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Spinal H-Sign in Syphilitic Myelitis Mimicking MOGAD.

INTRODUCTION: Longitudinally extensive transverse myelitis (LETM) is classically associated with aquaporin-4 antibody-mediated neuromyelitis … amination revealed spastic paraparesis with tetrapyramidal signs, saddle hypoesthesia, and impaired vibration sense. Thoracic spine MRI demonstrated LETM from T4 to T10 with central gray matter involvement forming the "H-sign." Postcontrast sequences showed intense pial and intramedullary enhancement with inversion of signal intensity ("flip-flop sign"), su …

Effect of Novel Laser Shoe Photobiomodulation on Neuropathic Pain and Plantar Pressure Profile in Type 2 Diabetes Mellitus with Peripheral Neuropathy.

BACKGROUND: Photobiomodulation (PBM) or Low-level laser is used to treat diabetic foot complications. The existing method of laser applicati … re treated with PBM by a specially designed novel Laser Shoe. Outcomes were clinical variables like Vibration Perception Threshold (VPT), Visual Analogue Scale (VAS), Michigan neuropathy screening instrument A&B, Ankle-Brachial Index (ABI), and Static dynamic gait parameters. RESULTS: Participants were with an average age of 62, and the average duration of …

Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference.

BACKGROUND: Noninvasive tests are crucial for the management and follow-up of patients with autoimmune hepatitis, but their validation is limited because of insufficient data. AIM: To investigate the diagnostic performance of three fibrosis noninvasive tests [FibroTest, vibration-controlled transient elastography (VCTE), and the fibrosis-4 index (FIB-4) and two activity biomarkers (alanine aminotransferase (ALT) and ActiTest]. METHODS: This study enrolled 103 patients for whom liver biopsy, hepatic elastography results, and laboratory markers were available. Diagnostic performance was assess…

Quality Measures to Enhance the Management and Treatment of Primary Biliary Cholangitis: A Delphi Consensus Study.

BACKGROUND & AIMS: Primary Biliary Cholangitis (PBC) is a chronic autoimmune liver disease characterised by bile duct destruction, leading t … SULTS: Strong consensus was reached on the appropriateness of non-invasive diagnostic tools such as Vibration-Controlled Transient Elastography (VCTE) and abdominal ultrasound for staging and monitoring fibrosis in chronic cholestasis. Different treatment options were evaluated in patients with inadequate response to UDCA, including compensated cirrhosis (C …

Non-porous silica nanoparticles as a cavitation sensitive vehicle for antibiotic delivery.

Ultrasound stimulated drug delivery is attractive for controlled dose and localised delivery to reduce excess loss of drug and side effects, … s particles, CPX ⊂ SiO2. Laser doppler vibrometry (LDV) was employed to characterise the ultrasonic vibration displacement of the sonotrode. Drug release from CPX ⊂ SiO2 was monitored for increasing the tip displacement. Clinically relevant quantities of CPX release (5.7 mg/L) occurred at 40 μm tip displacement in our studies. A strong correlation was obser …

Self-driven piezotronic effect enhances the photocatalytic bactericidal activity of polyvinylidene fluoride/bismuth sulfide.

The antimicrobial properties of dressings are critical for wound recovery, as they serve as the first line of defense against microbial inva … n the PVDF matrix significantly enhances the photocatalytic efficiency of Bi2S3. Furthermore, under vibration conditions, the piezotronic effect of the PVDF membrane further improved the photocatalytic sterilization efficiency of PVDF/Bi2S3 compared to static conditions. When applied as a dressing for trauma treatment in mice, the movement and limb traction …

A Comprehensive Investigation into the Mechanism Governing the ESDPT Behavior of Bis-3,6-(2-benzoxazolyl)pyrocatechol Regulated by Solvent Effects and Chalcogen Substitutions.

In this study, we investigated bis-3,6-(2-benzoxazolyl)pyrocatechol (BBPC) derivatives with symmetric structures and their intramolecular hy … conclusion was consistently verified through the calculation of geometric parameters, infrared (IR) vibration frequencies, and charge distributions. Frontier molecular orbital (MO) analysis showed that the HOMO/LUMO distribution of BBPC derivatives systematically shifts with the change in the electronegativity of chalcogen elements, providing an electronic …

Exploring the Changes in Pain Quality, Mechanical Allodynia, and Tactile Sensibility in Women With Persistent Postpartum Perineal Pain Treated With Somatosensory Rehabilitation: A Retrospective Case Series.

Background Persistent postpartum perineal pain (PPPP) is a prevalent condition characterized by provoked, unprovoked, or mixed pain. Somatos … s well as tactile sensibility (pressure perception threshold, static two-point discrimination test, vibration perception threshold). Results All patients showed a reduction in pain quality score and resolution of mechanical allodynia in the vulva, defined by the criteria of no significant exacerbation of pain upon touch with a 15.0-g Semmes-Weinstein monofi …

Early Injection Laryngoplasty: Acoustic and Aerodynamic Outcomes with a Modified General Anesthesia Approach.

Background and Objectives: This study aimed to evaluate postoperative changes in voice quality and glottic function following early injectio … cantly (p = 0.085). Videostroboscopic findings demonstrated improved glottic closure and vocal fold vibration. No major complications occurred. Conclusions: Early injection laryngoplasty with hyaluronic acid performed under general anesthesia and endoscopic guidance provides significant improvement in objective voice parameters and glottic efficiency in uni …

Integrated network toxicology and population-based analysis uncovers organophosphate flame retardant exposure as a risk factor for hepatic steatosis and fibrosis: mechanistic and clinical insights.

BACKGROUND: Laboratory evidence has recently shown that exposure to organophosphate flame retardants (OPFRs) can cause adverse liver outcomes, which lacks further validation. OBJECTIVE: This investigated the correlation and toxicological mechanism between OPFRs exposure and hepatic steatosis or fibrosis. METHOD: To explore the association of OPFRs exposure and hepatic steatosis or liver fibrosis, we conducted the population analysis using the data of urinary OPFRs monitoring and liver vibration-controlled transient elastography examinations from the National Health and Nutrition Examination …

Identification of Clinically Significant Portal Hypertension in cACLD Individuals With Spleen Stiffness Measurement.

BACKGROUND AND AIMS: The Baveno VII consensus recommends spleen stiffness measurement (SSM) for the detection of clinically significant portal hypertension (CSPH) in patients with compensated advanced chronic liver disease (cACLD). We aimed to evaluate the performance of SSM-based algorithms. METHODS: Consecutive cACLD individuals who underwent hepatic venous pressure gradient measurement, liver stiffness measurement (LSM), and SSM measured with the dedicated 100-Hz probe by vibration-controlled transient elastography were prospectively enrolled. RESULTS: From July 2021 to August 2024, a tot…

Feasibility of Early Vestibular Screening and Developmental Changes in Air- and Bone-Conducted Cervical Vestibular Evoked Myogenic Potentials in Infants and Children with Normal Hearing.

Objective: To evaluate the feasibility of vestibular screening in infants and investigate age-related changes in the characteristics of air-conducted sound cervical vestibular evoked myogenic potential (ACS-cVEMP) and bone-conducted vibration cervical vestibular evoked myogenic potential (BCV-cVEMP) in infants and children with normal hearing, aiming to provide new insights into the developmental trajectory of vestibular function during early childhood. Methods: A total of 159 subjects aged 3 months to 17 years old were divided into seven age groups. Additionally, 20 adults aged 18-30 years we…

Myofunctional Therapy and Its Effects on Retropalatal Narrowing and Snoring: A Preliminary Analysis of Rehabilitative Approaches.

Introduction: Snoring is a common and disturbing condition that is associated with sleep apnea in some cases. Retropalatal narrowing has been reported to be often associated with the condition, as it can lead to increased air turbulence and vibration of tissues in the throat during breathing. The activation of the tongue, soft palate, lateral wall of the pharynx, and face has been shown to keep the upper muscles open during sleep, potentially improving snoring. Therefore, this study aims to determine the effects of myofunctional therapy (MT) in patients with collapsed pharynx. Methods: A total…

Влияет ли на баланс кинезио у людей с множественным склерозом?

КОЛИЧЕСТВО: У лиц с множественным склерозом (MS) широко распространены расстройства баланса в результате совокупного воздействия отсутствия надлежащего постурального контроля, мышечной слабости, атаксии и отсутствия сенсорной информации. Цель этого исследования заключалась в оценке воздействия кинезио сканирования (КТ) на баланс между предметами и НР. Это было неконтролируемое исследование наблюдения. Была проведена последующая оценка удобной выборки из 30 человек с НР. КТ был применен непосредственно к коже под ногой. Клинические оценки проводились на базовом уровне непосредственно до и после

Совпадение в аннотации оригинала
BACKGROUND: Balance disorders are common in individuals with multiple sclerosis (MS) due to the combined effects of lack of adequate postura … on-dominant extremities (pbefore = .001, pafter = .002). There was a significant difference between vibration and two-point discrimination and balance (p > 0.05). There was no significant relationship between light touch sense and balance (p > 0.05). Further, except for tibialis anterior muscle strength, there was no significant difference between balance a …

Efficacy of imeglimin in patients with type 2 diabetes mellitus complicated by metabolic dysfunction-associated steatotic liver disease: A multicentre study.

AIMS: This study aimed to evaluate the effectiveness of imeglimin in improving liver function and fibrosis in patients with type 2 diabetes … ST) score. Liver fat content and stiffness were measured using controlled attenuation parameter and vibration-controlled transient elastography, which were measured using FibroScan. RESULTS: Compared with the control group, imeglimin treatment led to a significant reduction in HbA1c levels, fasting blood glucose and liver-related parameters, including AST, …

Liver fibrotic burden across the spectrum of hypothyroidism.

BACKGROUND: Data regarding the prevalence of hepatic fibrotic burden across the spectrum of hypothyroidism are scarce. Hence, we aimed to evaluate the prevalence of liver fibrotic burden across the spectrum of hypothyroidism. METHODS: 30,091 individuals who attended a Health Management Centre between 2019 and 2021 were cross-sectionally analyzed. Participants were categorized as having strict-normal thyroid function, low-normal thyroid function, subclinical hypothyroidism, and overt hypothyroidism. Hepatic fibrosis was assessed by vibration-controlled transient elastography (VCTE). Significan…

Association between Weight-Adjusted Waist Index and Depression in NAFLD: the modulating roles of sex and BMI.

BACKGROUND: The Weight-Adjusted Waist Index (WWI) is a novel indicator of obesity that accurately reflects body composition. However, the association between WWI and depression in patients with non-alcoholic fatty liver disease (NAFLD) remains unclear. This study aims to explore this relationship through a nationally representative cross-sectional analysis. METHODS: This study included adult participants diagnosed with NAFLD from NHANES 2017-2020. WWI was calculated as the waist circumference (cm) divided by the square root of body weight (kg). NAFLD diagnosis relied on vibration-controlled t…

FIB-4 Index and Liver Stiffness Measurement are Potential Predictors of Atherosclerosis in Metabolic Dysfunction-Associated Steatotic Liver Disease.

AIMS: Cardiovascular disease (CVD) is a common cause of death in patients with metabolic dysfunction-associated steatotic liver disease (MAS … es (Max-IMT) was measured by ultrasound. To predict liver fibrosis, liver stiffness was measured by vibration-controlled transient elastography and the fibrosis 4 (FIB-4) index was calculated. Coronary computed tomography angiography was performed to detect coronary artery stenosis based on a Max-IMT of ≥ 1.1 mm. RESULTS: The median Max-IMT was 1.3 mm, and …

Is Farming a Risk Occupation for Cardio-cerebrovascular Diseases? A Scoping Review on Cardio-cerebrovascular Disease Risk in Farmers.

OBJECTIVES: In Korea, cardio-cerebrovascular disease (CCVD) is recognized as an occupational disease when sufficient evidence of a work-rela … lack of holidays, and strenuous physical labor; physical factors (noise, cold, heat, humidity, and vibration); exposure to hazardous gases (diesel exhaust, carbon monoxide, hydrogen sulfide, carbon disulfide, nitrogen oxides, and polycyclic aromatic hydrocarbons), pesticides, and dust (particulate matter, silica, and organic dust); exposure to a hypoxic en …

Effects of a mat Pilates-based exercise program for low back pain in helicopter pilots of the Brazilian Air Force: Randomized controlled trial.

INTRODUCTION: Helicopter pilots may present chronic low back pain due to vibration exposure and asymmetric posture during flight. OBJECTIVES: To analyze the effects of a Pilates-based exercise program on low back pain of helicopter pilots of the Brazilian Air Force. METHODS: This is a randomized controlled trial with fifteen helicopter pilots of the Brazilian Air Force, who were assessed for pain intensity (Numerical Pain Rating Scale), disability associated with low back pain, and spine muscle endurance in three positions: trunk extension (Ito test) and left and right lateral bridge. Indivi…