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mRNA vaccine in cancer therapy: Current advance and future outlook.

Messenger ribonucleic acid (mRNA) vaccines are a relatively new class of vaccines that have shown great promise in the immunotherapy of a wide variety of infectious diseases and cancer. In the past 2 years, SARS-CoV-2 mRNA vaccines have contributed tremendously against SARS-CoV2, which has prompted the arrival of the mRNA vaccine research boom, especially in the research of cancer vaccines. Compared with conventional cancer vaccines, mRNA vaccines have significant advantages, including efficient production of protective immune responses, relatively low side effects and lower cost of acquisitio

ROS 2020 Abstract

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The landscape and trajectory of global CRISPR therapeutics.

With the first regulatory approval in 2023 of a CRISPR-based therapy for sickle cell disease followed by the recent demonstration of an accelerated, personalized CRISPR treatment for congenital severe carbamoyl-phosphate synthetase 1 deficiency, CRISPR-Cas9 genome editing has progressed from a laboratory technology into a clinical reality in just over a decade. While enthusiasm for deploying CRISPR-Cas9 to treat a range of human genetic diseases continues to grow, broad clinical application remains constrained due to technical, regulatory, manufacturing and economic challenges. Here, scientist

Clinical development of gene therapy: results and lessons from recent successes.

Therapeutic gene transfer holds the promise of providing lasting therapies and even cures for diseases that were previously untreatable or for which only temporary or suboptimal treatments were available. For some time, clinical gene therapy was characterized by some impressive but rare examples of successes and also several setbacks. However, effective and long-lasting treatments are now being reported from gene therapy trials at an increasing pace. Positive outcomes have been documented for a wide range of genetic diseases (including hematological, immunological, ocular, and neurodegenerativ

12-Month Teriparatide Treatment Reduces New Vertebral Compression Fractures Incidence And Back Pain And Improves Quality Of Life After Percutaneous Kyphoplasty In Osteoporotic Women.

PurposeDefine the effectiveness of teriparatide (TPTD) treatment on reducing the incidence of new vertebral compression fractures (NVCFs) and back pain and improving quality of life after percutaneous kyphoplasty (PKP).MethodsTwo years of clinical follow-up data from primary osteoporotic women who had experienced initial osteoporotic vertebral compression fractures (OVCFs) and received PKP plus 12-month TPTD (n=113) or basic treatment (BT) of calcium and vitamin D supplements (n=208) were retrospectively collected. The risk of NVCFs over each 6-month period in the TPTD group was evaluated and

Влияние возраста на изменение или прекращение болезней, изменяющих терапию при множественном склерозе.

Пожилые пациенты в возрасте ≥55 лет составляют почти половину от общей численности населения страны. Несмотря на то, что в результате возникновения заболеваний происходят такие точечные и подстрекательские процессы демиелионации и такие прогрессивные процессы, как разрозненное воспаление CNS, нейродегенерация и отказ компенсационных механизмов, наблюдается сдвиг в преобладающих болезнях с заметным клиническим прогрессом в течение пятого десятилетия жизни. Клинически это проявляется в уменьшении числа рецидивов в клинической области и активности МРТ в качестве лиц в возрасте MS, что приводит к

The Role of Extracellular Vesicles in Bone Regeneration and Associated Bone Diseases.

Extracellular vesicles (EVs) are nanoscale particles with a lipid bilayer membrane structure secreted by various cell types. Nearly all human cells secrete EVs, primarily mediating intercellular communication. In recent years, scientists have discovered that EVs can carry multiple biological cargos, such as DNA, non-coding RNAs (ncRNAs), proteins, cytokines, and lipids, and mediate intercellular signal transduction. Bone is a connective tissue with a nerve supply and high vascularization. The repair process after injury is highly complex, involving interactions among multiple cell types and bi

When Should Spinal Surgery Be Considered for Spinal Metastasis from Non-Small Cell Lung Cancer?-Propensity Score Matched Study between Surgery with Radiotherapy and Radiotherapy Alone.

(1) Background: Although metastatic spine disease is increasing, the debate on therapeutic modality remains due to the heterogeneity of tumors and patients. This study aims to evaluate the efficacies of surgery and risk factors for patients' survival from potentially unstable spinal metastasis of non-small cell lung cancer; (2) Methods: Twenty-two patients undergoing surgery and radiotherapy (group I) were compared with 22 patients undergoing radiotherapy alone (group II) using propensity score matching in a 1-to-1 format. Clinical outcomes included the performance status and ambulatory status

Цифровые сигнатуры усталости и износа у пациентов с множественным склерозом во время родов.

Симптомы выпадения (WoS) во время родовспоможения (NTZ) часто интерпретируются как субклинические заболевания у пациентов с множественным склерозом (PwMS), однако их значение остается неопределенным. В перспективном исследовании " SATURATE " ( " Один центр " )NCT05701423), мы изучили, связана ли ВОС с воспалительными или нейродегенеративными повреждениями и является ли износимость мониторинга улавливанием изменений, связанных с двигателем. Thirty-four :: были зачислены лица, прошедшие лечение в НТЗ; 28 завершено 6-month Последующая деятельность и 21 :: обеспечивала доступны

Случай тригеминального нервного нейросаркоида, который первоначально представлял собой изолированные неврологические выводы, имитирующие тригеминальную шванному: отчет о деле и обзор литературы.

Саркоидоз — грануломатное воспалительное заболевание, в первую очередь затрагивающее легкие. Задействование центральной нервной системы является редким и происходит примерно в 5-10% Количество дел. Изолированные повреждения краниального нерва, особенно затрагивающие тригеминальный нерв, являются еще менее распространенными. Эти повреждения могут быть очень похожи на более известные опухоли, такие, как тригеминальные шванномы, менингиома и множественный склероз, что может осложнить диагностику, когда в пещере Меккеля впервые обнаружена одиночная масса.ПРЕДОСТАВЛЕНИЕ СЛУЧАИ: Мы сообщаем о случае

Совпадение в полном тексте источника
… The patient was initially managed with medical therapy, including gabapentin for neuropathic pain; hydromorphone hydrochloride for breakthrough pain led to minimum to no improvement. …

Терапевтические достижения в педиатрии с множественным склерозом.

Педиатрический множественный склероз (POMS) является хроническим и иммунным расстройством, которое влияет на центральную нервную систему детей и подростков. Примерно 3-10% пациентов, страдающих синдромом MS, имеют место до достижения 18-летнего возраста. Подавляющее большинство случаев заболевания педиатрическим синдромом MS характеризуется повторной эрозией с высоким уровнем заболеваемости. Пациенты педиатрии, страдающие синдромом MS, традиционно проходили лечение без маркировки с различной степенью успеха. С одобрением многих новых методов лечения для взрослых МР быстро начали появляться аль

Lost in Translation (LiT): IUPHAR Review 6.

Translational medicine is a roller coaster with occasional brilliant successes and a large majority of failures. Lost in Translation 1 ('LiT1'), beginning in the 1950s, was a golden era built upon earlier advances in experimental physiology, biochemistry and pharmacology, with a dash of serendipity, that led to the discovery of many new drugs for serious illnesses. LiT2 saw the large-scale industrialization of drug discovery using high-throughput screens and assays based on affinity for the target molecule. The links between drug development and university sciences and medicine weakened, but t

Adoption value of support vector machine algorithm-based computed tomography imaging in the diagnosis of secondary pulmonary fungal infections in patients with malignant hematological disorders.

This study aimed to assess the feasibility of diagnosing secondary pulmonary fungal infections (PFIs) in patients with hematological malignancies (HM) using computerized tomography (CT) imaging and a support vector machine (SVM) algorithm. A total of 100 patients with HM complicated by secondary PFI underwent CT scans, and they were included in the training group. Concurrently, 80 patients with the same underlying disease who were treated at our institution were included in the test group. The types of pathogens among different PFI patients and the CT imaging features were compared. Radiomic f

Blastic Plasmacytoid Dendritic Cell Neoplasm: A Case Report.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an uncommon hematological tumor originating from the precursor of plasmacytoid dendritic cells (pDCs) with a persistent and progressive course of illness. Despite being an aggressive disease BPDCN has an initial indolent course manifested as skin lesions. Alongside or following the skin lesion, the extra-cutaneous manifestation develops and includes lymphadenopathy, splenomegaly, and hepatomegaly. The BPDCN diagnosis is mainly based on the immunophenotype.  Herein, we report the case of a 72-year-old male patient who presented with a hist

Efficacy and safety of isatuximab subcutaneous plus carfilzomib and dexamethasone in patients with relapsed/refractory multiple myeloma: results of the Phase 2 study IZALCO.

In the Phase 2 IZALCO study, we evaluated efficacy, patient preference, safety and pharmacokinetics for isatuximab administered SC by an innovative on-body injector (OBI) or manual injection, plus carfilzomib-dexamethasone (Kd) in relapsed/refractory multiple myeloma (RRMM) patients. In Part 1, isatuximab SC was injected manually (cycles 1-6). In Part 2, patients were randomized to isatuximab SC by manual injection (cycles 1-3) followed by OBI administration (cycles 4-6) or to isatuximab OBI (cycles 1-3) followed by manual injection (cycles 4-6). From cycle 7, all patients could choose either

Organoids as Innovative Models for Bone and Joint Diseases.

Bone is one of the key components of the musculoskeletal system. Bone and joint disease are the fourth most widespread disease, in addition to cardiovascular disease, cancer, and diabetes, which seriously affect people's quality of life. Bone organoids seem to be a great model by which to promote the research method, which further could improve the treatment of bone and joint disease in the future. Here, we introduce the various bone and joint diseases and their biology, and the conditions of organoid culture, comparing the in vitro models among 2D, 3D, and organoids. We summarize the differin

Талидомид взаимодействует с воспалением в идиопатическом фиброзе легких.

" Трагедия Талидомида " является важной вехой в истории фармацевтической промышленности. Несмотря на ограниченные клинические испытания, прилагаются постоянные усилия по изучению Талидомида в качестве лекарства от рака и подстрекательских заболеваний, таких, как ревматуидный артрит, проказа, и COVID-19. В рамках этого обзора основное внимание уделяется возможностям борьбы с воспалением путем повторного использования талидомида для лечения идиопатического фиброза легких (ИПФ). Статьи были найдены в базе данных Scopus, сортированы и рассмотрены отдельные статьи. Содержание включает в с

Current Advancements in the Diagnosis and Treatment of Metastatic Spinal Cord Compression and Its Postintervention Care: A Comprehensive Review.

Malignant spinal cord compression (MSCC) is a serious oncological emergency that can result in neurological impairment and significant pain. It is associated with high morbidity, mortality, and a decrease in quality of life. This review reviews the current literature concerning diagnosis, guidelines, timely intervention, and management options in oncology patients with MSCC. A literature search of PubMed using relevant keywords and MeSH terms yielded 604 articles. Of these, 31 studies met the predefined inclusion criteria and were selected for detailed data extraction and synthesis into a narr

Modified oral cryotherapy is associated with lower oral mucositis pain in HSCT recipients: a retrospective study.

PurposeTo assess modified oral cryotherapy (OC) for pain management in hematopoietic stem cell transplant (HSCT) recipients with oral mucositis (OM).MethodsA retrospective study included 361 HSCT patients (2023-2025) stratified into Conventional Nursing Practice (CNP) group (n=170) and optimized nursing protocol (ONP) group (n=191). The ONP protocol replaced saline ice slurry with Kangfuxin solution ice slurry and incorporated adjunctive bilateral cheek cryotherapy using ice packs. Outcomes compared OM severity and pain levels (Verbal Rating Scale).ResultsBoth groups showed comparable overall

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… This combined treatment approach integrates dual strategies of physical cooling and pharmacological therapy, providing a practical approach for pain management in oral mucositis, and allowing patients to use auxiliary cheek cryotherapy as needed during episodes of breakthrough pain. …

Case report: Cryoablation as a novel bridging strategy prior to CAR-T cell therapy for B cell malignancies with bulky disease.

Chimeric antigen receptor (CAR) T-cell therapy has emerged as a powerful immunotherapy in relapsed/refractory (R/R) hematological malignancies, especially in R/R B-cell acute lymphocytic leukemia (B-ALL), non-Hodgkin lymphoma (NHL), and multiple myeloma (MM). To prevent disease progression and reduce tumor burden during CAR-T cell manufacturing, bridging therapies prior to CAR-T cell infusion are crucial. At present, it has been demonstrated that targeted therapy, radiotherapy and autologous stem cell transplantation (ASCT) could serve as effective bridging strategies. However, whether cryoabl