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Prevalence and Cure of Primary Liver Cancer in Italy by Histologic Type.

BACKGROUND/OBJECTIVES: In Italy, one- and five-year survival of primary liver cancer patients have increased in recent decades and were higher after hepatocellular carcinoma (HCC) than after intrahepatic cholangiocarcinoma (ICC). This study aimed to estimate the complete prevalence and cure indicators (long-term survival) after liver cancer diagnosis by histologic type. METHODS: Data from 31 Italian cancer registries, covering 28,057,000 residents (47% of the population), were included. The complete prevalence was calculated in 2018. The mixture-cure model was used to estimate the cure fracti…

Parasitic surveillance in wolves of central Italy: a focus on the Abruzzo region.

BACKGROUND: Monitoring parasitic infections in wildlife is essential for assessing ecosystem health and pathogen dynamics, particularly in apex predators like the wolf (Canis lupus). As top-level carnivores with wide-ranging habitats and diverse interactions with prey, wolves can serve as effective sentinels for the circulation of parasitic agents within ecosystems. The present study aimed at monitoring parasitic infections, particularly those of zoonotic importance, in wolves from central Italy. METHODS: The study was conducted on 169 wolf carcasses recovered between 2018 and 2024. Leishmani…

Inequalities in Late Stillbirths: A Population-based Study in Northern Italy.

ABSTRACT: OBJECTIVE:  Inequalities contribute substantially to adverse perinatal outcomes; however, data on stillbirth risk and its etiologic diversity across maternal migrant status remain limited in Italy. Understanding these patterns is essential for developing targeted prevention strategies. The aim of the present study was to assess stillbirth risk and evaluate differences in underlying causes between Italian and migrant women in a large population-based cohort. ABSTRACT: STUDY DESIGN:  We conducted a retrospective cohort study including 323,635 births in Emilia-Romagna, Italy (2014-2023…

Listeriosis Outbreaks in Italy in 2022-2023: Management and Source Identification.

Implementation of effective teams that investigate listeriosis outbreaks is important to both limit the scope of outbreaks and to identify root causes and outbreak sources. This paper describes activities of the Italian outbreak investigation team, highlighting cross-sectoral collaboration in listeriosis surveillance and presenting a framework to strengthen national outbreak preparedness and response, using four Listeria monocytogenes (Lm) outbreaks investigated in Italy between 2022 and 2023. These outbreaks involved strains belonging to clonal complexes (CC) CC1, CC8, and CC155. Although CC1…

Detection of canine distemper virus in wildlife in Italy (2022-2024).

CDV has been detected in a wide range of domestic and wild animal also in Italy and it is highly prone to cross-species transmission, therefore representing a significant health risk. In this study the presence of CDV and other coinfecting selected viruses, in wild carnivorans of the family Mustelidae and Canidae and rodents of the family Hystricidae, collected in Southern Italy (Campania region), in 2022-2024, was investigated. Over a period of 3 years (2022-2024), tissue samples from 136 wild animals including stone martens, porcupines, otters, wolves, martens, badgers and foxes were examine…

Funnel-based antimicrobial resistance monitoring in Italy: the FUN-IT study.

Italy reports some of the highest antimicrobial resistance (AMR) rates in Europe. This necessitates multiple interventions among which improved surveillance is a key to solutions. Statistical Process Control (SPC) methods may help distinguishing between natural variability and significant regional trends. We applied specifically tailored SPC methods, namely funnel plots, Z-score charts, and chi-squared control charts to the AMR data from the AR-ISS surveillance system (2015-2023), focusing on bloodstream infections. Specifically, we analysed regional and temporal trends of carbapenem-resistant…

Fat vs. Sugar: The Case for a Saturated Fat Tax in Italy.

When judging the distributional impact of unhealthy food taxes, what matters is not just how much low income people would pay but how much the such taxes would benefit or harm them overall. In this paper, we assess the consumer welfare impact of a fat tax net of its expected benefits computed as savings from weight loss. Using Italian data, we estimate a censored Exact Affine Stone Index (EASI) incomplete demand system for food groups, simulating changes in purchases, calorie intake, consumer welfare, and the monetary value of short-run health benefits. While the Italian government has propose

The burden of prostate cancer and metastatic prostate cancer in Italy in 2024.

OBJECTIVE: The epidemiologic scenario of prostate cancer (PC) is changing rapidly. The present study updates to 2024 the estimates of PC in Italy, including incident and prevalent cases, deaths, and metastatic PC (mPC), which is further subdivided into de novo mPC (metastasis detected at diagnosis) and recurrent mPC (metachronous metastasis). METHODS: The study was based on updated data from the Italian Network of Cancer Registries and the National Institute of Statistics and the age-specific short-term PC projections made available by the International Agency for Cancer Research. For mPC, we…

Schistosomiasis in migrants: bridging the gap in Italy's treatment guidelines and access.

Schistosomiasis is a widespread disease that can cause serious health issues if not diagnosed and treated promptly. Fortunately, there is an effective and safe treatment available: praziquantel (PZQ). In countries with a high influx of migrants from schistosomiasis-endemic regions, it is crucial to ensure the availability of PZQ. This discussion will address the barriers and the need for PZQ in Italy.

Diagnosis of scabies and socio-economic status in Ferrara, Italy: is there an association?

BACKGROUND: The role of socioeconomic status (SES) in the individual risk of contracting scabies in industrialized countries has not been specifically examined. This study aimed to assess potential associations between SES and scabies diagnosis. METHODS: The SES of a retrospective cohort of subjects residing in the province of Ferrara, north-east Italy, who were diagnosed with scabies between 2016 and 2024, was evaluated. SES was represented through an ecological-based deprivation index that identified five subgroups, ranging from I (highest SES) to V (lowest SES). RESULTS: A total of 307 su…

Diagnosis and Treatment of Dirofilaria immitis in Two Cats From Italy.

Dirofilaria immitis is a mosquito-borne filarioid that primarily infects dogs. Infection of cats is infrequent, and diagnosis of feline cardiopulmonary dirofilariosis may be overlooked. Here we describe D. immitis infections in two cats from Central-Northern Italy, where heartworm disease is endemic in dogs. Both cats tested positive on a rapid heartworm point of care (POC) antigen test. Case 1, a 13-year-old male castrated domestic shorthair (DSH) cat was investigated for progressive respiratory signs, including cough, nasal discharge, dyspnea and reverse sneezing. By contrast, Case 2, a 7-ye…

Trends in pediatric vaccination coverage in Italy from 2000 to 2023.

Vaccination represents one of the most effective public health interventions. However, a decrease in pediatric vaccination coverage has been observed in Italy, with an increase in vaccine-preventable infectious diseases. To counter this phenomenon, the Italian government approved a compulsory vaccination law in 2017, increasing the number of mandatory vaccinations from four to 10. This study analyzes the trends of vaccination coverages in Italy from 2000 to 2023, with a focus on the impact of the law. Vaccination coverage data were obtained from the Italian Ministry of Health, sorted by antige…

The 2023 dengue outbreak in Lombardy, Italy: A one-health perspective.

INTRODUCTION: Here we reported the virological, entomological and epidemiological characteristics of the large autochthonous outbreak of dengue (DENV) occurred in a small village of the Lombardy region (Northern Italy) during summer 2023. METHODS: After the diagnosis of the first autochthonous case on August 18, 2023, public health measures, including epidemiological investigation and vector control measures, were carried out. A serological screening for DENV antibodies detection was offered to the population. In the case of positive DENV IgM, a second sample was collected to detect DENV RNA …

Optimizing Pregnancy Outcomes: The Role of Gynecologists in Preconceptional Care in Italy.

The preconceptional period is crucial for women and couples who desire children as it influences the progress and outcomes of a healthy pregnancy. Preconceptional care is now an accepted paradigm by most healthcare professionals. However, its implementation in healthcare programs is still in the early stages. Preconceptional care starts with communication and a collection of personal and family medical history. It then encompasses a variety of recommendations for lifestyle interventions, as well as preventive laboratory tests. This review will summarize current recommended procedures, from nut

Infections Management in the Lung Transplant Setting in Italy: A Web-Survey.

INTRODUCTION: Infections significantly impact morbidity and mortality in lung transplant (LuTx) recipients. This survey focused on documenting current practices regarding the prevention and management of infections in LuTx in Italy. METHODS: A 52-question survey was administered online in the period from December 1, 2023, to January 31, 2024, assessing center characteristics, Tx team organization, microbiological investigations, infection prevention, and management. All Italian LuTx centers were invited to participate. RESULTS: Nine out of 10 Italian LuTx centers answered. Most centers (6/9,…

Prevalence of ESBL-Resistant Genes in Birds in Italy-A Comprehensive Review.

Antimicrobial resistance (AMR) is a major global concern in both human and veterinary medicine. Among antimicrobial resistance (AMR) bacteria, Extended-Spectrum Beta-Lactamases (ESBLs) pose a serious health risk because infections can be difficult to treat. These Gram-negative bacteria can be frequently found in poultry and in Italy, where such protein production is established. ESBL-producing Escherichia coli, Salmonella and Klebsiella in chicken and turkey may pose a significant public health risk due to potential transmission between poultry and humans. This review aims to assess the preval…

Prevalence and molecular characterisation of Balantioides coli in pigs raised in Italy.

Balantioides coli is the only ciliated protist of both human and veterinary interest and colonises the large intestine of several hosts, including humans and pigs. Given the scarcity of data on B. coli circulation in pigs in Italy, a study was planned to record its prevalence and genetic types and compare the analytical sensitivity of two copromicroscopic techniques. For this purpose, 880 faecal samples were collected from pigs raised in 22 farms located in northern Italy and analysed with the sedimentation and the FLOTAC® dual technique, employing sodium chloride and zinc sulphate flotation s…

Социальные детерминанты здоровья при множественном склерозе в Италии: обзор аналитического исследования.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Социальные детерминанты здоровья могут влиять на некоторые результаты, связанные с множественным склерозом (МС), включая накопление инвалидности и прогрессирование заболеваний. Взаимосвязь между ОДХ и НР является сложной из-за взаимосвязи между факторами и двунаправленностью. Неравенство наблюдается также в странах с универсальной системой здравоохранения, таких, как Италия. ЦЕЛИ: Выявлять и синтезировать существующую и формирующуюся литературу по ряду ОДХ среди итальянского населения с НР: пол, пол и сексуальность; раса, этническая принадлежность и географическое простр

Совпадение в аннотации оригинала
BACKGROUND: Social determinants of health (SDH) can influence some outcomes related to multiple sclerosis (MS), including disability accrual and disease progression. The relationship between SDH and MS is complex, due to interplay between factors and bidirectionality. Inequities also occur in countries with universal health care system like Italy. OBJECTIVE…

Life Experience of Survivors of Gynecologic Cancers: A Survey Conducted in Italy.

BACKGROUND: The study of health-related quality of life in survivors of gynecologic cancers is becoming increasingly important as 1.5 million survivors of gynecologic cancer in the United States and more are expected due to advances in diagnosis and treatment. This project investigated the perceived needs and lived experiences of survivors of gynecological cancer to help design supportive activities to be implemented in clinical practice. METHODS: Patients were recruited in hospitals or through social media and responded to an online survey that was addressed to patients in Italy, specificall…

Francisella novicida infection in a patient with pulmonary infection and pancreatitis in Italy.

Tularemia is a rare but potentially life threatening zoonotic disease caused by Francisella tularensis. F. novicida, previously considered a … genome sequencing (WGS).This is the first reported case of human infection caused by F. novicida in Italy.Given the rarity of human cases and the lack of specific symptoms, this pathogen is difficult to identify and the diagnosis can be extremely challenging. In this case report, despite the lack of amplification of the gene encoding for 23 kDa protein, …