Результаты поиска

Platypnea-orthodeoxia syndrome (POS) in a patient who had undergone partial liver resection.

A South Asian male in his early 60s presented with acute-onset dyspnoea on postoperative day 4 after undergoing middle hepatic vein sacrificing partial liver resection for epithelioid angiomyolipoma. The patient's SpO2 on presentation was 65% in standing position which improved to 90% in left lateral decubitus. He was suspected of having platypnea-orthodeoxia syndrome (POS) which was confirmed on echocardiogram with microbubble contrast showing a large intracardiac right-to-left shunt. The patient was taken up for transcatheter closure of patent foramen ovale (PFO). A 30 mm Amplatzer PFO Occlu

Low-cost fluorescence microscope with microfluidic device fabrication for optofluidic applications.

Optofluidic devices have revolutionized the manipulation and transportation of fluid at smaller length scales ranging from micrometers to millimeters. We describe a dedicated optical setup for studying laser-induced cavitation inside a microchannel. In a typical experiment, we use a tightly focused laser beam to locally evaporate the solution laced with a dye resulting in the formation of a microbubble. The evolving bubble interface is tracked using high-speed microscopy and digital image analysis. Furthermore, we extend this system to analyze fluid flow through fluorescence-Particle Image Vel

Confirmation of endovenous placement of central catheter using the ultrasonographic "bubble test".

Insertion of central venous catheter (CVC) is the most common procedure to be performed in Intensive Care Units. Addition of ultrasonographic guidance to this procedure, which was initially performed blindly, has improved safety of this procedure. Confirmation of endovenous placement of CVC though, is tricky, as methods for confirmation are either operator dependent, time-consuming or not available at bedside. Prospective observational study was carried out to study feasibility of use of sonobubble test to confirm the presence of CVC within central vein. After insertion of CVC in the internal

Scalable Synthesis of Calcium Fluoride Nanoparticles as a Novel Ultrasound Contrast Agent for Imaging Tumor Targeted Delivery of Therapeutics.

Ultrasound (US) imaging is one of the most widely used noninvasive diagnostic techniques in clinical practice due to its safety, real-time c … s at 1 h postinjection, with contrast persisting up to 5 h, dramatically outperforming conventional microbubbles that typically dissipate within 10 min. Biosafety analyses confirmed excellent hemocompatibility and no detectable organ toxicity. To the best of our knowledge, this is the first report of CaF2 NPs functioning as a US contrast agent for in vivo tumo …

Multi-Parametric Super-Resolution Ultrasound for Evaluating Breast Cancer Characteristics: Improved Diagnostic Performance Over Contrast-Enhanced Ultrasound.

OBJECTIVE: To investigate the diagnostic superiority of super-resolution ultrasound (SRUS) imaging over conventional contrast-enhanced ultrasound (CEUS) in differentiating breast masses, and to evaluate its clinical potential as a non-invasive tool for predicting histological grade, molecular subtypes and immune microenvironment characteristics. METHODS: A prospective cohort of 84 patients (25 benign, 59 malignant) underwent pre-biopsy assessments of CEUS and SRUS parameters. CEUS evaluated qualitative features (shape after enhancement, feeding vessel) and quantitative indices (area under the

Blood product resuscitation mitigates the effects of aeromedical evacuation after polytrauma.

BACKGROUND: The combined injury of traumatic brain injury and hemorrhagic shock has been shown to worsen coagulopathy and systemic inflammat … on, tissue oxygenation, and intracranial pressure were unchanged among the six study groups. Venous microbubbles were not observed even with differing altitude or resuscitation strategy. Serum lactate levels from hour 2 of flight to the end of observation were significantly elevated in 22,000 + LR compared with 8,000 + LR and 22,000 + WB. Serum IL-6 levels wer …

Ultrasound-responsive and size-transformable self-carrier nanodroplets for augmented deep vein thrombosis therapy.

Deep vein thrombosis (DVT) treatment remains challenging due to the limited efficacy of conventional thrombolytic agents and the short half- … d irradiation triggers PFP vaporization, driving nanodroplet expansion from nanoscale dimensions to microbubbles that subsequently collapse, mechanically disrupting the fibrin-rich thrombus matrix while enhancing drug penetration depth. Importantly, LMWH-LA fragmentations reassemble into secondary nanoparticles, thereby prolonging the duration of anticoagulant …

Сфокусированные ультразвуки как Adeno-Associated Virus Gene Terrapy-Empowering Tool в несовершеннолетних мышах через Intracrebroventric Administration.

Системная доставка переносчиков адено-вирусных (AAV) вирусов, направленных на центральную нервную систему, способна устранить многие нейронные расстройства, однако это затрудняется эффектом фильтрации мозгового барьера в крови и системными осложнениями. Для того чтобы преодолеть это ограничение, мы попытались ввести в желудок вирусный вектор, выражающий Венеру, олигодендроцитно-селективный AAV9, вместе с липидными микробублями и подвергнуть их фокусированному ультразвуку (FUS); полученная в результате этого механическая стимуляция на желудках головного мозга позволяет открыть небольшие временн

Совпадение в аннотации оригинала
Systemic delivery of adeno-associated virus (AAV) vectors targeting the central nervous system has the potential to solve many neurodevelopm … Venus-expressing, oligodendrocyte-selective AAV9 viral vector in the ventricles together with lipid microbubbles and subjected them to focused ultrasound (FUS); the resulting mechanical stimulation on the brain ventricles is able to open small, temporary gaps from which vector particles can leak and spread. Our findings indicate that FUS can increase viral vec …

Intraarterial Transplantation of Mitochondria After Ischemic Stroke Reduces Cerebral Infarction.

BACKGROUND-: Transplantation of autologous mitochondria into ischemic tissue may mitigate injury caused by ischemia and reperfusion. METHODS-: Using murine stroke models of middle cerebral artery occlusion, we sought to evaluate feasibility of delivery of viable mitochondria to ischemic brain parenchyma. We evaluated the effects of concurrent focused ultrasound activation of microbubbles, which serves to open the blood-brain barrier, on efficacy of delivery of mitochondria. RESULTS-: Following intra-arterial delivery, mitochondria distribute through the stroked hemisphere and integrate into …

Cardiac allograft vasculopathy diagnosed by vasodilator myocardial contrast echocardiography perfusion imaging.

Cardiac allograft vasculopathy (CAV) remains a common long-term complication of cardiac transplantation. While invasive coronary angiography … lance. MCE at rest and after regadenason was performed using a continuous infusion of lipid-shelled microbubbles. We describe a case of normal microvascular function, diffuse microvascular dysfunction, patchy sub-endocardial perfusion defects and a focal sub-endocardial perfusion defect. Cardiac allograft vasculopathy can be heralded by several different perfu …

A review of potential applications of MR-guided focused ultrasound for targeting brain tumor therapy.

Magnetic resonance-guided focused ultrasound (MRgFUS) has been used extensively to ablate brain tissue in movement disorders, such as essent … mic drug delivery increases median survival times and delays tumor progression. Liposomes, modified microbubbles, and magnetic nanoparticles, combined with MRgFUS, more effectively deliver chemotherapy to brain tumors. MRgFUS has great potential to enhance brain tumor drug delivery, while limiting treatment toxicity to the healthy brain.

Recent advances in renal imaging.

Kidney diseases can be caused by a wide range of genetic, hemodynamic, toxic, infectious, and autoimmune factors. The diagnosis of kidney di … ndent (BOLD) MRI, allow functional imaging of the kidney. The use of novel contrast agents, such as microbubbles and nanoparticles, allows the detection of specific molecules in the kidney. These methods could greatly advance our ability to diagnose disease and also to safely monitor patients over time. This could improve the care of individual patients, and i …

Antidepressant effects of focused ultrasound induced blood-brain-barrier opening.

In many cases, hippocampal neurogenesis appears to be a hallmark of antidepressant treatments. One novel technique for inducing this type of neurogenesis is using focused ultrasound waves, in conjunction with circulating microbubbles, to open the blood-brain-barrier. The present experiment aimed to test whether this technique has antidepressant effects in a rodent model. Rats were subjected to 1, 2 or 3 weekly treatments of magnetic resonance-guided focused ultrasound in order to open the blood-brain-barrier in the hippocampal region. Before and after treatments, animals went through modified …

Tuning the Mechanical Properties of Recombinant Protein-Stabilized Gas Bubbles Using Triblock Copolymers.

Gas bubbles enhance contrast in ultrasound sonography and can also carry and deliver therapeutic agents. The mechanical properties of the bu … e our method of using a mixture of PEO-PPO-PEO and oleosin can potentially lead to the formation of microbubbles with stabilizing shells that can be functionalized and tailored for specific applications in ultrasound imaging and therapy.

High-Accuracy Ultrasound Contrast Agent Detection Method for Diagnostic Ultrasound Imaging Systems.

An accurate method for detecting contrast agents using diagnostic ultrasound imaging systems is proposed. Contrast agents, such as microbubbles, passing through a blood vessel during ultrasound imaging are detected as blinking signals in the temporal axis, because their intensity value is constantly in motion. Ultrasound contrast agents are detected by evaluating the intensity variation of a pixel in the temporal axis. Conventional methods are based on simple subtraction of ultrasound images to detect ultrasound contrast agents. Even if the subject moves only slightly, a conventional detection…

Acoustic accessibility investigation for ultrasound mediated treatment of glycogen storage disease type Ia patients.

Glycogen storage disease type Ia (GSDIa) is caused by an inherited defect in the glucose-6-phosphatase gene. The recent advent of targeted ultrasound-mediated delivery (USMD) of plasmid DNA (pDNA) to the liver in conjunction with microbubbles may provide an alternative treatment option. This study focuses on determining the acoustically accessible liver volume in GSDIa patients using transducer models of various geometries with an image-based geometry-driven approach. Results show that transducers with longer focal lengths and smaller apertures (up to an f/number of 2) are able to access large…

Patent foramen ovale in trigeminal autonomic cephalalgias and hemicrania continua: a non-specific pathophysiological occurrence?

Patent foramen ovale (PFO), a relatively common abnormality in adults, has been associated with migraine. Few studies also linked PFO with cluster headache (CH). To verify whether right-to-left shunt (RLS) is related to headaches other than migraine and CH, we used transcranial Doppler following microbubbles injection to detect shunts in 24 CH, 7 paroxysmal hemicrania (PH), one SUNCT, two hemicrania continua (HC) patients; and 34 matched controls. RLS was significantly more frequent in CH than in controls (54% vs. 25%, p=0.03), particularly above the age of 50. In the HC+PH+SUNCT group, RLS wa…

Versatile horizontal force probe for mechanical tests on pipette-held cells, particles, and membrane capsules.

We present a multipurpose nanomechanical force probe that combines a sideways-mounted elastic cantilever and an optical-lever detection modu … igonucleotide stretching, and extraction of individual lipids from surfactant-monolayer surfaces of microbubbles.

[Absent right superior vena cava with left superior vena cava draining to an unroofed coronary sinus].

We describe the case of a 1-month-old infant with a complete atrioventricular septal defect with right dominance, situs solitus, and drainag … injection of a small volume of stirred saline into an epicranial vein demonstrated the presence of microbubbles in the left cardiac cavities. A second operation was performed to prevent drainage from the left superior vena cava to the left atrium (via the unroofed coronary sinus) and to insert a PTFE conduit between the innominate vein and the right atrial ap …

Ultrasound contrast agents: clinical applications.

Ultrasound contrast agents (USCA) for intravenous injections are usually gas-filled microbubbles with a mean diameter less than that of a red blood corpuscle. There are only a few products on the market at the time of this writing, but several companies have various agents under development. This paper covers both established USCA on the market, and some new agents under clinical evaluation. The potential of improving ultrasound imaging using USCA depends on several factors. These factors include the pharmacokinetic and pharmacodynamic properties of the products, which determine the effects th…