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Hemophagocytic Lymphohistiocytosis (HLH) in Patients with Tick-Borne Illness: A Scoping Review of 98 Cases.

Hemophagocytic lymphohistiocytosis (HLH) secondary to tick-borne infections is a rare but potentially life-threatening syndrome. We performed a scoping review according to PRISMA guidelines to systematically analyze the existing literature on the topic. A total of 98 patients were included, with a mean age of 43.7 years, of which 64% were men. Most cases, 31%, were reported from the USA. Immunosuppression was present in 21.4%, with the most common cause being previous solid organ transplantation. Constitutional symptoms were the most common, observed in 83.7% of the patients, while fever was r

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… A new phlebovirus associated with severe febrile illness in Missouri N. Engl. J. Med. 2012 367 834 841 10.1056/NEJMoa1203378 22931317 94. Pastula D.M. Turabelidze G. Yates K.F. Jones T.F. Lambert A.J. Panella A.J. Kosoy O.I. Velez J.O. Fisher M. Staples E. …

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