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A serological survey of scrub, tick, and endemic typhus in Sabah, East Malaysia.

A seroepidemiological survey of 837 people and 383 febrile patients was performed in rural areas of Sabah. We determined that the rickettsial diseases scrub typhus and endemic typhus were uncommon causes of febrile illness, as was tick typhus, except in forest dwelling peoples. The rate of occurrence of SFGR specific antibody was 16.5% among 412 forest dwellers, indicating that tick typhus may be a frequent cause of illness in this population.

Scrub typhus in the Eastern Solomon Islands and Northern Vanuatu (New Hebrides).

Rickettsia tsutsugmushi has been isolated from Rattus rattus from Vanua Lava island in Northern Vanuatu (New Hebrides) and from R. exulans and Leptotrombidium akamushi on Ndende island in the Eastern Solomon Islands. The well-known vector mite L. deliense was found on Mota Lava and Vanua Lava in Vanuatu, but no isolation was made from pools of this mite. Serology confirms that R. tsutsugamushi infects humans in the Banks group of islands in Northern Vanuatu and that infection is much more widespread in the Solomon Islands than the limited isolations indicate.

Host defenses in experimental scrub typhus: genetics of natural resistance to infection.

Genetic resistance to lethal infection with Rickettsia tsutsugamushi was studied in over 30 inbred strains, inbred hybrids, and outbred stocks of mice. Inbred mice infected intraperitoneally with the Gilliam strain of R. tsutsugamushi showed three patterns of response: susceptible (A/HeJ, C3H/HeDub, C3H/HeJ, C3H/HeN, C3H/St, CBA/J, DBA/1J, DBA/2J, and SJL/J), resistant (AKR/J, BALB/cDub, BALB/cJ, C57BL/6J, C57L/J, and SWR/J), and selectively resistant (A/J). The selectively resistant pattern was characterized by random deaths occurring throughout the titration range and was also observed in th

Distribution of rats infected with Rickettsia tsutsugamushi (scrub typhus) in an edge habitat.

No focalization of rats (Rattus tiomanicus and R. argentiventer) infected with Rickettsia tsutsugamushi could be discerned over a 500 m trapping transect at the border between a forest and lalang grass (Imperata cylindrica). R. tiomanicus appeared to occupy 250 m of the transect on the average and had periods during which infections were observed which averaged 97 days. Calulations indicated that more than 50% of individuals become infected over their life-time. The high rate of infection in this and other areas described in earlier publications and the habits of the rats suggest that infected

Результаты беременности в связи с лечением тифа мурин и тифа чистки: когорта лихорадки и анализ рядов случаев.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Несмотря на то, что эти инфекции являются основными причинами недифференцированной лихорадки в Азии, число опубликованных докладов о результатах беременности после скруба и тифа муслина невелико. Цель этого исследования состояла в том, чтобы увязать результаты беременности с лечением тифа.МЕТОДОЛОГИЯ/PRINCIPAL FINDINGS: Были проанализированы следующие данные: i) беременные женщины с диагнозом скруба и/или муслинового тифа по результатам исследований группы лихорадок; ii) серия исследований, опубликованных в PubMed с использованием поисковых терминов "scrub tyhus" (ST), "

Совпадение в аннотации оригинала
BACKGROUND: There is a paucity of published reports on pregnancy outcome following scrub and murine typhus despite these infections being le … from a fever cohort studies; ii) case series of published studies in PubMed using the search terms "scrub typhus" (ST), "murine typhus" (MT), "Orientia tsutsugamushi", "Rickettsia tsutsugamushi", "Rickettsia typhi", "rickettsiae", "typhus", or "rickettsiosis"; and "pregnancy", until February 2014 and iii) an unpublished case series. Fever clearance time (FCT) …

Inter- and intra-operator variability in the reading of indirect immunofluorescence assays for the serological diagnosis of scrub typhus and murine typhus.

Inter- and intra-observer variation was examined among six microscopists who read 50 scrub typhus (ST) and murine typhus (MT) indirect immunofluorescence assay (IFA) immunoglobulin M (IgM) slides. Inter-observer agreement was moderate (κ = 0.45) for MT and fair (κ = 0.32) for ST, and was significantly correlated with experience (P = 0.03 and P = 0.004, respectively); κ-scores for intra-observer agreement between morning and afternoon readings (range = 0.35-0.86) were not correlated between years of experience for ST and MT IFAs (Spearman's ρ = 0.31, P = 0.54 and P = 0.14, respectively; P = 0.7…

Гепатическая дисфункция у индийских пациентов с острыми недифференцированными фебрилическими заболеваниями.

Scrub tyhus — фебрилальная болезнь, вызванная тромбульным клещом, укусом Orientia tsutsugamushi. Он часто не признается из-за его расплывчатых симптомов. Он встречается в районе Рева в Мадхья-Прадеше, Индия. Поэтому интерес представляет оценка печени в дисфункции и установление связи между параметрами испытания функции печени и остротой болезни в подтвержденных случаях тифа Scrub. Таким образом, с июля по сентябрь 2024 года в Шьям Шахском медицинском колледже, Рева, было рассмотрено 50 позитивных случаев, связанных с ИгМ ЭЛИСА. Данные были проанализированы с использованием программного обеспеч

Совпадение в аннотации оригинала
Scrub typhus is a febrile illness caused by through trombiculid mite, bite Orientia tsutsugamushi. It is often unrecognized due to its vague symptoms. It is prevalent in the Rewa region of Madhya Pradesh, India. Therefore, it is of interest to assess hepatic dysfunction and to establish the association between liver function test parameters and disease sever…

Epidemiological Characteristics and Spatiotemporal Cluster Analysis of Scrub Typhus - China, 2006-2023.

INTRODUCTION: Scrub typhus, also known as jungle typhus, is a vector-borne disease transmitted to humans through the bite of infected chiggers carrying Orientia tsutsugamushi. In recent years, it has reemerged as a significant public health concern in China, with cases being identified in an increasing number of previously unaffected regions. METHODS: Data were obtained from the China Information System for Disease Control and Prevention (CISDCP). We employed Joinpoint 5.1.0 for trend analysis and RStudio 4.4.1 for statistical analyses, including Mann-Whitney U tests (non-parametric), Cochran…

Scrub Typhus-Associated Acute Pancreatitis: A Comprehensive Review and New Case Series.

Scrub typhus, caused by Orientia tsutsugamushi, is a common endemic vector-borne disease in Asia that can lead to a range of systemic complications, including the rare but potentially life-threatening manifestation of acute pancreatitis. We conducted a systematic review of all reported cases of scrub typhus-associated acute pancreatitis from 1943 to 2024 using PubMed, including English, Japanese, and Chinese literature, and analyzed a total of 14 cases, including one newly identified case at our institution. Diagnostic criteria were based on compatible clinical features, elevated pancreatic en…

Guillain-Barre syndrome following scrub typhus: a case report and literature review.

BACKGROUND: Scrub typhus is an acute infectious disease caused by Orientia tsutsugamushi. Guillain-Barre syndrome (GBS) is an autoimmune-mediated peripheral neuropathy with a frequent history of prodromal infections, but GBS associated with scrub typhus is very rare. CASE PRESENTATION: We report a 51-year-old male patient who developed dysarthria and peripheral facial paralysis following the cure of scfrub typhus. CSF examination and electrophysiological findings suggested a diagnosis of GBS. After treatment with intravenous immunoglobulin, the patient's neurological condition improved rapidl…

First laboratory-confirmed case of scrub typhus in Shijiazhuang City, Hebei Province.

OBJECTIVE: Defining whether a suspected case was due to scrub typhus through laboratory testing, to understand the prevalence of scrub typhus in Shijiazhuang City, Hebei Province. METHODS: An epidemiological investigation was conducted on the suspected case, utilizing Weil-Felix test and indirect immunofluorescence assay (IFA) to detect specific antibodies against O. tsutsugamushi in serum specimens. Additionally, PCR amplification of the 56-kDa and groEL genes was performed, followed by constructing a phylogenetic tree to identify the genotype. RESULTS: The acute phase titer of the Weil-Fel…

Cerebral Venous Sinus Thrombosis Following Scrub Typhus Meningoencephalitis in a Pregnant Woman.

BACKGROUND: Scrub typhus, a mite-borne zoonosis caused by Orientia tsutsugamushi, is prevalent in the Asia Pacific region and presents with various neurological manifestations, including meningoencephalitis, polyneuropathy, and, rarely, cerebral venous sinus thrombosis (CVST). CASE REPORT: We report a unique case of CVST following scrub typhus meningoencephalitis in an 18-year-old pregnant woman from West Bengal, India. Her condition was complicated by fever, headache, neck stiffness, and altered sensorium. Laboratory tests revealed leukopenia and thrombocytopenia, while serologies for other …

Challenging Neurological Presentation: Scrub Typhus with Meningoencephalitis and Multiple Cranial Nerve Involvement.

A 40-year-old male farmer from rural West Bengal, India, presented with fever, headaches, seizure, eschar, and palsy of left cranial nerves VII, VIII, IX, and X as a rare clinical manifestation of scrub typhus. Positive IgM enzyme-linked immunosorbent assay tests in serum and cerebrospinal fluid confirmed the diagnosis, with brain magnetic resonance imaging showing meningoencephalitis findings. Treatment with steroids and doxycycline led to neurological improvement. This case highlights the need for heightened clinician awareness towards early detection of scrub typhus's atypical presentations…

Evaluation of Scrub Typhus Surveillance, Alwar District, Rajasthan, India, July-August 2020.

INTRODUCTION: Scrub typhus is one of the most underreported and fatal illnesses accounting for 23% of all febrile illness. Rajasthan reported cases during 2018-2019 in state reporting system but did not report any case to central Integrated Disease Surveillance Programme (IDSP) unit. We evaluated the Scrub typhus surveillance system in Alwar district, Rajasthan, with the objective of describing and evaluating the system and providing evidence-based recommendations to identify gaps. MATERIAL AND METHODS: In cross-sectional study, we reviewed records and conducted key informant interviews at di…

Diagnosis of severe scrub typhus infection by next-generation sequencing:a case report.

BACKGROUND: Scrub typhus is an acute febrile illness, which was caused by Orientia tsutsugamushi and transmitted through the bite of chiggers. The diagnosis of scrub typhus could be missed diagnosis due to the absence of the pathognomonic eschar. CASE PRESENTATION: A 76-year-old man was hospitalized with fever and kidney injury and was diagnosed of hemorrhagic fever with renal syndrome first. However, the situation of the illness deteriorated into refractory septic shock and multiple organ dysfunction rapidly,although the treatment of anti-sepsis was used in 3rd-5th day. Orientia tsutsugamush…

Scrub typhus in Jiangsu Province, China: epidemiologic features and spatial risk analysis.

BACKGROUND: With the increasing incidence of scrub typhus in recent years, it is of great value to analyse the spatial and temporal distribution of scrub typhus by applying micro-geographical studies at a reasonably fine scale, and to guide the control and management. METHODS: We explored the use of maximum entropy modelling method to confirm the spatial and temporal distribution of scrub typhus according to the occurrence locations of human cases in Jiangsu Province. The risk prediction map under specific environmental factors was therefore drawn by projecting the training model across China…