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Fetal and neonatal hepatic tumors.

BACKGROUND/PURPOSE: Although hepatic tumors are uncommon in the perinatal period they are associated with significant morbidity and mortality in affected patients. The purpose of this review is to focus on the fetus and neonate in an attempt to determine the various ways liver tumors differ clinically and pathologically from those found in the older child and adult and to show that certain types of tumors have a better prognosis than others. METHODS: The author conducted a retrospective review of perinatal hepatic tumors reported in the literature and of patients treated and followed up at Ch

Epidermal growth factor receptor targeted therapy in stages III and IV head and neck cancer.

QUESTION: What are the benefits associated with the use of anti-epidermal growth factor receptor (anti-EGFR) therapies in squamous cell carcinoma of the head and neck (HNSCC)? Anti-EGFR therapies of interest included cetuximab, gefitinib, lapatinib, zalutumumab, erlotinib, and panitumumab. PERSPECTIVES: Head-and-neck cancer includes malignant tumours arising from a variety of sites in the upper aerodigestive tract. The most common histologic type is squamous cell carcinoma, and most common sites are the oral cavity, the oropharynx, the hypopharynx, and the larynx. Worldwide, HNSCC is the sixt

Management of single brain metastasis: a practice guideline.

QUESTIONS: Should patients with confirmed single brain metastasis undergo surgical resection? Should patients with single brain metastasis undergoing surgical resection receive adjuvant whole-brain radiation therapy (wbrt)? What is the role of stereotactic radiosurgery (srs) in the management of patients with single brain metastasis? PERSPECTIVES: Approximately 15%-30% of patients with cancer will develop cerebral metastases over the course of their disease. Patients identified as having single brain metastasis generally undergo more aggressive treatment than do those with multiple metastases

Cooperation, Trust, and Antagonism: How Public Goods Are Promoted.

One of the most continually vexing problems in society is the variability with which citizens support endeavors that are designed to help a great number of people. In this article, we examine the twin roles of cooperative and antagonistic behavior in this variability. We find that each plays an important role, though their contributions are, understandably, at odds. It is this opposition that produces seeming unpredictability in citizen response to collective need. In fact, we suggest that careful consideration of the research allows one to often predict when efforts to provide a collectively

The Perinatal Committee report: Review of the progress of obstetric healthcare in Japan.

BACKGROUND: Japan's maternal mortality rate and perinatal mortality rate have shown one of the world's most significant declines, positioning Japan at the global forefront of the lowest levels. The nearly logarithmic annual decline in maternal and perinatal mortality rates suggests that, in addition to advances in medicine and healthcare, various types of care for mothers and newborns have played a crucial role in this achievement. METHOD: From the period of World War II to the postwar era, up to around 1980, and then every decade thereafter, the events and movements surrounding perinatal hea

Exercise dependence and orthorexia nervosa in Crossfit: exploring the role of perfectionism.

Sustainable employability (SE) is an important topic as it deals with employees' abilities to function adequately at work and in the labor market throughout their working lives. However, until now there has been only one attempt to define SE in the international literature (1). This first definition is a valuable contribution to the field as it rightfully describes SE as a multidimensional concept, recognizes the importance of both employee and work characteristics, and acknowledges the inherently longitudinal nature of SE. Despite these merits, we argue that this definition of SE has some ser

Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016.

S1 Health literacy and health education in adolescence Catarina Cardoso Tomás S2 The effect of a walking program on the quality of life and well-being of people with schizophrenia Emanuel Oliveira, D. Sousa, M. Uba-Chupel, G. Furtado, C. Rocha, A. Teixeira, P. Ferreira S3 Diagnosis and innovative treatments - the way to a better medical practice Celeste Alves S4 Simulation-based learning and how it is a high contribution Stefan Gisin S5 Formative research about acceptability, utilization and promotion of a home fortification programme with micronutrient powders (MNP) in the Autonomous Region o

Alternative management of proximal aortic dissection: concept and application.

Dear Editor, The chapter on mental, behavioural and neurodevelopmental disorders of the 11th revision of the International Classification of Diseases and Related Health Problems (ICD-11) has been now finalized. Reporting of health statistics by Member States to the World Health Organization (WHO) using the new diagnostic system will begin in 2022. The section on mood disorders of the ICD-11 is overall consistent with the corresponding section of the ICD-10. However, the definitions of a depressive and a manic episode have been slightly changed, making them consistent with the DSM-5 (see below)

Fostering next generation transplant physicians.

As opposed to the rapid expansion of hematopoietic cell transplantation (HCT) and other cellular therapies (CT), we are now facing a global shortage of transplant physicians and other professionals to support the activity of HCT/CT. To overcome this obstacle, a variety of approaches are now being undertaken in four international HCT societies. This article aims to share their current attempts to foster the next generation of transplant physicians and allied professionals needed to secure the continued global growth of HCT/CT.

A life span perspective on competencies for a healthy, physically active lifestyle: Findings of a data pooling initiative with over 7000 individuals.

Individuals are recommended to lead active lifestyles throughout the life course. The model of physical activity-related health competence (PAHCO) adopts a competence approach by integrating physical, cognitive, and motivational determinants for health-enhancing PA (movement competence, control competence, self-regulation competence). Drawing on a comprehensive dataset pooling, the goal of the present study was to model the idiosyncratic courses of 10 PAHCO indicators over the life span. We identified studies that empirically operationalized PAHCO, combining data of 7134 individuals (age range

Family caregiver ambassador support for caregivers of patients with newly diagnosed hematological cancer: a feasibility study.

PurposeThis study investigated the feasibility of a one-on-one peer support intervention in family caregivers of newly diagnosed patients with a hematological cancer during initial treatment.MethodsThe study was a one-arm feasibility study including family caregivers of newly diagnosed patients with hematological cancer (n = 26) and caregiver ambassadors who were family caregivers of previously treated patients as peer supporters (n = 17). The one-on-one peer support intervention consisted of three components: a caregiver ambassador preparatory course; 12 weeks of one-on-one peer support, and

'It was like taking an inner bath': A qualitative evaluation of a collaborative advance care planning-approach.

BackgroundImpaired readiness may hinder purposeful advance care planning in cancer patients. To reduce barriers to participation in end-of-life decision-making, a collaborative intervention was developed combining a psycho-oncological approach of dignity-based and cognitive-behavioural interventions, followed by a standardised advance care planning-process.AimTo evaluate the novel collaborative advance care planning-approach by synthetising cancer patient and carer perspectives on communicational and relational effects.DesignAs a sub-project of a mixed-methods evaluation study, we conducted an

Clinical, economic and organizational impact of pharmacist interventions on injectable antineoplastic prescriptions: a prospective observational study.

BackgroundPharmacists play a key role in ensuring the safe use of injectable antineoplastics, which are considered as high-alert medications. Pharmaceutical analysis of injectable antineoplastic prescriptions aims to detect and prevent drug related problems by proposing pharmacist interventions (PI). The impact of this activity for patients, healthcare facilities and other health professionals is not completely known. This study aimed at describing the clinical, economic, and organizational impacts of PIs performed by pharmacists in a chemotherapy preparation unit.MethodsA prospective 10-week

Past Happiness and Broken Future Horizon of Oncological Patients during Chemotherapy-A Quantitative Exploration of a Phenomenological Hypothesis.

Understanding the impact of cancer on the experience of time is crucial in the context of hope and recovery. This study, a follow-up to a previous qualitative study of ovarian cancer patients - explored two types of such experiences-the memory of past happiness and the limited future planning. A sociodemographic questionnaire with nine questions about the experience of time was used on a convenience sample of 202 patients with various cancers, predominantly women with breast, ovarian, and cervical cancer. It was found that the respondents experienced increased focus on the present, decreased f

Множественная миелома: многострановое исследование по смешанным методам, касающимся восприятия заболеваний и предпочтений лечения пациентов.

AIMS: Уяснить представления о заболеваниях и предпочтениях лечения пациентов с высокой степенью риска, страдающих множественным миэломой (HR-SMM) или множественной миэломой (MM), которая недавно прошла через HR-SMM, и оценить минимальный уровень выживаемости (мин-PFS), необходимый для того, чтобы принять лечение. МЕТОДЫ: Опрошенное исследование по смешанным методам 50 пациентов (HR-SMM и MM) 1::1) от США, Франции, Италии и Испании. Качественные полуструктурированные собеседования были посвящены изучению симптомов, качества жизни, а также осведомленности и ожиданий в отношении лечения SMM. Коли

Детские трудности и аутоиммунные заболевания: глобальный исследовательский ландшафт, < < горячие точки > > , связанные с иммунизацией, и новые тенденции, вытекающие из библиометрического анализа трех баз данных.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Детские трудности все чаще признаются в качестве важного психосоциального воздействия в раннем возрасте, которое может формировать долгосрочную иммунную функцию и способствовать аутоиммунным заболеваниям посредством хронического стресса, регулирования нейроэндокринной дистрибьюции и провокационной активации. Однако структура знаний, " горячих точек " исследований и тенденции в области развития в этой области остаются недостаточно характерными. МЕТОДЫ: С момента создания базы данных по 31 декабря 2025 года публикации, посвященные детским недугам и аутоиммунным з

Demographic, epidemiological, and health transitions: are they relevant to population health patterns in Africa?

BackgroundStudies of trends in population changes and epidemiological profiles in the developing world have overwhelmingly relied upon the concepts of demographic, epidemiological, and health transitions, even though their usefulness in describing and understanding population and health trends in developing countries has been repeatedly called into question. The issue is particularly relevant for the study of population health patterns in Africa and sub-Saharan Africa, as the history and experience there differs substantially from that of Western Europe and North America, for which these conce

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… The second strategy rests on a medicalized life course perspective on health and entails using data that are relatively culture-free (e.g. blood pressure) to objectively determine individual health by measuring its diminishing from healthy state through sickness and disability; hence, the health transition …

Collusion in Cancer Care: An Investigation into its Facets at a Tertiary Care Center in South India.

Background and aimsCollusion, the practice of concealing a diagnosis or prognosis from a close relative to prevent emotional distress, is a complex issue in cancer care. This study aimed to estimate the prevalence of collusion among cancer patients and identify the associated factors, including educational status, time since diagnosis, and prognosis.MethodsThis 6-month cross-sectional study recruited 121 consenting cancer patients (aged >18 years) via convenient sampling at a tertiary care center in South India. Patients with psychiatric conditions or communication difficulties were excluded.

Cost-effectiveness of enzyme replacement therapy for type 1 Gaucher disease.

ObjectiveTo evaluate the cost-effectiveness of enzyme replacement therapy (ERT) compared to standard medical care without ERT in the Dutch cohort of patients with type 1 Gaucher disease (GD I).DesignCost-effectiveness analysis was performed using a life-time state-transition model of the disease's natural course. Transition probabilities, effectiveness data and costs were derived from retrospective data and prospective follow-up of the Dutch study cohort.SettingThe tertiary referral center for Gaucher disease in the Netherlands.ParticipantsThe Dutch cohort of patients with GD I.InterventionERT

Воздействие внутрибольничных заболеваний, изменяющих лечение психических и физических расстройств у пациентов, имеющих кровосмешение.

ЦЕЛЬ: Люди с множественным склерозом (PwMS) могут нуждаться в высокой ежедневной помощи как для работы в помещениях, так и для работы на открытом воздухе. Обычно родственники или друзья оказывают ежедневную поддержку пациентам, потерявшим личную самостоятельность. Ряд факторов, таких, как уровень инвалидности и продолжительность болезни, могут влиять на бремя ухода за лицами, обеспечивающими уход за больными; однако до сих пор не изучена взаимосвязь между лечением с целью изменения болезней (ДМР) и работой по уходу за больными. Цель этого исследования заключается в изучении воздействия больнич