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Current and Emerging Therapy for Malignant Pleural Mesothelioma: Focus on CD26/Dipeptidyl Peptidase IV as a Therapeutic Target

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… In addition, the short 6 amino acid cytoplasmic region of CD26 plays a crucial role in MPM migration and invasion through upregulation of periostin [ 95 ]. … Through this mechanism, periostin production is increased, associated with an enhancement in the migratory potential and invasiveness of MPM, contributing to both progression of disease and metastases. …

Resolving the Complexity: A Comprehensive Review on Carbon Monoxide Diffusion Capacity in Chronic Obstructive Pulmonary Disease Patients.

This review comprehensively examines the intricate relationship between carbon monoxide (CO) diffusion capacity and chronic obstructive pulmonary disease (COPD). COPD, comprising chronic bronchitis and emphysema, presents a substantial global health burden, necessitating a nuanced understanding of pulmonary function parameters for effective diagnosis and management. The review delves into the physiological underpinnings, measurement techniques, and factors influencing CO diffusion capacity, emphasizing its pivotal role in assessing alveolar gas exchange efficiency. Key findings elucidate corre

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… Similarly, the biomarker periostin displayed higher levels in individuals with altered lung diffusion (1.11±0.07 vs 0.84±0.40, p=0.001) [ 40 ]. … These findings underscore the potential utility of MMP-7, periostin, D-dimer, gender, age, and peak RALE score as predictors or indicators of DLCO impairment. …

Отрицательное отношение к пневмониту и периферальной гипереосинофилии: Case Report and Literic Review.

Мы сообщаем о редком случае ретроактивности пневмонита и периферической гиперэосинофилии, вызванной натурализумабами, что является уникальным подтверждением соблюдения принципа повторной экспозиции, изложенного в шкале вероятности обратной реакции на наркотики Наранджо. 57-летняя самка с множественным склерозом, излучающим релапс и имеющим острые респираторные симптомы, эозинофилия 2,08 х 109/л, и вычисленная грудная клетка показывает консолидацию правой верхней и нижней долей. Ее септический и аутоиммунный анализ был отрицательным. Ей не удалось улучшиться с помощью широких спектральных антиб

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… Other factors implicated in the pathological process include IL‐33, vascular endothelial growth factor (VEGF), leukotriene B4, and periostin [ 6 ]. TABLE 1 Summary of reported cases of natalizumab‐induced pneumonitis with peripheral hypereosinophilia. …

Update on the role of bone turnover markers in the diagnosis and management of osteoporosis: a consensus paper from The European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO), International Osteoporosis Foundation (IOF), and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC).

PurposeThe International Osteoporosis Foundation (IOF) and the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) have proposed procollagen type I N propeptide (PINP) and β isomerized C-terminal telopeptide of type I collagen (β-CTX-I) as reference bone turnover markers (BTMs) for osteoporosis. This report examines the published literature since the 2011 IOF-IFCC position paper in order to determine the clinical potential of the reference BTMs and newer markers for the prediction of fracture risk and monitoring the treatment of osteoporosis.MethodsEvidence for the re

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… Periostin is a secreted carboxyglutamic acid-containing protein expressed mainly in the periosteum of adult individuals. Higher serum levels were predictive of incident fracture in postmenopausal women from the OFELY cohort [ 272 ]. … Cathepsin K-derived periostin was also a significant predictor of incident fracture in a cohort of postmenopausal women from Switzerland [ 273 ]. …

Update on preclinical models of cancer therapy-related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio-Oncology, and the ESC Working Group on Cellular Biology of the Heart.

New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the implementation of effective treatments. Therefore, there is a crucial need for appropriate preclinical models to understand the biological basis of their cardiotoxicity. This scientific statement summarizes the preclinical models hitherto used, from in

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… ; Postn −/− , periostin knockout; SBP, systolic blood pressure; s.c., subcutaneous; SerpinA3, serine protease inhibitor A3; SerpinE1, serine protease inhibitor E1; TAC, transverse aortic constriction; WT, wild‐type. … Remodelling factors that have been suggested as mediators of the tumour‐supporting effect of HF include serpinA3, periostin, nerve growth factor, connective tissue growth factor, fibronectin, and inflammatory cytokines. 112 , 113 , 114 , 115 , 117 , 120 , 121 Myocardial infarction (MI)‐induced epigenetic …

Dental extraction following zoledronate, induces osteonecrosis in rat's jaw.

Sarcoptic mange is a parasitic contagious disease that can lead to significant declines in wildlife populations. To identify the most used methods for diagnosing mange in free-ranging wildlife species, a systematic review was conducted across multiple databases: Scopus, PubMed, Web of Science, ProQuest Central and CABI. Citation screening was performed using the web-based platform, Covidence. A customized data extraction form, developed by the authors, was used to collect relevant information. This information was later exported and analyzed using Microsoft Excel. The objectives of this system

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… Zoledronate effects on systemic and jaw osteopenias in ovariectomized periostin-deficient mice. PLoS One. 2013;8:e58726. doi: 10.1371/journal.pone.0058726. 16. de Molon RS, Cheong S, Bezouglaia O, Dry SM, Pirih F, Cirelli JA. …

Keyword Index for Volume 95

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… , 496, 627 p53 mutation 1701 p53 target gene 1701 p75NTR 322 paclitaxel 159, 601, 729, 1005, 1642 palliative care 593, 966 pancreatic cancer 260, 307, 587 PATCHED 548 pathologic tumour-node-metastasis (pTNM) stage 1050 paxoral 794 PBSC 1326 PEA3 1404 pemetrexed 677 perceived needs 667 periostin …

Development of an Initial Conceptual Model of Multiple Myeloma to Support Clinical and Health Economics Decision Making.

Background. We aimed to develop and validate a conceptual model of multiple myeloma (MM) that characterizes the attributes affecting disease progression and patient outcomes, and the relationships between them. Methods. Systematic and targeted literature reviews identified disease- and patient-specific attributes of MM that affect disease progression and outcomes. These attributes were validated by a Delphi panel of four international MM experts, and a physician-validated model was constructed. Real-world clinical data from the Czech Registry of Monoclonal Gammopathies (RMG) was used to confir

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… Circulating periostin is elevated in patients with multiple myeloma and correlates with advanced disease features and high bone resorption. Blood. 2011;118(21):3922.21841164 127. Sampaio MS, Vettore AL, Yamamoto M, Chauffaille Mde L, Zago MA, Colleoni GW. … High levels of periostin in patients with multiple myeloma correlate with low bone formation, increased fracture rate and diffuse MRI pattern: implications into the biology of myeloma bone disease. Blood. 2012;120(21):3967. 133. Terpos E, Tasidou A, Roussou M, et al. …

Myeloma Bone Disease: The Osteoblast in the Spotlight.

Lytic bone disease remains a life-altering complication of multiple myeloma, with up to 90% of sufferers experiencing skeletal events at some point in their cancer journey. This tumour-induced bone disease is driven by an upregulation of bone resorption (via increased osteoclast (OC) activity) and a downregulation of bone formation (via reduced osteoblast (OB) activity), leading to phenotypic osteolysis. Treatments are limited, and currently exclusively target OCs. Despite existing bone targeting therapies, patients successfully achieving remission from their cancer can still be left with chro

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… Periostin, a cell-adhesion protein, also inhibits Wnt pathways, with elevated levels in MM associated with osteolysis [ 73 ]. … High levels of periostin correlate with increased fracture rate, diffuse MRI pattern, abnormal bone remodeling and advanced disease stage in patients with newly diagnosed symptomatic multiple myeloma. Blood Cancer J. 2016;6:e482. doi: 10.1038/bcj.2016.90. 74. …

Alternative Splicing: A Critical Regulator in Human Bone Biology and Tumor Progression.

Alternative splicing (AS) is the central mechanism of transcriptional regulation and generates diverse splice variants that influence protein structure, function, and intracellular activity. AS plays critical roles in tissue differentiation, organ development, and disease progression. This review focuses on the pivotal roles of AS in bone biology, highlighting its regulatory effects on osteoblasts, osteoclasts, chondrocytes, bone matrix remodeling, and bone remodeling, as well as the involvement of AS-related RNA-binding proteins in these processes. We also emphasize bone-specific AS events an

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… In addition, Periostin-4, an AS variant of Periostin lacking exons 17 and 21, has been identified as the predominantly expressed isoform in primary human osteoblasts. … Functionally, Periostin-4 acts as an extracellular signal integrator that substantially promotes osteoblast differentiation and mineralization in vivo [ 131 ]. To date, only a single transcript has been identified for OPG, and no AS variants have been reported. …

Program-Abstracts

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Anti-interleukin-13 and anti-interleukin-4 agents versus placebo, anti-interleukin-5 or anti-immunoglobulin-E agents, for people with asthma.

BACKGROUND: Targeting the immunoglobulin E pathway and the interleukin-5 pathway with specific monoclonal antibodies directed against the cy … ts with higher levels of inflammatory biomarkers (blood eosinophils, exhaled nitric oxide and serum periostin). AUTHORS' CONCLUSIONS: Based on the totality of the evidence, compared with placebo, anti-interleukin-13/-4 agents are probably associated with a reduction in exacerbations requiring hospitalisation or ED visit, at the cost of increased adverse ev …

EP300 as a Molecular Integrator of Fibrotic Transcriptional Programs.

Fibrosis is a condition characterized by the excessive accumulation of extracellular matrix proteins in tissues, leading to organ dysfunction and failure. Recent studies have identified EP300, a histone acetyltransferase, as a crucial regulator of the epigenetic changes that contribute to fibrosis. In fact, EP300-mediated acetylation of histones alters global chromatin structure and gene expression, promoting the development and progression of fibrosis. Here, we review the role of EP300-mediated epigenetic regulation in multi-organ fibrosis and its potential as a therapeutic target. We discuss

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… . | Decreasing levels of TGFβ1-induced αSMA and fibrosis markers COL1A, CTGF, fibronectin (FN), TNC, and periostin. … It was found that A6 treatment significantly reduced tissue pathological hallmarks of liver fibrosis as well as ameliorated the TGFβ1-induced increase in fibrotic proteins COL1A, CTGF, FN, TNC, and periostin. …

Conference Proceedings - 6th International Conference on Molecular Diagnostics and Biomarker Discovery (MDBD 2022): Building Resilience in Biomedical Research : Penang, Malaysia. 11-13 October 2022.

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Decoding the mechanisms underlying breast cancer brain metastasis: paving the way for precision therapeutics.

The development of brain metastasis is a major cause of significantly reduced survival in breast cancer patients. The initiation and progression of breast cancer brain metastasis (BCBM) involve multiple distinct molecular pathways and reprogramming of the tumor microenvironment (TME). This review systematically summarizes key mechanisms underlying BCBM, including epithelial-mesenchymal transition (EMT), extracellular matrix (ECM) remodeling, and the spatiotemporal dynamics of metabolic reprogramming regulated by critical signaling pathways during brain colonization. In particular, we highlight

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… Within the BCBM microenvironment, periostin (POSTN) is produced by POSTN-positive CAFs and promotes cancer cell proliferation by positively regulating the HGF-MET signaling pathway [ 191 ]. … Clinical cohorts Low–moderate (needs external validation) [ 200 ] Periostin (POSTN) Serum Prediction of distant metastasis Secreted by CAFs; elevated levels associated with distant metastasis. AUC≈0.78, comparable to CA153. …

CS-6-induced p62 accumulation exacerbates DNA damage in colorectal cancer.

BACKGROUND: Gamabufotalin (CS-6), a bufadienolide derived from Chansu, has been reported to exhibit anti-tumor effects in various cancers, including glioblastoma, nonsmall cell lung cancer, and breast cancer. However,its role in colorectal cancer (CRC) remains unexplored. OBJECTIVE: Our study aimed to evaluate the inhibition of CS-6 to CRC cells by cell viability assay, colony formation assay, comet assay, and cell cycle analysis firstly. And its molecular mechanism was studied by immunofluorescence (IF) assay, western blot (WB) assay, siRNA transfection, protein-protein interaction (PPI) net

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… Gamabufotalin suppressed osteosarcoma stem cells through the TGF-β/periostin/PI3K/AKT pathway . Chem. Biol. Interact. 331 , 109275 . 10.1016/j.cbi.2020.109275 33010222 Morazán-Fernández D. Mora J. Molina-Mora J. A. ( 2022 ). …

Elucidation of molecular basis of osteolytic bone lesions in advanced multiple myeloma.

Osteolytic bone lesion is a major cause of lower quality of life and poor prognosis in patients with multiple myeloma (MM), but molecular pathogenesis of the osteolytic process in MM remains elusive. Fms-like tyrosine kinase 3 ligand (FLT3L) was reported to be elevated in bone marrow (BM) and blood of patients with advanced MM who often show osteolysis. Here, we investigated a functional link of FLT3L to osteolytic process in MM. We recruited 86, 306, and 52 patients with MM, acute myeloid leukemia (AML), and acute lymphoblastic leukemia (ALL), respectively. FLT3L levels of patients with hemat

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… Cathepsin K controls cortical bone formation by degrading periostin. J Bone Miner Res. 2017;32(7):1432-1441. 38. Zhu B, Xue F, Li G, Zhang C. CRYAB promotes osteogenic differentiation of human bone marrow stem cells via stabilizing β-catenin and promoting the Wnt signalling. …

LncRNA OIP5‑AS1 aggravates house dust mite‑induced inflammatory responses in human bronchial epithelial cells via the miR‑143‑3p/HMGB1 axis.

Bronchial asthma poses a serious threat to human health. Previous studies have documented the role of long non‑coding RNAs (lncRNAs) in asthma. However, the molecular mechanism underlying bronchial asthma remains unclear. The aim of the present study was to evaluate the role of the lncRNA Opa‑interacting protein 5 antisense RNA1 (OIP5‑AS1) in the house dust mite‑induced inflammatory response in human bronchial epithelial cells. BEAS‑2B cells were treated with Dermatophagoides pteronyssinus peptidase 1 (Der p1) to establish an in vitro model of asthma. OIP5‑AS1 expression levels increased in BE

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… Recent developments regarding periostin in bronchial asthma. Allergol Int. 2015;64(Suppl):S3–S10. doi: 10.1016/j.alit.2015.04.012. 3. Alam S, Li Z, Mahadeva R. S86 Formation of Oxidised Alpha-1 antitrypsin induces inflammatory response in human bronchial epithelial cells. …

Mesenchymal Stromal Cells: Bridging the Gaps in Hematologic Disease Therapy.

Mesenchymal stromal cells (MSCs) have demonstrated therapeutic potential in hematologic diseases by modulating immune responses, supporting hematopoiesis, and remodeling the bone marrow microenvironment. Clinically, MSCs have been explored for graft-versus-host disease and hematopoietic stem cell transplantation support, while their applications in hematologic malignancies, including acute myeloid leukemia, multiple myeloma, and myelodysplastic syndromes, remain under investigation. However, therapeutic heterogeneity, safety concerns, and standardization challenges limit their clinical transla

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… Under pathological stress, MSCs shift their secretome toward pro-tumorigenic factors, including IL-6, IL-17 A, CXCL8, CXCL12, and periostin [ 97 – 101 ]. … In B-cell acute lymphoblastic leukemia (B-ALL), leukemic cells release CCL2, which activates STAT3 in MSCs, upregulating periostin (POSTN) expression [ 97 ]. …

Guided immunotherapy for residual solid tumor: integrating platelets and CAR T cells to reduce post-surgical recurrence.

Postoperative recurrence remains a major obstacle to durable remission in patients with solid tumors, even after complete macroscopic resection. Growing evidence suggests that surgery creates a transient yet highly permissive biological window characterized by inflammatory signaling, coagulation activation, endothelial disruption, and systemic immune suppression. Together, these processes foster a protective niche that enables microscopic residual disease to evade immune surveillance and initiate metastatic outgrowth. Although modern adjuvant therapies have improved outcomes, their effectivene

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… microenvironment involved in ECM remodeling and tumor progression Cellular component ECM-related function Tumor biological impact Core mediators/pathways Direction of effect Key studies Cancer-associated fibroblasts (CAFs) Major producers and organizers of tumor ECM; deposit collagen, fibronectin, periostin … perfusion, immune suppression; context can be size-dependent CD44, RHAMM, HAS2 Mostly pro-tumor, context-dependent [ 100 , 101 ] Tenascin-C Matricellular protein Enrichment in metastatic niches → survival of micrometastases and stemness support Integrins, niche-signaling pathways Pro-tumor [ 102 ] Periostin …