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[Necrotizing vasculitis: its manifestation as urticaria].

A case of urticarial vasculitis, a distinct form of necrotizing vasculitis is described. This entity is characterized by a chronic, persistent urticaria with petechiae and the histological features of necrotizing vasculitis. Serum complement is depressed and multisystem involvement can often be found. There is evidence for immune complexes to play a role in the pathogenesis of this disease.

[Acute abdomen in immune complex vasculitis].

The case of a 51 year old male with 6 months history of loss of weight and abdominal pain is discussed. Laparotomy revealed gangrene of the gall bladder and perforation of the small intestine with consecutive peritonitis. Postmortem examination showed hypertensive intracerebral bleeding and disseminated infarctions of the abdominal organs and the kidneys. Histological findings including immune-fluorescence methods revealed the final diagnosis of immune complex vasculitis.

[Etiopathogenesis of necrotizing arteritis (leukocytoclastic vasculitis)].

The small vessel's necrotizing angiitis (necrotizing microangiitis (NMA), leucocytoclastic angiitis) form a continuous spectrum from the exclusively cutaneous forms of Gougreot, to those which seriously affect the viscera, as the very acute and fatal cases of Zeek, passing through a series of intermediate phases, in which Schönlein-Henoch's purpura is found. In all of these clinical forms, the existence of an allergic mechanism has been suggested from their origin itself and in 1964 Alarcón-Segovia and Brown grouped them under the common denominator of allergic angiitis. Later investigations a

[Herpes infection and primary cerebral vasculitis].

OBJECTIVE: To investigate the presence of antibodies to herpes viruses (Varicella zoster virus [VZV], herpes simplex virus types I and II, Epstein-Barr virus, and cytomegalovirus) and their DNA in the cerebrospinal fluid (CSF) of patients with a history of ischemic stroke (IS) and/or transient cerebrovascular accident (TIA) caused by primary cerebral vasculitis (PCV); to evaluate their clinical significance. MATERIAL AND METHODS: Thirty-one patients (mean age 41.2±8.7 years, 18 males, 58%) with PCV and a history of IS and/or transient cerebrovascular accidents (TIA), which in 94% occurred in …

Expert Perspective: Hematologic Malignancies and Vasculitis.

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… Myeloid and lymphoid hematologic malignancy have long been recognized in association with vasculitis and were recognized by the 2012 Consensus Conference on the Nomenclature of Systemic Vasculitis as vasculitis associated with probable etiology (cancer‐associated). 4 We will refer to this as vasculitis … For patients with B cell malignancies and especially those with cryoglobulinemic vasculitis, we strongly favor using therapies that could treat both malignancy and vasculitis, such as RTX. …

Cocaine- and Levamisole-Induced Vasculitis (CLIV).

Cocaine- and levamisole-induced vasculitis (CLIV) is a distinct form of drug-induced vasculitis characterized by dual antineutrophil cytoplasmic antibody (ANCA) positivity, rapidly progressive glomerulonephritis (RPGN), and diffuse alveolar hemorrhage (DAH). This systematic review synthesizes data from case reports, case series, and reviews published between 2015 and 2024 to clarify clinical presentations, diagnostic approaches, and management strategies. A comprehensive search of PubMed and Google Scholar using terms such as "levamisole-induced vasculitis," "cocaine-associated vasculitis," "d…

Cardiovascular involvement in ANCA-associated vasculitis.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic necrotizing vasculitis with significant cardiovascular involvement, primarily manifesting in granulomatosis with polyangiitis, microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis. AAV patients face a 65% higher cardiovascular event risk, with common manifestations such as myocardial infarction, stroke and myocarditis, and less frequently, aortitis. Pathophysiology includes endothelial dysfunction, vascular inflammation, and direct inflammatory infiltration of cardiac tissue, exacerbated…

Cutaneous Vasculitis in Primary Sjögren Disease.

IMPORTANCE: Cutaneous vasculitis (CV) is a heterogenous and severe complication of primary Sjögren disease, often indicating systemic involvement and poor prognosis. Understanding its characteristics and outcomes is essential for patient management. OBJECTIVE: To describe the clinical features, management, and prognosis of different CV types in patients with Sjögren disease. DESIGN, SETTING, AND PARTICIPANTS: This retrospective multicenter cohort study included patients with Sjögren disease and CV from pathology departments of 3 university hospitals in Paris, France (2011-2021), and a nation…

Retinal vasculitis following intravitreal pegcetacoplan administration.

PURPOSE: To describe a case of retinal vaso-occlusive vasculitis with associated lid edema and conjunctivitis following intravitreal pegcetacoplan administration in a patient with geographic atrophy (GA). OBSERVATION: A 78 year old Caucasian woman presented with complaints of lid edema, conjunctival injection, loss of vision, and mild ocular discomfort eleven days after receiving an intravitreal pegcetacoplan injection in the left eye for geographic atrophy. Visual acuity on presentation was decreased to 20/400 from 20/200 previously in that eye. Eyelid edema and conjunctival injection were p…

Severe infections in systemic necrotizing vasculitis.

UNLABELLED: Infections in patients with systemic vasculitis represent one of the main causes of mortality. Corticosteroid use, immunosuppressive therapy, age, associated organic involvement and dialysis dependence are risk factors of infection. OBJECTIVES: To determine the prevalence of severe infection and associated factors in patients diagnosed with ANCA-associated vasculitis (AAV) and Polyarteritis Nodosa (PAN). METHODS: retrospective study was conduced in a single rheumatology center (2000-2018). We included patients diagnosed with AAV (Granulomatosis with Polyangiitis (GPA), Eosinophil…

IgA vasculitis following COVID-19 vaccination.

Immunoglobulin A (IgA) vasculitis is generally triggered by infectious causes, but it has also been reported after immunisation with various vaccines. Herein, we report two cases of IgA vasculitis after receiving the first or second dose of the Pfizer-BioNTech BNT16B2b2 mRNA vaccine. Two men, aged 22 and 30 years, developed palpable purpura on the extremities and arthritis. One patient also complained of fever and gastrointestinal symptoms. Laboratory findings revealed mild leucocytosis and slightly elevated C-reactive protein levels, although the platelet count and coagulation profile were wi…

Molecular imaging of large vessel vasculitis.

Large vessel vasculitis (LVV) affects mainly large arteries with giant cell arteritis (GCA) and Takayasu arteritis (TAK) being the two most frequent forms. Clinical symptoms can be non-specific, including headache, fatigue, weight loss, and change in vision. Untreated, LVV may also lead to serious complications such as blindness, aortic aneurysm and dissection. Therefore, rapid recognition of the disease leading to accurate diagnosis and appropriate treatment is essential. FDG-PET/CT imaging has emerged as a sensitive marker of active vascular inflammation and its use in the management of LVV …