Результаты поиска

Evaluation of prognostic preoperative factors in patients undergoing surgery for spinal metastases: Results in a consecutive series of 81 cases.

BackgroundSurgical treatment of spinal metastases should be tailored to provide pain control, neurological deficit improvement, and vertebral stability with low operative morbidity and mortality. The aim of this study was to analyze the predictive value of some preoperative factors on overall survival in patients undergoing surgery for spinal metastases.MethodsWe retrospectively analyzed a consecutive series of 81 patients who underwent surgery for spinal metastases from 2015 and 2021 in the Clinic of Neurosurgery of Ancona (Italy). Data regarding patients' baseline characteristics, preoperati

Acute Metastatic Spinal Cord Compression: Urgent Surgery versus Radiotherapy and Treatment Result Prediction versus Actual Results.

Background Context: The role of radiotherapy versus surgery in treating acute metastatic spinal cord compression (AMSCC) has changed over the years. Purpose: Our study evaluates neurological and functional outcomes following urgent surgery and radiotherapy (USFR) versus urgent radiotherapy alone in treating AMSCC. Study Design/Setting: A retrospective cohort of 54 patients with AMSCC with variable neurological deficits. Overall, 32 patients were treated with USFR, and 22 received urgent radiotherapy alone. Outcome Measures: Neurological status regarding the Asia and Frankel scores, continence

Совпадение в полном тексте источника
… Introduction Acute metastatic cord compression (AMSCC) is an epidural metastatic lesion displacing and compressing the spinal cord within the spinal canal [ 1 ]. It is a significant source of morbidity, causing paralysis and incontinence [ 2 ]. …

Common Neurologic Diseases in Geriatric Dogs.

The increase in the canine geriatric population means that veterinarians are more often confronted with diseases that are more prevalent in patients in this age group. As in other organ systems, degenerative, neoplastic, and vascular diseases are the most prevalent neurologic disorders in older dogs. A neurological disease in an older dog poses a challenge for the clinician due to the presence of concomitant diseases and age-related changes that make it difficult to interpret the neurological examination. In addition, given the age of the patients, some owners do not allow advanced imaging tes

Совпадение в полном тексте источника
… Occasionally, a pressure-enlarged intervertebral foramen will be noted from a nerve root tumour exiting the spinal canal [ 103 , 112 ]. Figure 4 Lateral radiographic view of a sacrum osteosarcoma. Notice the severe osteolysis of the vertebral body and arch of the sacrum (arrows). …

Одонтоид реконструировался с стабилизацией затылочного кондила у пациентов с метастатическим участием C2.

Зашифрованное соединение (OCJ) является сложным анатомическим районом, имеющим решающее значение для защиты нижнего ствола мозга, верхнего спинного мозга и нижних черепных нервов. Нестабильность в этой области может привести к таким серьезным последствиям, как хроническая боль, неврологические расстройства или смерть. Для стабилизации OCJ были разработаны различные хирургические методы, в частности с использованием затылочных кондитерских винтов, которые продемонстрировали свои перспективы в обеспечении стабильности и сохранении вращения шеи. Эта статья представляет two - случаи нестабильности

Совпадение в полном тексте источника
… In all spinal MRI and CT scans of the patient, infiltrative bone marrow signal changes, characterized by diffuse heterogeneous contrast enhancement after intravenous contrast material injection, were noted at the C 1-4 level, which causes narrowing in the spinal canal together with the expansile characteristic …

Intelligence Architectures and Machine Learning Applications in Contemporary Spine Care.

The rapid evolution of artificial intelligence (AI) and machine learning (ML) technologies has initiated a paradigm shift in contemporary spine care. This narrative review synthesizes advances across imaging-based diagnostics, surgical planning, genomic risk stratification, and post-operative outcome prediction. We critically assess high-performing AI tools, such as convolutional neural networks for vertebral fracture detection, robotic guidance platforms like Mazor X and ExcelsiusGPS, and deep learning-based morphometric analysis systems. In parallel, we examine the emergence of ambient clini

Bone Research Society 2021 Abstracts

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Preventing osteolytic lesions and osteomyelitis in multiple myeloma.

Multiple myeloma is a hematological malignancy affecting the plasma cells. It is the second most common hematologic cancer in adults. Over 90% of patients develop local osteolytic lesions and skeletal-related events at some point during the progression of the disease. Bone lesions can induce severe pain and immobility and can also increase the risk of fractures and osteomyelitis. Skeletal complications are associated with poor clinical outcomes, affecting quality of life and mortality. Current standards of care for myeloma, e.g., autologous stem-cell transplantation (ASCT) and chemotherapy, do

Совпадение в полном тексте источника
… Pain induced by vertebral fracture in multiple myeloma are common with additional causes such as spondylosis deformans, osteochondrosis, stenosis of the spinal canal and intervertebral nerve compression [101] . …

Okay, so I need to translate this medical title into Russian. Let me first read through the original text carefully. The title is: "Spinal Solitary Plasmacytoma With Minimal Marrow Involvement Presenting With Epidural Spinal Cord Compression." Hmm, medical terms here. Let me break it down. First, "Spinal Solitary Plasmacytoma" – that's a type of plasma cell tumor in the spine. In Russian medical terminology, "spinal" would be "спинальный", "solitary" is "одиночный" or "изолированный", "plasmacytoma" is "плазмоклеточная опухоль". Wait, but plasmacytoma is a specific term. Maybe "плазмоклеточная опухоль" is correct. Let me check. Wait, in Russian, "plasmacytoma" is often translated as "плазмоклеточная опухоль". So "Spinal Solitary Plasmacytoma" would be "Спинальная одиночная плазмоклеточная опухоль". Next part: "With Minimal Marrow Involvement" –

Одинарная плазмоцитома (СФК) — редкий тип плазменных клеток, характеризующийся распространением неопластических моноклонных плазменных клеток. Она может включать в себя кости или мягкие ткани без признаков системных заболеваний. Плазмоцитома, как правило, включает в себя оксиальный скелет, чаще всего позвонки. В этой статье говорится: 58-year-old Мужчина с историей болезни Паркинсона, гипертонии и дегенеративного сочленения позвоночника. Он прибыл в отделение скорой помощи с сильной грудной и поясничной болью в спине, сопровождаемой онемением и слабостью обеих ног, которые ухудшились в результ

Amyloids and the Heart: An Update.

Amyloids consist of fibrils that can be formed by a large variety of different precursor proteins. In localized amyloidosis, amyloids accumulate at the production site with a single organ being affected, whereas in systemic amyloidosis several organs are affected, with the heart being the most common, followed by the kidneys, liver, and the nervous system. The two most frequent systemic amyloidosis types affecting the heart in the vast majority (>95%) of cases are immunoglobulin light chain (AL) amyloidosis and transthyretin (TTR) amyloidosis (ATTR amyloidosis). Patients with amyloid cardiopat

Совпадение в полном тексте источника
… Further, an association between TTRwt deposition in ligaments and spinal canal stenosis [ 44 , 45 ] has been reported, suggesting a TTR tendency to deposit in organs vulnerable to shear stress [ 46 ]. … Amyloid deposits derived from transthyretin in the ligamentum flavum as related to lumbar spinal canal stenosis. Mod. Pathol. 2015;28:201–207. doi: 10.1038/modpathol.2014.102. 46. Koike H., Katsuno M. …

Percutaneous vertebroplasty in patients with osteoportic vertebral body fractures.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Retropulsed bone did prohibit the procedure because it allowed the PMMA to leak into the spinal canal. Exclusion criteria were bleeding disorders, and unstable fractures due to posterior element involvement. …

Идиопатический цервициальный трансверсальный миелит, преобладающий с нижним Лимбом слабая и автономная дисфункция: доклад о реалистическом случае.

Трансверсный миелит (TM) — это редкое нервно-воспалительное расстройство, которое может привести к значительной заболеваемости, если не диагностировать и не лечить. Мы сообщаем о случае 40-летней женщины, которая в течение двух месяцев испытывала постепенную двустороннюю слабость нижних конечностей и недержание мочеиспускания. Неврологическая экспертиза выявила верхние моторные нейроны и определенный уровень сенсорности, что вызывает подозрения в патологии спинного мозга. МРТ шейного отдела позвоночника выявила гиперинтенсивные повреждения, взвешенные на Т2 и Коротком тау инверсионном восстано

A new era in the management of spinal metastasis.

Despite the recent advances in cancer treatment, the incidence of patients with spinal metastases continues to grow along with the total number of cancer patients. Spinal metastases can significantly impair activities of daily living (ADL) and quality of life (QOL), compared with other types of bone metastases, as they are characterized with severe pain and paralysis caused by skeletal-related events. Reduced ADL can also lead to treatment limitations as certain anticancer agents and radiation therapy are not compatible treatments; thus, leading to a shorter life expectancy. Consequently, main

Совпадение в полном тексте источника
… Type 3: Concurrent Locomotive Dysfunction in Cancer Patients This category includes locomotive issues that coexist with cancer, including osteoporosis, lumbar spinal canal stenosis, and osteoarthritis. … Separation surgeries are utilized as a surgical technique to separate the anterior sulcus in the spinal canal and posterior edge of the vertebral body ( 118 ). …

Percutaneous vertebroplasty combined with chemotherapy in the treatment of multiple myeloma patients with vertebral compression fractures.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… The extravasated bone cement was mainly located in the intervertebral disc and paravertebral tissue, and there was no leakage into the spinal canal. …

Fixation, Stabilization, Dynamic Stabilization, Fusion, and Reconstruction in Spine Surgery- Decoding Terminologies!

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Anterior lumbar interbody fusion (ALIF) The anterior approach allows an anterior discectomy without entering the spinal canal or neural foramina. The ALIF procedure spares the posterior musculature and posterior ligamentous structures which are critical for spinal stability. …

Use of Cement-Augmented Percutaneous Pedicular Screws in the Management of Multifocal Tumoral Spinal Fractures.

STUDY DESIGN: Retrospective case series observational study. PURPOSE: Cancer patients are often aged and are further weakened by their illness and treatments. Our goal was to evaluate the efficiency and safety of using minimally invasive techniques to operate on spinal fractures in these patients. OVERVIEW OF LITERATURE: Vertebroplasty is now considered to be a safe technique that allows a significant reduction of the pain induced by a spinal tumoral fracture. However, few papers describe the kyphosis reduction that can be achieved by combining percutaneous fixation and anterior vertebral re

Seropositive Neuromyelitis Optica in a Case of Undiagnosed Ankylosing Spondylitis: A Neuro-Rheumatological Conundrum.

Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune astrocytopathy against foot processes of aquaporin-4 (AQP4) water channels. … is, subluxation of joints, ossification of anterior and posterior longitudinal ligaments, secondary spinal canal stenosis, bony (vertebral) fractures, and subsequent compressions over nerve radicles/roots/cauda equina, and inflammation-related (entrapment) peripheral neuropathies.12,16,17 Acute transverse myelitis can occur as a subset of several primary demye …

Prospective external validation of a three-predictor frailty model for 90-day survival and complications following spinal metastasis surgery.

Background contextSurgical decision-making in patients with spinal metastases remains complex due to the need to balance potential surgical benefits with limited survival and common frailty. Predictive models can assist in this process, but their clinical utility is often limited by complexity and lack of validation.PurposeTo externally validate a simple three-predictor frailty model for 90-day survival and complications, and to compare its performance with other commonly used tools.Study design/settingProspective external validation study conducted at a single tertiary cancer center.Patient s

Совпадение в полном тексте источника
… Local staging revealed an expansive neoplastic lesion compressing the spinal canal at S1 and S2. Distant staging demonstrated metastatic spread to pelvic lymph nodes and multiple skeletal sites (pelvis, thoracic spine, lumbar spine, and ribs). …

MRI Grading Scale Predicts Ambulatory Function After Radiotherapy for Metastatic Spinal Cord Compression: A Prospective Single-Institution Observational Study.

IntroductionAlthough magnetic resonance imaging (MRI) is an important modality for the diagnosis of metastatic spinal cord compression (MSCC), there are only a few reports on MSCC findings and symptoms after radiotherapy. We aimed to reveal the factors related to ambulatory function after treatment, including the MRI findings, in a prospective observational study.MethodsPatients with suspected MSCC who were treated with radiotherapy were included in this study. Orthopedic surgeons evaluated the neurological function according to the Frankel grade. All patients underwent spinal MRI, and the deg

Совпадение в полном тексте источника
… MRI also provides detailed information on the bone marrow and helps detect the extension of the tumor into the spinal canal. …

Intraventricular topotecan for the treatment of neoplastic meningitis: five case studies.

Many systemic cytotoxic agents cannot penetrate the blood-brain barrier. Because of this, in approximately 5% of cancer cases, metastatic disease is seen in the leptomeninges. Without treatment, patients with neoplastic meningitis (NM) generally survive for only a matter of weeks. In the treatment of NM, intraventricular (IVT) topotecan results in progression-free and overall survival outcomes similar to those seen with other IVT chemotherapies, while being particularly well tolerated by most patients. In this article, we present the case studies of five patients with NM, with various primary

Pamidronate disodium for palliative therapy of feline bone-invasive tumors.

This study sought to quantify in vitro antiproliferative effects of pamidronate in feline cancer cells and assess feasibility of use of pamidronate in cats by assessing short-term toxicity and dosing schedule in cats with bone-invasive cancer. A retrospective pilot study included eight cats with bone invasive cancer treated with intravenous pamidronate. In vitro, pamidronate reduced proliferation in feline cancer cells (P < 0.05). One cat treated with pamidronate in combination with chemotherapy and two cats treated with pamidronate as a single agent after failing prior therapy had subjective