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A phase I first-in-man study to investigate the pharmacokinetics and safety of liposomal dexamethasone in patients with progressive multiple myeloma.

Despite the introduction of multiple new drugs and combination therapies, conventional dexamethasone remains a cornerstone in the treatment of multiple myeloma (MM). Its application is, however, limited by frequent adverse effects of which the increased infection rate may have the strongest clinical impact. The efficacy-safety ratio of dexamethasone in MM may be increased by encapsulation in long-circulating PEG-liposomes, thereby both enhancing drug delivery to MM lesions and reducing systemic corticosteroid exposure. We evaluated the preliminary safety and feasibility of a single intravenous

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… Metselaar JM Complete remission of experimental arthritis by joint targeting of glucocorticoids with long-circulating liposomes Arthritis Rheum 2003 48 2059 2066 10.1002/art.11140 12847701 29. …

Managements of osteoporotic vertebral compression fractures: A narrative review.

Osteoporotic vertebral compression fractures (OVCFs) are the most common fragility fracture and significantly influence the quality of life in the elderly. Currently, the literature lacks a comprehensive narrative review of the management of OVCFs. The purpose of this study is to review background information, diagnosis, and surgical and non-surgical management of the OVCFs. A comprehensive search of PubMed and Google Scholar for articles in the English language between 1980 and 2021 was performed. Combinations of the following terms were used: compression fractures, vertebral compression frac

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… American College of Rheumatology Subcommittee on Osteoarthritis Guidelines Arthritis Rheum 2000 43 1905 1915 11014340 10.1002/1529-0131(200009)43:9<1905::AID-ANR1>3.0.CO;2-P 25 Gennari C Analgesic effect of calcitonin in osteoporosis Bone 2002 30 67 70 10.1016/s8756-3282(02)00713-5 12008161 26 Franklin …

The EHA Research Roadmap: Infections in Hematology.

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… Ann Rheum Dis. 2020;79:760–770. 26. Garlanda C, Bottazzi B, Bastone A, et al. Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility. Annu Rev Immunol. 2005;23:337–366. 27. Garlanda C, Hirsch E, Bozza S, et al. …

A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation.

Interleukin IL-17 is a proinflammatory cytokine that has been implicated in the pathogenesis of various autoimmune diseases. The single nucleotide polymorphism (SNP), rs2275913, in the promoter region of the IL-17 gene is associated with susceptibility to ulcerative colitis. When we examined the impact of rs2275913 in a cohort consisting of 438 pairs of patients and their unrelated donors transplanted through the Japan Marrow Donor Program, the donor IL-17 197A allele was found to be associated with a higher risk of acute graft-versus-host disease (GVHD; hazard ratio [HR], 1.46; 95% confidence

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… Arthritis Rheum. 2006;54:1122–1131. doi: 10.1002/art.21749. 6. Loong CC, Hsieh HG, Lui WY, Chen A, Lin CY. Evidence for the early involvement of interleukin 17 in human and experimental renal allograft rejection. J Pathol. 2002;197:322–332. doi: 10.1002/path.1117. 7. …

B cell lineage reconstitution underlies CAR-T cell therapeutic efficacy in patients with refractory myasthenia gravis.

B-cell maturation antigen (BCMA), expressed in plasmablasts and plasma cells, could serve as a promising therapeutic target for autoimmune diseases. We reported here chimeric antigen receptor (CAR) T cells targeting BCMA in two patients with highly relapsed and refractory myasthenia gravis (one with AChR-IgG, and one with MuSk-IgG). Both patients exhibited favorable safety profiles and persistent clinical improvements over 18 months. Reconstitution of B-cell lineages with sustained reduced pathogenic autoantibodies might underlie the therapeutic efficacy. To identify the possible mechanisms un

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… Leukemia 30:492–500 26369987 10.1038/leu.2015.247 PMC4746098 Takeshima Y Iwasaki Y Nakano M Narushima Y Ota M Nagafuchi Y Sumitomo S Okamura T Elkon K Ishigaki K Immune cell multiomics analysis reveals contribution of oxidative phosphorylation to B-cell functions and organ damage of lupus Ann Rheum … Ann Rheum Dis 81:845–853 35236659 10.1136/annrheumdis-2021-221464 Tirosh I Izar B Prakadan SM Wadsworth MH 2nd Treacy D Trombetta JJ Rotem A Rodman C Lian C Murphy G Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq Science 2016 352 189 196 10.1126/science.aad0501 …

Evaluation and Treatment of Obesity and Its Comorbidities: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity.

The goal of the 8th edition of the Clinical Practice Guidelines for Obesity is to help primary care physician provide safe, effective care to patients with obesity by offering evidence-based recommendations to improve the quality of treatment. The Committee for Clinical Practice Guidelines comprised individuals with multidisciplinary expertise in obesity management. A steering board of seven experts oversaw the entire project. Recommendations were developed as the answers to key questions formulated in patient/problem, intervention, comparison, outcomes (PICO) format. Guidelines underwent mult

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… Semin Arthritis Rheum. 2019;48:791–8. doi: 10.1016/j.semarthrit.2018.07.007. 23. Xie L, Chen Y, Tan A, Gao Y, Yang X, Mo Z, et al. Central obesity indicating a higher prevalence of lower urinary tract symptoms: a case-control matching analysis from a Chinese cross-sectional study in males. … Ann Rheum Dis. 2011;70:1798–803. doi: 10.1136/ard.2010.142018. 181. Espeland MA, Luchsinger JA, Neiberg RH, Carmichael O, Laurienti PJ, Pi-Sunyer X, et al. Long term effect of intensive lifestyle intervention on cerebral blood flow. J Am Geriatr Soc. 2018;66:120–6. doi: 10.1111/jgs.15159. 182. …

Nerve Growth Factor and Autoimmune Diseases.

NGF plays a crucial immunomodulatory role and increased levels are found in numerous tissues during autoimmune states. NGF directly modulates innate and adaptive immune responses of B and T cells and causes the release of neuropeptides and neurotransmitters controlling the immune system activation in inflamed tissues. Evidence suggests that NGF is involved in the pathogenesis of numerous immune diseases including autoimmune thyroiditis, chronic arthritis, multiple sclerosis, systemic lupus erythematosus, mastocytosis, and chronic granulomatous disease. Furthermore, as NGF levels have been link

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… Arthritis Rheum. 2010 40 109 126 10.1016/j.semarthrit.2009.03.002 19481238 131. Vincent T.L. Mechanoflammation in osteoarthritis pathogenesis Semin. Arthritis Rheum. 2019 49 S36 S38 10.1016/j.semarthrit.2019.09.018 31779850 132. Yu H. Huang T. Lu W.W. Tong L. Chen D. Osteoarthritis Pain Int. J. …

Vitamin D: Update 2013: From rickets prophylaxis to general preventive healthcare.

Vitamin D has received a lot of attention recently as a result of a meteoric rise in the number of publications showing that vitamin D plays a crucial role in a plethora of physiological functions and associating vitamin D deficiency with many acute and chronic illnesses including disorders of calcium metabolism, autoimmune diseases, some cancers, type 2 diabetes mellitus, infectious diseases and cardiovascular disease. The recent data on vitamin D from experimental, ecological, case-control, retrospective and prospective observational studies, as well as smaller intervention studies, are sign

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… Arthritis Rheum. 2004;50:72–7. doi: 10.1002/art.11434. 93. Nielen MM, van Schaardenburg D, Lems WF, van de Stadt RJ, de Koning MH, Reesink HW, Habibuw MR, van der Horst-Bruinsma IE, Twisk JW, Dijkmans BA. … Arthritis Rheum. 2006;54:3719–20. doi: 10.1002/art.22191. 94. Neve A, Corrado A, Cantatore FP. Immunomodulatory effects of vitamin D in peripheral blood monocyte-derived macrophages from patients with rheumatoid arthritis. Clin Exp Med. 2013 doi: 10.1007/s10238-013-0249-2. …

Фармакомикробиомика: От взаимодействия хост-микробиома-наркотики к клиническому переводу в докторскую медицину.

Заметная межиндивидуальная изменчивость реакции на наркотики по-прежнему является серьезной проблемой в области клинической фармакологии и не может быть в полной мере объяснена только генетикой принимающей страны. Растущие данные свидетельствуют о том, что кишечная микробиота является дополнительным фактором, определяющим эффективность и токсичность наркотиков посредством двустороннего взаимодействия с фармакологической терапией. Это признание привело к появлению фармакомикробиомики - области, которая изучает, как микробные сообщества влияют на утилизацию наркотиков и реагирование на них, и ка

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… Rheum. Dis. 2010;13:48–54. doi: 10.1111/j.1756-185X.2009.01449.x. 93. Li B., Kwok L.Y., Wang D., Li L., Guo S., Chen Y. Integrating metabolomics, bionics, and culturomics to study probiotics-driven drug metabolism. Front. Pharmacol. 2023;14:1047863. doi: 10.3389/fphar.2023.1047863. 94. …

The Impact of Monoclonal Antibody Usage on Hearing Outcomes: A Systematic Review.

ObjectiveTo ascertain trends in ototoxicity observed with monoclonal antibodies (mABs) and understand the impact they may have on hearing function.Data sourcesPubMed, Embase, Scopus.Review methodsA systematic review was performed following PRISMA guidelines. Data were reviewed for demographics, utilized mABs with respective indication and dosing, audiometric outcomes, and treatment for otologic effects.ResultsOf 757 studies reviewed, a total of 44 were included, encompassing 18,046 patients treated with mABs. Mean age of the sample was 57.8 years old. The search yielded 18 agents of ototoxicit

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… Arthritis Rheum. 2005;53(3):337‐342. 10.1002/art.21179. 64. Plotkin SR, Stemmer‐Rachamimov AO, Barker FG 2nd, et al. Hearing improvement after bevacizumab in patients with neurofibromatosis type 2. N Engl J Med. 2009;361(4):358‐367. 10.1056/NEJMoa0902579. 65. Balouch B, Meehan R, Suresh A, et al. …

Anti-PEG Antibodies and Their Biological Impact on PEGylated Drugs: Challenges and Strategies for Optimization.

Polyethylene glycol (PEG) has been widely utilized in optimizing therapeutics due to its excellent biocompatibility and chemical stability. However, multiple dosing of PEGylated drugs may result in toxicity due to PEG accumulation in tissues, leading to the formation of anti-PEG antibodies (APAs), which can accelerate drug clearance, reduce efficacy, and alongside enhanced side effects, such as allergic reactions. Notably, pre-existing APAs have also been detected in individuals with no prior exposure to PEGylated drugs, raising additional clinical concerns. This review summarizes the mechanis

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… Arthritis Rheum. 2021 51 347 352 10.1016/j.semarthrit.2021.01.005 33601190 62. Taguchi K. Ogaki S. Watanabe H. Kadowaki D. Sakai H. Kobayashi K. Horinouchi H. Maruyama T. Otagiri M. …

Health- related quality of life after surgery for spinal metastases.

BACKGROUND: Surgery for spinal metastases is almost always palliative and part of a multidisciplinary approach that has determined a significant increase of life expectancy in the last decade; thus, an improvement in health-related quality of life (HRQOL) is the main goal of the treatment of spinal metastases. We report here the results of a prospective study conducted with the aim of evaluating the impact of spinal surgery on HRQOL, measured by Patient-Reported Outcomes Measures (PROMs). We analyzed clinical outcomes (ambulatory status, performance status, pain, neurological status) and HRQOL

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… Visual analogue pain scales Ann Rheum Dis. 39 4 1980 Aug 414 10.1136/ard.39.4.414-a PMC1000571 7436569 21 EuroQol Group (1990) EuroQol--a new facility for the measurement of health-related quality of life. Health Policy 16:199–208. 10.1016/0168-8510(90)90421-9 10109801 22 Ware J.E. …

Advances in the research on myokine-driven regulation of bone metabolism.

The traditional view posits that bones and muscles interact primarily through mechanical coupling. However, recent studies have revealed that myokines, proteins secreted by skeletal muscle cells, play a crucial role in the regulation of bone metabolism. Myokines are widely involved in bone metabolism, influencing bone resorption and formation by interacting with factors related to bone cell secretion or influencing bone metabolic pathways. Here, we review the research progress on the myokine regulation of bone metabolism, discuss the mechanism of myokine regulation of bone metabolism, explore

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… Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system Arthritis Rheum. 54 11 2006 3551 3563 17075861 10.1002/art.22175 71 Juffer P. Jaspers R.T. Klein-Nulend J. Bakker A.D. …

Herpes Zoster and Cardiovascular Disease: Exploring Associations and Preventive Measures through Vaccination.

Herpes zoster, induced by the reactivation of the varicella-zoster virus (VZV), is a unilaterally distributed vesicular rash that can cause multiple complications. VZV not only causes neurological problems, including postherpetic neuralgia and ocular zoster, but also causes inflammatory vasculopathy and increases the incidence of hemorrhagic or ischemic complications. Therefore, understanding the association between the development of herpes zoster and the subsequent occurrence of acute stroke or cardiovascular diseases, including myocardial infarction and heart failure, is of great interest.

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… Arthritis Rheum. 2007;57:1431–1438. doi: 10.1002/art.23112. 28. Morena D., Lumbreras S., Rodriguez J.M., Campos C., Castillo M., Benavent M., Izquierdo J.L. Chronic Respiratory Diseases as a Risk Factor for Herpes Zoster Infection. Arch. …

Терапевтическая способность монометилфумарата и иона алюминия к уменьшению воспаления и окислительного стресса в псориазе.

Псориаз представляет собой хроническое воспалительное состояние кожи, характеризующееся эритематическими досками с белыми чешуями. Его патогенез тесно связан с окислительным стрессом и дисбалансом в иммунной реакции Th1/TH2. Нынешние методы лечения псориаза, такие, как актуальные агенты, системная терапия и фототерапия, часто не достигают полной ремиссии в клинических условиях. Монометилфумарат (MMF), который был утвержден Администрацией США по продуктам питания и наркотикам в 2020 году в отношении множественного склероза, продемонстрировал свою эффективность в борьбе с псориазом. Кроме того,

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… Rheum. Dis. 82 Suppl 1 2023 1148 2 Wang X.Y. Zhang C.L. Wang W.H. Time to relapse after treatment withdrawal for different biologics used to treat plaque psoriasis Chinese Med. J. Peking 133 24 2020 2998 3000 10.1097/CM9.0000000000001232 PMC7752671 33337760 3 Wronski A. Wojcik P. …

Risk factors for relapse in non-infectious cryoglobulinemic vasculitis, including type I cryoglobulinemia: a systematic review.

BackgroundData on non-infectious cryoglobulinemic vasculitis (NICV) is scarce, especially concerning the management of relapses, which are troublesome. We aimed to investigate risk factors for relapse in NICV.MethodsA systematic literature search of CINAHL, Embase, MEDLINE, Scopus, and the Web of Science databases was implemented until April 2023. Eligible studies included randomized control trials, observational studies, and case series with ≥4 patients. Two reviewers independently extracted data and assessed the quality of the eligible studies.ResultsA total of 3,724 articles were retrieved

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… Ann Rheum Dis ( 2013 ) 72 ( 3 ): 374–80 . doi: 10.1136/annrheumdis-2012-201405 22586172 34 Zaidan M Terrier B Pozdzik A Frouget T Rioux-Leclercq N Combe C . Spectrum and prognosis of noninfectious renal mixed cryoglobulinemic GN . …

Quantitative systems pharmacology modeling sheds light into the dose response relationship of a trispecific T cell engager in multiple myeloma.

In relapsed and refractory multiple myeloma (RRMM), there are few treatment options once patients progress from the established standard of care. Several bispecific T-cell engagers (TCE) are in clinical development for multiple myeloma (MM), designed to promote T-cell activation and tumor killing by binding a T-cell receptor and a myeloma target. In this study we employ both computational and experimental tools to investigate how a novel trispecific TCE improves activation, proliferation, and cytolytic activity of T-cells against MM cells. In addition to binding CD3 on T-cells and CD38 on tumo

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… Rheum. 2005;52:2996–3003. doi: 10.1002/art.21353. 48. Haagen I-A, et al. Unprimed CD4+ and CD8+ T cells can be rapidly activated by a CD3× CD19 bispecific antibody to proliferate and become cytotoxic. Cancer Immunol. Immunother. 1994;39:391–396. doi: 10.1007/BF01534426. 49. …

ESA, Iron Therapy and New Drugs: Are There New Perspectives in the Treatment of Anaemia?

Anemia is a well-known consequence of chronic kidney disease (CKD); it is mainly due to a relative insufficiency of erythropoietin synthesis by the failing kidneys. Over the years, the combination of erythropoiesis stimulating agents (ESA) and iron has become the standard of care of anemia. All ESAs effectively increase hemoglobin (Hb) levels in a substantial percentage of patients. However, in the last decade, their use has been surrounded by safety issues in increased cardiovascular risk, especially when used at high doses in inflamed and hyporesponsive patients. This has led to the definiti

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… Rheum. Dis. 2016 23 37 46 10.4078/jrd.2016.23.1.37 86. Pergola P.E. Devalaraja M. Fishbane S. Chonchol M. Mathur V.S. Smith M.T. Lo L. Herzog K. Kakkar R. Davidson M.H. …

Immunotherapies for Aging and Age-Related Diseases: Advances, Pitfalls, and Prospects.

Aging is characterized by a gradual decline in the functionality of all the organs and tissues, leading to various diseases. As the global population ages, the urgency to develop effective anti-aging strategies becomes increasingly critical due to the growing severity of associated health problems. Immunotherapy offers novel and promising approaches to combat aging by utilizing approaches including vaccines, antibodies, and cytokines to target specific aging-related molecules and pathways. In this review, we summarize the recent advancements of immunotherapies to eliminate senescence cells and

Длинная и извилистая дорога: гомеостатические и беспорядочные микроэкологические ниши: обзор описательной части.

Микроэкологические ниши Haematopoiet были охарактеризованы как "приемники" крови и иммунной системы. Эти ниши меняются во время онтгении, при этом костный мозг становится доминирующим местом гематопоисиса в послеродовой жизни в стабильных условиях. Для определения структуры и функции различных микроэкологических ниш гематопоиета необходимо четко определить конкретные подмножества гематопоиетических стеблей и потомковых клеток во время офгении и понять их временной внешний вид и анатомическое позиционирование. Различные гематопоиетические и негематопоиетические клетки способствуют появлению гем