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Mining Sudanese Medicinal Plants for Antiprotozoal Agents.

Neglected tropical diseases are major health hazards in developing countries. Annually, up to 30 million people are affected by either Chaga … anone A from Guiera senegalensis J.F.Gmel.; pseudosemiglabrin from Tephrosia apollinea (Delile) DC; ellagic acid and quercetin from Terminalia leiocarpa (DC.) Baill.; and catechin, ethyl gallate, and epicatechin gallate from Vachellia nilotica (L.) P.J.H.Hurter & Mabb. Also the extracts of Croton gratissimus var. gratissimus and Cuscuta hyalina Roth ex Schult. …

Analysis of immune-related genes and potential therapeutic drugs in refractory lupus nephritis: Comparison with drug-sensitive lupus nephritis based on RNA transcription data.

Based on the gene expression omnibus database, the immune-related genes associated with refractory lupus nephritis (RLN) are analyzed by com … tential were identified based on these central genes, including tanshinone IIA (Tan IIA), luteolin, ellagic acid, baicalein, and quercetin. The immune mechanism of RLN is complex, arising from a synergy of multiple factors, targets, and pathways. This approach is valuable for elucidating the mechanisms underlying RLN resistance and offers a novel perspective f …

Study of the Antioxidant Properties of Filipendula ulmaria and Alnus glutinosa.

The demographic situation of the last few decades is characterized by the increased numbers of elderly and senile people, i.e., by the aging … 3 µmol TE/g. These values are consistent with the total yields of the extracts and their content of ellagic acid. The ethyl acetate extracts of the both plants showed just minimal antioxidant activity. Thus, the considered extracts have an essential potential. This creates good prospects for the further use of herbal extracts of Filipendula ulmaria and Alnus g …

Assessing the Chemical Profile and Biological Potentials of Tamarix aphylla (L.) H.Karst. and Tamarix senegalensis DC. by In Vitro, In Silico, and Network Methodologies.

The present study aimed to investigate the chemical profile, antioxidant, and enzyme inhibition properties of extracts from fruits and aerial parts (leaves and twigs) of Tamarix aphylla and T. senegalensis. Hexane, dichloromethane, ethyl acetate (EtOAc), and methanol extracts were prepared sequentially by maceration. Results revealed that EtOAc extracts of T. senegalensis and T. aphylla fruits contained the highest total phenolic content (113.74 and 111.21 mg GAE/g) while that of T. senegalensis (38.47 mg RE/g) recorded the highest total flavonoids content. Among the quantified compounds; ella

Antifungal efficacy of Eugenia uniflora leaves extract: In vitro and insilico investigations against Candida albicans, C. auris and C. glabrata.

ETHNOPHARMACOLOGICAL RELEVANCE: Eugenia uniflora L. (Myrtaceae), commonly known as pitanga or Brazilian cherry, is widely used in traditional medicine across South America, particularly in Brazil's semi-arid regions, to treat fever, gastrointestinal disorders, and microbial infections. Its therapeutic potential is attributed to phenolic compounds such as myricitrin, gallic acid, and ellagic acid, which exhibit well-documented antimicrobial and anti-inflammatory properties. In the context of the growing global threat posed by multidrug-resistant fungal pathogens, especially species of the Candi…

Analysis of the biological mechanism of Gurigumu-13 in the treatment of non-alcoholic fatty liver disease based on network pharmacology.

CONTEXT: Gurigumu-13 (GR) was a classical Mongolian medicinal compound widely used in clinical practice for the treatment of non-alcoholic f … NS: The improvement of NAFLD by GR may be primarily achieved through its active components (such as ellagic acid and terchebin) via modulation of key targets (such as STAT3) and signaling pathways (such as PI3K/AKT/mTOR), thereby regulating lipid metabolism, alleviating oxidative stress and insulin resistance, and exerting therapeutic effects.

Anti-atherogenic mechanism of ethanol extract of Christia vespertilionis (L.f.) Bakh. F. Leaves in vitro.

BACKGROUND: Vascular inflammation is the key event in early atherogenesis. Pro-inflammatory endothelial cells induce monocyte recruitment in … compounds, including schaftoside, orientin, isovitexin, 6-caffeoyl-D-glucose, and 3,3'-di-O-methyl ellagic acid. Treatment of CV extract at a concentration range from 5 to 60 µg/mL for 24 h maintained HUVECs viability above 90 %, therefore concentrations of 20, 40 and 60 μg/mL were selected for the subsequent experiments. All concentrations of CV extract show …

Punicalagin, a pomegranate polyphenol sensitizes the activity of antibiotics against three MDR pathogens of the Enterobacteriaceae.

BACKGROUND: Multidrug resistance (MDR) in the family Enterobacteriaceae is a perniciously increasing threat to global health security. The d … s as 3.9, 7.8 and 7.8 mg/mL for S. typhi, S. typhimurium and E. coli, respectively. Punicalagin and ellagic acid were determined as predominant compounds by mass spectrometry. In plate assay, punicalagin (10 mg/mL) was active with hazy inhibition zones of 17, 14, and 13 mm against S. typhi, S. typhimurium and E. coli, respectively. However, in broth dilution a …

E-nose, HS-SPME-GC-MS and untargeted metabolomics reveal effects on 60Co gamma irradiation of Neng-An-Jun-Ning Pills: Changes in odor and chemical compositions.

Tibetan medicinal preparations are mainly composed of crude medicinal powder, which are susceptible to microbial contamination. Due to its h … rential volatile compounds. HPLC analysis showed that at 15 and 20 kGy, hydroxysafflor yellow A and ellagic acid decreased significantly, while eugenol content increased. Therefore, the overall results showed the optimal ⁶⁰Co gamma irradiation dose for NJP was 6 kGy, considering sterility compliance (dose ≥6 kGy), minimal odor, and major active ingredients' im …

Stimulatory and immunomodulatory effects of Lagenaria siceraria flower on growth performance, metabolic profile, intestinal integrity, and cytokine/immune-related gene expression in Nile tilapia (Oreochromis niloticus).

Natural immunomodulatory compounds have emerged as vital tools in sustainable aquaculture for their capacity to boost growth and immunity. T … LSF indicates that hesperidin (49.75%) was the primary constituent, followed by quercetin (11.6%), ellagic acid (11.56%), gallic acid (4.97%), and quercetin dihydrate (2.2%). Our results demonstrated that the supplementation of 2 or 3 g/kg LSF significantly improved growth performance indices (final body weight, weight gain, average weight gain, and specific …

CYP3A4-mediated Effects of Cranberry and Pomegranate Juices on Alprazolam Pharmacodynamics.

INTRODUCTION: Alprazolam, a frequently prescribed anxiolytic, is extensively metabolized in the liver mostly by the cytochrome P450 3A4 (CYP … Molecular docking analyses revealed strong binding affinities of anthocyanins from cranberries and ellagic acid from pomegranates to the CYP3A4 enzyme, suggesting their ability to inhibit its activity. Behavioral tests indicated considerable deficits in memory and motor coordination in groups receiving cranberry or pomegranate drinks in conjunction with alpra …

The Promising Pharmacological Effects and Therapeutic/Medicinal Applications of Punica Granatum L. (Pomegranate) as a Functional Food in Humans and Animals.

BACKGROUND: Punica granatum L. (pomegranate), is a shrub mostly available in the Mediterranean Sea region. The fruits have gained the substa … he ancient time the juice and seeds had considered the best therapy for throat and heart disorders. Ellagic acid is one of the main components of pomegranate with potent antioxidant activity. Results from different studies reported that Punica granatum L or its byproducts can be used as natural food additives in human and animal nutrition in order to boost imm …

Therapeutic effects of the n-butanol extract of Potentilla freyniana Bornm. in hepatocellular carcinoma cells.

OBJECTIVE: This study aimed to integrate network pharmacology, bioinformatics analysis, molecular docking, and experimental validation to co … Molecular docking and molecular dynamics results showed that the active components of PFB, such as ellagic acid, luteolin, berberrubine, procyanidin B1, and adenosine, had better affinity with these key target genes. By qPCR and Western blot assays, we verified that the expressions of CDK1 and EZH2 and the key factors of the MPAK signaling pathway were signif …

Effects of pomegranate exocarp extract on H. pylori-induced pancreatic EMT: Molecular mechanisms and therapeutic potential.

BACKGROUND: Previous studies have linked Helicobacter pylori infection with pancreatic diseases, including cancer. PURPOSE: To explore the … genes targeted by PEE. Furthermore, evaluation of drug-likeness and ADME properties indicated that ellagic acid possesses drug-like properties and has a high potential for oral absorption. In conclusion, PEE has shown significant therapeutic potential in reducing H. pylori load and improving pancreatic tissue health while influencing key molecular markers and …

Study on the potential active components and molecular mechanism of Xiao Huoluo Pills in the treatment of cartilage degeneration of knee osteoarthritis based on bioinformatics analysis and molecular docking technology.

BACKGROUND: Knee osteoarthritis is a common joint degenerative disease. Xiao Huoluo Pills (XHLP) has been used to treat degenerative disease … for the treatment of OA, mainly including quercetin, Stigmasterol, beta-sitosterol, Izoteolin, and ellagic acid. Knee osteoarthritis cartilage lesion sequencing data (GSE114007) was screened out of 1672 differentially expressed genes, including 913 upregulated genes and 759 downregulated genes, displayed as heat maps and volcano maps. Besides, 33 core target …

Multi - dimensional mechanism analysis of Choerospondias axillaris (Roxb.) Burtt et Hill in treating kidney stones: network pharmacology, molecular docking and in vitro experimental verification.

ETHNOPHARMACOLOGICAL RELEVANCE: Choerospondias axillaris (Roxb.) Burtt et Hill (CA) is a medicinal and edible plant fruit with national char … benzene-1,2- dicarboxylate, (2R)-5,7-dihydroxy-2-(4-hydroxyphenyl) chroman-4- one, beta-sitosterol, ellagic acid, kaempferol. There were 272 protein targets for the active ingredients and 3,525 for diseases. After intersecting the two sets, 187 potential targets were identified. PPI network analysis revealed that the top five core targets were AKT1, IL6, TNF, …

Novel Therapies to Inhibit Mucus Synthesis and Secretion in Airway Hypersecretory Diseases.

BACKGROUND: In asthma and chronic obstructive pulmonary disease (COPD), airway mucus hypersecretion contributes to impaired mucociliary clearance, mucostasis and, potentially, the development of mucus plugging of the airways. SUMMARY: Excess mucus production can be targeted via therapies that focus on inhibition mucin synthesis, via reducing expression of mucin (MUC) genes, and/or inhibition of mucin secretion into the airways. KEY MESSAGES: This review discusses a number of therapeutic approaches to reduce airway mucus in asthma and COPD, including the use of synthetic and natural products.

A proteomics-based study on the mechanisms of Terminalia chebula Retz processed Aconitum kusnezoffii Reichb against rheumatoid arthritis and its cardiotoxicity reduction.

BACKGROUND: Although the efficacy of Aconitum kusnezoffii Reichb (Caowu) in treating rheumatoid arthritis is well-established, its severe to … ng scores were observed between Ctsk and benzoylaconitine, Casp3 and aconitine, as well as Acp5 and ellagic acid. After long-term treatment of CIA rats with raw Caowu (RC) and HC, histopathological examination and electrocardiogram (ECG) detection indicated significant cardiotoxicity in the RC group, which was ameliorated by HC group. Subsequent biochemical an …

Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy.

The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. The possibility of combining conventional drugs-which are usually more aggressive than natural compounds-with polyphenols offers very valuable advantages such as the building of more efficient anticancer therapies with l

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… Ellagic Acid Ellagic acid is an antioxidant that is found in various natural resources: in oak species such as white oak (Quercus alba) and European red oak ( Quercus robur ) or in medicinal fungi ( Phellinus linteus ). … For years, the effects of treating tumors with ellagic acid have been studied by the evaluation of various alternatives (chemical modifications of ellagic acid or its encapsulation among other options) [ 146 ]. …

The Power of Phytochemicals Combination in Cancer Chemoprevention.

Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have recently received increased attention owing to their capability to modulate a myriad of molecular mechanisms with a less toxic effect. Increasing evidence from preclinical and clinical studies suggest that phytochemicals can favorably modulate several signaling pathways involved in cancer development and progression. Combinations of phytochemicals promote cell death, inhibit c

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… Ellagic acid Ellagic acid, found in Punica granatum (pomegranate), exhibits anti-proliferative capacities and promotes apoptosis in prostate cancer cells via the cyclin kinase inhibitor-cyclin cdk machinery. Ellagic acid down regulates Bcl-X L and BcL-2; cyclins D1, D2, cdk 2, 4 and 6 130 . … Ellagic acid was also shown to reduce metastasis in breast 131 and ovarian cancer 132 . Studies have indicated ellagic acid to have anti-cancer effects due to its ability to target histone deacetylase 6-related pathways 133 . …