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The impact of renal dysfunction after critical illness on the management of cancer.

A 67-year-old male patient with limited-stage diffuse large B-cell lymphoma was on an R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone) chemotherapy regimen. His Eastern Cooperative Oncology Group (ECOG) Performance Scale score was zero, indicating functional independence for activities of daily living. The patient was admitted to the intensive care unit (ICU) with septic shock in the presence of febrile neutropenia progressing to acute kidney injury, hypoxemic respiratory failure, and systemic arterial hypotension, in addition to the already established hematologic

Совпадение в полном тексте источника
… Author contributions TR: Conceptualization, Methodology, Project administration, Writing – original draft, Writing – review & editing. RC: Writing – original draft, Writing – review & editing. IA: Writing – original draft, Writing – review & editing. … HP: Writing – original draft, Writing – review & editing. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. …

POEMS syndrome misdiagnosed as liver cirrhosis: a case report.

POEMS syndrome is a rare multisystem paraneoplastic disorder characterized by polyneuropathy and monoclonal plasma cell proliferation, often leading to delayed diagnoses due to variable clinical manifestations. A 62-year-old woman presented with persistent bilateral eyelid edema as the initial symptom and abdominal distension as the predominant complaint. She was misdiagnosed with liver cirrhosis and remained undiagnosed for 6 years. Multidisciplinary evaluation revealed monoclonal IgA λ protein, markedly elevated vascular endothelial growth factor, and neurophysiological evidence of periphera

Совпадение в полном тексте источника
… Author contributions JX: Writing – original draft. WN: Writing – original draft. ZF: Writing – original draft. HZ: Writing – original draft. SL: Writing – original draft. FL: Writing – original draft. FG: Writing – original draft. LS: Writing – original draft. NW: Writing – review & editing. …

Балансирование иммунотерапии рака клеток CIK и PPAR Ligands: One Потенциальное терапевтическое приложение для злоумышленников CNS.

Клеточная терапия, вызванная цитокином (CCK), оказалась успешной в клинических испытаниях на глиобластому. Не менее важное значение имеют и намеки на то, что в центральной нервной системе (КНС) сосуществуют пероксисомные рецепторы (PPARs) с активированными рецепторами. Это служит обоснованием для изучения возможного синергического эффекта клеток CIK и PPAR. Methodology Мы изучали нейробластому и глиобластомные клеточные линии со зрелыми клетками CIK и PRAR antagonist GW-9662 для оценки воздействия на жизнеспособность клеток, потенциальное генное выражение (Wnt/β-ctenin сигнализация, DNMT1) и г

Совпадение в полном тексте источника
… Author Contributions Kira Vordermark: methodology (equal), writing – original draft (lead), writing – review and editing (equal). JingJing Pu: methodology (equal), writing – review and editing (equal). Amit Sharma: conceptualization (equal), writing – review and editing (equal). … Jarek Maciacyzk: conceptualization (equal), writing – review and editing (equal). Ingo G. H. Schmidt‐Wolf: conceptualization (equal), writing – review and editing (equal). Ethics Statement The authors have nothing to report. Consent The authors have nothing to report. …

Review Article: Immune Effector Cell-Mediated Enterocolitis Following CAR-T Cell Therapy-Clinical Features, Pathophysiology and Management.

BACKGROUND: Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionised the treatment of hematologic malignancies, and its use is expanding rapidly into numerous other disease states including autoimmune diseases. However, CAR-T therapy is associated with a spectrum of immune-related toxicities. In addition to the already well characterized cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, it has become apparent that rarely, CAR-T can cause gastrointestinal mucosal inflammation, termed immune effector cell-mediated enterocolitis (IEC-EC). AIMS: This

Совпадение в полном тексте источника
… Damianos: conceptualization, investigation, writing – original draft, methodology, validation, visualization, writing – review and editing, formal analysis, data curation. Navreet M. … Chowla: conceptualization, investigation, methodology, writing – original draft, validation, writing – review and editing, formal analysis, project administration, supervision, data curation, resources. Kenneth J. C. …

LimphoTEC: Ретроспективное исследование реального мира по восстановлению лимфоцитов после лимфопенсии у пациентов с множественным склерозом, обработанных диметилФумаратом во Франции.

ВВЕДЕНИЕ: Диметилфумарат (ДМФ) продемонстрировал благоприятную характеристику риска получения выгод у пациентов с множественным склерозом (РРМС), излучающим повторные выбросы. Некоторые пациенты могут развивать лимфопенцию на ДМФ; поэтому LimphoTEC произвела оценку абсолютного количества лимфоцитов (ALC) после прекращения ДМФ. МЕТОДЫ: " LimphoTEC " - это ретроспективное многоцентральное исследование пациентов с RRMS в регистре Français de la Sclerose en Plaques. Времена для восстановления АЛК и лимфакопии были оценены методом Каплан-Мейер. Университетский и многовариантный анализ поз

Совпадение в полном тексте источника
… Medical Writing/Editorial Assistance Biogen provided funding for medical writing and editorial support in the development of this manuscript. … – review and editing; Marilyn Gros, Marta Ruiz: Conceptualization; formal analysis; investigation; methodology; writing – review and editing; Hanyue Li: Data curation; formal analysis; writing – review and editing; Fabien Rollot: Data curation; formal analysis; investigation; writing – review and editing …

Lenalidomide in the treatment of anti-myelin-associated glycoprotein neuropathy: A phase 1 study to identify the maximum tolerated dose.

BackgroundAnti-myelin-associated glycoprotein (MAG) neuropathy is a debilitating demyelinating polyneuropathy with no approved therapies. Our primary objective was to ascertain lenalidomide safety and maximum tolerated dose (MTD) in anti-MAG neuropathy.MethodsThis phase 1b, open-label, single-arm, dose-finding trial was conducted from 2019 through 2022. The original design included a dose-escalation/extension phase followed by a dose-expansion phase. Three doses of lenalidomide were evaluated: 10, 15, and 25 mg. The main outcome was the MTD.ResultsEleven patients enrolled (10 men), with a mean

Совпадение в полном тексте источника
… Ben Murdock: Formal analysis; methodology; writing – review and editing; software. Maciej Pietrzak: Writing – review and editing; data curation; methodology; formal analysis; software. Gerard Loszanski: Software; formal analysis; supervision; methodology. David M. … Kline: Conceptualization; investigation; writing – review and editing; methodology; formal analysis; supervision. Yvonne Efebera: Conceptualization; investigation; writing – review and editing; methodology; formal analysis; supervision. …

Developing a patient portal for haematology patients requires involvement of all stakeholders and a customised design, tailored to the individual needs.

BackgroundElectronic patient portals are increasingly being implemented, also in (haemato) oncology. However, portal usage is low and depends on user and provider engagement. We explored wishes, expectations and thoughts of patients with a haematologic malignancy and their physicians with regard to the electronic patient portal.MethodsBased on insights from literature and a focus group discussion we built a 44-item questionnaire. This questionnaire was spread amongst patients with a haematologic malignancy at the outpatient clinic that was not yet exposed to patient portal facilities. Haematol

An exploratory randomized-controlled trial of the efficacy of the Src-kinase inhibitor saracatinib as a novel analgesic for cancer-induced bone pain.

Pain is a major symptom of bone metastases from advanced cancer and represents a clinical challenge to treat effectively. Basic neurobiology in preclinical animal models implicates enhanced sensory processing in the central nervous system, acting through N-methyl-D-aspartate (NMDA) glutamate receptors, as an important mechanism underpinning persistent pain. The non-receptor tyrosine kinase Src is thought to act as a hub for regulating NMDA receptor activity and the orally available Src inhibitor saracatinib has shown promise as a potential analgesic in recent animal studies. Here we tested the

Совпадение в полном тексте источника
… KJane Escott: Methodology, Resources, Writing - review & editing. Robert E Coleman: Conceptualization, Funding acquisition, Writing - review & editing. Sam H Ahmedzai: Conceptualization, Funding acquisition, Writing - review & editing. … Michael I Bennett: Investigation, Project administration, Supervision, Writing - review & editing. David Andrew: Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing - original draft, Writing - review & editing. …

Phosphodiesterase 7: a potential novel therapeutic target in ovarian cancer.

INTRODUCTION: Chemoresistance and disease relapses in epithelial ovarian cancer (EOC) highlight the need for novel therapeutic strategies. Here, we investigated phosphodiesterase 7A (PDE7A) as a potential target in ovarian cancer treatment. METHODS: Gene expression was performed by RNA sequencing data comparing high-grade serous ovarian carcinoma (HGSOC) and fallopian tube samples. The PDE7 inhibitor BRL 50481, alone or combined with paclitaxel (PTX), was tested in drug-sensitive A2780 and multi-resistant OVCAR3 cells by Diphenyltetrazolium bromide (MTT) assay. To validate data from the high

Совпадение в полном тексте источника
… Author contributions NT: Investigation, Methodology, Project administration, Writing - original draft, Writing - review and editing. IG: Writing - original draft, Writing - review and editing. DdS: Writing - review and editing. TH: Writing - review and editing. PL-J: Writing - review and editing. … LM: Writing - review and editing. JA: Writing - review and editing. IS: Visualization, Writing - original draft, Writing - review and editing. …

Реальная эффективность и терпимость комбинированной терапии на основе ixazomib в современных множественных миеломах и других плазменных новообразованиях клеток.

Ixazomib — пероральный протеазонный ингибитор для реактивной/охотничьей множественной миеломы (RRMM). Цель нашего исследования состояла в анализе эффективности и терпимости комбинированной терапии на основе ixazomib. Methods Мы провели ретроспективный анализ в одном центре 126 - пациенты с опухолью RRMM и другими плазменными клетками. 65 лет, с медианой two :: предыдущая терапия и 16.7% был тройным рефрактом. Общая доля ответивших (ОРС) 52.5%; у трехклассных пациентов, страдающих рефрактом, ОРР значительно ниже, чем у нереактивных органов контроля (см.10.5% vs. 60.2%, р 2 была увязана с более

Совпадение в полном тексте источника
… Julia Mersi: Data curation; Investigation; Writing – review & editing. Christine Riedhammer: Data curation; Formal analysis; Writing – review & editing. Maximilian J. Steinhardt: Data curation; Formal analysis; Methodology; Writing – review & editing. … Max Bittrich: Data curation; Formal analysis; Writing – review & editing. Stefan Knop: Methodology; Project administration; Writing – review & editing. Hermann Einsele: Funding acquisition; Investigation; Methodology; Project administration; Writing – review & editing. …

Изучение вопроса о том, имеет ли распространение информации во времени существенное значение для повторного выявления множественных склерозов.

Диагноз множественных склерозов (MS) требует как распространения в космосе (DIS), так и во времени (DIT); олиголональные полосы (OCB) в CSF могут заменить DIT на MRI. Мы изучили вопрос о том, необходим ли DIT (или положительный CSF) для диагностики MS у пациентов, отвечающих большому числу критериев СОП. Мы вероятно наняли пациентов с первым демиелинизирующим событием, которое оценивалось с помощью MRI мозга и спинного мозга. 3 месяцев начала. За пациентами следили клинически и с МРТ. Мы ретроспективно применяли критерии СОП, требующие нанесения повреждений ≥2/4, ≥3/4, или 4/4 регионов, обычно

Совпадение в полном тексте источника
… Davagnanam: drafting/revision of the manuscript for content, including medical writing for content; analysis or interpretation of data. S. Collorone: drafting/revision of the manuscript for content, including medical writing for content; major role in the acquisition of data. F. … Prados: drafting/revision of the manuscript for content, including medical writing for content; analysis or interpretation of data. B. Kanber: drafting/revision of the manuscript for content, including medical writing for content; analysis or interpretation of data. F. …

Marketing authorisation and pricing of FDA-approved cancer drugs in Brazil: a retrospective analysis.

BackgroundMost cancer drugs enter the US market first. US Food and Drug Administration (FDA) approvals of new cancer drugs may influence regulatory decisions in other settings. The study examined whether characteristics of available evidence at FDA approval influenced time-to-marketing authorisation (MA) in Brazil, and price differences between the two countries.MethodsAll new FDA-approved cancer drugs from 2010 to 2019 were matched to drugs with MA and prices approved in Brazil by December 2020. Characteristics of main studies, availability of randomised controlled trials (RCTs), overall surv

Совпадение в полном тексте источника
… Contributors AMIB: conceptualisation, data curation, formal analysis, investigation, writing original draft, writing—review, and editing. FLM: data curation, formal analysis, and writing—review. AKW: formal analysis, writing—review, and editing. … CGSOC: formal analysis, writing—review, and editing. SV: investigation, writing—review, and editing. EM: investigation, writing—review, and editing. CLTA: formal analysis, and writing—review. …

Safety and Efficacy of Combination Maintenance Therapy with Ixazomib and Lenalidomide in Patients with Posttransplant Myeloma.

PurposeIn this study, the addition of ixazomib to lenalidomide maintenance post-autologous stem cell transplant (ASCT) in 64 patients with newly diagnosed multiple myeloma was evaluated on the basis of the observed benefit of lenalidomide-only maintenance in prior studies.Patients and methodsPatients were started on maintenance therapy with lenalidomide and ixazomib within 60-180 days of stem cell infusion.ResultsResponse rates deepened over time from baseline post-ASCT for 39 patients. The complete response (CR)/stringent CR rate was 43% and median overall survival was not reached with a medi

Совпадение в полном тексте источника
… Lee: Supervision, writing–review and editing, enrollment and evaluation of patients. E.M. Manasanch: Supervision, writing–review and editing, enrollment of patients and evaluation/treatment. J. Olsem: Data curation, supervision, project administration, writing–review and editing. A. … Morphey: Data curation, supervision, investigation, writing–review and editing. X.J. Huo: Data curation, writing–review and editing. S.K. Thomas: Investigation, writing–review and editing, patient enrollment and care. Q. Bashir: Writing-review and editing, patient care, stem cell transplant. M.H. …

Persistent lactic acidosis in ALK-positive anaplastic large cell lymphoma: a case report and literature review.

Lactic acidosis is common in the ICU, but malignancy-associated type B lactic acidosis mediated by the clinical Warburg effect (CWE) is uncommon and easily missed when infection or organ dysfunction dominates the presentation. We report a 35-year-old man with a month of fever and progressive dyspnea who presented with persistent hyperlactatemia (peak 15.46 mmol/L) and markedly elevated LDH despite stable hemodynamics. Imaging revealed generalized lymphadenopathy, multifocal osteolytic lesions, and bilateral pleural effusions; infectious studies were unrevealing apart from chronic hepatitis B.

Совпадение в полном тексте источника
… Author contributions HJ: Conceptualization, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing. ZX: Supervision, Writing – review & editing. QA: Investigation, Supervision, Writing – original draft. QH: Investigation, Supervision, Writing – original draft. … XC: Investigation, Supervision, Writing – original draft. YL: Investigation, Writing – review & editing. PH: Investigation, Supervision, Writing – original draft. YQ: Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing. …

Impulsivity and sexual compulsivity - a comparison of untreated individuals with CSBD, individuals undergoing long-term treatment for CSBD, and a healthy control group.

BACKGROUND: Compulsive Sexual Behavior Disorder (CSBD) has been classified in the eleventh revision of the International Classification of Diseases (ICD-11) as an impulse control disorder. Impulsivity, risk-taking, and compulsivity play an important role in CSBD. AIMS: The present study aims to examine impulsivity and sexual compulsivity by comparing three groups: untreated individuals with CSBD, individuals undergoing long-term treatment for CSBD, and a healthy control group. The study aims to use questionnaires and computerized tasks measuring risk-taking and delay discounting in order to i

Совпадение в полном тексте источника
… MD: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Writing – original draft, Writing – review & editing. RA: Conceptualization, Investigation, Writing – original draft, Writing – review & editing. … YM: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Writing – original draft, Writing – review & editing. …

Экспериментальное вливание повреждений миелина в посмертных ломках человеческого мозга.

Механизмы, которые приводят к повреждению миелина, как это видно в таких демиелионирующих расстройствах, как множественный склероз, остаются неясными. Значительная часть наших нынешних знаний основана на моделях животных, но различия между видами ограничивают их актуальность в контексте человеческой патологии и могут объяснить, почему различные перспективные методы лечения не сработали во время клинического перевода. После смерти органотипные культуры мозга человека обеспечивают уникальную платформу для изучения биологии миелина человека, поскольку они сохраняют генетический, цитоархитектуальн

Совпадение в полном тексте источника
… B.’t.H. contributed to conceptualization, methodology, supervision, project administration, and writing – review & editing. B.C.P. contributed to methodology and writing – review & editing. M.B. contributed to methodology and writing – review & editing. … A.G. contributed to investigation, writing – review & editing, and visualization. N.W. contributed to investigation, writing – review & editing, and visualization. Ö.B. contributed to formal analysis, investigation, writing – review & editing, and visualization. …

Photobiomodulation therapy on chemo- and radiotherapy induced oral conditions: an umbrella review.

ObjectivesPhotobiomodulation (PBM) is a laser-based therapy used to promote tissue repair, reduce inflammation and pain, and has been extensively studied in chemo- and radiotherapy-induced oral mucositis (OM). This review examines the level of evidence of systematic reviews (SRs) that have investigated PBM in such cases of OM.Materials and methodsSRs evaluating PBM for both the treatment and prevention of OM in patients undergoing chemotherapy and/or radiotherapy and published before November 30, 2023, on PubMed, Cochrane, Embase, Web of Science, LILACS, TRIP and Open Grey databases were eligi

Совпадение в полном тексте источника
… Authors’ contributions Inês Rodrigues: Conceptualization; Data curation; Formal analysis; Investigation; Methodology; Writing - original draft; Writing - review & editing. Vanessa Machado: Methodology; Resources; Software; Writing - original draft; Writing - review & editing. … Luísa Bandeira Lopes: Writing - review & editing. Pedro Trancoso: Writing - review & editing. António Mano Azul: Writing - review & editing. José João Mendes: Supervision, Writing- Reviewing and Editing. Carlos Zagalo: Supervision, Writing- Reviewing and Editing. …

Rhabdomyolysis secondary to COVID-19 infection and vaccination: a review of literature.

Rhabdomyolysis (RML), characterized by the breakdown of skeletal muscle fibers and the release of muscle contents into the bloodstream, has emerged as a notable complication associated with Coronavirus disease 2019 (COVID-19) infection and vaccination. Studies have reported an increased incidence of RML in individuals with severe COVID-19 infection. However, the exact mechanisms remain unclear and are believed to involve the host's immune response to the virus. Furthermore, RML has been documented as a rare adverse event following COVID-19 vaccination, particularly with mRNA vaccines. Proposed

Совпадение в полном тексте источника
… KA: Writing – original draft. RN: Writing – original draft. MaM: Writing – original draft. FJ: Writing – original draft. PK: Writing – original draft. … MA: Writing – original draft, Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization. MS: Writing – original draft. MoM: Writing – original draft. …

The therapeutic role of γδT cells in TNBC.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer that presents significant therapeutic challenges due to the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression. As a result, conventional hormonal and targeted therapies are largely ineffective, underscoring the urgent need for novel treatment strategies. γδT cells, known for their robust anti-tumor properties, show considerable potential in TNBC treatment as they can identify and eliminate tumor cells without reliance on MHC restrictions. These cells de

Совпадение в полном тексте источника
… Author contributions WL: Conceptualization, Visualization, Writing – original draft, Writing – review & editing. XZ: Writing – original draft, Writing – review & editing. CR: Writing – original draft, Writing – review & editing. SG: Writing – review & editing. … QH: Writing – original draft, Writing – review & editing. ML: Writing – original draft, Writing – review & editing. XL: Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing. …

Beyond dual targeting: redefining the treatment horizon for true extramedullary myeloma? - a critical appraisal.

The management of relapsed/refractory multiple myeloma with true extramedullary disease (EMD) remains a critical challenge. The phase 2 RedirecTT-1 study evaluated the combination of two bispecific antibodies, talquetamab (anti-GPRC5D) and teclistamab (anti-BCMA), in this high-risk population. While the reported overall response rate of 79% and 12-month progression-free survival of 61% are promising, a balanced interpretation requires caution. The single-arm design, short follow-up (12.6 months), and indirect comparisons with CAR-T therapy preclude definitive conclusions about comparative effe

Совпадение в полном тексте источника
… Footnotes Edited by: David Gomez-almaguer , Autonomous University of Nuevo León, Mexico Reviewed by: Markus Maulhardt , University Medical Center Göttingen, Germany Author contributions QK: Conceptualization, Formal Analysis, Resources, Writing – original draft, Writing – review & editing. … SZ: Conceptualization, Formal Analysis, Writing – original draft, Writing – review & editing. Conflict of interest The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. …