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Paraventricular Hypothalamic GLP-1R Neurons Mediate Propofol-Induced Suppression of Food Intake.

BACKGROUND: Propofol is a widely used intravenous anesthetic, yet its impact on post-anesthetic feeding remains poorly characterized. The pa … their activity in response to feeding onset during the recovery. Neural circuits were mapped using rabies virus (retrograde tracing) and synaptophysin-based virus (anterograde tracing). RESULTS: An anesthetic dose of propofol (100 mg/kg, i.p.) suppressed food intake, regardless of circadian phase or metabolic state, whereas subanesthetic doses of propo …

A Neural Circuit from the Pedunculopontine Tegmental Nucleus to the Central Medial Thalamic Nucleus for the Regulation of Nociceptive and Anxiety-like Behaviors in Male Mice with Chronic Inflammatory Pain.

BACKGROUND: Chronic pain and anxiety exhibit a high degree of comorbidity, in which these conditions can mutually exacerbate each other. The … role of PPTg Glu and the PPTg Glu -CM pathway in regulating nociceptive and anxiety-like behaviors. Rabies-mediated retrograde tracing was used to map the anatomical connection from PPTg Glu to glutamatergic neurons in the CM (CM Glu ). Optogenetics combined with electrophysiologic recordings was used to verify the functional connectivity of this pathway …

Prioritization of zoonotic diseases in Bhutan through a One Health framework.

BACKGROUND: Zoonotic diseases pose an increasing threat to human, animal and environmental health, and identifying the zoonoses of greatest … ases for prioritization in the country. The workshop prioritized the top 10 zoonotic diseases viz., Rabies; Influenza A H5N1; Leptospirosis; Brucellosis; Escherichia coli infections; Dengue; Scrub Typhus; Bovine tuberculosis; Anthrax; and Salmonellosis. Joint action areas for the top five zoonotic diseases were developed to effectively address each disea …

The transdisciplinary research process and participatory research approaches used in the field of neglected tropical diseases: A scoping review.

INTRODUCTION: Neglected tropical diseases (NTDs) comprise a group of twenty diverse diseases or conditions that pose significant public heal … ng use of TDR and participatory approaches to address common NTDs such as leprosy, schistosomiasis, rabies, Buruli ulcer, and trypanosomiasis. These approaches engaged diverse stakeholders to develop practical, community-oriented solutions. Key strategies included enhancing public awareness, improving screening programmes, and implementing measures to co …

Development of human targeted extracellular vesicles loaded with shRNA minicircles to prevent parkinsonian pathology.

BACKGROUND: Neurological disorders are the second leading cause of death and the leading cause of disability in the world. Thus, the development of novel disease-modifying strategies is clearly warranted. We have previously developed a therapeutic approach using mouse targeted rabies virus glycoprotein (RVG) extracellular vesicles (EVs) to deliver minicircles (MCs) expressing shRNA (shRNA-MCs) to induce long-term α-synuclein down-regulation. Although the previous therapy successfully reduced the pathology, the clinical translation was extremely unlikely since they were mouse extracellular vesi…

От мыши к худшему: роль мышей в вирусном зоонозе.

Все чаще наблюдаются зоонотические инфекции, и мыши (Chiroptera) играют здесь ключевую роль. В отношении генипавируса (семейства: парамиксовирусы) была выявлена причинно-следственная цепь событий. Обезлесение в сочетании с изменением климата привело к сокращению источников продуктовых мышей Pteropus и привлекло их к фруктовым деревьям, посаженным вокруг свиней в Малайзии, передав вирус Нипах свиням в качестве усиливающих носителей, а затем свиньи-фермеры и скотобойни. Аналогичные сценарии наблюдались в Австралии, где Pteropus bats передали вирус Гендра лошадям в качестве промежуточных носителе

Совпадение в аннотации оригинала
Zoonotic infections are increasingly observed and bats (Chiroptera) are playing a pivotal role here. The causal chain of events has been elu … in caves transmitted the Marburg virus (family: filovirus) to miners in Africa. Most cases of human rabies in North America were caused by bat lyssaviruses (family: Rhabdoviruses). Bats are viral reservoir species for various virus families (reovirus, Hepacivirus of Flavivirus family, influenza A viruses). Bats are the only flying mammals which opened en …

Zoonotic diseases awareness and food safety practices among livestock farmers in Nepal.

Interactions between humans and livestock could increase the risk of zoonotic disease transmission. In addition, limited knowledge of zoonos … . The majority of the farmers who had dogs (83%) and cats (89.4%) in their homes or farms knew that rabies can be transmitted to humans from dogs or cats. The multivariable logistic regression analysis revealed that farmers from the Rupandehi district (aOR: 5.56; 95% CI: 2.18-14.22) and Chitwan (aOR: 6.52; 95% CI: 2.46-17.25) had a higher odds of having …

Disrupted basolateral amygdala circuits supports negative valence bias in depressive states.

Negative bias is an essential characteristic of depressive episodes leading patients to attribute more negative valence to environmental cue … implicated in negative and positive valence attribution could be studied in mice. Combining CTB and rabies-based tracing with ex vivo measurements of neuronal activity, we demonstrated that negative valence bias is supported by disrupted activity of specific BLA circuits during depressive states. Chronic CORT administration induced decreased recruitment …

mRNA Vaccines Against COVID-19 as Trailblazers for Other Human Infectious Diseases.

UNLABELLED: mRNA vaccines represent a milestone in the history of vaccinology, because they are safe, very effective, quick and cost-effecti … egalovirus, Zika, respiratory syncytial virus, metapneumovirus/parainfluenza 3, Chikungunya, Nipah, rabies, varicella zoster virus, and herpes simplex virus 1 and 2), bacterial (tuberculosis), and parasitic (malaria) diseases. RESULTS: RNA viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV)-2, HIV, and influenza, are characterized …

Using One Health assessments to leverage endemic disease frameworks for emerging zoonotic disease threats in Libya.

Continued emergence, re-emergence and spread of zoonotic diseases demonstrates the imperative need for multisectoral communication and joint … go assessment: highly pathogenic avian influenza, brucellosis, Rift Valley fever, leishmaniasis and rabies. Through decisive acknowledgement of Libya's unique health setting, we mapped how patient and sample information is both communicated within and between the human, animal and environmental health sectors, spanning from local index case identificatio …

One Health at gunpoint: Impact of wild boars as exotic species in Brazil - A review.

Wild boars have been listed among the 100 most invasive species worldwide, spreading impacts to all continents, with the exception of Antarc … chinellosis, and hepatitis E. Wild boars have been also associated with Brazilian spotted fever and rabies, infected while providing plentiful exotic blood supply for native ticks and hematophagous bats. Due to their phylogenetic proximity, wild boars may present ecological niche overlapping and direct disease risk to native white-lipped and collared pec …

Global burden and trends of neglected tropical diseases from 1990 to 2019.

BACKGROUND: An updated analysis of neglected tropical diseases (NTDs) from a global perspective is missing from the literature. We aimed to … e low SDI region presented a decreasing trend. Children and older adults were vulnerable to dengue, rabies and leishmaniasis (cutaneous and mucocutaneous). Females had a higher ASIR but a lower ASMR and age-standardized DALY rate than males. CONCLUSIONS: NTDs still represent a serious problem for public health, and the increasing ASIR and incident cases …

Reduced IFN-ß inhibitory activity of Lagos bat virus phosphoproteins in human compared to Eidolon helvum bat cells.

Eidolon helvum bats are reservoir hosts for highly pathogenic lyssaviruses often showing limited disease upon natural infection. An enhanced … V-GH P blocked the activation of the human IFN-β promoter less efficiently compared to a prototypic Rabies virus P protein (range LBV P 52-68% vs RVP 71-95%) in two different human cell lines (HEK-293T, A549). The same pattern was seen for two prototypic LBV P variants suggesting an overall reduced LBV P IFN-ß inhibitory activity in human cells as compar …

A systematic and thematic analysis of the top 100 cited articles on mRNA vaccine indexed in Scopus database.

The success of mRNA vaccines against SARS-CoV-2 implies that this technology can be applied to target any pathogen. However, the scientific … r, 8% on influenza virus, 4% on COVID-19 and kidney disease, 3% COVID-19 and myocarditis, and 3% on rabies virus, among others. The findings of this systematic and thematic analysis provided the knowledge basis for further research on mRNA vaccines globally.

Combined Biomimetic MOF-RVG15 Nanoformulation Efficient Over BBB for Effective Anti-Glioblastoma in Mice Model.

INTRODUCTION: The blood-brain barrier (BBB) is a key obstacle to the delivery of drugs into the brain. Therefore, it is essential to develop an advanced drug delivery nanoplatform to solve this problem. We previously screened a small rabies virus glycoprotein 15 (RVG15) peptide with 15 amino acids and observed that most of the RVG15-modified nanoparticles entered the brain within 1 h of administration. The high BBB penetrability gives RVG15 great potential for brain-targeted drug delivery systems. Moreover, a multifunctional integrated nanoplatform with a high drug-loading capacity, tunable fu…

Review of the neglected tropical diseases programme implementation during 2012-2019 in the WHO-Eastern Mediterranean Region.

INTRODUCTION: The 2012-2020 WHO NTD roadmap set targets for control, elimination, and eradication of neglected tropical diseases (NTDs). It … ountries also needed priority public health action for cutaneous leishmaniasis, and 5 countries for rabies and trachoma. Visceral leishmaniasis is on the increase in Afghanistan, Libya, Syria, and Yemen. CONCLUSION: Since the first roadmap of NTDs in 2012, the EMR has made a substantial progress. Nevertheless, many challenges remain in the prevention an …

Management practices of dog and cat owners in France (pet traveling, animal contact rates and medical monitoring): Impacts on the introduction and the spread of directly transmitted infectious pet diseases.

A number of owner practices among the pet dog and cat population can influence the dynamics of directly transmitted infectious dog and cat d … seases in France, especially when considering zoonoses with a significant potential impact, such as rabies.