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Accuracy of transthoracic ultrasound for the prediction of chest wall infiltration by lung cancer and of lung infiltration by chest wall tumours.

BACKGROUND: We wanted to determine the accuracy of transthoracic ultrasound in the prediction of chest wall infiltration by lung cancer or lung infiltration by chest wall tumours. METHODS: Patients having preoperative CT-scan suspect for lung/chest wall infiltration were prospectively enrolled. Inclusion criteria for lung cancer were: obliteration of extrapleural fat, obtuse angle between tumour and chest wall, associated pleural thickening. The criteria for chest wall tumours were: rib destruction and intercostal muscles infiltration with extrapleural fat obliteration and intrathoracic exten

Patients with benign hand tumors are indicated for surgery according to patient-rated outcome measures.

INTRODUCTION: This study assessed the treatment outcomes of upper extremity benign tumors using the patient-rated outcome measures of Hand20 … y improved after surgery in patients with ganglion cysts, giant cell tumors of the tendon sheath, enchondromas, or pyogenic granulomas. For patients with hemangiomas, schwannomas, or glomus tumors, although the mean pain scores improved significantly following surgery, there were no significant changes in the mean Hand20 scores. However, the statistical pow …

Function after injection of benign bone lesions with a bioceramic.

BACKGROUND: A novel calcium sulfate-calcium phosphate composite injectable bone graft substitute has been approved by the FDA for filling bo … one cyst (13), aneurysmal bone cyst (10), nonossifying fibroma (eight), fibrous dysplasia (five), enchondroma (four), chondroblastoma (four), and other (12). We obtained a Musculoskeletal Tumor Society (MSTS) functional evaluation on all patients. The minimum followup was 26 months (average, 42 months; range, 26-57 months). RESULTS: The average MSTS score …

Treatment of bone tumours by radiofrequency thermal ablation.

Radiofrequency thermal ablation (RFTA) is considered the treatment of choice for osteoid osteomas, in which it has long been safely used. Other benign conditions (chondroblastoma, osteoblastoma, giant cell tumour, etc.) can also be treated by this technique, which is less invasive than traditional surgical procedures. RFTA ablation is also an option for the palliation of localized, painful osteolytic metastatic and myeloma lesions. The reduction in pain improves the quality of life of patients with cancer, who often have multiple morbidities and a limited life expectancy. In some cases, these

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… One study described the treatment of two intracortical chondromas, preoperatively misdiagnosed as osteoid osteomas and treated with RFTA. Radiofrequency appears to have cured the tumour in one patient, whereas the other required surgery [ 26 ]. … Intracortical chondroma simulating osteoid osteoma treated by radiofrequency. Skeletal Radiol. 2002;31:597–602. doi: 10.1007/s00256-002-0501-4. 27. Corby RR, Stacy GS, Peabody TD, et al. Radiofrequency ablation of solitary eosinophilic granuloma of bone. …

Primary Spinal Intradural Extramedullary Ewing's Sarcoma/Peripheral Neuroectodermal Tumour Masquerading Clinically as a Neurogenic Tumour: A Case Report and Review of Literature.

Ewing's Sarcomas (ES)/Peripheral neuroectodermal tumour (pPNET) are heterogenous group of rare, highly malignant, undifferentiated primitive round-cell neoplasms of neuroectodermal origin. pPNETs are seldom observed to involve the spine of which Spinal Intradural Extramedullary Extraosseous Primary ES/pPNET are extremely rare. We report a case of a 23-year-old male with complaints of low backache and hip pain radiating to the left inguinal region for four months. Radiology findings were suggestive of a neurogenic tumour. Cytomorphology, histomorphology and immunohistochemistry evaluation were

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… Multiple Myeloma | Meningioma | Meningioma | Astrocytoma | Hemangioblastoma | Angiomyolipoma Osteoblastoma | Metastasis | Neurofibroma | Neurofibroma | Ependymoma | Lymphoma | Angiolipoma Haemangioma | Haemangioma | Schwannoma | Schwannoma | Myxopapillary Ependymoma | Metastasis | Epidural lipomatosis Chondroma …

Multifocal intraosseous hemangioma: A case report.

RationaleMultifocal intraosseous hemangioma, which affects multiple body parts, is rare. The selection of appropriate lesion sites for biopsy and effective treatment in multifocal intraosseous hemangioma is challenging. Here, we report a case of multifocal intraosseous hemangioma.Patient concernsA 49-year-old woman was admitted to our department with a chief complaint of aggravated lumber pain for 10 days.DiagnosesRadiographic imaging revealed lesions involving the bilateral ribs, lumbar vertebrae, ilium, pubis, and proximal femur. Open biopsy in the ilium established the pathological diagnosi

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… The differential diagnosis of a rib tumor may include metastatic and primary malignant tumors (chondrosarcoma, osteogenic sarcoma, myeloma, and Ewing sarcoma) or benign tumors (fibrous dysplasia, eosinophilic granuloma, chondroma, and hemangioma). [ 5 ] The imaging results of rib hemangiomas characteristically …

Craniovertebral Junction Instability after Oncological Resection: A Narrative Review.

The craniovertebral junction (CVJ) is a complex transition area between the skull and cervical spine. Pathologies such as chordoma, chondrosarcoma and aneurysmal bone cysts may be encountered in this anatomical area and may predispose individuals to joint instability. An adequate clinical and radiological assessment is mandatory to predict any postoperative instability and the need for fixation. There is no common consensus on the need for, timing and setting of craniovertebral fixation techniques after a craniovertebral oncological surgery. The aim of the present review is to summarize the an

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… Primary neoplasms of extradural origin include chordomas, nerve sheath tumors, paragangliomas, osseous benign neoplasms (fibrous dysplasia, osteoid osteoma, osteoblastoma, aneurysmal bone cyst, giant cell tumors, osteochondroma, chondroma and eosinophilic granuloma), osseus malignant neoplasms (chondrosarcoma … Differently from chondromas, they rarely occur in the midline and do not express brachyury [ 64 , 65 ]. 3.5. Secondary Tumors of the CVJ Secondary tumors of the CVJ are primarily plasmacytomas and metastases. …

The Correspondence Between Magnetic Resonance Images and the Clinical and Intraoperative Status of Patients with Spinal Tumors.

ABSTRACT INTRODUCTION: Surgical treatment of tumors, particularly metastases to the spine, has become increasingly common owing to the progress in anesthesiology and spinal surgery and greater detectability. The patients qualified for surgeries are those with mechanical pain, fracture or at risk of vertebral fracture or neurological complications. The basis for qualification for different types of surgeries is clinical and imaging examination, particularly MRI and CT. Qualification should always be multidisciplinary and requires understanding and knowledge of its most essential aspects. When c

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… Osteomas, cartilagineous exostoses, eosinophilic granuloma and chondromas are most frequent. Amongst primary malignant bone, osteosarcomas, chondrosarcomas and chordomas are most often identified [ 1 , 2 ]. Spinal metastases occur much more frequently. …

The Musculoskeletal Tumor Society Scoring system is a valid subjective and objective tool to evaluate outcomes of surgical treatment of patients affected by upper and lower extremity tumors.

PURPOSE: The main purpose of the present study was to evaluate if there is a difference between objective or subjective administration of the MSTS score in a cohort of patients affected by musculoskeletal oncological diseases. MATERIALS AND METHODS: All patients who underwent surgery for bone or soft tissue localization of neoplastic disease in lower or upper limb from June 2015 to June 2020 were considered eligible. In order to administer the score as a PROM, the MSTS was first translated and cross-culturally adapted in Italian. During follow up visits, all patients filled out Italian versio

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… Osteosarcoma | 3 (5) Chondrosarcoma | 1 (2) Liposarcoma | 5 (8) Other soft tissue sarcomas | 8 (14) Lipoma | 8 (14) Fibrolipoma | 1 (2) Mixoma | 2 (3) Schwannoma | 3 (5) Exostosis | 2 (3) Well differentiated liposarcoma | 1 (2) Cyst | 6 (10) Giant cell tumor | 2 (3) Hemangioma | 3 (5) Osteoid osteoma | 1 (2) Chondroma …

The pathological anatomical collection of the Natural History Museum Vienna.

The pathological anatomical collection Vienna (Pathologisch-Anatomische Sammlung Wien; PASW) is a living and still growing research collection. It was established as early as 1796 as part of the Medical University of Vienna, acquired the status of an independent federal museum in 1971, and was assigned to the Natural History Museum Vienna in 2012. It houses a wide range of human wet and dry specimens and further objects, such as moulages, medical devices, microbiological and histological specimens, and a photo archive (approximately 50,000 objects), which, as a meaningful source, may contribut

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… Other examples of diseases manifested in the respiratory system and reported by Sedivy [ 24 ] include cases of tracheitis (originating in diphtheria), fibrosis, carcinoma, chondroma, or are caused by external impacts such as respirable dust ( Staublungen , silicosis, asbestosis, etc.). …

Biopsy Techniques for Musculoskeletal Tumors: Basic Principles and Specialized Techniques.

Biopsy is a pivotal component in the diagnostic process of bone and soft tissue tumors. The objective is to obtain adequate tissue without compromising local tumor dissemination and the patient's survival. This review explores contemporary principles and practices in musculoskeletal biopsies, emphasizing the critical role of diagnostic accuracy while also delving into the evolving landscape of liquid biopsies as a promising alternative in the field. A thorough literature search was done in PubMed and Google Scholar as well as in physical books in libraries to summarize the available biopsy tec

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… Omission of the biopsy may be justified only in instances when there is clear clinical and radiographic evidence of benign lesions, such as chondroma, osteochondroma, osteoid osteoma, simple bone cysts, fibrous dysplasia, or non-ossifying fibroma [ 1 , 2 ]. …

Advances in the mechanism and therapies of achondroplasia.

Achondroplasia (ACH), is the prevailing type of genetic dwarfism in humans, caused by mutations in fibroblast growth factor receptor 3 (FGFR3) that are inherited in an autosomal dominant manner. FGFR3 is mainly expressed in condensed mesenchyme, chondrocytes, and mature osteoblasts and osteoclasts, in which it regulates the formation, development, growth, and remodeling of the skeletal system. Mutations in FGFR3 causing ACH result in enhanced FGFR3 signaling through combined mechanisms including enhancing FGF dimerization and tyrosine kinase activity and stabilizing FGF receptors. In ACH, supp

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… FGFR3 deficiency causes multiple chondroma-like lesions by upregulating hedgehog signaling. PLoS Genet. 2015;11(6) doi: 10.1371/journal.pgen.1005214. 55. Li M., Seki Y., Freitas P.H.L., et al. …

Metabolic Alterations in Cancer Cells and the Emerging Role of Oncometabolites as Drivers of Neoplastic Change.

The mitochondrion is an important organelle and provides energy for a plethora of intracellular reactions. Metabolic dysregulation has dire consequences for the cell, and alteration in metabolism has been identified in multiple disease states-cancer being one. Otto Warburg demonstrated that cancer cells, in the presence of oxygen, undergo glycolysis by reprogramming their metabolism-termed "aerobic glycolysis". Alterations in metabolism enable cancer cells to gain a growth advantage by obtaining precursors for macromolecule biosynthesis, such as nucleic acids and lipids. To date, several molec

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… IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours. J. Pathol. 2011;224:334–343. doi: 10.1002/path.2913. 77. …

Rare Diseases of the Orbit.

This article provides an overview of rare orbital diseases. Congenital malformations, inflammatory diseases, benign and malignant neoplasias are described. Although it represents a relatively small area of the body the orbit contains multiple different tissues. Therefore, a great variety of diseases can be found within the orbital space. That is the reason, why both the completeness and the level of detail in the description of particular diseases must be somewhat limited. Nevertheless, clinical manifestations, important aspects of diagnosis, treatment strategies, and, when specific data are a

Modern therapeutic approaches in cholangiocarcinoma: A narrative review of key biomarkers and clinical trials.

Cholangiocarcinoma (CCA), the second most common hepatic malignancy after hepatocellular carcinoma, presents a significant clinical challenge. This epithelial cell malignancy occurs in various anatomical subtypes, including intrahepatic, perihilar, and distal, each associated with unique genetic aberrations, clinical presentations, and treatment options. Early diagnosis is challenging, leading to poor survival rates, especially in advanced cases. Precision medicine offers hope for improved management of CCA by tailoring treatments based on molecular profiling. In recent years, the investigatio

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… IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours J. Pathol. 224 3 2011 334 343 10.1002/path.2913 21598255 56 Nakagawa M. Sekimizu M. Endo M. Kobayashi E. Iwata S. Fukushima S. …

A Critical Appraisal of the Application of Frailty and Sarcopenia in the Spinal Oncology Population.

Study designSystematic review and clinimetric analysis.ObjectivesFrailty and sarcopenia predict worse surgical outcomes among spinal degenerative and deformity-related populations; this association is less clear in the context of spinal oncology. Here, we sought to identify frailty and sarcopenia tools applied in spinal oncology and appraise their clinimetric properties.MethodsA systematic review was conducted from January 1st, 2000, until June 2022. Study characteristics, frailty tools, and measures of sarcopenia were recorded. Component domains, individual items, cut-off values, and measurem

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… 49 SD 19 Both Metastatic tumors: 13%, primary tumors: 87%; proportion of primary tumors: Malignant (66%) and benign (34%); primary bone tumor types: Chordoma (34%), chondrosarcoma (12%), GCT (8%), osteoblastoma/osteoid osteoma (8%), high-grade sarcoma (7%), MPNST (5%), hemangioma (4%), enchondroma/chondroma … SD 19 | Both | Metastatic tumors: 13%, primary tumors: 87%; proportion of primary tumors: Malignant (66%) and benign (34%); primary bone tumor types: Chordoma (34%), chondrosarcoma (12%), GCT (8%), osteoblastoma/osteoid osteoma (8%), high-grade sarcoma (7%), MPNST (5%), hemangioma (4%), enchondroma/chondroma …

Резюме ESPR 2013Европейское общество педиатрической радиологии 50th Ежегодное совещание и 36th Курсы для аспирантов. Июнь 3–7 2013. Будапешт, Венгрия.

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