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Talaromyces marneffei Infection Misdiagnosed as Lung Cancer and Retrospective Literature Analysis.

BACKGROUND: Talaromyces marneffei (TM), an opportunistic fungal pathogen, causes severe infections in immunocompromised individuals. While endemic to tropical regions of Southeast Asia and South Asia, sporadic cases have been reported in non-endemic areas. Diagnosis is often delayed due to nonspecific clinical and laboratory features, contributing to high mortality. CASE PRESENTATION: A HIV-positive patient subsequently developed TM pulmonary infection. Clinical symptoms and laboratory test results were non-specific. Imaging studies revealed pulmonary masses, and the patient was misdiagnosed …

Global Prevalence of Spinal Muscular Atrophy in 204 Countries and Territories, 1960-2024: A Systematic Review and Bayesian Modeling Study.

BACKGROUND: Despite major therapeutic advances, the global epidemiology of spinal muscular atrophy (SMA) remains poorly characterized, with … -0.021). Prevalence was highest in high-income countries (0.027% [0.000-0.067]) and lowest in South Asia and sub-Saharan Africa (both 0.002% [0.002-0.003]). The global estimated prevalence among newborns was 0.020% (0.007-0.043) and among children was 0.008% (0.002-0.016). Western Europe showed the highest regional prevalence while South Asia and sub-S …

Incidence, Risk Factors, and Temporal Trends of Tongue Cancer: A Population-Based Study.

BACKGROUND: Tongue cancer is the most prevalent form of cancer in the intraoral region across many countries. This study aims to explore the … ndardized rate (ASR) of 1.7 per 100,000 population. The highest ASRs were observed in South-Central Asia (3.4), Northern America (2.3), and Northern Europe (2.1). Males were found to have a higher ASR (2.6) compared to females (0.86). Tongue cancer incidence was significantly linked to a higher prevalence of smoking (β = 0.038, CI: 0.016-0.059, p = 0.0 …

The global landscape of non-Hodgkin lymphoma incidence and mortality in 2022 and projections to 2045.

INTRODUCTION: Updated estimates of the current and future burden of non-Hodgkin lymphoma (NHL) are critical for evaluating global cancer con … ew Zealand (ASIR 12.05), reported elevated incidence compared to low-HDI regions like South-Central Asia (ASIR 2.79). East Asia, led by China (14.6% of cases), had the largest case volume. ASIR strongly correlated with HDI (r = 0.655, p = 3.21E-22), while ASMR showed no significant correlation (r = 0.002, p = 0.982). By 2045, NHL cases are projected to …

Burden of tracheal, bronchus, and lung cancer based on GBD 2021.

BACKGROUND: Tracheal, bronchus, and lung (TBL) cancer remains a leading cause of cancer-related mortality worldwide. This study provides com … 2.22 million) deaths. The age-standardized DALY rate (ASDR) was 533 (480.1–586.4) per 100,000. East Asia exhibited the highest ASPR (57.1 per 100,000), ASIR (43.4), ASMR (38.5), and ASDR (869.5). The high-middle SDI region showed the highest overall burden, while the low-SDI region had the lowest. Across all metrics, males had consistently higher rates …

Global, regional and national burden of major blindness-associated ophthalmologic conditions, 1990-2021, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2021.

BACKGROUND: The global burden of blindness and vision loss continues to increase, yet comprehensive analyses of underlying causes remain lim … e rate in 2021 at 16 741.4 (13 187.8-21 129.5), whereas the highest DALY rate was observed in South Asia at 497.1 (345.3-691.6). While the overall burden of blindness did not differ significantly by sex, glaucoma showed a higher burden in males. From 1990 to 2021, cataract DALY rates attributable to household air pollution decreased by 38.4%, with proj …

Implementation of a national clinical guideline for cauda equina syndrome improves referral quality and reduces delays to MRI.

BACKGROUND: Cauda equina syndrome (CES) is a neurological emergency with significant potential for permanent morbidity and medicolegal conse … rral-to-MRI times. Secondary outcomes encompassed documentation of post-void residual volume (PVR), ASIA score, and red flag symptoms. RESULTS: 124 pre-guideline and 71 post-guideline referrals were included. Mean triage-to-MRI time decreased from 20.5 to 13.0 h (36.5% reduction; p = 0.017), with standard deviation falling from 16.2 to 7.7 h, indicati …

Salmonella Outbreaks in Low- and Middle-Income Countries over the Last Decade: A Systematic Review and Meta-Analysis of Transmission Dynamics, Clinical Outcomes, and Antimicrobial Resistance.

BACKGROUND: Salmonella outbreaks persist as a public health burden in low- and middle-income countries (LMICs), yet comprehensive synthesis … nt (37.5%), predominating in Africa (83.3%), whereas foodborne and fecal-oral routes were common in Asia. Pooled laboratory confirmation rate was 28.02% (95% CI: 12.2-52.1; observed range: 1.5-100%), varying by region: Southeast Asia 54.2% (95% CI: 4.3-96.9), Western Pacific 27.6% (95% CI: 8.0-56.9), and Africa 6.1% (95% CI: 5.3-6.9). The pooled case f …

Распространение CMV, EBV, HPV и HSV среди здорового населения Южной Азии: систематический обзор и метаанализ.

Cytomegalovirus (CMV), Epstein-Barr (EBV), Human papillomavirus (HPV) и Herpes simlex вирус (HSV) являются вирусами ДНК, которые широко распространены среди населения. Хотя распространенность каждого из этих вирусов изучалась отдельно среди населения Южной Азии, никаких исследований, касающихся совместного распространения этих вирусов среди здоровых людей в Южной Азии, не проводилось. Систематический поиск проводился с использованием three базы данных (PubMed, Scopus и Cochrane Bibrary) и one поисковая система (научный сотрудник Google) для первоначальных исследований населения Южной Азии (опу

Совпадение в аннотации оригинала
Cytomegalovirus (CMV), Epstein-Barr virus (EBV), Human papillomavirus (HPV), and Herpes simplex virus (HSV) are DNA viruses which are highly prevalent among the general population. Although the prevalence of each of these viruses has been studied separately within South Asian populations, there are no studies regarding the pooled prevalence of these viruses …

Global epidemiology of Helicobacter pylori iceA genotypes: heterogeneity and virulence implications.

UNLABELLED: The contact-induced epithelium gene A (iceA), with allelic variants iceA1 and iceA2, remains a controversial virulence factor in Helicobacter pylori due to inconsistent clinical outcomes. In this study, we analyzed 1,427 H. pylori genomes from the NCBI database and 200 clinical isolates from Shenzhen, China, to elucidate the global distribution of iceA genotypes and their associations with other virulence factors, bacterial gene expression, and the relationship with gastric diseases. We found that iceA genotypes varied significantly across regions, with iceA1 predominating in Asia …

Genomic divergence between clinical and environmental Pseudomonas aeruginosa within ST-matched high-risk and sporadic lineages: A case study.

Pseudomonas aeruginosa is a major opportunistic pathogen and a leading cause of nosocomial infections in the Asia-Pacific region. This comparative genomic case study investigated 18 P. aeruginosa isolates, categorized into nine ST-matched sets to minimize phylogenetic noise and identify genomic divergence between clinical and environmental habitats. The isolates represent both globally distributed high-risk clones (ST235, ST357, ST308) and sporadic lineages (ST274, ST316, ST381). The genomes possessed a mean size of 6.7 ± 0.2 Mbp and shared a core genome of 4639 genes. Virulence profiling reve…

High sodium intake: a silent killer driving global gastric cancer burden.

BACKGROUND: High sodium intake is a recognized risk factor for increased gastric cancer mortality. This study examines the trends and distri … bal gastric cancer deaths and 7.92% of DALYs were linked to high sodium intake. Populations in East Asia and those with a high-middle Sociodemographic Index (SDI) bore the heaviest burden. Over the 32-year period, the global age-standardized mortality rate [Net drift = -2.33(95%CI:-2.37 to -2.28)] and age-standardized DALYs rate [Net drift = -2.56(95%C …

Exploring research hotspots and trends in periodontal regeneration from 2000 to 2023: a bibliometric analysis.

The aim of this bibliometric analysis was to evaluate research interest and trends in the field of periodontal regeneration from 2000 to 202 … he United States were the most productive countries, while contributions from developing nations in Asia and Africa, as well as several Chinese dental institutions, increased significantly. Sculean A was the most prolific author and established a global collaboration network. Seventy-seven high-frequency keywords were identified, with recent trends hig …

Assessing and projecting the global impacts of female infertility: a 1990-2040 analysis from the Global Burden of Disease study.

Background This study aims to assess the global burden of female infertility from 1990 to 2040. Methods Data on disability-adjusted life yea … projected to have the highest age-standardized rate at 29.37 (95% UI: 24.58-34.16), whereas Australasia is expected to have the lowest at 0.78 (95% UI: 0.72-0.84). Age-specific projections show a consistent decline in infertility rates across all age groups. Countries such as Kenya, Chad and Peru exhibit EAPCs exceeding 9.00, whereas Mali and South Af …

Anterior cervical discectomy and fusion for subaxial cervical spine injuries; management challenges and early outcome in a neurosurgical center.

BACKGROUND: Anterior cervical discectomy and fusion (ACDF) is an effective technique in managing subaxial cervical spine injury (SCSI). The … otor vehicular accident was the most common injury mechanism (71.6%), and the majority (59.5%) were ASIA A. C5/6 was the most common level of injury (40.7%), and the mean subaxial cervical spine injury classification system (SLIC) score was 7.8 ± 1.40. Fifty-eight (71.6%) patients presented late (>48 h after injury). ASIA A injuries, high SLIC score, a …

Natural history parameters for enteric pathogens to inform modeling studies of diarrhea among children in low-resource settings: results from the MAL-ED longitudinal birth cohort.

BACKGROUND: Policy decisions may rely on mathematical modelling to predict intervention impacts. Information for key model parameters is lim … teropathogenic E. coli (tEPEC) - among children aged 2 years or younger in South America, southeast Asia, and sub-Saharan Africa. METHODS: We analyzed stool specimens from MAL-ED, a multisite longitudinal birth cohort with active surveillance of children in South America, southeast Asia, and sub-Saharan Africa. We defined unique infections using longi …

Global Prevalence of Infertility Attributable to Sex Chromosome Abnormalities: Insights from the Global Burden of Disease Study.

BACKGROUND: Klinefelter syndrome (KS) and Turner syndrome (TS) are chromosomal disorders characterized by gonadal dysgenesis, leading to mal … the highest rates in Western and Eastern Europe (ASPR 19-20/100,000) and the fastest growth in East Asia (AAPC=0.44, P<0.05). In contrast, the prevalence of female infertility associated with TS slightly declined globally (ASPR decreased from 6.55 to 6.3/100,000, AAPC=-0.12, P<0.05), particularly in North America and Western Europe. Although absolute Y …

The global burden of osteoarthritis hand: lessons from the Global Burden of Disease Study 1990-2021.

BACKGROUND: Hand osteoarthritis (HOA), a disabling musculoskeletal disorder, poses a significant global burden but remains understudied rela … regions had the highest absolute burdens, whereas high SDI regions showed the highest ASRs. Central Asia emerged as a burden hotspot, while minimal health system regions and sub-Saharan Africa had the lowest rates. From 1990 to 2021, global incidences increased 142%. Low/middle-income regions (such as South Asia) saw significant increases, contrasting …

Burden of headache disorders among women of childbearing age in 204 countries and territories from 1990 to 2021 and future prediction to 2050.

BACKGROUND: Headache disorders are a group of highly prevalent and disabling neurological diseases worldwide, particularly affecting women o … haran Africa reported the lowest age-standardized prevalence rate (36,714.07/100,000) in 2021. East Asia experienced the most significant increases in the age-standardized prevalence rate of headache disorders from 1990 to 2021, with an EPAC of 0.25 (95% CI: 0.21 to 0.30), and its age-standardized DALY rate was projected to increase to 891.03/100,000. …

Global, regional and national trends in the burden of nutritional deficiencies in children, 1990-2021.

BACKGROUND: The objective of this study was to systematically assess global, regional, and national trends in the prevalence and burden of n … and the age-standardized incidence rate (ASIR) of protein-energy malnutrition were highest in South Asia (1103.19 and 3185.45 respectively). Age-standardized DALYs of protein-energy malnutrition increased substantially in high-income North America (EAPC: 3.30) and Western Europe (EAPC: 2.29). The age group with the greatest burden of nutritional defici …