Результаты поиска

Новое развитие аутоиммунного расстройства после лечения иммунной реконституции при множественном склерозе.

Иммунная реконституционная терапия (IRT) является относительно новым и высокоэффективным средством лечения множественного склероза (MS). Неопределенность в отношении развития аутоиммунных расстройств (АД) после сохранения некоторых методов лечения. Цель этого исследования состояла в том, чтобы провести оценку новых разработок в области АД после IRT у пациентов с РС и описать характер этих АД и время их начала. В исследование было включено в общей сложности 179 пациентов с множественным склерозом (37 после аналоговой трансплантации гематопоэтических стволовых клеток (АХСТ), 19 пациентов после а

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… Antithyroid drug alone | Remission after treatment 14 | M | 36 | ALE | 35 | Autoimmune thyroid disorder, hyperthyroidism | 13 | Grade 2 | Antithyroid drug alone | Remission after treatment 15 | F | 45 | CLA | 52 | Psoriasis | 10 | Grade 2 | Topical therapy | Only symptoms improved 16 | M | 27 | CLA | 36 | Vitiligo … In our cohort, two new autoimmune diseases, vitiligo and psoriasis, were diagnosed after CLA in the early follow-up. Our cases are the first to show new autoimmune disease development after the administration of CLA tablets. …

Cutaneous adverse events to systemic antineoplastic therapies: a retrospective study in a public oncologic hospital.

BackgroundMucocutaneous adverse events are common during anticancer treatment, with variable consequences for the patient and their therapeutic regimen.ObjectiveTo evaluate the most common adverse events, as well as the drugs associated with their appearance and the consequences for cancer treatment.MethodsA retrospective study was carried out through the analysis of patients treated at the Clinical Dermatology Unit of a public oncologic hospital.ResultsA total of 138 patients with 200 adverse events were evaluated. The most commonly identified adverse events were nail and periungual changes (

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… subacute lupus after paclitaxel use (one case); toxic epidermal necrolysis due to imatinib (one case); plaque psoriasis due to pembrolizumab (one case); keratosis pilaris due to sorafenib (one case); Sweet syndrome after filgrastin use (one case); perforating folliculitis due to sorafenib (one case); vitiligo … Among them, nine had more than one concomitant AE (two EPP and paronychia; one PPE and xerosis; one PPE and HFR; one onycholysis and photosensitivity; one HFR and onycholysis; one xerosis and fissures; one PPE and periungual pyogenic granuloma; one HFS and vitiligo repigmentation). …

Utilization of Stem Cells in Medicine: A Narrative Review.

Regenerative medicine holds significant promise for addressing diseases and irreversible damage that are challenging to treat with conventional methods, making it a prominent research focus in modern medicine. Research on stem cells, a key area within regenerative medicine due to their self-renewal capabilities, is expanding, positioning them as a novel therapeutic option. Stem cells, utilized in various treatments, are categorized based on their differentiation potential and the source tissue. The term 'stem cell' encompasses a broad spectrum of cells, which can be derived from embryonic tiss

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… Vitiligo The popularity of cell and tissue grafts in treating vitiligo is increasing. … Meanwhile, dermal MSCs inhibit the proliferation of CD8+ lymphocytes, which play a crucial role in the pathogenesis of vitiligo [ 82 ]. 3.2.4. Epidermolysis Bullosa Various types of stem cells have been investigated for the treatment of epidermolysis bullosa. …

The role of tumor types in immune-related adverse events.

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block inhibitors of T cell activation and function. With the widespread use of ICIs in cancer therapy, immune-related adverse events (irAEs) have gradually emerged as urgent clinical issues. Tumors not only exhibit high heterogeneity, and their response to ICIs varies, with "hot" tumors showing better anti-tumor effects but also a higher susceptibility to irAEs. The manifestation of irAEs displays a tumor-heterogeneous pattern, correlating with the tumor type in terms of the affected organs, incidence, median onset time, and se

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… This dual presence of antigens can mediate effective anti-tumor responses, but may also lead to the occurrence of skin irAEs such as vitiligo [ 69 , 70 ]. The shared antigen theory still applies when discussing irAEs in patients with lung cancer. … Vitiligo under anti–programmed cell death-1 therapy is associated with increased survival in melanoma patients. J Am Acad Dermatol. 2020;82(3):770–2. 31734192 10.1016/j.jaad.2019.11.017 70. …

Mixed-Methods to Define Meaningful Change using Exit Interviewand Clinical Trial Data in Patients with Tenosynovial Giant Cell Tumor (TGCT).

BACKGROUND: Tenosynovial giant cell tumor (TGCT) is a locally aggressive neoplasm associated with limited range of motion (ROM), stiffness, joint damage, pain, and reduced physical functioning (PF). The MOTION Phase 3 trial (NCT05059262) was a randomized, placebo-controlled, double-blind study of vimseltinib among patients with TGCT. The objective of the current study was to define meaningful changes in clinical outcome assessments (COAs) measuring active ROM, PF, and stiffness using qualitative and quantitative data from patients in the MOTION trial. METHODS: Embedded exit interviews with pa

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… Several prior studies have used mixed-methods in osteomalacia [ 16 ], atopic dermatitis [ 17 , 18 ], non-segmental vitiligo [ 19 ], multiple myeloma [ 20 ], and aphasia [ 21 ]. … Psychometric properties and meaningful change thresholds of the Vitiligo Area Scoring Index. JAMA Dermatology . 10.1001/jamadermatol.2024.4534 39475960 10.1001/jamadermatol.2024.4534 PMC11581646 20. …

Аутоиммунные заболевания в эпоху COVID-19:: новые механизмы, клинические последствия, соображения, связанные с вакцинацией, и направления будущей деятельности.

Болезнь коронавируса 2019 (В тыс.COVID-19) пандемия высветила сложную двунаправленную связь между SARSCoV-2 инфекция и аутоиммунные заболевания. В настоящем обзоре рассматривается вопрос о том, каким образом SARS-CoV-2 Инфекция влияет на частотность, прогресс и результаты five Крупные аутоиммунные заболевания: системный волшебный эритематос, ревматоидный артрит, множественный склероз, воспалительный кишечник и синдром Гильен-Барре. Пациенты с аутоиммунными заболеваниями подвергаются повышенному риску серьезных заболеваний. COVID-19 Из-за иммунной дисрегуляции и использования иммуновосприимчиво

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… 3,767,039 COVID-19 cohort: 287.6 days Control cohort: 287.7 days Alopecia areata 3,301 (13.51) 3,060 (10.43) 1.11 (1.07–1.15) * Alopecia totalis 228 (0.92) 203 (0.68) 1.24 (1.09–1.42) * Primary cicatricial alopecia 140 (0.57) 158 (0.53) 1.03 (0.87–1.21) Psoriasis 1,456 (5.94) 1,791 (6.10) 1.01 (0.96–1.06) Vitiligo … Sarcoidosis 266 (0.54) 124 (0.25) 2.14 (1.73–2.65) * Ankylosing spondylitis 263 (0.54) 194 (0.4) 1.36 (1.13–1.63) * Ankylosing spondylitis with medication 82 (0.17) 64 (0.13) 1.29 (0.93–1.78) Celiac disease 229 (0.47) 148 (0.3) 1.55 (1.26–1.90) * Alopecia areata 198 (0.4) 152 (0.31) 1.30 (1.05–1.61) * Vitiligo …

Clindamycin-induced Maculopapular Exanthema with Preferential Involvement of Striae Distensae: A Koebner phenomenon?

Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneo … atoses can develop along SD skin lesions (like plaque psoriasis, pustular psoriasis, lichen planus, vitiligo, discoid lupus erythematosus, lupus vasculitis, urticarial vasculitis, or chronic graft-versus-host disease) (9). Bevacizumab, etretinate, and corticosteroid-induced ulcers, hyperpigmentation caused by bleomycin, and urticariform lesions triggered b …

Hematopoietic stem cell transplantation in Zagreb: the first 40 years.

Hematopoietic stem cell transplantation is the most effective treatment for acute leukemia, severe aplastic anemia, and some hereditary hematological disorders. The principal source of stem cells in this procedure are bone marrow and peripheral blood cells. In recent years, the transplantation outcome has significantly improved. The availability of the donor no longer poses a problem, as transplantation has been performed routinely from related, unrelated, and haploidentical donors. A high success rate has been reported in elderly patients transplanted with reduced-intensity conditioning. Impr

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… The clinical observation about the increased incidence of skin manifestations, including vitiligo and alopecia areata, is also a contribution to the clinical settings of cutaneous chronic GVHD ( 82 ). … Front Immunol 2020 11 602547 10.3389/fimmu.2020.602547 33424849 PMC7786047 82 Čeović R Desnica L Pulanić D Serventi Seiwerth R Ilić I Grce M High frequency of cutaneous manifestations including vitiligo and alopecia areata in a prospective cohort of patients with chronic graft-vs-host disease. …

MicroRNA-17-92a-1 Host Gene (MIR17HG) Expression Signature and rs4284505 Variant Association with Alopecia Areata: A Case-Control Study.

Accumulating evidence indicates the implication of microRNAs (miRs) in cutaneous and hair follicle immunobiology. We evaluated, for the first time, the miR-17-92a-1 cluster host gene (MIR17HG) expression in peripheral blood of 248 unrelated alopecia areata (AA) patients compared to 244 matched controls using Real-Time qPCR. We also tested its association with different rs4284505A>G genotypes (based on TaqMan allelic discrimination PCR) and the available clinical data. The adjusted odds ratio (OR) and 95% confidence interval (CI) were calculated for each genetic association model. The upregulat

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… The exclusion criteria included being a relative of the individuals in the alopecia areata patients or having a history of other autoimmune diseases, such as inflammatory bowel disease, thyroid disease, systemic lupus erythematosus, psoriasis, or vitiligo. … Almost all patients had concomitant comorbidity disease, particularly insulin-dependent type 1 diabetes, vitiligo, rheumatoid arthritis, and SLE. …

Соучастие в синдроме Дауна и множественном склерозе.

OBJECT: Синдром Дауна (DS) часто ассоциируется с аутоиммунными заболеваниями; однако о его связи с множественным склерозом (MS) сообщалось редко. В одном из предыдущих докладов совпадение DS и MS продемонстрировало негативную связь. Здесь мы искали совпадение с DS и MS и попытались решить эту негативную связь, сосредоточившись на эффекте дозировки генов, используя доступные отчеты. ФАКУЛЬТАТИВНОЕ ПРЕДСТАВЛЕНИЕ: 44-летняя женщина с сержантом переживала постепенное ухудшение походки на начальном этапе. Автоиммуно-антитела, включая аквапорин-4, были отрицательными. На основе результатов магнитног

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… , people with DS have a 10-fold or even higher prevalence of certain autoimmune disorders, particularly origin-specific diseases of the endocrine glands (e.g., Hashimoto thyroiditis, Graves’ disease, and type I diabetes mellitus), as well as of the gut (celiac disease) and skin (alopecia areata and vitiligo …

Clinical impact of checkpoint inhibitors as novel cancer therapies.

Immune responses are tightly regulated via signaling through numerous co-stimulatory and co-inhibitory molecules. Exploitation of these immune checkpoint pathways is one of the mechanisms by which tumors evade and/or escape the immune system. A growing understanding of the biology of immune checkpoints and tumor immunology has led to the development of monoclonal antibodies designed to target co-stimulatory and co-inhibitory molecules in order to re-engage the immune system and restore antitumor immune responses. Anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) antibodies were among t

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… per 8-week cycle) | 296 | 70 % ( n = 207), including fatigue 24 %, nausea 8 %, decreased appetite 8 % | 14 % ( n = 41), including fatigue 2 %, abdominal pain 1 %, hypophosphatemia 1 %, lymphopenia 1 % | All grades: 41 % ( n = 122), including rash 12 %, diarrhea 11 %, pruritus 9 %, pneumonitis 3 %, vitiligo … Potential immune-related select AEs were also commonly reported: dermatologic toxicities (pruritus ≤24 % all grades, <1 % grade 3/4; rash 6–20 % all grades, <1 % grade 3/4; vitiligo ≤11 % all grades, 0 % grade 3/4), gastrointestinal toxicities (diarrhea 7–16 % all grades, ≤1 % grade 3/4; nausea 6–12 …

Негативные события, связанные с лечением, заменяют собой реакцию на блокаду контрольно-пропускных пунктов.

ОКРУЖАЮЩАЯ СРЕДА: Иммунная блокада контрольно-пропускных пунктов (МКБ) дает надежду многим пациентам, страдающим раком на поздней стадии, однако ее показатель реагирования остается неясным. Мы разработали гипотезу о том, что связанные с лечением неблагоприятные явления (TRAE) могут предсказать объективную долю ответов (ORR) на ICB. Мы рассчитали операционную против любого класса. 3 в адрес 5 (В тыс.G3-5) ТРАЭ различных типов рака путем проведения мета-анализа с использованием линейной регрессии. Результаты: Мы определили 113 приемлемые исследования, включая 25 - виды негативов, обработанных с

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… Integumentary TrAEs are most common, presenting as hives, eczema, vitiligo, etc. Gastrointestinal TrAEs include enterocolitis, pancreatitis, etc. …

Eosinophilic fasciitis (Shulman's disease): review and comparative evaluation of seven patients.

ObjectivesEosinophilic fasciitis (EF) was described in 1974 by Shulman as a rare fibrosing connective tissue disease of unknown etiology. An undetermined trigger is thought to lead to the degranulation of eosinophils that interact with fibroblasts and express fibrogenic cytokines including the transforming factor of tumor growth a and b and interleukins 1 and 6. The purpose of this study was to summarize seven cases of EF in a central hospital.Material and methodsThis was a retrospective and descriptive study of a population with EF of a central hospital. All patients diagnosed with EF in a ho

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… – | + | + | + | + | + Forearm | – | – | – | + | + | + | + Hands | + | – | + | – | – | – | – Abdomen | – | + | – | + | – | – | + Thighs | – | – | + | + | + | – | + Ankle | + | – | – | – | – | – | – Familiar history autoimmune disease | + | – | – | – | – | – | – Personal history autoimmune disease | Vitiligo …

Systemic adverse effects and toxicities associated with immunotherapy: A review.

Immunotherapy is rapidly evolving secondary to the advent of newer immunotherapeutic agents and increasing approval of the current agents by the United States Food and Drug Administration to treat a wide spectrum of cancers. Immunotherapeutic agents have gained immense popularity due to their tumor-specific action. Immunotherapy is slowly transforming into a separate therapeutic entity, and the fifth pillar of management for cancers alongside surgery, radiotherapy, chemotherapy, and targeted therapy. However, like any therapeutic entity it has its own adverse effects. With the increasing use o

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… The presence of a Vitiligo-like lesion has been associated with higher objective tumor response rates. Monoclonal antibodies are also frequently linked to dermatological adverse events. … Ipilimumab, a CTLA-4 inhibitor used in the treatment of melanoma, has a diverse range of dermatologic adverse effects associated with its use such as rashes, folliculitis, mucositis, rosacea, SJS and vitiligo[ 20 ]. …

Ассоциация неизгладимых неблаговидных мероприятий, связанных с эффективностью иммунных контрольно-пропускных пунктов и общим выживанием в раковых заболеваниях: системный обзор и метаанализ.

ЦЕЛИ: Ингибиторы на контрольно-пропускных пунктах иммунного типа (ИПК) приносят значительные выгоды пациентам, страдающим раком, несмотря на то, что они часто сопровождаются неблагоприятными иммунными явлениями (ОРАЭ). Мы поставили перед собой цель изучить связь IRAE с эффективностью и общим выживанием у больных раком, которые проходят лечение в рамках ICI, и еще больше количественно оценить эту связь за счет стратификации подгрупп. МЕТОДЫ: Пубмед, ЭМБАСЕ и Кокрейнская библиотека с момента создания базы данных 29 Август 2019 систематически подвергались обыску. Были включены статьи, содержащие

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… Gallen | NSCLC | PD-1 | 40 | 7 | 33 | Skin | 5 | 7 | / | / | / 13 | Hua et al. ( 27 ) | 2016 | prospective | France, Gustave Roussy Institute | Melanoma | PD-1 | 67 | 17 | 50 | vitiligo | 12 | 14 | / | / | / 14 | Nakamura et al. ( 28 ) | 2016 | retrospective | Japan, Keio University Hospital | Melanoma … Association of Vitiligo With Tumor Response in Patients With Metastatic Melanoma Treated With Pembrolizumab. JAMA Dermatol (2016) 152:45–51. 10.1001/jamadermatol.2015.2707 28. Nakamura Y, Kitano S, Takahashi A, Tsutsumida A, Namikawa K, Tanese K, et al. …

The phenotypic and genetic association between endometriosis and immunological diseases.

STUDY QUESTION: Is there an increased risk of immunological diseases among endometriosis patients, and does a shared genetic basis contribute to this risk? SUMMARY ANSWER: Endometriosis patients show a significantly increased risk of autoimmune, autoinflammatory, and mixed-pattern diseases, including rheumatoid arthritis, multiple sclerosis, coeliac disease, osteoarthritis, and psoriasis, with genetic correlations between endometriosis and osteoarthritis, rheumatoid arthritis, and multiple sclerosis, and a potential causal link to rheumatoid arthritis. WHAT IS KNOWN ALREADY: The epidemiologi

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… thyroid disease, Graves’ disease, Hashimoto’s disease, coeliac disease, dermatomyositis/polymyositis, multiple sclerosis, myasthenia gravis, pemphigus/pemphigoid, primary biliary cirrhosis, rheumatoid arthritis, Sjögren's syndrome, systemic lupus erythematosus, systemic sclerosis, type 1 diabetes, vitiligo … A total of 14 immune conditions were excluded from analysis due to the number of cases being <500: reactive arthritis, Behcet’s syndrome, acute respiratory distress syndrome, erythema nodosum associated disease, pemphigus/pemphigoid, systemic sclerosis, vitiligo, primary biliary cirrhosis, Addison’s …

Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation.

We examined the effectiveness of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade, alone or in combination with a granulocyte/macrophage colony-stimulating factor (GM-CSF)-expressing tumor cell vaccine, on rejection of the highly tumorigenic, poorly immunogenic murine melanoma B16-BL6. Recently established tumors could be eradicated in 80% (68/85) of the cases using combination treatment, whereas each treatment by itself showed little or no effect. Tumor rejection was dependent on CD8(+) and NK1.1(+) cells but occurred irrespective of the presence of CD4(+) T cells. Mice surviving

Систематический обзор и метаанализ посттравматического стрессового расстройства как фактора риска множественных аутоиммунных заболеваний.

Посттравматический стрессовый расстройство (ПТСР) является распространенным и изнурительным психическим заболеванием, связанным с плохим состоянием здоровья и повышенным риском возникновения хронических заболеваний, включая множественные аутоиммунные заболевания, такие, как системный лейкоцит (SLE), инфламматический болезнь Боул (IBD), ревматоидный артрит (RA) и множественный склероз (MS). АИМ: Этот метаанализ позволяет оценить эпидемиологические исследования в этой области и кратко изучить гипотетические нейробиологические и иммунологические механизмы, которые могут лежать в основе связи межд

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… autoimmune disease No Dai, 2021 ( 15 ) Posttraumatic Stress Disorder and the Associated Risk of Autoimmune Skin Diseases National Health Insurance Research Database in Taiwan Retrospective Cohort 49,005 9,801 39,204 PTSD (n=9,801) Psoriasis, Lichen Planus, Alopecia Areata, Autoimmune Bullous diseases, and vitiligo …

The Role of Gamma Delta T Lymphocytes in Physiological and Pathological Condition-Focus on Psoriasis, Atopic Dermatitis, Autoimmune Disorders, Cancer and Lymphomas.

Gamma delta (γδ) T cells are a heterogeneous population of cells that play roles in inflammation, host tissue repair, clearance of viral and bacterial pathogens, regulation of immune processes, and tumor surveillance. Recent research suggests that these are the main skin cells that produce interleukin-17 (I-17). Furthermore, γδ T cells exhibit memory-cell-like characteristics that mediate repeated episodes of psoriatic inflammation. γδ T cells are found in epithelial tissues, where many cancers develop. There, they participate in antitumor immunity as cytotoxic cells or as immune coordinators.

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… Growing evidence indicates that inappropriately activated γδ T cells may drive the pathogenesis of autoimmune diseases such as psoriasis, vitiligo, autoimmune hepatitis, autoimmune thyroid disease, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and lymphomas [ 10 , 25 ]. … Inappropriately activated γδ T cells may drive the pathogenesis of autoimmune diseases such as psoriasis, vitiligo, autoimmune hepatitis, autoimmune thyroid disease, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and lymphomas. …

Application and Challenges of Chimeric Antigen Receptor T Cell Therapy in Systemic Rheumatic Diseases and Autoimmune Disorders.

Chimeric antigen receptor T (CAR-T) cell therapy, originally developed for hematologic malignancies, has emerged as a transformative candidate for systemic rheumatic diseases and autoimmune disorders (AIDs). Its unique efficacy in refractory AIDs relies on depleting autoreactive B cells and driving antigen-naïve immune reconstitution, achieving durable drug-free remission in early-phase trials. Despite promising clinical and serological responses lasting 2-5 years without long-term immunosuppression, the field faces unmet needs: complex manufacturing, limited tissue penetration, antigen escape