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Atypical bone and synovial metastases from colorectal adenocarcinoma: A case report.

Colorectal cancer (CRC) is a prevalent malignancy globally, ranking third in incidence and second in cancer-specific mortality. Despite advancements in diagnosis and treatment, the incidence of CRC, especially in younger individuals and developing countries, is rising. We present a unique case of a woman initially diagnosed with cecal adenocarcinoma who developed metachronous atypical bone and soft tissue metastases, including involvement of the left knee synovium. This case underscores the diagnostic and therapeutic complexities in managing CRC patients with atypical metastatic disease. The p

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… Metastatic adenocarcinoma of synovium presenting as an acute arthritis: diagnosis by closed synovial biopsy Arthritis Rheum 18 1975 107 110 1131279 10.1002/art.1780180202 16 Graham DF. …

The Clinical Impact of a Multidisciplinary Strategy: Diagnostic and Therapeutic Flow-Chart for Vertebral Metastases with Spinal Cord Compression.

Introduction: Metastatic spinal cord compression (MSCC) is a life-threatening complication caused by the involvement of the spinal cord or nerve roots. It can result in severe neurological deficits, including paralysis, sensory loss, and bladder or bowel dysfunction, significantly affecting patients' quality of life. Prompt diagnosis and intervention are critical to minimizing these outcomes and improving neurological recovery. This study evaluates the efficacy of a diagnostic and therapeutic protocol introduced at our institution in 2022, designed to enhance early detection, optimize manageme

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… Rheum. Dis. 2014 73 968 974 10.1136/annrheumdis-2013-204428 24665116 12. Van der Linden Y.M. Dijkstra S.P. Vonk E.J. Marijnen C.A. Leer J.W. …

Причинная роль общих аутоиммунных заболеваний в межститиальном цистите/болезнечном синдроме пузырьков: исследование менделианского случайного заболевания (MR).

Результаты наблюдений свидетельствуют о том, что на показатели межститиального цитита/болезненного синдрома пузырей (IC/BPS) могут влиять аутоиммунные заболевания (AID), хотя причинно-следственные связи трудно определить на основе данных наблюдений из-за риска остаточного смешения. Мы использовали менделианскую случайность (MR) для изучения причинно-следственной связи нескольких AID на IC/BPS. Наша двунаправленная two- анализ МОР был основан на обобщенных статистических данных, полученных в ходе самых последних всеобъемлющих исследований, касающихся всего генома. Этот конкретный подход был исп

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Observational studies suggest that interstitial cystitis/bladder pain syndrome (IC/BPS) indices might be influenced by autoimmune diseases ( … amined a range of AIDs such as ulcerative colitis, Crohn disease, celiac disease, Sjogren syndrome, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, primary biliary cirrhosis, psoriasis, asthma, eczema, ankylosing spondylitis, type 1 diabetes, and primary sclerosing cholangitis. Our primary analytical approach involved using the i …

Comparison of the prophylactic use of ibandronate and its use in early-stage osteonecrosis in rats with steroid-induced osteonecrosis of the femoral head.

OBJECTIVES: The aim of this study was to investigate the effects of ibandronate before and after the onset of osteonecrosis in rats with steroid-induced osteonecrosis of the femoral head. MATERIALS AND METHODS: A total of 24 female Sprague-Dawley rats were used in this study. Three groups were formed with eight rats in each group. The first group was the prophylactic group that received ibandronate treatment before and after the onset of osteonecrosis (Group PT). The second group received ibandronate treatment three weeks after the development of osteonecrosis (Group TAO). The third group was

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… Arthritis Rheum. 2012;64:1572–1578. doi: 10.1002/art.33498. 29. Agarwala S, Jain D, Joshi VR, Sule A. Efficacy of alendronate, a bisphosphonate, in the treatment of AVN of the hip. A prospective open-label study. Rheumatology (Oxford) 2005;44:352–359. doi: 10.1093/rheumatology/keh481. 30. …

Clinical characteristics and risk factors of patients with eosinophilic fasciitis associated with pleural effusion.

To investigate the risk factors of eosinophilic fasciitis (EF) associated with pleural effusion (PE). A retrospective analysis was performed on 22 patients with EF diagnosed by skin biopsy in our hospital, and they were divided into EF-PE and EF according to chest computed tomography examination. The clinical characteristics, clinical manifestations, comorbidities and laboratory test indicators of the two groups were collected and compared, and the risk factors for occurring PE in patients with EF were determined by multivariate logistic regression analysis. Among 22 patients with EF, 8 had PE

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… Arthritis Rheum. 1988;17(4):221–231. doi: 10.1016/0049-0172(88)90008-X. 13. Lebeaux D, Sène D. Eosinophilic fasciitis (Shulman disease) Best Pract. Res. Clin. Rheumatol. 2012;26(4):449–458. doi: 10.1016/j.berh.2012.08.001. 14. Iwamoto Y, Tatsumi F, Katakura Y, et al. …

Recurrent acute interstitial nephritis: what lies beneath.

BACKGROUND: Acute interstitial nephritis (AIN) is an emerging cause of acute kidney disease. While this disease usually follows an acute course, it may occasionally recur, representing a major challenge for the clinician. METHODS: We performed a retrospective, observational cohort study in 13 nephrology departments belonging to the Spanish Group for the Study of Glomerular Diseases. Patients with biopsy-proven AIN between 1996 and 2018 were included. RESULTS: The study group consisted of 205 patients with AIN, 22 of which developed recurrent AIN (RAIN) after a median of 111 days from diagnos

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… Rheum Dis Clin North Am 2018 ; 44 : 619 – 633 30274627 10.1016/j.rdc.2018.06.009 10 Su T , Gu Y , Sun P et al Etiology and renal outcomes of acute tubulointerstitial nephritis: a single-center prospective cohort study in China . …

Прогрессивная многофукальная лейкоэнцефалопатия как осложнение лечения множественным склерозом, которое может привести к изменению болезней

Обзор дает современное представление о патогенезе прогрессивной многофукальной лейкоэнцефалопатии (ПМЛ), которая представляет собой серьезную и потенциально фатальную форму расстройства белых позвоночников головного мозга. Анализируется информация о частотности его развития у пациентов, которые проходят курс лечения множественным склерозом. В этой категории пациентов с множественным склерозом подробно описаны алгоритмы оптимизации рисков PML. Обобщаются данные о наиболее важных биомаркерах PML, поиск которых в настоящее время ведется во многих центрах по всему миру. Первый случай PML в России

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… Arthritis Rheum 2009; 60: 3761–3765. DOI: 10.1002/art.24966. PMID: 19950261. Информация об авторах: Захарова Мария Николаевна – д.м.н., рук. 6-го неврологического отд. ФГБНУ НЦН, Москва, Россия; Лысогорская Елена Владимировна – к.м.н., н.с. 6-го неврологического отд. …

Osteolytic Breast Cancer Causes Skeletal Muscle Weakness in an Immunocompetent Syngeneic Mouse Model.

Muscle weakness and cachexia are significant paraneoplastic syndromes of many advanced cancers. Osteolytic bone metastases are common in advanced breast cancer and are a major contributor to decreased survival, performance, and quality of life for patients. Pathologic fracture caused by osteolytic cancer in bone (OCIB) leads to a significant (32%) increased risk of death compared to patients without fracture. Since muscle weakness is linked to risk of falls which are a major cause of fracture, we have investigated skeletal muscle response to OCIB. Here, we show that a syngeneic mouse model of

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… Arthritis Rheum ( 2009 ) 60 ( 11 ): 3280 – 9 . 10.1002/art.24907 19877058 21 Vera-Ramirez L Sanchez-Rovira P Ramirez-Tortosa MC Ramirez-Tortosa CL Granados-Principal S Lorente JA Free radicals in breast carcinogenesis, breast cancer progression and cancer stem cells. …

Imatinib and dasatinib as salvage therapy for sclerotic chronic graft-vs-host disease.

AimTo assess the toxicity, tolerance, steroid-sparing capacity, effectiveness, and response rate to imatinib and dasatinib for the treatment of severe sclerotic chronic graft-vs-host disease (scGVHD).MethodsThis retrospective study analyzed 8 consecutive patients with severe refractory scGVHD who received salvage therapy with imatinib. Patients intolerant and/or refractory to imatinib received dasatinib treatment.Results7 patients discontinued imatinib treatment (1 achieved complete response, 5 were resistant and/or intolerant, and 1 developed grade IV neutropenia) and 1 patient achieved prolo

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… Arthritis Rheum 2008 58 1475 84 10.1002/art.23436 18438865 18 Akhmetshina A Dees C Pileckyte M Maurer B Axmann R Jüngel A Dual inhibition of c-abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis. …

KIF11 promotes rheumatoid arthritis pathogenesis by activating M1 macrophage polarization and promoting inflammatory cytokine secretion.

BACKGROUND AND OBJECTIVE: KIF11, a mitotic kinesin, has been implicated in oncogenesis, but its specific role and mechanism in RA pathogenesis remain largely unexplored. We aim to explore functional role and molecular mechanism of KIF11 to promote RA progression. METHODS: Bioinformatics analysis was first performed on public RA datasets (GSE55457, GSE55235, GSE2053, GSE12021, and GSE1919) to identify KIF11-associated DEGs and their enriched pathways using GO/KEGG and GSEA analysis. Lentivirus-mediated shRNA was employed to knock down KIF11 expression in MH7A cells and M1-polarized macrophages

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… Int J Rheum Dis. 2025;28(10):e70445. doi: 10.1111/1756-185x.70445 23. Zhu L, Chen C, Kang M, Ma X, Sun X, Xue Y, et al. KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia. J Cancer Res Clin Oncol. 2023;149(17):15609–22. doi: 10.1007/s00432-023-05240-w 24. …

Association between Gut Microbiota and Biological Aging: A Two-Sample Mendelian Randomization Study.

Recent observational studies revealed an association between gut microbiota and aging, but whether gut microbiota are causally associated with the aging process remains unknown. We used a two-sample Mendelian randomization approach to investigate the causal association between gut microbiota and biological age acceleration using the largest available gut microbiota GWAS summary data from the MiBioGen consortium and GWAS data on biological age acceleration. We further conducted sensitivity analysis using MR-PRESSO, MR-Egger regression, Cochran Q test, and reverse MR analysis. Streptococcus (IVW

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… Rheum. Dis. 2021 80 1575 1583 10.1136/annrheumdis-2021-220687 34426398 PMC8600607 56. Li W. Wu X. Hu X. Wang T. Liang S. Duan Y. Jin F. Qin B. Structural changes of gut microbiota in Parkinson’s disease and its correlation with clinical features Sci. …

Hematopoietic stem cell transplantation therapy for refractory' Crohn disease: A systematic review and meta-analysis.

BackgroundDespite the availability of numerous treatments for Crohn disease, there are patients who do not respond to any therapy, thereby diminishing their quality of life. The aim of this review is to analyze the efficacy and safety of autologous hematopoietic stem cell transplantation therapy for refractory Crohn disease.MethodsThis work is a systematic review with meta-analysis conducted in accordance with the guidelines of the Preferred Reporting Items for Systematic Review and Meta-Analyses. Electronic databases such as PubMed, Scopus, Web of Science, and ClinicalTrials were consulted. T

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… Arthritis Rheum. 2007;56:2410–21. [59] Lindsay JO, Allez M, Clark M, et al.; ASTIC trial group. Autologous stem-cell transplantation in treatment-refractory Crohn’s disease: an analysis of pooled data from the ASTIC trial. Lancet Gastroenterol Hepatol. 2017;2:399–406. …

Role of bone marrow adipocytes in bone metastasis development and progression: a systematic review.

PurposeBone marrow adipocytes (BMAs) are the most plentiful cells in the bone marrow and function as an endocrine organ by producing fatty acids, cytokines, and adipokines. Consequently, BMAs can interact with tumor cells, influencing both tumor growth and the onset and progression of bone metastasis. This review aims to systematically evaluate the role of BMAs in the development and progression of bone metastasis.MethodsA comprehensive search was conducted on PubMed, Web of Science, and Scopus electronic databases, following the Preferred Reporting Items for Systematic Reviews and Meta-Analys

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… Arthritis Rheum ( 2009 ) 60 : 3374–7 . doi: 10.1002/art.24881 19877065 10 Fan Y Hanai JI Le PT Bi R Maridas D DeMambro V . Parathyroid hormone directs bone marrow mesenchymal cell fate . …

Amyloidoses in Onco-Nephrology Practice: A Multidisciplinary Case-Based Conference Report.

Introduction and objectiveAmyloidoses are a heterogeneous group of disorders resulting from deposition of amyloid fibrils into extracellular tissues. While the kidneys are one of the most frequent sites of amyloid deposition, amyloid deposits can also affect a wide range of organ systems, including the heart, liver, gastrointestinal tract, and peripheral nerves. The prognosis of amyloidosis, especially with cardiac involvement, remains poor; however, a collaborative approach applying new tools for diagnosis and management may improve outcomes. In September 2021, the Canadian Onco-Nephrology In

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… Arthritis Rheum . 2007 ; 56 ( 11 ): 3858 - 3868 . 17968927 10.1002/art.22959 42 Rapezzi C Lorenzini M Longhi S , et al . Cardiac amyloidosis: the great pretender . Heart Fail Rev . 2015 ; 20 ( 2 ): 117 - 124 . 25758359 10.1007/s10741-015-9480-0 43 Mayo C. …

Cancer Patients at Risk for Medication-Related Osteonecrosis of the Jaw. A Case and Control Study Analyzing Predictors of MRONJ Onset.

The goal of this investigation was to identify potential risk factors to predict the onset of medication-related osteonecrosis of the jaw (MRONJ). Through the identification of the multiple variables positively associated to MRONJ, we aim to write a paradigm for integrated MRONJ risk assessment built on the combined analysis of systemic and local risk factors. The characteristics of a cohort of cancer patients treated with zoledronic acid and/or denosumab were investigated; beyond the set of proven risk factors a new potential one, the intake of new molecules for cancer therapy, was addressed.

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… Rheum. Dis. 2006;65:785–790. doi: 10.1136/ard.2005.040428. 29. Bedogni A., Fusco V., Agrillo A., Campisi G. Learning from experience. …

Polyphenols enhance the activity of alkylating agents in leukaemia cell lines.

Polyphenols have been shown to sensitize solid tumours to alkylating agents such as cisplatin, and induce apoptosis and/or cell-cycle arrest. Here, we assess the effects of five polyphenols alone and in combination with three alkylating agents: cisplatin, cyclophosphamide and chlorambucil in lymphoid and myeloid leukaemia cells lines, and non-tumour control cells. In lymphoid leukaemia cell lines there was a synergistic reduction in ATP and glutathione levels, an induction of cell cycle arrest, DNA damage and apoptosis when quercetin, apigenin, emodin and rhein were combined with cisplatin and

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… Arthritis Rheum . 1995 ; 38 : 1120 – 27 . 10.1002/art.1780380815 . 7639809 10 Kirshon B , Wasserstrum N , Willis R , Herman GE , McCabe ER Teratogenic effects of first-trimester cyclophosphamide therapy . …

HDAC Inhibitors: Therapeutic Potential in Fibrosis-Associated Human Diseases.

Fibrosis is characterized by excessive deposition of the extracellular matrix and develops because of fibroblast differentiation during the process of inflammation. Various cytokines stimulate resident fibroblasts, which differentiate into myofibroblasts. Myofibroblasts actively synthesize an excessive amount of extracellular matrix, which indicates pathologic fibrosis. Although initial fibrosis is a physiologic response, the accumulated fibrous material causes failure of normal organ function. Cardiac fibrosis interferes with proper diastole, whereas pulmonary fibrosis results in chronic hypo

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… Rheum. Dis. 2017 76 277 285 10.1136/annrheumdis-2015-209064 27457515 PMC5264225 25. Guo W. Shan B. Klingsberg R.C. Qin X. Lasky J.A. Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition Am. J. Phys. Lung Cell. Mol. …

R-spondin signaling as a pivotal regulator of tissue development and homeostasis.

R-spondins (Rspos) are cysteine-rich secreted glycoproteins which control a variety of cellular functions and are essential for embryonic development and tissue homeostasis. R-spondins (Rspo1 to 4) have high structural similarity and share 60% sequence homology. It has been shown that their cysteine-rich furin-like (FU) domain and the thrombospondin (TSP) type I repeat domain are essential for initiating downstream signaling cascades and therefore for their biological functions. Although numerous studies have unveiled their pivotal role as critical developmental regulators, the most important

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… Arthritis Rheum. 2010;62(8):2303–2312. doi: 10.1002/art.27496. 56. Wang H., Brennan T.A., Russell E., Kim J.H., Egan K.P., Chen Q. R-Spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis. J Mol Med (Berl) 2013;91(12):1421–1429. doi: 10.1007/s00109-013-1068-3. 57. …

Cellular miRNA-31 and miRNA-125b as predictors of remission and major disease improvement in patients with early rheumatoid arthritis.

Rheumatoid arthritis (RA) is an autoimmune disease that impairs quality of life, highlighting the need for novel biomarkers for early diagnosis and improve disease management. This study explored the cellular microRNAs (miRNAs) profile in early RA to identify potential predictors of therapeutic response. We measured a panel of 768 miRNAs in peripheral blood mononuclear cells (PBMCs) from two early RA cohorts (< 6 months), stratified by sustained SDAI/CDAI remission and non-response to conventional therapy over 12 months. Initial screening identified 13 differentially expressed miRNAs (≥ 1.5-fo…

An Italian cartography of VEXAS-related thrombosis.

Thrombotic events (TEs) occur in up to 40% of patients with vacuoles, E1 enzyme, X-linked, autoinflammatory, and somatic (VEXAS) syndrome, but data on its clinical-genomics features and anticoagulation strategies are limited. To gain more insight into this, we conducted a two-step study evaluating the prevalence and outcome of TE in VEXAS. First, among 1086 patients followed for TEs, 198 were men aged >40 years with unprovoked thrombosis and no known thrombophilia; 21 also had at least one VEXAS-compatible feature and underwent UBA1 exon 3 testing. No UBA1 mutation was detected in these 21 pat

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… Semin Arthritis Rheum. 2025;73:152736. 10.1016/j.semarthrit.2025.152736 30. Emmi G, Bettiol A, Hatemi G, Prisco D. Behçet's syndrome. Lancet. 2024;403(10431):1093‐1108. 10.1016/S0140-6736(23)02629-6 31. Guy A, Garcia G, Gourdou‐Latyszenok V, et al. …