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Sciatic nerve regeneration after traumatic injury using magnetic targeted adipose-derived mesenchymal stem cells.

Traumatic peripheral nerve injuries constitute a huge concern to public health. Nerve damage leads to a decrease or even loss of mobility of … ated axons. Also, a very remarkable restoration in myelin basic protein organization, indicative of remyelination, was observed. This resulted in an improvement in nerve conduction, demonstrating functional recovery. In summary, our results demonstrate that magnetically assisted delivery of AdMSC, using a non-invasive and non-traumatic method, is a highly promi …

Reduced inflammation accompanies diminished myelin damage and repair in the NG2 null mouse spinal cord.

BACKGROUND: Multiple sclerosis (MS) is a demyelinating disease in which blood-derived immune cells and activated microglia damage myelin in the central nervous system. While oligodendrocyte progenitor cells (OPCs) are essential for generating oligodendrocytes for myelin repair, other cell types also participate in the damage and repair processes. The NG2 proteoglycan is expressed by OPCs, pericytes, and macrophages/microglia. In this report we investigate the effects of NG2 on these cell types during spinal cord demyelination/remyelination. METHODS: Demyelinated lesions were created by microi…

Hypoxia-induced conversion of sensory Schwann cells into repair cells is regulated by HDAC8.

After a peripheral nerve injury, Schwann cells (SCs), the myelinating glia of the peripheral nervous system, convert into repair cells that foster axonal regrowth, and then remyelinate or re-ensheath regenerated axons, thereby ensuring functional recovery. The efficiency of this mechanism depends however on the time needed for axons to regrow. Here, we show that ablation of histone deacetylase 8 (HDAC8) in SCs accelerates the regrowth of sensory axons and sensory function recovery. We found that HDAC8 is specifically expressed in sensory SCs and regulates the E3 ubiquitin ligase TRAF7, which d

Обновленная информация о новых методах склероза: от мрачного поражения до сцинтилляционного успеха.

ЦЕЛЬ ОБЗОРА: Обзор новых методов склероза (МС), используемых в настоящее время при клинических испытаниях. ПОСЛЕДНИЕ ВЫВОДЫ: Sixty-seven Клинические испытания были отобраны и сгруппированы по следующим категориям: ингибиторы тирозиновой киназы Брютона, ремиелионирующие методы лечения, иммуномодуляторы, клеточная терапия B, добавки/микробиомы и клеточные методы лечения. К числу важных выводов относятся успешные испытания Tolebrutinib в невозобновляющемся вторичном прогрессивном MS, которые замедлили процесс CDP по сравнению с плацебо и неспособность Simvastatin продемонстрировать влияние на инв

Совпадение в полном тексте источника
… Although some MS plaques remyelinate, oligodendroglial precursor cells can be found in MS plaques but appear to be unable to remyelinate presumably due to inhibitory signals [ 14 ]. … Preclinical studies of clemastine showed robust evidence of remyelination in some models and a phase 2 trial in chronic optic neuropathy revealed a physiologically detectable reduction in full field visual evoked potential latency, an effect consistent with possible remyelination [ 19 , 20 ]. …

[Mechanisms of Neurodegeneration in Multiple Sclerosis].

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which results in the formation of primary demyelinating lesions in the white and gray matter, as well as diffuse axonal and neuronal damage. Although there has been substantial progress in drug research in relapsing-remitting MS, treatment of progressive forms of the disease, can be challenging. Diffuse and compartmentalized lymphocyte and macrophage infiltration of the CNS tissue inhibits the differentiation of myelinating mature oligodendrocytes, disrupting the process of remyelination. Chronic inflammat…

The time course and phenotype of Uhthoff phenomenon following optic neuritis.

As there is little information regarding the recovery from Uhthoff phenomenon (UP) in the multiple sclerosis (MS) literature, the objective … om the onset of ON, then recovery appears to be uncommon and may therefore be a surrogate marker of remyelination in future drug trials.

Hypomyelination in three Weimaraner dogs.

Hypomyelination syndrome of the Weimaraner dog is a disease characterised by a reduction or absence of myelin in the axons of the central ne … ig2(+) cells in the demyelinated areas. The immunohistochemical findings suggested a myelination or remyelination failure because of the smaller population of oligodendrocytes. However, PLP gene mutations may also be the cause of the decrease of PLP expression as described in other species.

Peripheral nerve pathology in two rottweilers with neuronal vacuolation and spinocerebellar degeneration.

Neuronal vacuolation and spinocerebellar degeneration in young Rottweiler dogs is a neurodegenerative condition characterized by neuronal vacuolation of several nuclei in the central nervous system and degeneration of the spinal cord white matter. Here, we describe the morphologic and ultrastructural findings in laryngeal muscles and peripheral nerves of a 16-week-old female and a 32-week-old female Rottweiler dog affected by progressive ataxia and tetraparesis associated with laryngeal paralysis. Lesions were characterized by neurogenic muscle atrophy of the intrinsic laryngeal muscles, and a

Treatment of multiple sclerosis with intravenous immunoglobulin: review of clinical trials.

Intravenous immunoglobulin (IVIG) is an established therapy for a number of neuroimmune disorders, including Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy. IVIG exerts a number of effects that may be beneficial in multiple sclerosis (MS): reduction of inflammation, inhibition of macrophages, and promotion of remyelination. Four double-blind trials have been performed of IVIG in relapsing-remitting MS. A meta-analysis of the four trials has shown that IVIG reduces the relapse rate, new MRI lesions, and disease progression. IVIG does not seem to be of any benefit …

[Ulnar nerve palsy in leprosy without skin changes: biopsy of the superficial branch of the ulnar nerve in the hand].

Leprosy is one of the most common diseases of peripheral nerves in the world. In Brazil it is particularly frequent, being a major health pr … nly of: loss of fibers (14 cases), inflammatory infiltration (13), fibrosis (12), demyelination and remyelination (9), presence of granuloma (6) and presence of bacilli (5 cases). We conclude that in case of ulnar nerve palsy in leprosy without skin changes, the biopsy of the dorsal sensory branch of this nerve in the hand is a good procedure for the diagnosis …

Demyelinating changes in sural nerve biopsy of patients with HTLV-I-associated myelopathy.

We describe the sural nerve pathology in 3 patients with HTLV-I-associated myelopathy (HAM). These patients showed remarkable symptoms of myelopathy and had high HTLV-I titers in the serum and CSF. The common pathologic findings in the sural nerves were as follows: slightly decreased density in myelinated fibers (6,567/mm2, 6,488/mm2, and 7,159/mm2; control 9,999 +/- 3,446/mm2), frequent occurrence of demyelinated and remyelinated fibers, and many degenerating fibers with globule-like myelin changes. Teased-fiber analysis indicated the globule-like changes (Dyck's G change) to be accompanied b

Neuronal type of Charcot-Marie-Tooth disease with a syndrome of continuous motor unit activity.

The clinical, genetic and electrophysiological study of 3 patients with an association of a neuronal form of Charcot-Marie-Tooth Disease (CM … d electrophysiological findings indicated that axonal degeneration with secondary demyelination and remyelination underlie the hereditary motor and sensory neuropathy (HMSN) in our patients. The hyperexcitability and hyperactivity of peripheral motor axons probably induced by the hereditary neuropathy may, in this instance, be the causative condition of the syn …

A novel oxygen-releasing bilayer delivery system for cell survival and peripheral nerve regeneration.

Peripheral nerve injuries with long-gap defects pose a major regenerative challenge due to hypoxic microenvironments that impair cell surviv … a 15 mm critical-sized sciatic nerve defect in rats, resulting in augmented axonal regeneration and remyelination, and superior functional recovery compared with controls. Collectively, our oxygen-delivery bilayer system provides a robust microenvironment that supports cell viability and promotes nerve regeneration, offering a translational platform for enhanci …

Transplantation of olfactory ensheathing cells embedded in the GelMA-F127DA hydrogel promotes the repair of spinal cord injury.

Spinal cord injury (SCI) is a highly disabling condition. Olfactory ensheathing cells (OECs) are important transplantable cells for treating … OECs embedded in the GEF hydrogel effectively repaired SCI, promoted neuronal regeneration and axon remyelination, and improved locomotor function. Accordingly, this treatment strategy offers a new perspective for SCI repair.

A morphological and morphometric study of the peripheral process of the human vestibular nerve following posterior cranial fossa neurectomy.

Three vestibular nerve specimens removed at transmeatal neurectomy were studied in order to understand better retrograde degeneration and re … all diameters and Schwann cell proliferation around the soma of vestibular ganglion cells reflected remyelination. We conclude that peripheral processes of vestibular nerve fibres can undergo retrograde degeneration and subsequent regeneration after transection of the central process.

Уровни БДФ в сыворотке и ВСБ связаны с клинорадиологическими характеристиками агрессивных заболеваний у пациентов с МЗ.

BDNF все больше привлекает к себе внимание как ключевая молекула, контролирующая ремиелионацию, играющая видную роль в нейропластике и нейрозащите. Тем не менее остается неясным, как БДФ соотносится с клинорадиологическими характеристиками, особенно на ранней стадии заболевания, когда решающее значение имеет точный прогноз для дальнейшего курса МУ. МЕТОДЫ: Концентрации БДН, NfL и GFAP в сыворотке и CSF были оценены в 106 лечение пациентов с синдромом MS (PwMS), а также 73 больные другими воспалительными/невоспалительными неврологическими или соматоформальными расстройствами с использованием ед

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BACKGROUND: BDNF has increasingly gained attention as a key molecule controlling remyelination with a prominent role in neuroplasticity and neuroprotection. Still, it remains unclear how BDNF relates to clinicoradiological characteristics particularly at the early stage of the disease where precise prognosis for the further MS course is crucial. METHODS: BD…

Zebrafish optic nerve regeneration involves resident and retinal oligodendrocytes.

JOURNAL/nrgr/04.03/01300535-202602000-00049/figure1/v/2025-05-05T160104Z/r/image-tiff The visual system of teleost fish grows continuously, … yte progenitor cells in the optic nerve and retina proliferate and differentiate for the purpose of remyelination. As new axons arise from the surviving retinal ganglion cells, new sox10:tagRFP oligodendrocytes arise from residual oligodendrocyte progenitor cells to guide, nourish and myelinate them. Thus, oligodendrocytes play an active role in zebrafish axon …

От Молекулеса к моделям: miRNAs и усовершенствованные человеческие платформы нейродегенерации и ремонта в мультиклерозе.

Помимо потенциальной роли микроРНК (миРНК) в качестве биомаркеров, их участие в различных биологических и патологических процессах, наблюдаемых при множестве склерозов (МС), таких, как нейроинфламмация, нейродегенерация и ремиелиляция, делает их подходящими кандидатами для терапевтического применения в нейрорепэре. Большинство исследований, посвященных этому репаративному подходу, проводились с использованием систем моделей in vitro или in vivo. Вместе с тем были описаны функциональные различия между муринными и человеческими клетками в центральной нервной системе (КНС), и некоторые механизмы

Совпадение в аннотации оригинала
Beyond the potential role of microRNAs (miRNAs) as biomarkers, their participation in different biological and pathological processes observed in multiple sclerosis (MS) such as neuroinflammation, neurodegeneration and remyelination, makes them suitable candidates for therapeutic applications in neurorepair. Most studies addressing this reparative approach h…

Повторное изучение роли сексуальных гормонов в демиелинской центральной нервной системе.

Различия по признаку пола характеризуют множественный склероз, аутоиммунную, подстрекательскую и нейродегенеративную болезнь, характеризующуюся более высокой заболеваемостью среди женщин, а также различиями в уязвимости и прогрессировании. Помимо клинических особенностей, молекулярные и клеточные различия, связанные с сексуальными гормонами, постепенно улучшали наше понимание механизмов, связанных с этим заболеванием. Самые последние выводы могут привести к выявлению новых терапевтических перспектив, которые могли бы удовлетворить настоятельную потребность в лечении, предотвращающем переход от

Совпадение в аннотации оригинала
Sex-related differences characterize multiple sclerosis, an autoimmune, inflammatory and neurodegenerative disease displaying higher inciden … elated to these hormones and their age-related changes and relationship with failure of spontaneous remyelination, likely impacting the inexorable progression of multiple sclerosis towards irreversible disabilities.

Treatment and Relapse Prevention of Typical and Atypical Optic Neuritis.

Optic neuritis (ON) is an inflammatory condition involving the optic nerve. Several important typical and atypical ON variants are now recog … long-term. Moreover, emerging therapeutic approaches and novel steps in the direction of achieving remyelination are discussed.