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Development of a Person-Centred Coordinated Care Pathway in Swedish Healthcare for Low Back Pain.

INTRODUCTION: This project aimed to develop a Person-Centred Co-ordinated Care (P3C) pathway for low back pain (LBP). DESCRIPTION: A national working group was formed consisting of representatives from all regional healthcare organisations in Sweden and included all relevant healthcare professions, academia, and patient organisations. A mixed method iterative design and consensus approach was applied in the development of the P3C pathway. DISCUSSION: As a foundation, patient interviews along with a review of literature were conducted investigating the evidence base for healthcare interventio…

Heart over head? A selective review of a career in research.

This paper supports the award of the 2024 H. Barry Collin Research medal and gives an overview of my pathway through a research career. Firs … for assessing dry eye. In conclusion, my career has benefitted from interaction with colleagues in academia, industry and clinical practice, as well as with my fantastic students, both past and present.

От гладких мозгов до скалистых гор: Квентин Питтман в карьере в Канаде.

Цель настоящего комментария состоит в том, чтобы почтить память д-ра Квентина Питтмана, который отступает от активной роли в научных кругах. Работа Питтмана оставляет наследие новых открытий, безупречных исследований и щедрых наставников. Его работа по терморегулированию, вазопрессину, перинатальному программированию и гипоталамической функции заложила значительную часть основы психонейроиммунологических исследований, которые мы проводим сегодня. Его интерес к нейроинфламмации привел к важным открытиям в животных моделях хронического периферического воспаления, включая колит и центральные подс

Совпадение в аннотации оригинала
This commentary is to honour Dr Quentin Pittman as he steps back from an active role in academia. Pittman's work leaves a legacy of ground-breaking discoveries, impeccable research, and generous mentorship. His work on thermoregulation, vasopressin, perinatal programming, and hypothalamic function laid a good part of the foundation of the psychoneuroimmunolo…

Lewy body dementia: Overcoming barriers and identifying solutions.

Despite its high prevalence among dementias, Lewy body dementia (LBD) remains poorly understood with a limited, albeit growing, evidence bas … gaps and creates the framework for collaboration in that endeavor. HIGHLIGHTS: A group representing academia, government, industry, and consulting expertise was convened to discuss current progress in Dementia with Lewy Body care and research. Consideration of expert opinion,natural language processing of the literature as well as publicly available data b …

Lessons learned from the risk-informed urban development initiative in the SADC region.

UNLABELLED: This study presents the systemisation of lessons learned from the urban sector in which the measures based on the guiding princi … ers. About 14 SADC member states and 26 cities represented by city officials, local governments and academia participated in this process. Results along the risk-based decision frameworks lead to a clustering of recurring topics during the peer-to-peer exchange, which are presented along legal and organisational setups; budget and funding; risk assessment …

Conversion of Lignin to Nitrogenous Chemicals and Functional Materials.

Lignin has long been regarded as waste, readily separated and discarded from the pulp and paper industry. However, as the most abundant aromatic renewable biopolymer in nature, lignin can replace petroleum resources to prepare chemicals containing benzene rings. Therefore, the high-value transformation of lignin has attracted the interest of both academia and industry. Nitrogen-containing compounds and functionalized materials are a class of compounds that have wide applications in chemistry, materials science, energy storage, and other fields. Converting lignin into nitrogenous chemicals and …

A patent review of lactate dehydrogenase inhibitors (2014-present).

INTRODUCTION: Lactate dehydrogenase (LDH) is a key enzyme in glycolysis responsible for the conversion of pyruvate into lactate and vice ver … reventing human pathologies, but also for treating animal diseases. The published patents from both academia and the pharmaceutical industry highlight the persistent high interest of the scientific community in developing efficient LDH inhibitors.

Institutional disparities in the distribution of the American Society of Clinical Oncology grants.

BACKGROUND: Disparities in academia are increasingly recognized, but what has historically been underrecognized is the cancer institutional disparities in the distribution of grants. We sought to characterize grants awarded by the American Society of Clinical Oncology (ASCO) ove the last 38 year with focus on grants awarded for career development and professional growth. METHODS: We used ASCO online database that contains grant and award recipients (1984-December 2021). We included all grants that were awarded for more than one year with $10,000 or more in annual funds. RESULTS: More than a …

Targeting Human Proteins for Antiviral Drug Discovery and Repurposing Efforts: A Focus on Protein Kinases.

Despite the great technological and medical advances in fighting viral diseases, new therapies for most of them are still lacking, and existing antivirals suffer from major limitations regarding drug resistance and a limited spectrum of activity. In fact, most approved antivirals are directly acting antiviral (DAA) drugs, which interfere with viral proteins and confer great selectivity towards their viral targets but suffer from resistance and limited spectrum. Nowadays, host-targeted antivirals (HTAs) are on the rise, in the drug discovery and development pipelines, in academia and in the pha…

A causal roadmap for generating high-quality real-world evidence.

Increasing emphasis on the use of real-world evidence (RWE) to support clinical policy and regulatory decision-making has led to a proliferation of guidance, advice, and frameworks from regulatory agencies, academia, professional societies, and industry. A broad spectrum of studies use real-world data (RWD) to produce RWE, ranging from randomized trials with outcomes assessed using RWD to fully observational studies. Yet, many proposals for generating RWE lack sufficient detail, and many analyses of RWD suffer from implausible assumptions, other methodological flaws, or inappropriate interpret…

Palmprint recognition based on gating mechanism and adaptive feature fusion.

As a type of biometric recognition, palmprint recognition uses unique discriminative features on the palm of a person to identify his/her identity. It has attracted much attention because of its advantages of contactlessness, stability, and security. Recently, many palmprint recognition methods based on convolutional neural networks (CNN) have been proposed in academia. Convolutional neural networks are limited by the size of the convolutional kernel and lack the ability to extract global information of palmprints. This paper proposes a framework based on the integration of CNN and Transformer…

Omnidirectional Printing of PEDOT:PSS for High-Conductivity Spanning Structures.

Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), a prominent conducting polymer, holds significance in both industry and academia. However, prevailing fabrication techniques struggle to build spanning features of PEDOT:PSS with both high electrical conductivity and fine resolution due to layerwise assembly in the xy plane. Here, we report an "omnidirectional printing and secondary doping" strategy to construct spanning, filamentary and out-of-plane 3D PEDOT:PSS with high conductivity. The pristine PEDOT:PSS suspension is homogeneously concentrated to form a printable ink wi…

Bonding wood with uncondensed lignins as adhesives.

Plywood is widely used in construction, such as for flooring and interior walls, as well as in the manufacture of household items such as furniture and cabinets. Such items are made of wood veneers that are bonded together with adhesives such as urea-formaldehyde and phenol-formaldehyde resins1,2. Researchers in academia and industry have long aimed to synthesize lignin-phenol-formaldehyde resin adhesives using biomass-derived lignin, a phenolic polymer that can be used to substitute the petroleum-derived phenol3-6. However, lignin-phenol-formaldehyde resin adhesives are less attractive to ply…

Metabolic Disorders among Children Presenting with Acute Encephalopathy.

OBJECTIVE: To study the clinicoetiological profile of children presenting with acute noninfectious encephalopathy (NIE) and identify the pro … with female preponderance. The IEMs included lactic acidosis (4), glutaric aciduria (3), isovaleric academia (1), and hyperhomocysteinemia (1). History of previously affected siblings and consanguinity between the parents were important indicators of IEM. MS/MS and mutation analysis were the mainstay of diagnosis in these patients. IEMs contributed to the …

MAC Protocols for mmWave Communication: A Comparative Survey.

With the increase in the number of connected devices, to facilitate more users with high-speed transfer rate and enormous bandwidth, millimeter-wave (mmWave) technology has become one of the promising research sectors in both industry and academia. Owing to the advancements in 5G communication, traditional physical (PHY) layer-based solutions are becoming obsolete. Resource allocation, interference management, anti-blockage, and deafness are crucial problems needing resolution for designing modern mmWave communication network architectures. Consequently, comparatively new approaches such as me…

Muscarinic Acetylcholine Receptor Agonists as Novel Treatments for Schizophrenia.

Schizophrenia remains a challenging disease to treat effectively with current antipsychotic medications due to their limited efficacy across … chronic schizophrenia. These unexpected clinical findings have prompted considerable efforts across academia and industry to target mAChRs as a new approach to potentially treat schizophrenia and other psychotic disorders. The authors discuss recent advances in mAChR biology and pharmacology and the current understanding of the relative roles of the variou …

Why we dehumanize illegal immigrants: A US mixed-methods study.

Dehumanization is a topic of significant interest for academia and society at large. Empirical studies often have people rate the evolved nature of outgroups and prior work suggests immigrants are common victims of less-than-human treatment. Despite existing work that suggests who dehumanizes particular outgroups and who is often dehumanized, the extant literature knows less about why people dehumanize outgroups such as immigrants. The current work takes up this opportunity by examining why people dehumanize immigrants said to be illegal and how measurement format affects dehumanization rating…

Antimicrobial Resistance in Neisseria gonorrhoeae: Proceedings of the STAR Sexually Transmitted Infection-Clinical Trial Group Programmatic Meeting.

The goal of the Sexually Transmitted Infection Clinical Trial Group's Antimicrobial Resistance (AMR) in Neisseria gonorrhoeae (NG) meeting was to assemble experts from academia, government, nonprofit and industry to discuss the current state of research, gaps and challenges in research and technology and priorities and new directions to address the continued emergence of multidrug-resistant NG infections. Topics discussed at the meeting, which will be the focus of this article, include AMR NG global surveillance initiatives, the use of whole genome sequencing and bioinformatics to understand m…

Amorphous Flowerlike Goethite FeOOH Hierarchical Supraparticles: Superior Capability for Catalytic Hydrogenation of Nitroaromatics in Water.

Fabrication of anilines from the corresponding nitroaromatics is a hot topic both for academia and for industry; however, conducting this protocol in water over a noble-metal-free catalytic system is still a great challenge. Continuous efforts are being made on exploiting novel catalysts for this transformation. In this work, we developed a scalable method for synthesizing the uniform flowerlike amorphous α-FeOOH hierarchical supraparticles. The well-defined amorphous α-FeOOH was prepared through an environmentally benign method, which is hydrolysis of the self-assembled iron glycolate at room…

Computational Structural Pharmacology and Toxicology of Voltage-Gated Sodium Channels.

Voltage-gated sodium channels are targets for many toxins and medically important drugs. Despite decades of intensive studies in industry and academia, atomic mechanisms of action are still not completely understood. The major cause is a lack of high-resolution structures of eukaryotic channels and their complexes with ligands. In these circumstances a useful approach is homology modeling that employs as templates X-ray structures of potassium channels and prokaryotic sodium channels. On one hand, due to inherent limitations of this approach, results should be treated with caution. In particul…