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Tales from the Jazz ASH: highlights from the 2013 American Society of Haematology meeting.

The 55th annual ASH meeting was held in pleasant New Orleans and was the largest in its history, with 22,495 participants coming from 113 nations. A 'bench-to-bedside and back' attitude characterises haematology probably more than any other discipline in medicine and, as usual, this was reflected in the extremely wide breadth of the topics covered, including the last results from clinical trials and cutting-edge advancements in basic science. This year, the balance was arguably skewed: few truly clinical practice-changing results were presented. On the other hand, a great number of basic and t

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… Dr Matthew J Walter from Washington University in St Louis illustrated his group’s studies in elucidating the clonal evolution of secondary AMLs (sAML) in the context of myelodysplastic syndromes (MDS). … Further along this line, a paradigm-shifting talk was offered by Dr Terrence Wong from Washington University in St Louis, who investigated the genetic basis of therapy-related AMLs. …

High prevalence of potential drug interactions affecting mycophenolic acid pharmacokinetics in nonmyeloablative hematopoietic stem cell transplant recipients.

ObjectiveMycophenolic acid (MPA) exposure is associated with clinical outcomes in hematopoietic cell transplant (HCT) recipients. Various drug interaction studies, predominantly in healthy volunteers or solid organ transplant recipients, have identified medications which impact MPA pharmacokinetics. Recipients of nonmyeloablative HCT, however, have an increased burden of comorbidities, potentially increasing the number of concomitant medications and potential drug interactions (PDI) affecting MPA exposure. Thus, we sought to be the first to characterize these PDI in nonmyeloablative HCT recipi

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… The drug interaction databases evaluated were the University of Washington Drug Interaction Database [ 9 ], Stockley’s Drug Interactions [ 10 ], Lexicomp™ [ 11 ], Micromedex ® [ 12 ] and Drugs.com [ 13 ]. … University of Washington Metabolism and Transport Drug Interacton Database [Internet]. 2011. [accsessed November 15, 2011]. Available from: http://www.druginteractioninfo.com . 10. Stockley’s Drug Interactions [Internet]. 2011. [accessed November 15, 2011]. …

Seasonal clustering of sinopulmonary mucormycosis in patients with hematologic malignancies at a large comprehensive cancer center.

BackgroundInvasive Mucorales infections (IMI) lead to significant morbidity and mortality in immunocompromised hosts. The role of season and climatic conditions in case clustering of IMI remain poorly understood.MethodsFollowing detection of a cluster of sinopulmonary IMIs in patients with hematologic malignancies, we reviewed center-based medical records of all patients with IMIs and other invasive fungal infections (IFIs) between January of 2012 and August of 2015 to assess for case clustering in relation to seasonality.ResultsA cluster of 7 patients were identified with sinopulmonary IMIs (

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… All data presented within 1 km of inpatient cancer units (University of Washington Medical Center [ a ] and the ambulatory clinic (Seattle Cancer Care Alliance [ b ]). … All data presented within 1 km of inpatient cancer units (University of Washington Medical Center [ a ] and the ambulatory clinic (Seattle Cancer Care Alliance [ b ]). …

Биология и болезни крыс

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Тенденции в области смертности, связанной с множественной миеломой в Соединенных Штатах, 1999-2023.

Несмотря на значительные терапевтические достижения, большое число миелом (ММ) по-прежнему является важным фактором смертности от рака в Соединенных Штатах. Понимание долгосрочных моделей смертности имеет важное значение для разработки справедливых стратегий в области клинического и общественного здравоохранения. 1999-2023 для оценки связанных с MM смертей среди взрослых ≥25 Годы. Коэффициенты смертности, скорректированные с учетом возраста, рассчитывались на основе прямой стандартизации 2000 Население США. Временные тенденции были изучены с использованием регрессии " Compoint " для

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… Most states exhibited a downward trend (ranging from dark to light blue), with significant declines noted in Alaska, Washington, Oregon, California, Texas, and much of the New England region. In contrast, several states such as Oklahoma and West Virginia showed little change or slight increases. … States with the steepest declines included Montana, North Dakota, Washington, and Maine, whereas states such as Oklahoma and West Virginia exhibited smaller decreases, with data missing in a few regions. …

Three- размерная структура комплекса Palbociclib-HIV TAR.

Мы представляем структуру HIV-1 элемент реакции на трансактивацию (TAR), связанный с киназным ингибитором palbociclib, однозначным лигандом nM и ингибитором с низким значением nM комплекса супер удлинения. Маленькая молекула перестраивает РНК, чтобы создать глубокий связующий карман в новой структуре ТАР. Он заменяет A22 на "интермолекулярную пару" с U40, создавая постоянно сложенную пару. 11 спираль, которая включает в себя three :: новые три базы, включая саму A22 и нуклеотиды UCU. Мутация нуклеотидов в связующем кармане или небольшие модификации малой молекулы, отменяющей связующую способно

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… Contributor Information Ravikanth Reddy Ramireddy, Department of Chemistry, University of Washington, Seattle, WA 98195-1700, United States. Venkata Vidalala, Department of Chemistry, University of Washington, Seattle, WA 98195-1700, United States. … Bhawna Chaubey, Department of Chemistry, University of Washington, Seattle, WA 98195-1700, United States. Gregory L Olsen, Department of Chemistry, University of Washington, Seattle, WA 98195-1700, United States. …

Knowledge Mapping of Acupuncture for Cancer Pain: A Scientometric Analysis (2000-2019).

OBJECTIVE: This study aimed to demonstrate the state of the present situation and trends concerning the global use of acupuncture for cancer pain in the past 20 years. METHODS: Searched the Web of Science database from 2000 to 2019 related to acupuncture for cancer pain, and then used CiteSpace to conduct scientometric analysis to acquire the knowledge mapping. RESULTS: Yearly output has increased year by year, and the growth rate has become faster after 2012. According to the cluster analysis of institutions, authors, cited references, and keywords, 4, 4, 15, and 14 categories were obtained

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… 7 | Univ Texas MD Anderson Canc Ctr | 9 | 0.10 | Univ Michigan 8 | Beijing Univ Chinese Med | 8 | 0.09 | Mem Sloan Kettering Canc Ctr 9 | Guangzhou Univ Chinese Med | 8 | 0.09 | Harvard Med Sch 10 | China Med Univ | 7 | 0.08 | Korea Inst Oriental Med 11 | Univ Washington | 6 | 0.06 | Natl Cheng Kung … The relationship network in the category of publication trend (#1) is a cooperative network between Univ Washington, Beijing Univ Chinese Med, Harvard Med Sch, and Oakland Univ. Furthermore, the earliest research in this direction can be traced back to Univ of Washington 2004. …

Demographic, epidemiological, and health transitions: are they relevant to population health patterns in Africa?

BackgroundStudies of trends in population changes and epidemiological profiles in the developing world have overwhelmingly relied upon the concepts of demographic, epidemiological, and health transitions, even though their usefulness in describing and understanding population and health trends in developing countries has been repeatedly called into question. The issue is particularly relevant for the study of population health patterns in Africa and sub-Saharan Africa, as the history and experience there differs substantially from that of Western Europe and North America, for which these conce

Orthogonal targeting of osteoclasts and myeloma cells for radionuclide stimulated dynamic therapy induces multidimensional cell death pathways.

Rationale: Multiple myeloma (MM) is a multifocal malignancy of bone marrow plasma cells, characterized by vicious cycles of remission and relapse that eventually culminate in death. The disease remains mostly incurable largely due to the complex interactions between the bone microenvironment (BME) and MM cells (MMC). In the "vicious cycle" of bone disease, abnormal activation of osteoclasts (OCs) by MMC causes severe osteolysis, promotes immune evasion, and stimulates the growth of MMC. Disrupting these cancer-stroma interactions would enhance treatment response. Methods: To disrupt this cycle

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… DiPersio (Washington University School of Medicine, WUSM, St. Louis). … Siteman Cancer Center at Washington University School of Medicine and Barnes-Jewish Hospital in St. Louis, MO, and the Institute of Clinical and Translational Sciences (ICTS) at Washington University in St. Louis, for the use shared facilities. …

Использование стационарной гемато-онкологической службы до, во время и после COVID-19 Ограничения в румынском Третичном центре.

Введение Болезнь коронавируса 2019 (В тыс.COVID-19) пандемия помешала диагностике и лечению рака, однако имеющиеся в больницах данные об использовании стационарного гемато-онкологического обслуживания в Восточной Европе остаются ограниченными. В ходе этого исследования была проведена оценка того, как период пандемии повлиял на улавливание, диагностическое подтверждение, повторное стационарное лечение, госпитализацию и больничные дни среди взрослых с лимфомой, лейкемией или множественными миеломой в румынском высшем центре. В больнице скорой помощи округа Сибиу, Сибиу, Румыния, был проведен рет

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… Statistical analyses were performed using IBM SPSS Statistics for Windows, version 26 (released 2018; IBM Corp., Armonk, New York, United States), GraphPad Prism version 8.0.1 (Boston, Massachusetts, United States), and Microsoft Excel 2016 (Microsoft Corporation, Redmond, Washington, United States). … Image Credit: Author; created using Microsoft PowerPoint 2016 (Microsoft Corporation, Redmond, Washington, United States) After population normalization, initially identified patients decreased during the pandemic period compared with the pre-pandemic period, although the difference was not statistically …

Cost-Effectiveness of a National Sugar-Sweetened Beverage Tax to Reduce Cancer Burdens and Disparities in the United States.

BackgroundSugar-sweetened beverage (SSB) consumption contributes to obesity, a risk factor for 13 cancers. Although SSB taxes can reduce intake, the health and economic impact on reducing cancer burdens in the United States are unknown, especially among low-income Americans with higher SSB intake and obesity-related cancer burdens.MethodsWe used the Diet and Cancer Outcome Model, a probabilistic cohort state-transition model, to project health gains and economic benefits of a penny-per-ounce national SSB tax on reducing obesity-associated cancers among US adults aged 20 years and older by inco

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… The most recent publications on SSB taxes reported a 21% reduction in SSB sales after implementing a penny-per-ounce tax in Cook County, Illinois, and a 22% reduction in SSB sales after implementing a 1.75 cents-per-ounce tax in Seattle, Washington ( 53 ). … Capital rivals: the cola wars in Washington. OpenSecrets.org. 2011 https://www.opensecrets.org/news/2011/09/the-cola-wars-in-washington/ . …

Dusquetide: Reduction in oral mucositis associated with enduring ancillary benefits in tumor resolution and decreased mortality in head and neck cancer patients.

Innate immunity is a key component in the pathogenesis of oral mucositis, a universal toxicity of chemoradiation therapy (CRT). Dusquetide, a novel Innate Defense Regulator, has demonstrated both nonclinical and clinical efficacy in ameliorating severe oral mucositis (SOM). Long term follow-up studies from the Phase 2 clinical study evaluating dusquetide as a treatment for SOM in head and neck cancer (HNC) patients receiving CRT have now been completed. Extended analysis indicates that dusquetide therapy was well-tolerated and did not contribute to increased infection, tumor growth or mortalit

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… University, Spartanburg Regional Medical Center, Temple University Hospital, University Hospitals, Seidman Cancer Center, University of Illinois at Chicago, University of Kentucky, University of Michigan Medical Center, University of Rochester, University of Wisconsin-Carbone Cancer, University of Washington … Medical Center, VA Long Beach Health System, VA Puget Sound Health Care System, Wake Forest Health Sciences Medical Center, Washington Cancer Institute, Washington University, Willis-Knighton Cancer Center and Virginia Mason Medical Center. …

2021 ACMT Annual Scientific Meeting Abstracts-Virtual.

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… Washington, DC, USA. 3 Brigham and Women's Hospital, Department of Emergency Medicine, Boston, MA, USA. 4 Rutgers University School of Medicine, Department of Emergency Medicine, Newark, NJ, USA. 5 MedStar Washington Hospital Center, Department of Emergency Medicine, Washington, DC, USA Background: … Washington Hospital Center, Washington, DC, USA. 3 MedStar Health, Colombia, MD, USA. 4 Rutgers University, Newark, NJ, USA Background: The COVID-19 pandemic has adversely affected vulnerable patient populations and can exacerbate substance use disorder. …

2018 Ежегодное совещание СНГ: Североамериканская конференция по вопросам неадекватности и регулирования.

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… (5) Submission ID#427200 A Case of Hyper-IgE Syndrome with Novel Variants in DOCK8 Gene Jamie Allison Rosenthal , MD 1 , Lahari Rampur, MD 2 1 Allergy/Immunology Fellow, University of Washington 2 Assistant Professor, University of Washington Introduction/Background: Dedicator of cytokinesis 8 …

Primary Care Considerations for Elderly U.S. Veterans of World War II and the Korean War: A Narrative Review.

Many of the United States' more than 18 million veterans obtain healthcare through the Department of Veterans Affairs' (VA) Veterans Health Administration system; however, recent legislative changes have expanded veterans' access to non-VA care in their communities, particularly for those who do not live near VA medical centers. Veterans are seen by physicians in outpatient practice across the United States and are admitted to non-VA hospitals; this is particularly salient for older veterans, who may require a more frequent and high level of care. We present a review of characteristics of U.S.

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… Washington, DC: National Academies Press; 1993. Veterans at Risk: The Health Effects of Mustard Gas and Lewisite; p. 1993. 46. Centers for Disease Control and Prevention. … Washington, DC: National Academies Press; 2006. Noise and Military Service: Implications for Hearing Loss and Tinnitus. 48. Agency for Toxic Substances and Disease Registry. …

Средний показатель воздействия выборочной обработки на анализ обработанных веществ (САТТ) с использованием контрфактического объяснения указывает на БМТ и SARS-CoV-2 вакцинация как защитные факторы риска, связанные COVID-19 Сильность и выживаемость у пациентов с множественной миеломой.

Пациенты с множественной миеломой (ММ), возрастной неоплазмой плазменных клеток, производящих антитела, скомпрометировали иммунную систему и могут подвергаться повышенному риску сильного воздействия COVID-19 :: результаты. Это исследование характеризует факторы риска, связанные с клиническими показателями COVID-19 Суровая и всепричинная смертность у пациентов миэломы с использованием национальной базы данных по сотрудничеству в области КОВИД (N3C). Консорциум N3C представляет собой крупный централизованный ресурс данных, представляющий собой крупнейшую многоцентровую группу COVID-19 - случаи и

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… Children’s Research Institute—UL1TR001876: Clinical and Translational Science Institute at Children’s National (CTSA-CN) • George Washington University—UL1TR001876: Clinical and Translational Science Institute at Children’s National (CTSA-CN) • Indiana University School of Medicine—UL1TR002529: Indiana … Kenneth and Dianne Wright Center for Clinical and Translational Research • Wake Forest University Health Sciences—UL1TR001420: Wake Forest Clinical and Translational Science Institute • Washington University in St. …

HTLV-1 viral oncogene HBZ induces osteolytic bone disease in transgenic mice.

Adult T-cell leukemia/lymphoma (ATL) is an aggressive T cell malignancy that occurs in HTLV-1 infected patients. Most ATL patients develop osteolytic lesions and hypercalcemia of malignancy, causing severe skeletal related complications and reduced overall survival. The HTLV-1 virus encodes 2 viral oncogenes, Tax and HBZ. Tax, a transcriptional activator, is critical to ATL development, and has been implicated in pathologic osteolysis. HBZ, HTLV-1 basic leucine zipper transcription factor, promotes tumor cell proliferation and disrupts Wnt pathway modulators; however, its role in ATL induced o

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… Animal studies were performed under protocols approved and monitored by the Washington University Institutional Animal Care and Use Committee. … Washington University School of Medicine for use of the Zeiss Axio Scan Z1 Brightfield/Fluorescence Slide Scanner and the St. …

Bone metastasis and pain research through the dual lens of bibliometrics and bioinformatics: knowledge structure, frontiers, and core pathway analysis (2015-2024).

BackgroundCancer-induced bone pain (CIBP) represents a formidable clinical challenge with complex mechanisms, and existing treatments remain unable to effectively control pain in many patients. This study combined bibliometric and bioinformatic approaches to delineate key research trends, principal themes and future directions in the field of bone metastasis and pain research over the past decade (2015-2024).MethodsWe selected 1,822 relevant documents from the Web of Science Core Collection for bibliometric analysis to identify major research characteristics, collaboration networks and emergin

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… This was followed by the University of Texas MD Anderson Cancer Center (USA, 42 publications), University Medical Center Utrecht (Netherlands, 32 publications), Mayo Clinic (USA, 28 publications) and the University of Washington (USA, 28 publications). … Institutions such as the University of Texas MD Anderson Cancer Center, Mayo Clinic and the University of Washington demonstrated balanced performance in high output and high influence. …

Inhaled medications for chronic obstructive pulmonary disease predict surgical complications and survival in stage I non-small cell lung cancer.

BackgroundLung function is routinely assessed prior to surgical resection for non-small cell lung cancer (NSCLC). Further assessment of chronic obstructive pulmonary disease (COPD) using inhaled COPD medications to determine disease severity, a readily available metric of disease burden, may predict postoperative outcomes and overall survival (OS) in lung cancer patients undergoing surgery.MethodsWe retrospectively evaluated clinical stage I NSCLC patients receiving surgical treatment within the Veterans Health Administration from 2006-2016 to determine the relationship between number and type

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… S.T. was supported in part by the Washington University School of Medicine (WUSM) Surgical Oncology Basic Science and Translational Research Training Program grant T32CA009621 from the NCI. … Washington (DC): Department of Veterans Affairs (US); 2017. 38. Heiden BT, Eaton DB, Jr, Chang SH, et al. Racial Disparities in the Surgical Treatment of Clinical Stage I Non-Small Cell Lung Cancer Among Veterans. Chest 2022;162:920-9. 10.1016/j.chest.2022.03.045 39. …

Racial and ethnic variations in caregiving-related physical, emotional, and financial strain during COVID-19 among those caring for adult cancer patients.

PurposeCancer caregiving is shown to be a burdensome experience in typical times. The purpose of this study was to describe cancer caregivers' emotional, physical, and financial strain during the COVID-19 pandemic and compared to preCOVID-19, and explore racial and ethnic variations in caregiver strain.MethodsWe conducted a cross-sectional online survey using Lucid, LLC, incorporating quotas for race, ethnicity, gender and age. Caregivers had to be adults living in the USA and currently providing unpaid care to an adult cancer patient (i.e., during COVID-19) and prior to the pandemic. We asses

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… Washington, D.C. 24. Lee E. Do technology-based support groups reduce care burden among dementia caregivers? A review. J Evid Inf Soc Work. 2015;12(5):474–487. doi: 10.1080/15433714.2014.930362. 25. Benson JJ, et al. … Washington DC: The National Academies Press; 2001. 27. IOM . Retooling for an aging America: building the health care workforce. Washington, DC: The National Academies Press; 2008. 28. Wolff JL, Feder J, Schulz R. Supporting family caregivers of older americans. …