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In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study.

BACKGROUND: Perfluoroalkyl and polyfluoroalkyl substances are classed as endocrine disrupting compounds but continue to be used in many products such as firefighting foams, flame retardants, utensil coatings, and waterproofing of food packaging. Perfluoroalkyl exposure aberrantly modulates lipid, metabolite, and bile acid levels, increasing susceptibility to onset and severity of metabolic diseases, such as diabetes and metabolic dysfunction-associated steatotic liver disease. To date, most studies in humans have focused on perfluoroalkyl-exposure effects in adults. In this study we aimed to s

Update on Occupational Cancer for Better Cancer Prevention and Control.

Occupational cancer remains an ongoing and emerging issue in cancer prevention and control and is more easily preventable in practice than other causes. As of 2024, changes in various aspects, such as methods for estimating the burden of cancer, evidence on novel carcinogens and classification systems, modernization of working conditions, job characteristics, occupational exposure, and societal changes have played a significant role. Furthermore, advances in technology, including wearable devices, exposome, and biomedical technology, offer more precise methods for identifying the associations

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… Additionally, various work environments and conditions, such as those faced by firefighters exposed to multiple carcinogens, have been evaluated as human carcinogens or IARC Group 1 [ 23 ]. … | This occupation may encounter exposure to combustion products from fires (such as PAHs and particulate matter), building materials (including asbestos), chemicals found in firefighting foams (such as per- and polyfluorinated substances), flame retardants, diesel exhaust, and other hazards like night …

Fate and effects of acrolein.

Acrolein is a highly toxic, reactive, and irritating aldehyde that occurs as a product of organic pyrolysis, as a metabolite of a number of … mon mode of human contact, particularly in industries that involve combustion of organic compounds. Firefighters, in particular, are exposed to extremely high levels during the extinguishment and overhaul phases of their work. Water may contain significant levels of the herbicide. It has been found in paper mill and municipal effluents at 20-200 micrograms/L, …

Experiences and perceptions of family members of emergency first responders with post-traumatic stress disorder: a qualitative systematic review.

OBJECTIVE: The objective of this review was to examine the perceptions and experiences of family members of emergency first responders (EFRs … r family members, or limitations on recency of service. EFRs included police, ambulance/paramedics, firefighters, and rescue personnel. METHODS: The databases searched included MEDLINE (PubMed), PsycINFO (Ovid), Embase, CINAHL (EBSCOhost), and Scopus. Hand-searching of relevant journals was conducted across Australian Paramedic , Australasian Journal of Param …

[Pre-hospital management of adults with life-threatening emergencies].

In France, acute life-threatening situations are handled by the French Secours a Personne (assistance to persons) and emergency medical faci … (Service Départemental d'Incendie et de Secours--the French fire brigade) is in use, ensuring that firefighters are often the first on the spot, while the knowledge and skills of the dispatching physician are essential to ascertain the patient's needs, to preserve life and vital functions, and to ensure the patient is sent to the appropriate emergency healthc …

Circadian time organization of professional firemen: desynchronization-tau differing from 24.0 hours-documented by longitudinal self-assessment of 16 variables.

We investigated the circadian synchronization/desynchronization (by field-study assessment of differences in period, τ, of 16 coexisting and well-documented rhythms) of 30 healthy firemen (FM) exposed to irregular, difficult, and stressful nocturnal work hours who demonstrated excellent clinical tolerance (allochronism). Three groups of FM were studied (A = 12 FM on 24-h duty at the fire station; B = 9 FM on 24-h duty at the emergency call center; C = 9 day-shift administrative FM) of mostly comparable average age, body mass index, career duration, chronotype-morningness/eveningness, and trait

Epidemiology, genetics and treatment of multiple myeloma and precursor diseases.

Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of plasma cells. The incidence of MM worldwide is increasing with greater than 140 000 people being diagnosed with MM per year. Whereas 5-year survival after a diagnosis of MM has improved from 28% in 1975 to 56% in 2012, the disease remains essentially incurable. In this review, we summarize our current understanding of MM including its epidemiology, genetics and biology. We will also provide an overview of MM management that has led to improvements in survival, including recent changes to diagnosis and therapi

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… Multiple myeloma and its precursor disease among firefighters exposed to the world trade center disaster . JAMA Oncol . 2018 ; 4 : 821 ‐ 827 . 29710195 10.1001/jamaoncol.2018.0509 PMC6145680 45 Pukkala E , Martinsen JI , Weiderpass E , et al. … Cancer incidence among firefighters: 45 years of follow‐up in five Nordic countries . Occup Environ Med . 2014 ; 71 : 398 ‐ 404 . 24510539 10.1136/oemed-2013-101803 46 Hemminki K , Försti A , Tuuminen R , et al. …

SUBJECT INDEX Volume 125 (JANUARY–JUNE, 2004)

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… admitted to ICU with chest pain and irregular pulse, 775 pulmonary function and sputum production in patients with cystic fibrosis: a pilot study comparing the PercussiveTech HF device and standard chest physiotherapy, 1507 symptoms, pulmonary function changes and respirator use among New York City firefighters … expression and transforming growth factor-β 1 in pulmonary lymphangioleiomyomatosis, 1063 Fibrosing alveolitis, cryptogenic: See Alveolitis Fibrous tumors, pleural: See Pleural neoplasms Finland, variations in pediatric asthma hospitalization rates and costs between and within Nordic countries, 1680 Firefighters …

Decoding Cancer Risk: Understanding Gene-Environment Interactions in Cancer Development.

While lifestyle choices or behavioral patterns remain the most significant factors influencing cancer risk, environmental exposure to certain chemicals, both manufactured and natural, may also contribute to an individual's likelihood of developing cancer. This interplay of factors, coupled with an aging demographic and shifting lifestyle patterns, has led to an increasing prevalence of cancer in recent years. This study examines the environmental and behavioral factors that contribute to anomalies in the immune system and increase the risk of developing cancer. Significant environmental and oc

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… According to studies, firefighters who are exposed to smoke from these occurrences may have an increased risk of acquiring lung cancer [ 34 ]. … Wildland firefighter smoke exposure and risk of lung cancer and cardiovascular disease mortality. Navarro KM, Kleinman MT, Mackay CE, et al. Environ Res. 2019;173:462–468. doi: 10.1016/j.envres.2019.03.060. 35. US EPA O. …

Impact of World Trade Center-Related Health Research: An Application of the NIEHS Translational Framework.

The World Trade Center Health Program (WTCHP) has a research mission to identify physical and mental health conditions that may be related to the 9/11 terrorist attacks as well as effective diagnostic procedures and treatments for WTC-related health conditions. The ability of the WTCHP to serve its members and realize positive impacts on all of its stakeholders depends on effective translation of research findings. As part of an ongoing assessment of the translational impact of World Trade Center (WTC)-related research, we applied the National Institute of Environmental Health Sciences (NIEHS)

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… A representative from the Uniformed Firefighters’ Association noted both this unique opportunity and its life-saving implications during Meeting One of the STAC in 2011, This language speaks directly to the intent of Congress to have the basis for inclusion be on biological plausibility… rather than … Early assessment of cancer outcomes in New York City firefighters after the 9/11 attacks: An observational cohort study. Lancet. 2011;378:898–905. doi: 10.1016/S0140-6736(11)60989-6. 26. …

Психиатрические результаты первого two спустя годы после октября 7 - нападения: систематический обзор последствий посттравматического стресса, беспокойства, депрессии и наркомании.

ЦЕЛИ: октябрь 7 :: нападения и последовавшая за ними война создали условия для устойчивой, многоплановой травмы. В настоящем систематическом обзоре обобщаются результаты исследований, проведенных в ходе первого обзора. two годы войны, чтобы прояснить раннее распространение симптомов посттравматического стресса (ПТСС), тревоги, депрессии и связанных с наркоманией последствий среди израильского населения. МЕТОДЫ: ПОСЛЕ ПРИСМА 2020 :: были проведены обыски по ПубМеду, Психиндо, Скопусу и веб-сайту науки с целью выявления исследований, опубликованных в период с октября 7, 2023 и октябрь 7, 2025 (з

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… FRs (i.e. firefighters, paramedics, police force members, and active military service; n = 77), non-FRs (n = 297) | 39.24 | 50.8 | 1 Post | Traumatic stress symptoms (TSS) | PCL-5 | Traumatic stress symptoms (TSS) were negatively associated with resilience among first responders and civilians, but this … association was not significant among first responders actively engaged in assistance.* | Low Saar-Ashkenazy et al. ( 65 ) | Cross sectional | 295 | Online survey among residents of southern Israel | First responders (police, firefighters, paramedics, emergency medical staff, security forces) and civilian …

Health Impacts of High BMI in China: Terrible Present and Future.

Temporal trends and future expectations of health effects due to high body mass index (BMI) remain uncertain in China. The trends of high-BMI-related death in China were evaluated and predicted until 2040 using data and methods from the Global Burden of Disease study. The absolute numbers and age-standardized rates of death and disability-adjusted life years (DALYs) were also calculated by age, gender, and cause. From 1990 to 2019, the high-BMI-related death percent, number and rate were all significantly increased in China, and death rate may exceed that globally in the next 10 years. High BM

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… Cardiovascular Disease Risk Factors by BMI and Age in United States Firefighters. Obesity. 2021;29:1186–1194. doi: 10.1002/oby.23175. 6. Wei J., Liu X., Xue H., Wang Y., Shi Z. …

Proactive Resilience Programmes for Improving Resilience and Psychological Adaptation in Employees in High-Risk Occupations: A Systematic Review.

BACKGROUND: Promoting positive mental health is important due to its beneficial influence on not only educational attainment, productivity, … cipants from health occupations (71%), followed by military (14%) and police (9%). Only 3% analysed firefighters and first responders and the final 3% did not fall into any of the above categories. The majority of studies were randomised controlled trials. The weighted average SMDs for resilience, stress, anxiety, depression and PTSD symptoms in the short term …

Интерпретируемая скорость и возможные выгоды от ожирения, диабета и множественного склероза: систематический обзор случайных клинических испытаний.

В последние годы популярна практика интермитирования скорости, которая в споре представляется в качестве возможного терапевтического адъюнктора. Был проведен библиографический обзор литературы по вопросам периодического быстрого роста и ожирения, диабета и множественного склероза. Научное качество методологии и полученные результаты оценивались по парам. Промежуточный пост оказывает благоприятное воздействие на профиль липидов, и он связан с потерей веса и модификацией распределения брюшного жира у людей с ожирением и типом 2 диабет, а также улучшение контроля за глицемическими уровнями. У пац

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… fat mass, and total cholesterol. 1+ A Waldman et al., 2020 [ 30 ] Alabama, USA Review Non-analytical studies, such as a case report or case series To research the benefits of time-restricted eating in relation to the prevention of cardiometabolic diseases in high-stress occupations, such as police, firefighters …

A critical care outreach team under strain - Evaluation of the service provided to patients with haematological malignancy during the Covid-19 pandemic.

PurposeCritical Care Outreach Teams (CCOTs) have been associated with improved outcomes in patients with haematological malignancy (HM). This study aims to describe CCOT activation by patients with HM before and during the Covid-19 pandemic, assess amny association with worse outcomes, and examine the psychological impact on the CCOT.Materials and methodsA retrospective, mixed-methods analysis was performed in HM patients reviewed by the CCOT over a two-year period, 01 July 2019 to 31 May 2021.ResultsThe CCOT increased in size during the surge period and reviewed 238 HM patients, less than in

Oncology Nursing During a Pandemic: Critical Reflections in the Context of COVID-19.

ObjectivesTo provide a critical reflection of COVID-19 in the context of oncology nursing and provide recommendations for caring for people affected by cancer during this pandemic.Data sourcesElectronic databases, including CINAHL, MEDLINE, PsychINFO, Scopus, professional web sites, and grey literature were searched using Google Scholar.ConclusionNurses are key stakeholders in developing and implementing policies regarding standards of care during the COVID-19 pandemic. This pandemic poses several challenges for oncology services. Oncology nurses are providing a pivotal role in the care and ma

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… Social systems were disrupted, including telephone service, public transportation (train and taxi operators became ill), and nurses, firefighters, teachers, and priests were sick and absent from work. …

Genetic architecture of multiple myeloma: From somatic alterations to germline susceptibility and clinical implications.

Multiple myeloma (MM) is best understood as a dynamically evolving genomic ecosystem shaped by inherited susceptibility, early oncogenic events, and continuous selective pressures. We propose an evolutionary genomics framework integrating germline risk, disease initiation, clonal diversification, and therapeutic adaptation into a unified model of MM biology. Polygenic risk burden, rare predisposing variants, and alterations in DNA repair and telomere pathways create a permissive background that influences precursor states and immune interactions. Primary cytogenetic events, particularly immuno

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… Meta-analyses report elevated risk in selected occupational groups, including firefighters, who exhibit nearly a 50% increased risk, and hairdressers, with approximately a 40% higher risk [ 25 ]. … MM | Germline susceptibility variants; shared familial factors | [ 52 , 53 ] Obesity / high BMI | Increased MGUS and MM risk | OR ∼1.7–2.0; +17% risk per 5 kg/m² adult BMI | MGUS/MM | Chronic inflammation, IGF-1 signaling, adipokine dysregulation | [ 28 , 29 ] Occupational exposure | Elevated risk | Firefighters …

Differential Diagnosis and Therapeutic Advances in Multiple Myeloma: A Review Article.

Multiple myeloma (MM) is a hematologic malignancy characterized by the abnormal clonal proliferation of plasma cells that may result in focal bone lesions, renal failure, anemia, and/or hypercalcemia. Recently, the diagnosis and treatment of MM have evolved due to a better understanding of disease pathophysiology, improved risk stratification, and new treatments. The incorporation of new drugs, including proteasome inhibitors, immunomodulatory drugs, anti-CD38 antibodies and high-dose chemotherapy followed by hematopoietic stem cell transplantation, has resulted in a significant improvement in

Экологические и профессиональные факторы риска, связанные с множественной миеломой: многоцентральное, больничное и параллельное исследование конкретных случаев.

ВВЕДЕНИЕ: Множественная миелома (ММ), гематологическая порча, вызванная распространением неопластических плазменных клеток, по-прежнему недостаточно характеризуется факторами профессионального и экологического риска и их воздействием на качество жизни пациентов (QoL). В этом исследовании изучается изменяемое воздействие на Западном берегу, Палестина, и оценивается их связь с рисками, связанными с ММ, и результатами по конкретным заболеваниям. МЕТОДЫ: В период между 2018 и 2025, включая 227 Пациенты ММ и 176 Совпадающие с контрольными. Спички основывались на возрасте, поле, госпитализации и тип

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… This is exemplified by emerging recommendations for proactive MGUS screening in high-risk, exposure-defined populations such as WTC-exposed firefighters, aiming to facilitate treatment at a stage that improves survival (Kazandjian et al.) [ 78 ],.Physicians should also educate patients about reducing …

The roles of Cryptochrome-1: the circadian clock as a control point in cancer therapy.

In this review, we carefully describe the composition and operation of cryptochrome-1 (CRY1). We introduce four related signaling pathways, namely cAMP/PKA/CREB signaling way, HIFα signaling way, NF-κB signaling way, STAT3 signaling way, FOXO signaling pathway and Hedgehog (HH) signaling pathway. We also emphasize the current understanding of the complex roles CRY1 plays in the progression of various solid tumors. We propose that its function represents a novel therapeutic target that could pave the way for new cancer treatments. Additionally, we summarize three emerging therapeutic strategies

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… This association persists across multiple professions with night-shift exposure, including healthcare workers, firefighters, and police officers [ 208 , 210 ]. …