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Dynamic Changes in Brain Mesenchymal Perivascular Cells Associate with Multiple Sclerosis Disease Duration, Active Inflammation, and Demyelination.

Vascular changes, including blood brain barrier destabilization, are common pathological features in multiple sclerosis (MS) lesions. Blood vessels within adult organs are reported to harbor mesenchymal stromal cells (MSCs) with phenotypical and functional characteristics similar to pericytes. We performed an immunohistochemical study of MSCs/pericytes in brain tissue from MS and healthy persons. Post-mortem brain tissue from patients with early progressive MS (EPMS), late stage progressive MS (LPMS), and healthy persons were analyzed for the MSC and pericyte markers CD146, platelet-derived gr…

Воздействие боли, утомления и качества сна на повседневную жизнь пациентов с множественным склерозом по признаку пола: исследование описи из Турции.

Множественный склероз (MS) является хроническим неврологическим заболеванием, которое развивается с кризисом и ремиссией и вызывает серьезные психосоциальные проблемы. По сообщениям, наиболее частыми проблемами, которые могут измениться по признаку пола и потенциально повлиять на повседневную жизнь, являются расстройства, связанные с утомлением и сном. АИМ: Цель этого исследования заключалась в изучении последствий боли, усталости и качества сна для повседневной жизни пациентов с множественным склерозом в разбивке по полу. В этом перекрестном исследовании приняли участие 188 пациентов с синдро

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is a chronic neurological disease that progresses with crisis and remission and causes significant psychosocial problems. Fatigue and sleep disorders are reported to be the most frequent problems that could change by gender and potentially affect daily living activities. AIM: This study aimed to examine the effects of pai…

Teeth loss after teriflunomide treatment: Casual or causal? A short case series.

BACKGROUND: Teriflunomide is a once-daily oral immunomodulator approved for the treatment of relapsing-remitting multiple sclerosis (RRMS) with a consistent safety profile in clinical trials. We report three cases of multiple teeth loss during teriflunomide treatment. CASE REPORTS: Case 1: a 39 year-old woman started teriflunomide for RRMS, switching from interferon beta. Four months later she complained about mandibular pain followed by the sudden loss of 4 teeth, in the absence of bleeding or trauma. Suspecting a causal role, we discontinued teriflunomide and started the accelerated elimina…

[XVII Post-ECTRIMS Meeting: Review of the New Developments Presented at the 2024 ECTRIMS Congress (I)].

INTRODUCTION: The XVII edition of the post-European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) meeting was held on 4-5 October 2024 in Madrid. This event was attended by Spanish neurologists specialized in multiple sclerosis (MS), who presented a summary of the most relevant advances discussed at the ECTRIMS congress, held days before in Copenhagen. AIM: To present new developments in neurodegeneration and progression, the prodromal phase and diagnosis, the clinical use of biomarkers and neuroimaging, as well as the current role of patient-reported outcomes and digit…

Urinary Exosomal microRNAs as a Novel Approach to Study People with Multiple Sclerosis and Severe Gait Disability: A Preliminary Observation.

Background: MiRNAs within extracellular vesicles can encompass body barriers, reflecting stage, progression, and response to treatments of various diseases, including multiple sclerosis (MS)-a chronic immune-mediated disease of the central nervous system that causes progressive disability, with highly variable clinical courses. In this context, urinary exosomal miRNAs could be an appealing source of biomarkers, thanks to their non-invasive and easily repeatable collection. Methods: In this exploratory investigation, we tried to assess if profiling urinary exosomal miRNAs could reveal subtle di…

Scleroderma.

The prototypic autoimmune diseases involving skin (lupus, dermatomyositis) typically result in epithelial injury and autoantibodies to characteristic cellular antigens. Disease-specific autoantibodies are also found in scleroderma, but scleroderma is different from other cutaneous autoimmune diseases because epithelial injury does not occur. Multiple factors and combinations of factors (immune system, vascular and extracellular matrix abnormalities) are the most likely triggers in an individual with a genetic predisposition to scleroderma. These lead to increased synthesis of normal collagen i

AAV1.NT3 генная терапия смягчает остроту аутоиммунного энцефаломиэлита в модели мыши для множественных склерозов.

Множественный склероз (MS) — хроническое воспалительное и нейродегенеративное заболевание центральной нервной системы (КНС), которое оказывает воздействие более чем на организм человека. 2.5 million Пациенты по всему миру. Хроническое обезвоживание в ЦНС играет важную роль в увековечении аксоновых потерь и увеличивает трудности в поощрении воспоминаний. Поэтому стратегии регенерации и нейрозащиты имеют важное значение для преодоления этого препятствия для сохранения аксоновой целостности и функции. Нейропофин 3 (В тыс.NT-3) обладает иммунодуляционными и антивоспалительными свойствами, помимо ш

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is an immune-mediated chronic inflammatory and neurodegenerative disease of the central nervous system (CNS) affecting more than 2.5 million patients worldwide. Chronic demyelination in the CNS has an important role in perpetuating axonal loss and increases difficulty in promoting remyelination. Therefore, regenerative, and neuroprote…

Movement Disorders in Multiple Sclerosis: An Update.

BACKGROUND: Multiple sclerosis (MS), a subset of chronic primary inflammatory demyelinating disorders of the central nervous system, is closely associated with various movement disorders. These disorders may be due to MS pathophysiology or be coincidental. This review describes the full spectrum of movement disorders in MS with their possible mechanistic pathways and therapeutic modalities. METHODS: The authors conducted a narrative literature review by searching for 'multiple sclerosis' and the specific movement disorder on PubMed until October 2021. Relevant articles were screened, selected…

[Optical coherence tomography in the diagnosis of multiple sclerosis].

UNLABELLED: Multiple sclerosis (MS) is a chronic autoimmune-inflammatory and neurodegenerative disease. PURPOSE: This study explores the main structural changes in patients with MS and their relationships with the activity and type of disease course. MATERIAL AND METHODS: This prospective study included 159 patients (318 eyes) with an established diagnosis of MS: group (44 eyes; 13.84%) - relapsing-remitting type MS (RRMS) lasting up to 1 year without a history of optic neuritis (ON); group 2 (30 eyes; 9.43%) - RRMS up to 1 year with ON; group 3 (56 eyes; 17.61%) - RRMS lasting from 1 to 10 …

[New trends in neuropathy practice: clinical approach to CIDP].

Our recent study showed that the overall prevalence of CIDP was estimated as 2.2 per 100,000 population in Aomori Prefecture, in Northan Honshu of Japan. In our series of more than 80 cases with CIDP, a chronic acquired inflammatory demyelinating polyneuropathy, nearly 30% showed clear laterality of weakness, and electrophysiologic laterality or multifocality was apparent in almost all cases. Nearly 90% of patients were able to walk without walking aids or other assistance. Sixty% showed distal dominant muscular weakness. In 12 patients with age of onset under 15, pes cavus deformity was seen

Infectious Agents in Multiple Sclerosis: Viral Triggers, Antibody-Mediated Autoimmunity, and Parasitic Immunomodulation.

Multiple sclerosis (MS) is a chronic immune-mediated disease of the central nervous system characterized by demyelination, neuroinflammation, and progressive neurodegeneration. While there is a small component of genetic susceptibility to MS risk, environmental factors, including infectious exposures, are gaining increased recognition as playing a critical role in MS initiation and progression. Viral infections, especially by Epstein-Barr virus (EBV), have emerged as strong candidates and triggers of MS symptoms, through antibody-mediated molecular mimicry and B-cell dysregulation. In contrast…

Suppressor T cells are activated in vivo in patients with multiple sclerosis coinciding with remission from acute attack.

By a variety of assays, investigators (1-4) from several laboratories previously observed changes in numbers of thymus-derived suppressor lymphocytes (Ts) in patients with acute active multiple sclerosis (MS). Changes in numbers of Ts in the peripheral blood compartment of such patients closely follow disease activity. Extending these observations we now report Ts are activated in the peripheral blood of certain patients with MS. This activation occurred in vivo in the majority of patients with active disease, but only during remission after an acute episode of MS. In contrast, activated Ts we…

Усугубляемость (SWI): Технические аспекты и применение в МРТ мозга при нейродегенеративных расстройствах.

Снимки, взвешенные по сузуптуальности (SWI), представляют собой последовательность магнитных резонансных изображений (MRI), чувствительных к веществам, изменяющим местное магнитное поле, таким, как кальций и железо, что позволяет проводить различие между фазной информацией. SWI представляет собой 3D-эчо-градиентную последовательность с высоким пространственным разрешением, которая обеспечивает эффект как фазового, так и масштабного эффекта. Взаимодействие парамагнитных (таких, как гемосидрин и деоксигемоглобин), диамагнитных (включая кальцинацию и минералы) и железомагнитных веществ с местным

Совпадение в аннотации оригинала
Susceptibility-weighted imaging (SWI) is a magnetic resonance imaging (MRI) sequence sensitive to substances that alter the local magnetic f … SWI findings are known in Parkinson's disease, Lewy body dementia, atypical parkinsonian syndromes, multiple sclerosis, cerebral amyloid angiopathy, amyotrophic lateral sclerosis, hereditary ataxias, Huntington's disease, neurodegeneration with brain iron accumulation, and chronic traumatic encephalopathy. This review will assist radiologists in understanding the te …

Efficacy and tolerability of folate-aminopterin therapy in a rat focal model of multiple sclerosis.

BACKGROUND: Activated macrophages in the experimental model of multiple sclerosis (MS) express folate receptor-β (FR-β), representing a promising target for the treatment of MS. Here, we both evaluated the efficacy of a novel folate-aminopterin construct (EC2319) in a rat focal model of multiple sclerosis (MS) and investigated the utility of 68Ga-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid-conjugated folate (68Ga-FOL) for assessing inflammatory lesions. In addition, we investigated whether FR-β is expressed in the brain of patients with MS. METHODS: Focal delayed-type hypersensitivit…

Elevated BAFF levels in the cerebrospinal fluid of patients with neuro-Behçet's disease: BAFF is correlated with progressive dementia and psychosis.

Neuro-Behçet's disease (NBD) is a serious complication of Behçet's disease. Generally, NBD patients with a chronic course are refractory to immunosuppressive treatment, resulting in the deterioration of personality. In this study, levels of B cell-activating factor belonging to the TNF family (BAFF) were measured in the cerebrospinal fluid (CSF) from 18 patients with NBD, 27 patients with epidemic aseptic meningitis (AM), 24 patients with multiple sclerosis (MS) and 34 healthy controls. BAFF levels in patients with NBD were significantly elevated compared with healthy controls, but showed no s…

Качество жизни пациентов с множественным склерозом: связь с принятием заболеваний, оптимизмом и поведением, способствующим укреплению здоровья.

Множественный склероз (MS) является хроническим, прогрессивным заболеванием центральной нервной системы, которое затрагивает прежде всего лиц в раннем возрасте и является одной из главных причин инвалидности среди молодежи. Несмотря на успехи в понимании его этиологии, в настоящее время нет лекарства от склероза. Непредсказуемость, прогресс и связанные с ним симптомы могут значительно ухудшить повседневное, семейное, социальное и профессиональное функционирование пациентов, тем самым существенно понизив качество их жизни. Цель этого исследования состояла в том, чтобы оценить качество жизни (Qo

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a chronic, progressive disease of the central nervous system, primarily affecting individuals in early adulthood and serving as a leading cause of disability among young adults. Despite advancements in understanding its etiology, there is currently no cure for MS. The disease's unpredictability, progression, and associated symptoms…

Оценка деформируемости скелетной мышцы во время клинического паралича в EAE, модели мыши множественного склероза.

Множественный склероз (MS) и его модель мыши, экспериментальный аутоиммунный энцефаломиэлит (EAE), являются нейродегенеративными заболеваниями, связанными с воспалением и обезвоживанием центральной нервной системы, часто приводящими к серьезному моторному дефициту, включая постепенный паралич и спастичность. Несмотря на широкое описание неврологических аспектов MS и EAE, влияние прогрессии заболеваний на скелетную мышечную структуру и механику остается в основном неизученным полем. В настоящем исследовании мы провели оценку деформируемости мышечной мышцы в период паралича, вызванного EAE, с ис

Совпадение в аннотации оригинала
Multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE), are neurodegenerative diseases associated with inflammation and demyelination of the central nervous system, often leading to severe motor deficits, including progressive paralysis and spasticity. Although the neurological aspects of MS and EAE are widely described,…

Регулирование сетей транскрипции, регулирующих олигодендрогенез в связи с возрастной специализацией CNS.

В демиелинизирующих болезнях, таких как множественный склероз (MS), эффективная ремиелинация имеет решающее значение для функционального восстановления. Эффективность реминификации снижается с возрастом и связана с постепенной инвалидностью. Система регулирования генов, лежащая в основе ремиэлизации, и то, как она изменяется со старением, остается неясной. Здесь мы представляем сравнительный анализ секвенирования воспоминаний у молодых и пожилых мышей с использованием метода < < один нуклеус > > и АТАК. Мы выявили генетические модули, динамически выраженные по всей олигодендроцитно

Совпадение в аннотации оригинала
In demyelinating diseases like multiple sclerosis (MS), efficient remyelination is critical for functional recovery. Remyelination efficiency declines with age, and is linked to progressive disability. The gene regulatory network underlying remyelination, and how it is altered with aging, remains unclear. Here we present a comparative single-nucleus RNA and …

Abnormal electrocardiogram in a patient with amyotrophic lateral sclerosis mimicking myocardial ischaemia.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that almost exclusively involves motor neurons although autonomic dysfunction has also been reported. We present an 84-year-old female with no documented history of heart disease, who was admitted with negative T waves in the electrocardiogram precordial leads mimicking myocardial ischaemia. No other abnormalities were shown in the rest of the cardiologic evaluation, suggesting autonomic nervous system dysfunction. A neurophysiological study demonstrated acute and chronic denervation in multiple muscles with normal

Plasma exchange therapy in steroid-unresponsive relapses in patients with multiple sclerosis.

BACKGROUND: Plasma exchange (PE) is well established for conditions such as rapid progressive vasculitis associated with autoantibodies agai … Only small case series have previously shown that PE is also effective in relapses in patients with multiple sclerosis (MS). METHODS: We report our experiences of PE therapy in a series of 20 patients with 21 steroid unresponsive MS relapses. RESULTS: A marked-to-moderate clinical response with clear gain of function in 76% of patients with uni- or bilateral optic …