socio-economic factors among primary school children in the Eastern region of Saudi Arabia.

A randomized control trial was performed to evaluate the effectiveness and safety of absorbable polymeric clips for appendicular stump closure in laparoscopic appendectomy (LA). Patients were randomly enrolled into an experimental group (ligation of the appendicular base with Lapro-Clips, L-C group) or control group (ligation of the appendicular base with Hem-o-lok Clips, H-C group). We identified 1,100 patients who underwent LA between April 1, 2012 and February 3, 2015. Overall, 99 patients (9.0%, 99/1,100) developed a complication following LA (47 [8.5%] in the L-C group and 52 [9.5%] in th

Photoresponsive diseases.

Photoresponsive diseases are skin diseases or conditions that are known to respond with partial or complete clearing to ultraviolet exposure. Phototherapy may be used as a single therapy or as combination therapy with other treatments. Health care professionals providing phototherapy treatment are responsible for educating patients regarding the benefits and risks of phototherapy.

Immunologic disorders of the skin and mucous membranes.

This article provides a practical approach to those dermatologic disorders in which an immunologic mechanism is involved in the pathophysiology. There is a brief discussion of evaluation and management for many of these disorders.

The efficacy of microwave therapy combined with focused ultrasound or white spot ointment combined with infrared light in the treatment of female vulvar sclerotic lichen.

This study aims to investigate the effectiveness of microwave therapy combined with focused ultrasound or white spot ointment combined with … ensions compared to the other 2 groups, with statistical significance (P < .05). The combination of vitiligo cream and infrared light has a significant effect on the treatment of sclerotic lichen of the external genitalia in gynecology. It can reduce the levels of inflammatory factors in the patient's body, improve itching, and improve quality of life.

Autoimmune Skin Diseases and Survival Outcomes After Antineoplastic Treatment in Patients With Cancer.

IMPORTANCE: Autoimmune skin diseases (ASDs) and cancer both involve immune system dysregulation, with ASDs characterized by heightened immun … alyzed from July 2023 to April 2025. EXPOSURES: ASDs, including alopecia areata, Sjögren syndrome, vitiligo, cutaneous lupus erythematosus, psoriasis, lichen planus, autoimmune bullous diseases, systemic sclerosis, morphea, hidradenitis, and dermatomyositis. MAIN OUTCOME AND MEASURES: All-cause mortality and cancer-specific mortality were assessed during …

Defining D-irAEs: consensus-based disease definitions for the diagnosis of dermatologic adverse events from immune checkpoint inhibitor therapy.

With an increasing number of patients eligible for immune checkpoint inhibitors, the incidence of immune-related adverse events (irAEs) is o … the second round of ratings. Consensus definitions were achieved for 10 core D-irAE diagnoses: ICI-vitiligo, ICI-lichen planus, ICI-psoriasis, ICI-exanthem, ICI-bullous pemphigoid, ICI-Grover's, ICI-eczematous, ICI-eruptive atypical squamous proliferation, ICI-pruritus without rash, and ICI-erosive mucocutaneous. A standard evaluation for D-irAE was also …

Optimal antiplatelet therapy after revascularization of left subclavian artery during TEVAR.

BACKGROUND: Thoracic endovascular aortic repair (TEVAR) is a minimally invasive technique used to treat type B aortic dissections. Left subc … cted the occurrence of hemorrhagic events. Chronic conditions in this study encompassed depression, vitiligo, and cholecystolithiasis. Carotid subclavian bypass (CSB) group (HR:0.29, 95% CI: 0.12-0.68, P = 0.004) and single-branched stent graft (SBSG) group (HR:0.26, 95% CI: 0.13-0.50, P < 0.001) had a lower rate of ischemic events than fenestration TEVAR …

Psoralea corylifolia L. seed extract attenuates dexamethasone-induced muscle atrophy in mice by inhibition of oxidative stress and inflammation.

ETHNOPHARMACOLOGICAL RELEVANCE: The seeds of Psoralea corylifolia (PCS), also called "Boh-Gol-Zhee" in Korean, have been used in traditional medicine. PCS is effective for the treatment of vitiligo, cancer, inflammatory diseases, neurodegenerative diseases, kidney diseases, and musculoskeletal diseases. AIM OF THE STUDY: In this study, we validated the beneficial effects of PCS extract on dexamethasone (DEX)-induced muscle atrophy in mice. MATERIALS AND METHODS: DEX (20 mg/kg/day, 10 days) was intraperitoneally injected into C57BL/6 male mice to induce muscular atrophy. Oral administration o…

New-Onset Primary Adrenal Insufficiency and Autoimmune Hypothyroidism in a Pediatric Patient Presenting with MIS-C.

INTRODUCTION: There is emerging speculation that the inflammatory state associated with SARS-CoV-2 infection may trigger autoimmune conditions, but no causal link is established. There are reports of autoimmune thyroiditis and adrenal insufficiency in adults post-COVID-19. We describe the first pediatric report of adrenal insufficiency and autoimmune hypothyroidism after COVID-19. CASE PRESENTATION: A 14-year-old previously healthy girl, with vitiligo, presented in shock following 1 week of fever, lethargy, diarrhea, and vomiting. Three weeks prior, she had congestion and fatigue and known fa…

Association Between Alopecia Areata and Natural Hair Color Among White Individuals.

IMPORTANCE: Alopecia areata (AA) is a complex immune-mediated disorder that causes nonscarring hair loss. Previous reports have documented p … or before graying. The variables considered included diabetes, hypothyroidism, hyperthyroidism, and vitiligo. RESULTS: Of 464 353 participants, 254 505 (54.8%) were women, and the mean (SD) age for those with alopecia areata was 46.9 (16.5) years. Alopecia areata was significantly more common in individuals with black (adjusted odds ratio [aOR], 2.97; 95% …