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Control of viral infections by epigenetic-targeted therapy.

Epigenetics is defined as the science that studies the modifications of gene expression that are not owed to mutations or changes in the genetic sequence. Recently, strong evidences are pinpointing toward a solid interplay between such epigenetic alterations and the outcome of human cytomegalovirus (HCMV) infection. Guided by the previous possibly promising experimental trials of human immunodeficiency virus (HIV) epigenetic reprogramming, the latter is paving the road toward two major approaches to control viral gene expression or latency. Reactivating HCMV from the latent phase ("shock and k

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… Cytomegalovirus induced up-regulation of LFA-3 (CD58) and ICAM-1 (CD54) is a direct viral effect that is not prevented by ganciclovir or foscarnet treatment. Transplantation. 1996;62:1102–1108. doi: 10.1097/00007890-199610270-00014. 99. Cobbs CS, Soroceanu L, Denham S, Zhang W, Kraus MH. …

The 48th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Poster Session (P001 - P578).

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Abstracts of the Cell Therapy Transplant Canada 2024 Annual Conference.

On behalf of Cell Therapy Transplant Canada (CTTC), we are pleased to present the Abstracts of the CTTC 2024 Annual Conference. The conference was held on 1-3 May 2024 in beautiful Victoria, British Columbia, at the Victoria Conference Centre, and attracted 293 in-person delegates and five virtual attendees. Several plenary sessions were held on topics such as gene therapy for hemoglobin disorders, optimizing donor selection, graft-versus-host disease (GvHD) strategies, collaborative care, survivorship, graft failure, and CAR-T therapy. Poster authors presented their work during a lively and e

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… 5.1%) Acute GVHD at the time of Letermovir initiation | All grades | 18 (46.1%) Grade III/IV | 0 CMV viral load (IU/mL) triggering pre-emptive treatment (median, range) | 707 (316–1400) Pre-emptive treatment for CMV before Letermovir initiation | Valganciclovir | 36 (92.3%) Ganciclovir | 6 (15.4%) Foscarnet … secondary prophylaxis | 4 (10.3%) Follow up after stopping Letermovir secondary prophylaxis (median, range), days | 287 (29–757) Relapse | 8 (20.5%) Death | 15 (38.5%) By definition, all patients had previously received treatment for CMV infection (36 with valganciclovir; six with ganciclovir; two with foscarnet …

Development and Clinical Translation of Approved Gene Therapy Products for Genetic Disorders.

The field of gene therapy is striving more than ever to define a path to the clinic and the market. Twenty gene therapy products have already been approved and over two thousand human gene therapy clinical trials have been reported worldwide. These advances raise great hope to treat devastating rare and inherited diseases as well as incurable illnesses. Understanding of the precise pathomechanisms of diseases as well as the development of efficient and specific gene targeting and delivery tools are revolutionizing the global market. Currently, human cancers and monogenic disorders are indicati

Infectious Diseases

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Update on Contrast-Induced Nephropathy: Recent Developments in Its Prevention, Early Diagnosis, and Therapy.

Contrast-induced nephropathy (CIN), now more accurately referred to as contrast-induced acute kidney injury (CI-AKI), remains a major cause of hospital-acquired acute kidney injury (AKI) and is associated with increased morbidity and mortality, particularly in high-risk patients. This condition occurs following the intravascular administration of iodinated radiocontrast media (RCM), especially in individuals with pre-existing chronic kidney disease (CKD), diabetes mellitus, heart failure, advanced age, or exposure to high contrast volumes. The pathophysiology of CI-AKI is multifactorial and in

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… Specific preventive measures are typically recommended and include: Both volume depletion and the administration of nephrotoxic drugs should be avoided [ 56 ], particularly NSAIDs, aminoglycosides, amphotericin B and some antivirals (foscarnet, acyclovir). …

Практические рекомендации в отношении инфекционных профилактических мероприятий и вакцинации нескольких пациентов, страдающих миэломой.

Инфекции по-прежнему являются одной из основных причин заболеваемости и смертности во множестве миеломы (ММ), обусловленной взаимосвязью между иммунной дисфункцией, вызванной болезнями, и иммунодепрессией, связанной с лечением. Внедрение протеазных ингибиторов, иммуномодуляционных препаратов, моноклонных антител, биконкретных антител и химеорической антигенной рецепторной терапии Т (CAR-T) заметно улучшило выживание при одновременном изменении ландшафта инфекционных рисков. Различные стратегии обращения ставят под угрозу иммунитет в рамках различных механизмов. Обычная химиотерапия и некоторые

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… Treatment of CMV reactivation is recommended with oral valganciclovir, intravenous ganciclovir, or foscarnet ( 57 ). Prophylaxis for Epstein–Barr virus (EBV) and human herpesvirus 6 (HHV-6) is also not recommended ( 9 ). …

Aminopeptidase N: a multifunctional and promising target in medicinal chemistry.

Aminopeptidase N (APN) is a zinc metalloproteinase present in almost all types of organisms and has various functions. Many of them are unrelated to its catalytic activity, which is why APN is sometimes classified as a moonlighting enzyme. APN is involved in carcinogenesis and angiogenesis. It also works as an entrance receptor for some coronaviruses and acts as a mediator during skin inflammation. Additionally, APN removes and helps to recycle regulatory proteins including neuropeptides, which is why its inhibitors hold therapeutic potential for a wide range of diseases, making the design and

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… Currently available antiviral agents—such as ganciclovir, its prodrug valganciclovir, cidofovir, and foscarnet—function primarily as viral polymerase inhibitors. …

From Lab to Clinic: Success Stories of Repurposed Drugs in Treating Major Diseases.

Drug repurposing, the process of identifying new therapeutic uses for existing drugs, has emerged as a cost-effective and time-saving alternative to traditional drug development. This strategy leverages the known pharmacological and safety profiles of approved or investigational drugs to accelerate their clinical application for other diseases. In recent years, repurposed drugs have played a crucial role in addressing treatment gaps in complex and multifactorial diseases such as cancer, neurodegenerative disorders and infectious diseases. This review highlights prominent examples where repurpo

Acute and Chronic Respiratory Failure in Cancer Patients

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… True infection warrants treatment with ganciclovir or foscarnet. Interestingly, increased incidence of co-infection with Nocardia and molds such as Aspergillus has been documented in patients with CMV pneumonia [ 44 ]. …

Radiation-Induced Oral Mucositis.

Radiation-induced oral mucositis (RIOM) is a major dose-limiting toxicity in head and neck cancer patients. It is a normal tissue injury caused by radiation/radiotherapy (RT), which has marked adverse effects on patient quality of life and cancer therapy continuity. It is a challenge for radiation oncologists since it leads to cancer therapy interruption, poor local tumor control, and changes in dose fractionation. RIOM occurs in 100% of altered fractionation radiotherapy head and neck cancer patients. In the United Sates, its economic cost was estimated to reach 17,000.00 USD per patient with

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… grade 3/4 | Palliative rinses, narcotics, palifermin in the BMT setting Aphthous stomatitis | Etiology not identified | Single painful ulcer | Localized, but painful; maximum grade 2 | Topical Herpetic mucositis | HSV1 | Usually several spots; ulcerative | Usually grade 1–2 | Acyclovir, valacyclovir, foscarnet …

:: 45th Ежегодное совещание Европейского общества по трансплантации крови и костного мозга: Врачи - сессия плаката.

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Respiratory and Thoracic Medicine

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… 17542698 10.2460/ajvr.68.6.643 50 MacPhail CM Bennet AD Gibbons DS The esophageal transit time of tablets or capsules following administration with FlavorRx pill glide or pill delivery treats J Vet Intern Med 23 2009 736 51 Maggs DJ Clarke HE In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet …

The leptomeninges as a critical organ for normal CNS development and function: First patient and public involved systematic review of arachnoiditis (chronic meningitis).

BACKGROUND & IMPORTANCE: This patient and public-involved systematic review originally focused on arachnoiditis, a supposedly rare "iatrogenic chronic meningitis" causing permanent neurologic damage and intractable pain. We sought to prove disease existence, causation, symptoms, and inform future directions. After 63 terms for the same pathology were found, the study was renamed Diseases of the Leptomeninges (DLMs). We present results that nullify traditional clinical thinking about DLMs, answer study questions, and create a unified path forward. METHODS: The prospective PRISMA protocol is pu

Selected Abstracts from the 13th Annual Meeting of the Clinical Immunology Society: 2022 Annual Meeting: Immune Deficiency and Dysregulation North American Conference

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The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians - Oral Session.

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Diseases of the Nervous System

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The 46th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Oral Session (O010-O173).

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2018 Ежегодное совещание СНГ: Североамериканская конференция по вопросам неадекватности и регулирования.

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Abstracts from the 37th Annual Meeting of the Society of General Internal Medicine, 2014, San Diego, CA, USA.

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