Результаты поиска

Resolution of pachymeningeal enhancement is a radiographic marker for effective treatment of spontaneous intracranial hypotension: patient series.

BACKGROUND: Spontaneous intracranial hypotension (SIH) may result in positional headaches, tinnitus, vestibular symptoms, and cognitive dysfunction. Pachymeningeal enhancement may be seen on contrast-enhancing imaging. Notably, the time course of pachymeningeal enhancement resolution has previously been shown to resolve within 17 hours of surgical repair. The authors sought to determine whether radiographic stigmata of SIH could be used as a marker for effective treatment. OBSERVATIONS: A retrospective review of 14 patients who underwent open surgical management for SIH was conducted. Clinica

A MIND-Based Diet With or Without Digital Cognitive Training Improves Cognitive Function and Nutritional Status in Older Adults With Mild Cognitive Impairment.

BACKGROUND: Given the growing prevalence of mild cognitive impairment (MCI) among the aging population, there is a critical need for multifaceted lifestyle interventions that combine nutritional support with cognitive stimulation to prevent further decline. OBJECTIVE: This study aimed to evaluate the effects of a cognitive function improvement management diet (Diet), with or without a digital cognitive enhancement program (SUPERBRAIN for group; SG), on cognitive function in adults aged 65 years or older with MCI attending daycare centers. METHODS: This 12 week cluster-randomized controlled t…

Cognitive-exercise dual-task training delays natural aging/D-galactose-induced cognitive decline in mice.

BACKGROUND: Cognitive–exercise dual-task training has been shown to enhance cognitive function through mechanisms such as suppression of chronic inflammation, reduction of oxidative stress, and enhancement of synaptic plasticity. However, the precise mechanisms underlying the ability of dual-task training to delay aging-related cognitive decline remain incompletely understood. METHODS: Aged male C57BL/6J mice were subjected to a 12-week intervention program consisting of cognitive training, exercise, or cognitive–exercise dual-task training. Cognitive and physical function were assessed using

Non-invasive brain stimulation and cognitive training for depressive symptoms and cancer-related cognitive impairment in breast cancer survivors (ONCODEP).

PURPOSE: Depression and cancer-related cognitive impairment (CRCI) are frequent after-effects in breast cancer survivors (BCS). Despite being closely related and sharing some features, there is no intervention addressing them comprehensively. Transcranial direct current (tDCS) and alternating stimulation (tACS), combined with computerized cognitive training (CCT), provided benefits for improving mood and cognition in several populations and have several advantages, but evidence in BCS is limited. This study aims to explore the effectiveness and feasibility of a home-based combined intervention

[Lymphocytic primary angiitis of the central nervous system with fan-shaped linear enhancement converging to the lateral ventricles: a case report].

We report a case of lymphocytic primary angiitis of the central nervous system (PACNS) with a characteristic gadolinium-enhancement pattern on magnetic resonance imaging (MRI). A 48-year-old, right-handed man presented with a 3-month history of tremor and progressing dementia. Neurologic examination revealed cognitive decline with anterograde amnesia and postural tremor of the fingers. Except for the positive result of serum antinuclear antibody, intense investigations for infectious, rheumatic and neoplastic diseases were negative. Analysis of cerebrospinal fluid showed mild pleocytosis (14 c

Обновленная информация о лечении и лечении когнитивной дисфункции у пациентов с множественным склерозом.

ВВЕДЕНИЕ: Когнитивное расстройство (CI) происходит у 34-70% пациентов с множественным склерозом (MS), что оказывает значительное воздействие на качество жизни. CI может происходить независимо от физических недостатков, даже в тех, у кого "benign MS". Когнитивные дефициты являются разнородными, но общие области, затронутые этим, включают скорость обработки, память и исполнительные функции.ОБЛОЖКА: Был проведен всеобъемлющий поиск литературы по таким базам данных, как PubMed и Google Scientific, с использованием таких ключевых слов, как "MS", "Когда" и "когнитивная реабилитация". Мы сосредоточил

Совпадение в аннотации оригинала
INTRODUCTION: Cognitive impairment (CI) occurs in 34-70% of multiple sclerosis (MS) patients, significantly impacting quality of life. CI ca … search should prioritize defining optimal training intensities, integrating therapies for sustained cognitive enhancement, and exploring neuromodulation and neuroimaging biomarkers within randomized controlled trials aimed at improving cognitive functioning in MS.

Therapeutic effects of CORM3 and NaHS in chronic kidney disease induced cognitive impairment via the interaction between carbon monoxide and hydrogen sulfide on Nrf2/HO-1 signaling pathway in rats.

Cognitive impairment is one of the major complications of chronic kidney disease (CKD). The present study aims to evaluate the protective effects of carbon monoxide (CO) and hydrogen sulfide (H2S) and their interactions on CKD-induced cognitive deficits by considering the Nrf2/HO-1 signaling pathway. Sixty rats were divided into six experimental groups: sham, five-sixth (5/6) nephrectomy (CKD), CKD + H2S donor (NaHS), CKD + CO-releasing molecule (CORM3), CKD + NaHS and zinc protoporphyrin IX (Znpp), CKD + CORM3 and amino-oxy acetic acid (AOAA). Eleven weeks after 5/6Nx, behavioral tests (Novel

Cognitive effects of dorsolateral versus medial prefrontal anodal transcranial direct current stimulation in healthy individuals.

OBJECTIVES: Transcranial direct current stimulation (tDCS) is a noninvasive and safe brain stimulation technique with the potential to modulate cognitive functions in both healthy and clinical populations. However, previous studies in healthy individuals have reported mixed results, with outcomes ranging from cognitive enhancement to no observable effects. The present study aimed to investigate the cognitive effects of anodal frontal tDCS in healthy adults, with a particular focus on the medial prefrontal cortex (mPFC), a relatively underexplored target for neuromodulation. MATERIALS AND METH…

Prevalence of and motives for pharmacological neuroenhancement in Switzerland--results from a national Internet panel.

AIMS: To estimate the prevalence of self-reported pharmacological neuroenhancement (PNE) with prescription or recreational drugs among the S … harmacological mood enhancement (3.1%; 95% CI = 2.76, 3.44) was more prevalent than pharmacological cognitive enhancement (1.4%; 95% CI = 1.17, 1.63). Fifty-four participants reported both (0.5%; 95% CI = 0.36, 0.64). PNE was associated with studying rather than full-time [odds ratio (OR) = 0.35; 95% CI = 0.21, 0.57] or part-time employment (OR = 0.39; 95% CI = 0.23, 0 …

Tai Chi modulating multimodal connectivity patterns and cognitive function in cerebral small vessel disease.

Cerebral small vessel disease (CSVD) significantly contributes to cognitive decline and poses potential risk factors for both dementia and acute cerebrovascular events. Tai Chi has been recognized as an effective mind-body intervention for enhancing cognitive function and promoting neural plasticity. However, the neurobiological mechanisms that underlie how Tai Chi exercises affect cognitive improvement in patients with CSVD remain unclear. We recruited 51 patients with CSVD, randomly assigning them to either a 24-week Tai Chi exercise group (n = 26) or a health education control group (n = 25

'Shelter From the Storm': A FINGER-Like Five-Domain Lifestyle Intervention to Promote Cognitive Health and Well-Being in Older Adults in Taiwan.

OBJECTIVE: This study aimed to promote cognitive health and emotional well-being in older adults by implementing a culturally adapted Five-Domain Lifestyle Intervention (FDLI) in Taiwan. Building upon the internationally recognised Finnish FINGER model, the FDLI included core components-nutritional guidance, physical activity, cognitive training and cardiometabolic risk management-while integrating nostalgic music as a culturally meaningful fifth domain to enhance emotional engagement. METHODS: An 8-month quasi-experimental intervention study was conducted among 38 community-dwelling older ad

The effect of glucagon-like peptide 1 (GLP-1) receptor agonists on cognition: A systematic review of systematic reviews and meta-analyses.

BACKGROUND: Results from extant studies indicate that type 2 diabetes mellitus (T2DM) is associated with decreased cognitive function and increased risk for dementia, notably Alzheimer's Disease (AD). Herein, we aimed to evaluate the effect of glucacon-like peptide-1 receptor agonists (GLP-1 RAs) on cognitive measures in persons with cognitive impairment and T2DM from available systematic reviews and meta-analyses. METHODS: A literature search was conducted using Web of Science and MEDLINE from inception to July 15, 2025. Article screening and data extraction were conducted by three reviewers

Effects of repetitive transcranial magnetic stimulation on cognition through sleep slow-wave activity in older adults.

BACKGROUND: Increases in slow-wave activity (SWA) during sleep are associated with improvements in overnight memory retention and cognitive performance in young adults. Links between SWA and overnight improvements in cognition among older populations, however, are poorly understood. This proof-of-concept pilot study used a single session of excitatory repetitive transcranial magnetic stimulation (rTMS) during wakefulness to increase SWA during subsequent sleep in older adults with subjective cognitive decline. We examined whether this single night increase in SWA led to improvements in overnig

Gut microbiome modulation can improve cognitive function in older adults: a systematic review and meta-analysis.

BACKGROUND: Age-related cognitive decline and dementia exert increasing pressure on healthcare systems. Gut microbiome modulation may offer a novel approach to improving cognitive health. OBJECTIVE: To establish the effect of gut microbiome modulation on cognitive function in older adults. METHODS: A systematic search was conducted of PubMed, Cochrane Library, Medline and Embase (OVID) to identify randomised controlled trials (RCTs) and observational studies assessing cognitive outcomes in adults aged ≥60. Interventions aimed at modifying the gut microbiome (prebiotics, probiotics, synbiotic

The Feasibility and Acceptability of a Remotely Delivered, Combined Exercise Intervention on Cognitive Function in Patients With Breast Cancer Following Chemotherapy: Randomized Controlled Trial.

BACKGROUND: Cognitive impairments, a prevalent quality-of-life concern in breast cancer (BC), are particularly pronounced in women having undergone adjuvant chemotherapy. These impairments-affecting executive function, attention, and processing speed-are often underdiagnosed, with no established treatments. Exercise is a potential intervention to mitigate cancer-related cognitive impairment (CRCI). Since virtual care delivery is feasible, remotely delivered exercise interventions for CRCI management in patients with BC may be explored. OBJECTIVE: We examined the feasibility of an 8-week remot

Neuro-navigated rTMS Targeting Left Angular Gyrus Promotes White-Gray Matter Remodelling to Improve Cognitive Function in Amnestic Mild Cognitive Impairment Patients: Evidence for Early Alzheimer's Intervention.

INTRODUCTION: Repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive neuromodulation technique, has been increasingly applied in early intervention for amnestic Mild Cognitive Impairment (aMCI). However, the mechanism of changes in brain structure after rTMS treatment remains unclear. METHODS: A total of 54 aMCI patients received neuro-navigation rTMS targeting the left angular gyrus for 4 weeks (rTMS group: n=28; sham group: n=26). All participants received multimodal MRI and cognitive assessments before and after rTMS. A white matter network was constructed, and Local Diffusion

Are There Cognitive and Anxiety Improvements in People With Parkinson's Disease After Xbox Kinect Training Compared With No Intervention? A Non-Randomized Controlled Trial.

BACKGROUND AND PURPOSE: Cognitive impairment manifests early in Parkinson's disease (PD), adversely affecting patients' daily activities and mental health. Utilizing exergames via the Xbox 360 Kinect (XBK) console presents a promising therapeutic avenue to mitigate cognitive decline in PD. This study aimed to assess the efficacy of the XBK system in enhancing cognitive performance and reducing anxiety levels among individuals with PD. METHOD: A non-randomized controlled trial, controlled, single-blind clinical trial was conducted. Forty-three PD participants were selected through convenience

AMPK activation by Aldometanib from Bigujing improves metabolic and cognitive dysfunction in aging mice.

Aging-related cognitive decline is closely associated with disrupted energy metabolism and impaired autophagic clearance in the brain. Aldometanib, an active ingredient from the traditional formulation Bigujing, exerts systemic metabolic benefits, but its effects on brain aging and the underlying mechanisms remain unclear. This study aims to evaluate the efficacy of Aldometanib in mitigating cognitive decline in D-galactose-induced aging mice, and to elucidate its potential mechanisms involving AMPK-mediated energy metabolism and autophagy regulation. Male C57BL/6 J mice were treated with D-ga

Auditory Stimulation of Slow-Wave Sleep Promotes Recovery after Brain Injury in an Animal Model.

OBJECTIVE: Traumatic brain injury (TBI) significantly reduces the quality of life for millions of survivors worldwide, causing persistent brain tissue damage and cognitive impairments, with no established therapeutic interventions currently available. Slow-wave activity, a hallmark of deep sleep, has been implicated in recovery after TBI, but pharmacological approaches to enhance it lack specificity and scalability, complicating efforts to identify slow-wave activity as a direct mechanistic contributor and severely limiting clinical translation. METHODS: To overcome these limitations, we deve

Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: A systematic review.

Modafinil is an FDA-approved eugeroic that directly increases cortical catecholamine levels, indirectly upregulates cerebral serotonin, glutamate, orexin, and histamine levels, and indirectly decreases cerebral gamma-amino-butrytic acid levels. In addition to its approved use treating excessive somnolence, modafinil is thought to be used widely off-prescription for cognitive enhancement. However, despite this popularity, there has been little consensus on the extent and nature of the cognitive effects of modafinil in healthy, non-sleep-deprived humans. This problem is compounded by methodologi…