Результаты поиска

Myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia - overlap, differences, and emerging insights.

BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and fibromyalgia (FM) are debilitating chronic illnesses with considerable symptom overlap. Their symptoms include profound fatigue, widespread pain, post-exertional deterioration, sleep disturbance, dysautonomia, and cognitive impairment. These illnesses frequently co-occur; ME/CFS often develops first, particularly after infection. This overlap creates a diagnostic grey area and contributes to severe reductions in quality of life. Despite these shared features, key distinctions remain essential. ME/CFS is characterised b…

Apolipoprotein E Deficiency Attenuates Neuroinflammatory Responses and Demyelination in Experimental Autoimmune Encephalomyelitis.

The precise etiology of multiple sclerosis (MS) remains incompletely understood, despite a well-established genetic predisposition. Clinical and epidemiological studies have identified an association between apolipoprotein E (ApoE) and MS progression; however, the underlying mechanisms remain largely unresolved. In this study, we investigated the role of ApoE in MS progression using an experimental autoimmune encephalomyelitis (EAE) model in ApoE knockout mice. EAE was induced in female C57BL/6 wild-type (WT) and ApoE knockout (ApoE KO) mice via immunization with myelin oligodendrocyte glycopr…

Fibronectin inhibition restores myelination in endothelial TNFR2-dependent nonremitting experimental autoimmune encephalomyelitis.

In multiple sclerosis (MS), spontaneous remyelination occurs in early disease; however, this process becomes inefficient over time, resulting in sustained neurodegeneration and clinical deterioration. It is known that global tumor necrosis factor receptor 2 (TNFR2) deletion in experimental autoimmune encephalomyelitis (EAE), the murine MS model, causes a severe nonremitting disease; however, the underlying mechanism is poorly understood. Here, through bulk and single nucleus RNA sequencing, we identify endothelial TNFR2 deletion as the driver of nonremitting disease, as it is sufficient to dri…

Липосомальная обратная вакцина защищает мышей от артрита и экспериментального аутоиммунного энцефаломиэлита.

Хронические самовоспалительные заболевания, такие, как ревматуидный артрит и множественный склероз, не поддаются лечению, а текущее иммунодепрессивное лечение часто приводит к системным нецелевым последствиям. Для удовлетворения этой неудовлетворенной потребности мы ранее разработали «обратную вакцину» на основе анионовых фосфатидилглицеролов липосолов с антигенным антигеном, содержащимся в дексаметазоне. Здесь мы оцениваем терапевтическую эффективность и иммунодуляторные механизмы этой платформы в двух мюриновых моделях автономного иммунитета. В модели протеогликанского артрита одна администр

Совпадение в аннотации оригинала
Chronic autoinflammatory diseases such as rheumatoid arthritis and multiple sclerosis lack curative therapies, and current immunosuppressive … h encapsulation efficiency (∼60%), demonstrating platform modularity. In an experimental autoimmune encephalomyelitis mouse model, two injections of Dex-K4-MOG liposomes (one before disease induction and one after) strongly suppressed disease development compared with controls. Together, these findings demonstrate that antigen-specific inverse vaccination using ani …

Cognitive Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome-Aetiology and Potential Treatments.

Systemic infection and inflammation impair mental function through a combination of altered attention and cognition. Here, we comprehensively review the relevant literature and report personal clinical observations to discuss the relationship between infection, peripheral inflammation, and cerebral and cognitive dysfunction in patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Cognitive dysfunction in ME/CFS could result from low-grade persistent inflammation associated with raised pro-inflammatory cytokines. This may be caused by both infectious and non-infectious stim…

Thapsigargin suppresses porcine hemagglutinating encephalomyelitis virus replication by disrupting host energy metabolism.

Coronaviruses (CoVs) are a large family of human and animal pathogens that cause significant health and economic burdens worldwide. Thapsigargin (Tg) is a plant-derived sesquiterpene lactone with potent antiviral effects; however, the underlying mechanism remains unclear. Here, we show that Tg exhibited strong antiviral activity against the neurotropic swine CoV porcine hemagglutinating encephalomyelitis virus (PHEV) both in vivo and in vitro. Tg also exhibited inhibitory activity against other three swine coronaviruses in cell lines. Specifically, Tg treatment significantly inhibited the repl…

MRI cortical thickness in paediatric auto-immune encephalitis and acute disseminated encephalomyelitis.

OBJECTIVE: Paediatric autoimmune encephalitis and acute disseminated encephalomyelitis (ADEM) are neuroinflammatory disorders that can cause acute MRI abnormalities. Recent analyses suggest brain volume reductions months to years after disease onset. This study aimed to verify whether decreased gray matter thickness would also be observed in whole-brain cortical thickness as well as in temporal polar and orbitofrontal cortices. METHODS: A cohort of children previously diagnosed with autoimmune encephalitis (including anti-NMDA encephalitis and ADEM) were recruited at least two years after ini…

Воздействие ингибиторов выступов от сипаруна брасилиенза на экспериментальный аутоиммунный энцефаломиэлит.

ЦЕЛЬ: В качестве перспективных кандидатов на модуляцию аутоиммунных заболеваний появились ингибиторы выступов. В этом исследовании оценивается фармакологический потенциал ингибиторов выступа, извлекаемых из листьев сипаруна брасилиенсиса, в экспериментальной аутоиммунной энцефаломиелита, предклинической модели множественного склероза. МЕТОДЫ: Женские мыши C57BL/6 были иммунизированы с помощью пептида MOG35-55 для стимулирования EAE. Затем мыши были разделены на группы и обработаны либо PBS, либо бразилинозными ингибиторами выступа Сипаруна при температуре 500 мг/кг или 1000 мг/кг через перорал

Совпадение в аннотации оригинала
OBJETIVE: Protease inhibitors have emerged as promising candidates for modulating autoimmune diseases. This study evaluates the pharmacological potential of protease inhibitors extracted from leaves of Siparuna brasiliensis in an experimental autoimmune encephalomyelitis model, a preclinical model of multiple sclerosis. METHODS: Female C57BL/6 mice were imm…

FOXP3+ Macrophage-Derived Amphiregulin способствует ремонту белых материалов экспериментального аутоиммунного энцефаломиэлита.

Множественный склероз (MS) характеризуется эпизодами подстрекательского обезвоживания, за которым следуют различные степени ремилеляции. Ключевую роль в обоих процессах играют макроматериалы. Понимание того, как макрофаги изменяют свою пластичность, чтобы облегчить воспоминание в MS, обладает значительным терапевтическим потенциалом, однако этот механизм по-прежнему недостаточно изучен. В этом исследовании мы показываем, что пищеварение миелинового мусора макрофагами приводит к активации сигнала FOXP3, который вызывает прорегенеративный фенотип. В частности, мы создали специфическую для макроф

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is characterized by episodes of inflammatory demyelination followed by varying degrees of remyelination. Macrophages … iregulin (AREG), a neurotrophic factor. This mechanism enhances recovery in experimental autoimmune encephalomyelitis. These findings suggest that FOXP3+ macrophages could serve as a promising therapeutic target in MS.

Evaluating Therapeutic Plasma Exchange in Pediatric Acute Disseminated Encephalomyelitis: A Comprehensive Review.

Acute disseminated encephalomyelitis (ADEM) is a rare autoimmune disorder characterized by brain and spinal cord inflammation. In pediatric patients, ADEM presents unique challenges due to its potential for rapid progression and long-term neurological sequelae. Therapeutic plasma exchange (TPE) has emerged as a potential treatment option by targeting the underlying autoimmune process and modulating the inflammatory response. This comprehensive review evaluates the role of TPE in pediatric ADEM, synthesizing evidence from clinical studies and providing insights into its efficacy, safety, and po…

РНК-Сек, базирующаяся на RNA-Seq, обнаруживает воспаление олигодендроглиевой линии в аутоиммунном энцефаломиелите.

Клетки олигодендроглиевой линии (ООК) имеют решающее значение для нейронных функций поддержки, включая минелинирование и воспоминание. Появляющиеся данные свидетельствуют об их активной роли в нейроинфламмации, особенно в таких условиях, как Множественный склероз (MS). В рамках этого исследования изучается возбудительный транслатом ОРЦ в начале экспериментального аутоиммунного энцефаломиелита (EAE), который представляет собой установленную модель НР. Использование последовательности РНК на основе RiboTag в генетически модифицированных системах Olig2-Cre Мыши RiboTag, мы опознали 1,556 Регулиру

Совпадение в аннотации оригинала
Oligodendroglial lineage cells (OLCs) are critical for neuronal support functions, including myelination and remyelination. Emerging evidenc … udy explores the inflammatory translatome of OLCs during the early onset of experimental autoimmune encephalomyelitis (EAE), an established MS model. Using RiboTag-based RNA sequencing in genetically modified Olig2-Cre RiboTag mice, we identified 1,556 upregulated and 683 downregulated genes in EAE OLCs. Enrichment analysis indicated heightened immune-related pathw …

Influenza B-induced longitudinally extensive transverse myelitis and bithalamic acute disseminated encephalomyelitis.

In the COVID-era, other viral pathogens, like influenza B, gain less attention in scientific reporting. However, influenza still is endemic, and rarely affects central nervous system (CNS). Here, we report the case of a 35-year-old male who presented with fever since 1 week, and developed acute ascending flaccid paralysis and urinary retention. The clinical presentation of paraparesis in combination with the inflammation proven by the lumbar puncture, and the MRI full spine, fulfilled the diagnostic criteria of longitudinally extensive transverse myelitis (LETM). In this case, it is most likel

Case report: atypical presentation of acute disseminated encephalomyelitis after tick-borne encephalitis.

Acute disseminated encephalomyelitis (ADEM) is a rare and an immune- mediated inflammatory illness of the central nervous system that normally demonstrates as a monophasic disorder connected with multifocal neurologic symptoms. Herein, we report atypical presentation of ADEM presenting as single lesions in a middle-aged woman after tick-borne encephalitis.

Pharmacological targeting of coagulation factor XI attenuates experimental autoimmune encephalomyelitis in mice.

Multiple sclerosis (MS) is the most common causes of non-traumatic disability in young adults worldwide. MS pathophysiologies include the fo … es showed that reducing FXII levels was protective in a murine model of MS, experimental autoimmune encephalomyelitis (EAE). Our objective was to determine if pharmacological targeting of FXI, a major substrate of activated FXII (FXIIa), improves neurological function and attenuates CNS damage in the setting of EAE. EAE was induced in male mice using murine myelin …

Fatal Acute Disseminated Encephalomyelitis Post-COVID-19 Vaccination: A Rare Case Report.

Acute disseminated encephalomyelitis (ADEM) is a disease of the brain and spinal cord that is an immune-mediated inflammatory and demyelinating disorder, which is commonly preceded by an infection. Some reports have also shown the association of acute demyelination of the central nervous system (CNS) with vaccination. Primarily, the involvement of the white matter of the cerebral hemispheres, brain stem, and spinal cord is observed. Such lesions should be considered as the differentials of ADEM. We would like to report a case of a 77-year-old female who was of post-COVID-19 vaccination status …