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Epidemiologic, histopathological, and prognostic analysis of cancer of unknown primary in an Iranian population.

BACKGROUND: Cancer of unknown primary (CUP) is characterized by metastatic cancer cells with no identifiable primary tumor despite extensive diagnostics. This study investigates the epidemiologic, histopathological, and prognostic factors in 352 CUP cases in Iran. MATERIALS AND METHODS: This retrospective study reviewed the clinical documents of CUP patients registered in MACSA, a charity-based referral center in central Iran, Isfahan, within 2016-2021. The patients' data were analyzed, and survival associations were assessed using Cox proportional hazards regression models. RESULTS: Altoget…

Iranian early childhood dental caries: a comprehensive systematic review and meta-analysis of prevalence and associated risk factors.

OBJECTIVES: Early childhood dental caries (ECC) is a prevalent dental condition affecting infants and young children, characterized by one or more carious lesions in primary teeth. ECC risk factors include malnutrition, genetic predisposition, specific dietary habits, lack of fluoride, and prolonged bottle feeding. A comprehensive prevalence estimate is crucial for understanding the extent of dental caries in the population. So, this study aimed to determine the prevalence of ECC and its associated risk factors in Iranian children. METHODS: A comprehensive literature search was conducted in S…

The Effect of Vitamin D3 on Serum Creatine Phosphokinase Level in Patients with Multiple Trauma: A Pilot Randomized Clinical Trial.

The dental pulp is essential for tooth health and sensory function. However, conventional treatments for infected or necrotic pulp, such as … mixture into the root canal. This project was conceived and executed as a joint project in Bushehr (Iran), Shiraz (Iran), and Aktobe (Kazakhstan) from 2022 to 2024. Exosomes were isolated and characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Clinical evaluations, including visual inspection, palpation, p …

A machine learning approach to carbon emissions prediction of the top eleven emitters by 2030 and their prospects for meeting Paris agreement targets.

The continued rise in global carbon dioxide ([Formula: see text]) emissions challenges international climate policy, particularly the goals of the Paris Agreement. This study forecasts [Formula: see text] emissions through 2030 for the eleven highest-emitting nations-China, the United States, India, Russia, Japan, Iran, Indonesia, Saudi Arabia, Canada, South Korea, and Germany-while assessing their progress toward Nationally Determined Contributions (NDCs). Using data from 1990 to 2023, we apply a robust data pipeline comprised of six machine learning models and sequential squeeze feature sele…

Unraveling Hemoglobin D's Influence: A Comprehensive Analysis of Clinicopathological Parameters in Hemoglobin D Patients.

This prospective cross-sectional study was conducted at the Department of Hematology at Armed Forces Institute of Pathology Rawalpindi, Paki … ing), High Performance Liquid Chromatography (on Bio-Rad D10) for differentiating Hb D-Punjab and D-Iran. Molecular studies (using PCR) were performed on samples in which a co-existing β thalassemia mutation was suspected on hemoglobin electrophoresis. Data collected was analyzed on Jamovi v2.4. Over 18 months, 2,171 individuals were tested for hemoglo …

Isolation and genetic profiling of Yersinia enterocolitica strains from diarrheal samples of Iranian children under 5: PCR ribotyping insights.

Yersinia enterocolitica is a common pathogen between humans and animals and is one of the important bacterial pathogens causing gastrointest … typing method, which identified 3 SR. The outbreak of highly pathogenic Y. enterocolitica 1B/O:8 in Iran may be a serious threat to the public health of Iran.

Effectiveness of nutrition counseling in managing gestational weight gain and infant outcomes: a retrospective cohort study.

BACKGROUND: Gestational weight gain (GWG) plays a crucial role in maternal and fetal health outcomes during pregnancy. Excessive weight gain is associated with various complications, emphasizing the importance of effective management strategies. Nutrition counseling has been proposed as a promising intervention to optimize GWG and improve maternal and infant outcomes. The aim of this study was to evaluate the effectiveness of nutrition counseling for pregnant women experiencing unfavorable weight gain during pregnancy, who were referred to a registered dietitian at health centers in Iran. MET…

Predictors of Sleep Habits in Premature Infants: A Cross-Sectional Study.

OBJECTIVES: Despite the significant frequency of sleep disorders in premature infants, the specific causes remain unclear. Thus, pediatricians and other caregivers may be able to prevent the onset of sleep disorders in children. Accordingly, the present study aimed to assess the predictors of sleep habits among preschoolers born preterm. MATERIALS & METHODS: This cross-sectional, retrospective study included 174 preterm infants from the Semnan clinic in Iran between 2019 and 2020. All children between the ages of four and seven years old who were born before 37 weeks were included. Informatio…

Detection and Identification of Leishmania major, Leishmania tropica, and Leishmania infantum in Clinical Samples Based on Size Polymorphism of Partially Amplified Ribosomal DNA.

Accurate Leishmania species identification is crucial for epidemiological aspects and disease management. This study aimed to detect and identify the main causative species of human cutaneous and visceral leishmaniasis in Iran using nested polymerase chain reaction (PCR) based on size polymorphism of the ribosomal DNA (rDNA) intergenic region. In total, 180 clinical samples, including 156 confirmed positive cases, 24 confirmed negative cases, and 33 suspected cases that tested negative by microscopy, were collected from skin lesions, bone marrow, and lymph nodes across five provinces in Iran. …

Избежание распространения информации о здоровье и грамотность в области электронного здравоохранения у пациентов с множественным склерозом: перекрестное корреляционное исследование.

ИСТОРИЯ ВОПРОСА И АИСЮ: Избежание информации означает преднамеренное уклонение или задержку доступа к свободно доступной, но нежелательной информации, а грамотность в области электронного здравоохранения означает способность людей понимать, оценивать, находить и использовать медицинские знания, полученные из электронных источников. Цель настоящего исследования состоит в том, чтобы изучить уровень распространения медицинской информации и грамотности в области электронного здравоохранения среди пациентов с множественным склерозом (МС) в провинции Фарс, Иран, а также их взаимосвязь друг с другом.

Совпадение в аннотации оригинала
BACKGROUND AND AIMS: Information avoidance refers to deliberately evading or delaying access to freely accessible but undesired information, … on avoidance and eHealth literacy levels in patients with multiple sclerosis (MS) in Fars Province, Iran, and their correlation with each other. METHODS: The present research method was a cross-sectional correlational study. The studied population included all patients with MS in Fars Province, Iran, in 2023. The sampling method was convenience sampli …

Mutations in COL6A Gene Family Responsible for Muscular Dystrophies in Three Unrelated Families.

BACKGROUND: Muscular dystrophy is an inherited disease with clinical and genetic heterogeneity. Muscle weakness is the primary symptom of these disorders that often leads to disability and death. The overall prevalence for all types of muscular dystrophies worldwide is 19.8-25.1 per 100,000 population. Autosomal recessive types of muscular dystrophies are more common in Iran, likely due to the high rate of consanguineous marriage. We aimed at deciphering molecular defects in three unrelated families with muscular dystrophies not related to Duchene muscular dystrophy (MD) or limb girdle muscula…

Factors associated with suicidal ideation among medical residents in Tehran during the COVID-19 pandemic: A multicentric cross-sectional survey.

BACKGROUND: The mental health of medical residents, challenged by their intensive training, is of utmost concern. In light of reported suicides among Iranian medical residents in 2021, this study investigates the factors behind suicidal ideation among medical residents during the COVID-19 pandemic in Tehran. METHODS: This study conducted a cross-sectional online survey among medical residents in various specialties in Tehran, Iran, amidst the COVID-19 pandemic. Suicidal ideation was assessed using the Beck Scale for Suicidal Ideation (BSSI), while depression, anxiety, and stress were measured…

Detection and characterization of Brucella species in rodents: A threat for the persistence of brucellosis in livestock farms.

Brucellosis, caused by various Brucella species, poses a significant threat to global public health and livestock industries. This study aims to fill the knowledge gap concerning the presence of Brucella spp. in rodents on livestock farms in Iran. Both bacteriological and molecular surveys were conducted to assess the prevalence of Brucella spp. in these rodent populations. A total of 16 rodents were captured in four seropositive dairy cattle farms (n = 7) and two seropositive sheep farms (n = 9) and were then examined for the presence of the Brucella-infection. Five cow milk samples and 53 bo…

Age at menarche by birth cohort: A pooled analysis of half a million women in Asia.

OBJECTIVES: To evaluate changes in the age at menarche in Asian populations. STUDY DESIGN: Retrospective cohort study. METHODS: We include … nd by country. RESULTS: The study includes data from cohorts in six Asian countries namely, China, Iran, Japan, Korea, Malaysia and Singapore. Birth cohorts ranged from 1873 to 1995. The mean age of menarche was 14.0 years with a standard deviation (SD) of 1.4 years, ranged from 12.6 to 15.5 years. Over 100 years age at menarche showed an overall decr …

Non-inferiority of reverse hybrid regimen versus standard concomitant regimen for H. pylori eradication in a randomized-controlled trial.

BACKGROUND: Helicobacter pylori (H. pylori) infection is strongly related to peptic ulcer disease, chronic gastritis, and gastric malignancies. Therefore, H. pylori eradication is necessary in these cases. This study was aimed to compare the efficacy of 14-day reverse hybrid therapy with standard 14-day concomitant regimen for H. pylori eradication in Iran. METHODS: Of the 317 patients with dyspepsia and H. pylori infection enrolled in the study, 153 and 164 patients were randomly assigned to reverse hybrid and concomitant groups, respectively. The reverse hybrid regimen containing pantoprazo…

Internet-Based Versus Face-to-Face Cognitive-Behavioral Therapy for Social Anxiety Disorder: A Randomized Control Trial.

During the COVID-19 epidemic, face-to-face mental health services faced obstacles. Using Internet-based interventions was a good solution and had the potential to overcome these treatment barriers. However, there is no strong research evidence about the effectiveness of these methods for social anxiety disorder in different cultures and developing countries. Therefore, the present study aimed to investigate the effectiveness and application of Internet-based cognitive-behavioral therapy for social anxiety disorder in Iran. The current study was a pretest-posttest follow-up experimental design.…

Prevalence of Orthopedic Pains in Children and Adolescents: A Systematic Review and Meta-analysis.

CONTEXT: Musculoskeletal disorders are among the main causes of death and disability and can impose high costs on individuals and countries. Considering the importance of pain, the present meta-analysis study aimed to investigate the prevalence of orthopedic pains in Iranian children and adolescents. METHODS: The present study was reported in line with PRISMA. The searching process was carried out using keywords, including adolescents, pain, youth, school-age children, shoulder pain, neck pain, shoulder, and neck, AND/OR operators for the articles published during 2000 and 2022 in Scopus, Emb…

Comparison of a Multiplex Real-Time PCR Technique with Oxford Nanopore Technologies Next-Generation Sequencing for Identification of SARS-CoV-2 Variants of Concern.

INTRODUCTION: The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and their potential to endangering the global health has increased the demand for a fast-tracking method in comparison to the next-generation sequencing (NGS) as a gold standard assay, particularly in developing countries. This study was designed to evaluate the performance of a commercial multiplex real-time PCR technique (GA SARS-CoV-2 OneStep RT-PCR Kit, Iran) for identification of SARS-CoV-2 variants of concern (VOCs) compared to the Oxford Nanopore NGS assay. METHODS: A total of 238…

Influence of sexually transmitted infections on the cervical cytological abnormalities among Iranian women: A cross-sectional study.

BACKGROUND: Sexually transmitted infections (STIs) are one of the world's most severe health challenges. The existence of STIs such as human papillomavirus (HPV) might cause cervical cell changes leading to cervical cancer. OBJECTIVE: This study aims to assess the association of STIs with cervical cytological abnormalities and genital warts among women in northeastern Iran. MATERIALS AND METHODS: This cross-sectional study was carried out on 190 women referred to the central laboratory of Academic Center for Education, Culture, and Research, Mashhad, Iran from March to July 2022. The presenc…

Sleep characteristics of Iranian people and their effects on daytime functioning: a population-based study.

Sleep characteristics vary between populations. Detrimental sleep habits have cognitive consequences leading to daytime functioning debilitation. Until now no study has been done to investigate sleep characteristics in Iran thoroughly. In this study, we aimed to evaluate Iranians' sleep characteristics and their association with daytime functioning. We conducted a population-based study from January 2017 to May 2019 on people more than 18 years old who lived in 11 urban destricts and 3 rural areas of Tehran, Iran. We randomly selected the participants using a multistage random stratified clust…