Результаты поиска

Reduced glomerular filtration rate can maintain a rise in plasma bicarbonate concentration in humans.

In humans, deficiency of chloride and potassium were found to perpetuate the hyperbicarbonatemia that attends metabolic alkalosis induced by gastric aspiration partly by increasing renal bicarbonate reabsorption, commensurate with the attendant increase in filtered bicarbonate load, and partly by decreasing glomerular filtration rate (GFR), which minimizes the degree of which the filtered bicarbonate load increases and thereby minimizes the requisite increase in bicarbonate reabsorption. The relative contribution of stimulated renal bicarbonate reabsorption might increase, however, if the supp…

Бремя хронической почечной болезни по категориям KDIGO Glomerular Filtration Standard and Albuminuria: системный обзор.

ВВЕДЕНИЕ: Заболевание почек: улучшение глобальных результатов (KDIGO) 2012 Руководящие принципы рекомендуют категоризировать пациентов по гломерулярной скорости фильтрации (GFR) и альбуминурии для прогнозирования хронического заболевания почек (CKD). Цель этого систематического обзора заключалась в изучении эпидемиологического бремени ОВД, стратифицированного КДИГО 2012 категории. МЕТОДЫ: МЕДЛИНЕ и Эмбасе были найдены для наблюдения за пациентами с ККД, результаты которых были стратифицированы в соответствии с KDIGO 2012 классификация. В числе исследованных результатов можно назвать распростра

Совпадение в аннотации оригинала
INTRODUCTION: The Kidney Disease: Improving Global Outcomes (KDIGO) 2012 guidelines recommend classifying patients by glomerular filtration rate (GFR) and albuminuria to predict chronic kidney disease (CKD) prognosis. The aim of this systematic review was to explore the epidemiological burden of CKD stratified by the KDIGO 2012 categories. METHODS: MEDLINE®…

Comparing the effect of faecal microbiota and faecal filtrate transplantations on intestinal health in weaned piglets.

BACKGROUND: Faecal microbiota transplantation (FMT) and faecal filtrate transplantation (FFT) have emerged as promising methods to prevent intestinal dysbiosis and diarrhoea in piglets after weaning. The aim of this study was to compare the effects of FMT and FFT on intestinal health and faecal microbiota dynamics in weaned piglets. Thirty-six 28-day old piglets were allocated into three groups (Control, FMT, and FFT, n = 12 each) at an experimental farm. Intact and filtered faeces from healthy sows were lyophilised, encapsulated, and administered upon arrival (day 0) and after 4 days (day 4).

USP10 Silencing Prevents Scarring and Inflammation in a Modified Rabbit Model of Glaucoma Filtration Surgery.

PURPOSE: Trabeculectomy remains the gold standard for lowering intraocular pressure (IOP) in glaucoma, but postoperative scarring and inflammation can cause bleb failure. Because USP10 knockdown is anti-inflammatory and anti-fibrotic in the cornea, we tested whether USP10 silencing reduces bleb scarring and inflammation in a rabbit glaucoma filtration surgery model. METHODS: Primary rabbit Tenon's fibroblasts (RTFs) were transfected with fully modified in vivo self-delivering siRNA targeting USP10 (sdRNA, US09) or non-targeting control sdRNA (NTC) to assess myofibroblast conversion and fibron…

Efficient Cell Removal and Impurity Reduction for Poxvirus Purification in a Single Step Alluvial Filtration.

Modified Vaccinia virus Ankara (MVA) is a potent vector for the development of vaccines and novel cancer treatment strategies. Since it is a … impurity depletion by DE binding while maintaining a complete virus recovery. The optimal alluvial filtration conditions were achieved with a PURAFIX® CH 09 depth filter with a 10-30 µm retention rate. The optimal conditions were identified as a combination of a Celpure® C1000 precoat and a Celpure® C300 additive added to the feed. This robust process achie …

Bedroom Air Filtration and Home Blood Pressures of Older Adults Living in a Residential Facility.

Portable air cleaners (PACs) can reduce blood pressure (BP) by decreasing fine particulate matter (PM2.5) air pollution exposure. However, t … index showed trends for modifying the benefits by active PAC. We showed for the first time that air filtration in the bedroom alone can successfully reduce PM2.5 exposures. While systolic BPs were not lowered over 4 weeks in the entire cohort, some individuals may have benefited.

A biomimetic in vitro glomerular filtration barrier model for investigating renal barrier dysfunction in hyperglycemia.

Hyperglycemia and hypertension are primary contributors to chronic kidney disease (CKD), typically managed by dialysis or kidney transplanta … l microenvironment of the native kidney. To address this, a biomimetic diabetic in vitro glomerular filtration barrier (GFB) using kidney-derived decellularized extracellular matrix hydrogel coating on a nanofibrous bacterial cellulose (BC) membrane. This scaffold provides both architectural support and essential cues that promote the attachment and growth o …

Influence of Mesh Design on Hemodynamic Performance and Embolic Filtration in Distal Embolic Protection Filters.

BACKGROUND: Distal net-type embolic protection filters (EPDn) are widely used during endovascular interventions to reduce embolic complications. However, the impact of mesh design on filtration performance and flow dynamics remains poorly defined. METHODS: A controlled in vitro experimental model simulating arterial flow under physiological pulsatile conditions was developed. Four EPDn were evaluated. A standardized bolus of 140 μm microspheres was injected. Filtration performance was assessed using capture efficacy (CE), overall efficacy (OE), and particle leakage fraction (PLF), while hemod…

Pediatric Reference Ranges for Glomerular Filtration Rate Determined by a Single Injection of 99mTc-DTPA.

Determination of glomerular filtration rate (GFR) with 99mTc-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA) is a validated method to assess renal function, but there are no well-established pediatric reference ranges for GFR. The aim of this study was to establish reference GFRs in children and young adults. Methods: GFR was calculated for 235 reference subjects (median age, 4.86 y; range, 20 d to 24.8 y) using 99mTc-DTPA at Boston Children's Hospital between 2000 and 2020. This included 220 patients for prechemotherapy evaluation and 15 potential kidney donors. GFR was determined usi…

Application of Tin Spectral Filtration for CT Colonography: Impact on Image Quality and Radiation Dose.

RATIONALE AND OBJECTIVES: The purpose of this study was to evaluate image quality and radiation dose when using tin spectral filtration for computed tomography colonography (CTC) screening. MATERIALS AND METHODS: A phantom wrapped in fat-attenuation rings simulated five patient sizes. Noise-dose relationships were acquired by scanning the phantom using conventional 120-kV and tin-filtered 100-kV (100Sn) and 150-kV (150 Sn) protocols at 1 mGy volume CT dose index (CTDIvol) increments. These protocols were applied in 100 patients undergoing CTC in supine and decubitus positions, with each posit…

A transcriptomic analysis of the interplay of ferroptosis and immune filtration in endometriosis and identification of novel therapeutic targets.

Endometriosis is an inflammatory disease, involving immune cell infiltration and production of inflammatory mediators. Ferroptosis has recently been recognized as a mode of controlled cell death and the iron overload and peroxidative environment prevailing in the ectopic endometrium facilitates the occurrence of ferroptosis. In the current investigation, gene expression data was obtained from the dataset GSE7305.The variation in infiltration of immune cells amongst the samples with endometriosis and normal tissue was analysed using the CIBERSORTx tool which revealed higher infiltration of T ce…

Monitoring of bacterial and potentially toxic elements contamination in the Rawal Lake tributaries and filtration plant.

This study examines bacterial and potentially toxic elements pollution in Jinnah Stream, Nurpur Stream, and Rawal Lake filtration plant during dry and wet seasons; Rawal Lake serves as a key source of water supply for the twin cities of Rawalpindi and Islamabad. Three growth media (Salmonella-Shigella agar, Brilliant Green agar, and Chromo-select agar) were used for microbial plating targeting Escherichia coli, Shigella spp., Salmonella spp., Citrobacter freundii spp., and Klebsiella pneumoniae spp. qPCR Taqman Probe-based assay was used for detection of E. coli (uidA), Salmonella (invA), Camp…

Effect of Subconjunctival Healaflow in Filtrating Surgery with Preserflo MicroShunt in Primary Open Angle Glaucoma.

Background/Objectives: This work aims to clarify whether the subtenon use of the sodium hyaluronate product Healaflow in filtrating surgery with PreserFlo MicroShunt positively influences the early postoperative course in terms of control of intraocular pressure, hypotony, and needling rate. Methods: A retrospective, randomized controlled, interventional, single-center trial was performed at the Ludwig Maximilians-University Munich from January 2024 to July 2024. Only patients with primary open angle glaucoma (POAG) were included. In all patients, a complete ophthalmological examination includ

Menopause is associated with a reduction in glomerular filtration rate, independent of body composition and metabolic syndrome.

OBJECTIVES: This study examines the relationship between menopause and glomerular filtration rate (GFR), independent of body composition and metabolic profile, both known risk factors for GFR decline. STUDY DESIGN: Cross-sectional study involving 3918 women aged 40-55 years. MAIN OUTCOME MEASURES: Participants provided information about medical history, menopausal status, and current medication use. Participants underwent nutritional and anthropometric assessments. Blood samples were collected to measure biochemical parameters. Menopause was defined as no menstrual cycle for 12 months or mor…

Effect of MgO-HPAM nanocomposite on the rheological and filtration properties of water-based drilling fluids.

This research explores the novel enhancement of water-based drilling fluids using MgO-HPAM nanocomposites, focusing on improving their rheological and filtration properties. The study introduces an innovative approach to address the critical challenges in drilling technologies, emphasizing the need for stable and efficient drilling fluids in the oil and gas industry. Unlike traditional formulations, MgO-HPAM nanocomposites leverage the synergistic interaction between MgO nanoparticles and hydrolyzed polyacrylamide (HPAM) to overcome limitations such as instability and poor fluid performance in…