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[Susceptibilities of bacteria isolated from patients with lower respiratory infectious diseases to antibiotics (1996)].

The bacteria isolated from the patients with lower respiratory tract infections were collected by institutions located throughout Japan, sin … nem (FRPM) showed the next potent activity with MIC80 of 0.125 microgram/ml. The other drugs except erythromycin (EM), clindamycin (CLDM) and tetracycline (TC) were active against S. pneumoniae tested with MIC80s of 8 micrograms/ml or below. 3) H. influenzae The activities of all drugs were potent against H. influenzae tested with MIC80s of 4 micrograms/ml or …

[Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (1995). I. Susceptibility distribution].

The frequencies of isolation and susceptibilities to antimicrobial agents were investigated on 704 bacterial strains isolated from patients … e All drugs except gentamicin (GM) were active against S. agalactiae. ABPC, cefmenoxime (CMX), IPM, erythromycin (EM), clindamycin (CLDM) and clarithromycin (CAM) showed the highest activities. The MICs for all strains were lower than 0.125 microgram/ml. The MIC90S of the others were 2 micrograms/ml or below. 5. Citrobacter freundii IPM showed the highest acti …

Treatment of community-onset pneumonia in neutropenic cancer patients: β-lactam monotherapy versus combination antibiotic regimens.

BackgroundAlthough β-lactam monotherapy may be sufficient in non-critically ill patients with community-acquired pneumonia, the value of combination antibiotic regimens in community-onset neutropenic pneumonia remains unclear.MethodsA retrospective cohort study was conducted to compare the effects of combination antibiotic regimens to those of β-lactam monotherapy in cancer patients with community-onset neutropenic pneumonia. Electronic medical records of patients diagnosed with community-onset neutropenic pneumonia between March 1995 and February 2015 at a tertiary care center were reviewed.R

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… Lin E Stanek RJ Mufson MA Lack of synergy of erythromycin combined with penicillin or cefotaxime against Streptococcus pneumoniae in vitro Antimicrob Agents Chemother 2003 47 3 1151 1153 10.1128/AAC.47.3.1151-1153.2003 12604560 PMC149295 25. … Johansen HK Jensen TG Dessau RB Lundgren B Frimodt-Moller N Antagonism between penicillin and erythromycin against Streptococcus pneumoniae in vitro and in vivo J Antimicrob Chemother 2000 46 6 973 980 10.1093/jac/46.6.973 11102417 26. …

Adverse events of antibody-drug conjugates on the ocular surface in cancer therapy.

Antibody-drug conjugates consist of a monoclonal antibody attached to a cytotoxic therapeutic molecule by a connector. This association allows a highly specific therapy, which increases their effectiveness and decreases their potential toxicity. This new therapy emerged approximately 20 years ago; since then, numerous combinations have appeared in the field of treatment-related neoplasms as an alternative for patients who do not achieve good results with conventional treatment options. Adverse effects of these drugs on the ocular surface are frequent and varied. Their prevalence ranges from 20

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… mcMMAF, Anti-5T4 monoclonal antibody) | Humanized igg1 anti-antigen 5T4 + MMAF + non-cleavable maleimidocaproyl linker 43 | Cell-surface tumor-associated antigen 5T4 43 | – | Photophobia, dry eye, eye pain, blurred vision, conjunctivitis, increased lacrimation, keratitis, and limbal deficiency 43 | Erythromycin … Treatment of AEs on the ocular surface Erythromycin ointment and ophthalmic prednisolone acetate, with no changes in PF-06263507 administration, were used to treat conjunctivitis, with no drug discontinuation. …

Unraveling the Anti-Cancer Mechanisms of Antibiotics: Current Insights, Controversies, and Future Perspectives.

Cancer persists as a significant global health challenge, claiming millions of lives annually despite remarkable strides in therapeutic innovation. Challenges such as drug resistance, toxicity, and suboptimal efficacy underscore the need for novel treatment paradigms. In this context, the repurposing of antibiotics as anti-cancer agents has emerged as an attractive prospect for investigation. Diverse classes of antibiotics have exhibited promising anti-cancer properties in both in vitro and in vivo studies. These mechanisms include the induction of apoptosis and cell cycle arrest, generation o

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… Erythromycin, one of the earliest macrolides, has demonstrated anti-tumor activity in human neuroblastoma cells by initiating apoptosis. … Antitumor activity of erythromycin on human neuroblastoma cell line (SH-SY5Y) J. Univ. Sci. Technol. Med. Sci. 2011;31:33–38. doi: 10.1007/s11596-011-0146-4. 53. Hamada K., Kita E., Sawaki M., Mikasa K., Narita N. Antitumor Effect of Erythromycin in Mice. …

Acute Pneumonia

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… Iatrogenic manipulations that bypass or interfere with the usual host defenses of the upper airways (endotracheal tubes, nasogastric tubes, and respiratory therapy machinery) all predispose to infection. 32 A variety of commonly prescribed drugs including aspirin, erythromycin, and aminophylline have …

Disorders of the Gastrointestinal System

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Cabozantinib Cutaneous Toxicity-Comprehensive Review.

BackgroundIn the context of modern cancer therapy, the management of adverse effects of systemic therapies can lead to the avoidance of underdosing and withdrawal and increases in the quality of the therapeutic act and the quality of life. This review offers an overview of the skin-related toxicities associated with Cabozantinib, a multikinase inhibitor (MKI) that is approved for treating advanced kidney cancer, hepatocellular carcinoma, and medullary thyroid cancer. It covers the most common dermatological side effects, such as palmar-plantar erythrodysesthesia, stomatitis, hair alterations,

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… Triamcinolone acetonide ointment, doxycycline mouthwash (two tablets dissolved in 250 mL water), and erythromycin (250–350 mg). No dose modification is required. … Grade 3 | All the above plus erythromycin 500 mg or minocycline 100 mg and systemic corticosteroid 30–60 mg pulse therapy or 1 mg/kgc 1 week with tapering. …

Acute kidney injury manifesting as renal tubular acidosis with proximal and distal renal tubular dysfunction in a dog with acute pancreatitis.

OBJECTIVE: To describe the clinical presentation and management of a critically ill dog with profound renal tubular acidosis (RTA) with proximal and distal renal tubular dysfunction. CASE SUMMARY: A 3-year-old neutered female Border Terrier was presented with frequent regurgitation resulting from acute pancreatitis with severe ileus. Venous acid-base analysis and complete urinalysis confirmed the presence of normal anion gap metabolic acidosis with inappropriately alkaline urine (pH 8), consistent with distal RTA. Urinalysis, urine amino acids, and urinary fractional excretion of electrolytes

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… Hartmann's solution b was administered intravenously at 6 ml/kg/h with 15 mmol/L potassium chloride. m Prokinetic therapy with metoclopramide n (2 mg/kg/day, IV, as a constant rate infusion) and erythromycin o (1 mg/kg, IV, q 8 h) was used for treatment of ileus. … Erythromycin lactobionate, 1 g powder for solution for infusion, Advanz Pharma, London, UK. Omeprazole, 40 mg powder for solution for infusion, Bowmed Ibisqus Limited, Chirk, Wrexham. Aqupharm 18 solution for infusion, Animalcare Ltd, York, North Yorkshire. …

Review of clinical profile and bacterial spectrum and sensitivity patterns of pathogens in febrile neutropenic patients in hematological malignancies: A retrospective analysis from a single center.

BackgroundThe aim of this study was to study clinical profile with bacterial spectrum and susceptibility patterns of pathogens in culture positive febrile neutropenic (FN) patients of hematological malignancies.Materials and methodsWe retrospectively reviewed the medical records of 23 hematological malignancy patients admitted with chemotherapy induced febrile neutropenia with culture positive results, at our institute between June 2011 and December 2011.ResultsA total of 23 patients were studied 12 males and 11 females, with a median age of 35 years. Most common diagnosis was acute leukemia (

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… Lastly for S. aureus main sensitive antibiotics were vancomycin, linezolid and gentamicin and resistant one were penicillin, erythromycin and ciprofloxacin. …

Endoscopic diagnosis and management of peptic ulcer bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2026.

ABSTRACT: This guideline is an update of the 2021 ESGE Guideline on Endoscopic diagnosis and management of nonvariceal upper gastrointestinal hemorrhage. The following are the new and/or revised recommendations. PRE-ENDOSCOPY MANAGEMENT: 1: ESGE does not recommend the routine use of video capsule endoscopy or telemetric blood-sensing capsules in the management of patients with suspected upper gastrointestinal hemorrhage (UGIH). PRE-ENDOSCOPY MANAGEMENT: 2: ESGE suggests, if intravenous erythromycin is unavailable, pre-endoscopy administration of intravenous metoclopramide in selected patient…

Regional specifics of microbial landscape in outpatients with lower respiratory tract infections.

BACKGROUND: The last years have witnessed progressive growth of antimicrobial resistance (AMR) both in hospital-acquired and community-acqui … timicrobials. The highest numbers of cases with resistance were detected to Ciprofloxacin (25%) and Erythromycin (20%). 10% strains of mycoplasma showed resistance to Doxycycline and Ofloxacin, while only 5% of mycoplasmas were identified as having non-sensitivity to Clarithromycin and Azithromycin. CONCLUSIONS: The results of the research carried out in the …

[Sex, erectile dysfunction, and the heart: a growing problem].

BACKGROUND: Erectile dysfunction (ED) is defined as the inability to attain and/or maintain penile erection sufficient for satisfactory sexu … tors of the P450 3A4 pathway may increase the plasma concentrations of sildenafil, like cimetidine, erythromycin, digitoxin, and CSE inhibitors (simvastatin, atorvastatin, etc.). A creatinine clearance < 30 ml/min also increases plasma levels of sildenafil. SAFETY PROFILE OF SILDENAFIL: Sildenafil is safe in healthy subjects. In a postmarketing study on 6,527 …

Minocycline for acne vulgaris: efficacy and safety.

BACKGROUND: Minocycline is a tetracycline antibiotic that is commonly used in the treatment of moderate to severe acne vulgaris. Although it … racycline (1), tetracycline (6), doxycycline (7), lymecycline (2), topical clindamycin (3), topical erythromycin/zinc (1), cyproterone acetate/ ethinyloestradiol (1), oral isotretinoin (2), topical fusidic acid (1) and there was one dose response study. Two studies are ongoing and it remains to be clarified whether one further study is a RCT. Major outcome mea …

Irritable Bowel Syndrome.

I believe there are four essential elements in the management of patients with irritable bowel syndrome (IBS): to establish a good physician … ncluding ventricular arrhythmias and torsades de pointes. These drugs include the azole fungicides; erythromycin, clarithromycin, and troleandomycin; some antidepressants; HIV protease inhibitors; and others. In patients with IBS with mild to moderate co-morbid depression, I have found that the use of SSRIs such as paroxetine, fluoxetine, or sertraline may be …

Emerging therapeutics in the management of COVID-19.

The severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019, COVID-19) pandemic has placed a tremendous burden on healthcare systems globally. Therapeutics for treatment of the virus are extremely inconsistent due to the lack of time evaluating drug efficacy in clinical trials. Currently, there is a deficiency of published literature that comprehensively discusses all therapeutics being considered for the treatment of COVID-19. A review of the literature was performed for articles related to therapeutics and clinical trials in the context of the current COVID-19 pandemic. We

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… Azithromycin Structural Composition: Azithromycin is an azalide which is a subclass of macrolide antibiotics derived from the prototype Erythromycin[ 111 ]. Azithromycin has a nitrogen added to the 14-membered ring of erythromycin, creating a new 15 membered compound[ 111 ]. … The addition of nitrogen creates a dibasic molecule which results in improved antimicrobial activities, pharmacokinetics and fewer side effects as compared with Erythromycin[ 112 ]. …

Marine Natural Products, Multitarget Therapy and Repurposed Agents in Alzheimer's Disease.

Alzheimer's disease (AD) is a multifactorial disease characterized by the presence of amyloid plaques, neurofibrillary tangles, and nerve cell death that affects, mainly, older people. After decades of investigation, the search for an efficacious treatment for AD remains and several strategies can be and are being employed in this journey. In this review, four of the most promising strategies, alongside with its most promising agents under investigation or development are highlighted. Marine natural products (MNP) are a source of unique chemical structures with useful biological activities for

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… Starting with antimicrobials, azithromycin and its analogue erythromycin are macrolide antibiotics that target bacterial RNA causing bacteriostasis [ 130 ]. They alter APP processing, reducing cerebral Aβ levels, and erythromycin might also have neuroprotective properties [ 129 , 130 ]. … RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine Curr. Alzheimer Res. 2006 3 221 227 10.2174/156720506777632835 16842099 131. Balducci C. Forloni G. …

Paediatric intestinal pseudo-obstruction: a scoping review.

Paediatric intestinal pseudo-obstruction (PIPO) encompasses a group of rare disorders in which patients present with the clinical features of bowel obstruction in the absence of mechanical occlusion. The management of PIPO presents a challenge as evidence remains limited on available medical and surgical therapy. Parenteral nutrition is often the mainstay of therapy. Long-term therapy may culminate in life-threatening complications including intestinal failure-related liver disease, central line thrombosis and sepsis. Intestinal transplantation remains the only definitive cure in PIPO but is a

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… It is postulated that octreotide may have a synergistic effect with erythromycin, which mimics motilin and evokes gastric phase III MMC, overcoming the inhibitory effects of octreotide on gastric emptying [ 49 , 53 ]. … The efficacy of erythromycin has not been extensively investigated with concerns regarding tachyphylaxis, macrolide resistance and cardiovascular safety (including torsades de pointes and sudden cardiac death) [ 49 , 51 , 67 ]. …

Доклад о деле: Распространенный в ЛНДР случай категорического листериоза после аппендицита.

БАКГРЕСС: &quot; Listeria monocitogenes &quot; является пищевым патогеном, который является редкой причиной бактерии и менингита у пациентов, страдающих иммунодепрессией, и имеет высокий уровень смертности. Скромные проявления листериоза редки и обычно связаны с прямой прививкой кожи. Case: A 41-year-old Женщинам, первоначально попавшим в лаосскую больницу с аппендицитом, был диагностирован распространённый листериоз с скромным участием. Внутриабдоминальная патология, вероятно, способствовала вторжению бактериальной крови. Первичное лечение миропеном было переключено на ампицилин на основе наи

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… The isolates from both blood and pus were sensitive to penicillin, meropenem, co-trimoxazole and erythromycin, as determined by disk diffusion testing ( https://www.eucast.org ). …

Abstracts cont.

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… Isolates that were clindamycin-sensitive (CL-S) but erythromycin-resistant (E-R) were tested for inducible resistance by the D-test. … The same results were obtained by using azithromycin instead of erythromycin. All 408 staphylococcal isolates tested were found to be susceptible to quinupristin-dalfopristin. …