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[Juices in a healthy diet: recommendations for consumption based on chemical composition data].

Juices from fruits and vegetables show a complex composition, they contain several hundred different substances. In addition to water and co … es from juices are polyphenolic compounds (flavonoids, phenolic acids) and carotenoids (β-carotene, lycopene). All juices also contain significant level of potassium and magnesium, and they can serve a source of some vitamins and minerals (depending on the individual nutrient profile): citrus juices are the source of vitamin C and folates, pineapple - of m …

The epidemiology of prostate cancer.

The etiology of prostate cancer remains virtually unknown. Although there are a number of new leads with regard to risk factors for prostate … lic health initiatives can be promoted. Potential candidates include vitamin E, selenium, zinc, and lycopene as dietary supplements. There are other agents that may be appropriate for pharmaceutical development, including inhibitors of COX-2 and IGF-1 activity. It is important that chemoprevention trials are followed-up for a sufficient period of time and …

HDL composition and HDL antioxidant capacity in patients on regular haemodialysis.

Recent evidence suggests that HDL can directly inhibit LDL oxidation, a key early stage in atherogenesis. Patients with chronic renal failure are at increased cardiovascular risk, have reduced HDL levels and altered HDL composition. We have therefore investigated whether compositional changes in HDL lead to decreased HDL antioxidant capacity in these patients. In comparison to control subject HDL, patient HDL contained less total cholesterol, cholesterol esters, phospholipids and alpha-tocopherol. LDL, HDL and LDL + HDL were standardised for protein and oxidised in the presence of Cu2+. The ra

Dietary omega-6/omega-3 fatty acids and risk of prostate cancer; Is there any potential interaction by organophosphate insecticides among the agricultural health study population.

BACKGROUND: In the United States (US), the average annual increase in the incidence of prostate cancer (PCa) has been 0.5% between 2013 and … ), physical activity (hours/week), smoking (yes/no), terbufos (yes/no), fonofos (yes/no), diabetes, lycopene intake (milligrams/day), family history of PCa, and the interaction of N-6/N-3 with age, terbufos and fonofos. Pesticide exposure was assessed by self-administrated questionnaires collecting data on ever/never use of mentioned pesticides during life …

Association of serum vitamins and carotenoids with breast cancer status among adult women in NHANES 2017-2018: a cross-sectional study.

BACKGROUND: Breast cancer remains a major public health burden among women worldwide. Circulating vitamins and carotenoids may be related to … y detection (HPLC-PDA). The analytes included vitamin C, retinol, α-tocopherol, γ-tocopherol, total lycopene, α-carotene, α-cryptoxanthin, β-cryptoxanthin, and lutein and zeaxanthin. Baseline characteristics were described using standardized mean differences (SMDs), and associations were evaluated using Firth penalized logistic regression with adjustment f …

Anti-carcinogenic and Anti-bacterial Properties of Selected Spices: Implications in Oral Health.

"Let food be thy medicine and medicine be thy food", as said by the father of medicine, Hippocrates in 431 B.C. Nature has provided us with a variety of treatment modalities in the form of food. For the first 5,000 years of civilization, humans relied on herbs and foods for medicine. Only in the past 60 years have we forgotten our medicinal "roots" in favor of patented medicines. While pharmaceutical ingredients have their value, we should not overlook the well-documented, non-toxic and inexpensive healing properties of food. As an individual we consume food several times a day without a compl

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… Anticarcinogenic properties Non oxidative mechanism for anticarcinogenic effects of lycopene is through regulation of gap junction communication [ 44 ]. Lycopene is a significant anticancer agent by its various mechanisms. … Lycopene also inactivates free radicals which are responsible for lipid peroxidation process thus preventing tissue damage [ 42 ]. …

Angioprevention of Urologic Cancers by Plant-Derived Foods.

The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney tumors, are no exceptions to this rule. Moreover, the fact that many of these tumors are detected in early stages lengthens the duration of their treatment, with a significant increase in health care costs. In this scenario, prevention offers the most cost-effective long-term strategy for the global control of these diseases. Although specialized diets are not the only way to

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… The antiangiogenic activity shown by this carotenoid reinforce the role of lycopene in angioprevention. … FDA for their lycopene-containing products. Chemopreventive role of lycopene in other types of urologic cancers cannot be discarded. Accordingly, an increase in lycopene intake among postmenopausal women could be correlated with a lower risk of RCC [ 232 ]. …

The Mediterranean Diet, a Rich Source of Angiopreventive Compounds in Cancer.

Diet-based chemoprevention of cancer has emerged as an interesting approach to evade the disease or even target its early phases, reducing its incidence or slowing down tumor progression. In its basis in the essential role of angiogenesis for tumor growth and metastasis, angioprevention proposes the use of inhibitors of angiogenesis in cancer prevention. The anti-angiogenic potential exhibited by many natural compounds contained in many Mediterranean diet constituents makes this dietary pattern especially interesting as a source of chemopreventive agents, defined within the angioprevention str

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… Tomato is an important source of vitamin C, potassium, folic acid, and carotenoids, such as lycopene. The postulated cancer chemopreventive potential of lycopene [ 141 , 142 , 143 , 144 ] ( Figure 3 ) could be reinforced by the use of this compound in angioprevention. … Can the consumption of tomatoes or lycopene reduce cancer risk? Integr. Cancer Ther. 2002;1:121–132. doi: 10.1177/153473540200100203. 142. Palozza P., Simone R.E., Catalano A., Mele M.C. Tomato Lycopene and Lung Cancer Prevention: From Experimental to Human Studies. …

Understanding CAM Natural Health Products: Implications of Use Among Cancer Patients and Survivors.

Herbs, vitamins, and other natural health products are being used by cancer patients and survivors with increasing prevalence in the United States. These complementary and alternative medicine (CAM) products, which are also referred to as natural health products in Canada and abroad, are used during cancer treatment and the survivorship period to ease the burden of symptoms such as pain, fatigue, insomnia, anxiety, and depression and hence improve overall quality of life. Data indicate that while patients choose these products for self-treatment, they often do not inform their health-care prov

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… Research is also needed to distinguish effects of lycopene found in food products as compared with lycopene supplementation on cancer prevention, treatment, and recurrence (Natural Standard, 2013). … Serum lycopene concentration and prostate cancer risk: results from the Prostate Cancer Prevention Trial. …

Phytochemicals in Cancer Treatment and Cancer Prevention-Review on Epidemiological Data and Clinical Trials.

Phytochemicals are a non-nutritive substances that are present in plants and contribute significantly to their flavor and color. These biologically active compounds are classified into five major groups, namely phenolics, carotenoids, organosulfur compounds, nitrogen-containing compounds, and alkaloids, and are known for their potential health benefits in the prevention of various diseases, including cancer. The purpose of this review article is to explore the potential therapeutic benefits of the dietary phytochemicals, such as flavonoids, phenolic acids, phytosterols, carotenoids, and stilbe

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… In a meta-analysis of 42 studies that involved almost 700,000 participants, it was found that the risk of prostate cancer decreased by 1% for every additional 2 mg of lycopene consumed in the diet and by 4% for every additional 10 μg dL −1 of circulating lycopene [ 172 ]. … In a 2013 study, comparing the highest and lowest quartiles of lycopene exposure, both dietary and blood lycopene were not found to be associated with gastric cancer, but an interesting finding was that increased tomato consumption was linked to a reduced risk of gastric cancer [ 190 ]. 3.5.5. …

A Perspective on Withania somnifera Modulating Antitumor Immunity in Targeting Prostate Cancer.

Medicinal plants serve as a lead source of bioactive compounds and have been an integral part of day-to-day life in treating various disease conditions since ancient times. Withaferin A (WFA), a bioactive ingredient of Withania somnifera, has been used for health and medicinal purposes for its adaptogenic, anti-inflammatory, and anticancer properties long before the published literature came into existence. Nearly 25% of pharmaceutical drugs are derived from medicinal plants, classified as dietary supplements. The bioactive compounds in these supplements may serve as chemotherapeutic substance

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… Lycopene blocks NF- κ B signaling to inhibit prostate cancer cell growth in vitro and reduces in vivo prostate cancer growth in mice [ 72 , 73 ]. … In a chronic prostatitis rat model, the intragastric lycopene administration (20 mg/kg, daily for four weeks) reduces inflammation in the prostate and the serum level of IL-1 β , TNF- α , IL-2, and IL-6 cytokines [ 74 ]. …

Humanistic Health Management and Cancer: Associations of Psychology, Nutrition, and Exercise with Cancer Progression and Pathogenesis.

The incidence rate of cancer is increasing year by year due to the aging of the population, unhealthy living, and eating habits. At present, surgery and medication are still the main treatments for cancer, without paying attention to the impact of individual differences in health management on cancer. However, increasing evidence suggests that individual psychological status, dietary habits, and exercise frequency are closely related to the risk and prognosis of cancer. The reminder to humanity is that the medical concept of the unified treatment plan is insufficient in cancer treatment, and a

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… intake and serum lycopene levels were negatively correlated with various cancers, such as breast, prostate, cervical, ovarian, liver, and other organ cancers. … Since then, multiple studies have reported that with increased lycopene intake and serum levels of lycopene, the risk of cancer has been reduced significantly. [ 52 ] Studies by Giovannucci et al. showed that daily consumption of lycopene‐rich foods was associated with a 30%–40% reduction in prostate …

Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy.

Despite the great advancements made in cancer treatment, there are still many unsatisfied aspects, such as the wide palette of side effects and the drug resistance. There is an obvious increasing scientific attention towards nature and what it can offer the human race. Natural products can be used to treat many diseases, of which some plant products are currently used to treat cancer. Plants produce secondary metabolites for their signaling mechanisms and natural defense. A variety of plant-derived products have shown promising anticancer properties in vitro and in vivo. Rather than recreating

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… Furthermore, an important class of colored secondary metabolites is represented by carotenoids such as Beta-carotene and lycopene. … Lycopene is another carotenoid, extremely potent as an antioxidant, that exhibits anti-proliferative and anticancer properties. …

The Power of Phytochemicals Combination in Cancer Chemoprevention.

Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have recently received increased attention owing to their capability to modulate a myriad of molecular mechanisms with a less toxic effect. Increasing evidence from preclinical and clinical studies suggest that phytochemicals can favorably modulate several signaling pathways involved in cancer development and progression. Combinations of phytochemicals promote cell death, inhibit c

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… Lycopene Lycopene, a carotenoid extracted from vegetables and fruits is found in high concentration in tomatoes 115 . … Lycopene in the Prevention of Radiation-Induced Esophagitis. Nutr Cancer. 2017;69:319–29. doi: 10.1080/01635581.2017.1265133. 120. Mahmoodnia L, Mohammadi K, Masumi R. Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patient. …

Tumor angiogenesis as a target for dietary cancer prevention.

Between 2000 and 2050, the number of new cancer patients diagnosed annually is expected to double, with an accompanying increase in treatment costs of more than $80 billion over just the next decade. Efficacious strategies for cancer prevention will therefore be vital for improving patients' quality of life and reducing healthcare costs. Judah Folkman first proposed antiangiogenesis as a strategy for preventing dormant microtumors from progressing to invasive cancer. Although antiangiogenic drugs are now available for many advanced malignancies (colorectal, lung, breast, kidney, liver, brain,

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… Lycopene Lycopene, a type of natural pigment in the carotenoid family, gives tomatoes and other fruits such as watermelon and papayas their bright red color. Lycopene is an angiogenesis inhibitor which suppresses signaling by PDGF and Platelet Activation Factor in vitro [ 197 ]. … In animal studies, lycopene suppresses spontaneous mammary tumors, hepatocarcinogenesis, colonic crypt foci, prostate cancer, and hepatoma metastases [ 198 ]. Two interventional studies have also demonstrated potent biologic effects of lycopene in the setting of malignancy. …

Antioxidant Intake and Antitumor Therapy: Toward Nutritional Recommendations for Optimal Results.

The role of the induction of oxidative stress as the mechanism of action of many antitumor drugs is acquiring an increasing interest. In such cases, the antitumor therapy success may be conditioned by the antioxidants present in our own body, which can be synthesized de novo (endogenous) or incorporated through the diet and nutritional supplements (exogenous). In this paper, we have reviewed different aspects of antioxidants, including their classification, natural sources, importance in diet, consumption of nutritional supplements, and the impact of antioxidants on health. Moreover, we have f

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… An example is the tomatoes, since their content in lycopene is available only when they are processed by heat [ 74 , 75 ]. 5. … Effects of lycopene against cisplatin-induced nephrotoxicity and oxidative stress in rats. Toxicology. 2005;212(2-3):116–123. doi: 10.1016/j.tox.2005.04.016. 140. Meyer F., Galan P., Douville P., et al. …

Primary Osteoporosis Induced by Androgen and Estrogen Deficiency: The Molecular and Cellular Perspective on Pathophysiological Mechanisms and Treatments.

Primary osteoporosis is closely linked to hormone deficiency, which disrupts the balance of bone remodeling. It affects postmenopausal women but also significantly impacts older men. Estrogen can promote the production of osteoprotegerin, a decoy receptor for RANKL, thereby preventing RANKL from activating osteoclasts. Furthermore, estrogen promotes osteoblast survival and function via activation of the Wnt signaling pathway. Likewise, androgens play a critical role in bone metabolism, primarily through their conversion to estrogen in men. Estrogen deficiency accelerates bone resorption throug

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… Lycopene Considering the plentiful presence of lycopene in human food like guavas, watermelon, cooked tomatoes, papaya, grapefruit, and mangos, along with its exceptional antioxidant capabilities, it is fascinating to investigate the role of lycopene in preventing osteoporosis. … A randomized controlled trial carried out by Mackinnon et al. showed that lycopene supplementation in postmenopausal women significantly boosted antioxidant capacity while reducing oxidative stress and the bone resorption marker N-telopeptide (NTx), suggesting that lycopene may lower bone resorption …

Frailty in Aging and the Search for the Optimal Biomarker: A Review.

In the context of accelerated aging of the population worldwide, frailty has emerged as one of the main risk factors that can lead to loss of self-sufficiency in older people. This syndrome is defined as a reduced state of physiological reserve and functional capacity. The main diagnostic tools for frailty are based on scales that show deficits compared to their clinical application, such as the Fried frailty phenotype, among others. In this context, it is important to have one or more biomarkers with clinical applicability that can objectively and precisely determine the degree or risk of fra

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… The redox balance is altered in frail elderly people, showing that natural antioxidants that can be incorporated into the diet, such as lycopene, lutein/zeaxanthin, and β-cryptoxanthin, can be affected. … Lycopene as a Natural Antioxidant Used to Prevent Human Health Disorders Antioxidants 2020 9 706 10.3390/antiox9080706 PMC7464847 32759751 91. Eisenhauer B. Natoli S. Liew G. Flood V.M. …

Natural Products/Bioactive Compounds as a Source of Anticancer Drugs.

Cancer is one of the major deadly diseases globally. The alarming rise in the mortality rate due to this disease attracks attention towards discovering potent anticancer agents to overcome its mortality rate. The discovery of novel and effective anticancer agents from natural sources has been the main point of interest in pharmaceutical research because of attractive natural therapeutic agents with an immense chemical diversity in species of animals, plants, and microorganisms. More than 60% of contemporary anticancer drugs, in one form or another, have originated from natural sources. Plants

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… Lycopene sensitizes the cervical cancer cells to cisplatin via targeting nuclear factorkappaB (NF- B) pathway Turk. J. Med. Sci. 2021 51 368 374 10.3906/sag-2005-413 32718121 PMC7991865 81. Cheng J. Miller B. Balbuena E. Eroglu A. … Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC Carcinogenesis 2013 34 277 286 10.1093/carcin/bgs351 23129580 84. Lin S. Zhuang J. Zhu L. Jiang Z. …

Curcumin and Its Derivatives as Anticancer Agents in Head and Neck Cancer: Molecular Mechanisms and Preclinical Evidence

Head and neck cancer (HNC), particularly oral squamous cell carcinoma (OSCC), remains a major clinical challenge due to its aggressive behavior, high recurrence rates, and frequent resistance to conventional therapies. Natural compounds, especially curcumin and its derivatives, have gained increasing attention as potential anticancer agents due to their ability to target multiple molecular pathways involved in tumor progression. This review critically evaluates the current preclinical and translational evidence supporting curcumin and its derivatives as monotherapeutic agents in HNC, with part

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… Two separate studies reported that curcumin significantly reduced burning sensation and improved mouth opening; however, lycopene, a carotenoid, demonstrated superior clinical outcomes [ 251 , 252 ]. In other trials, both lycopene and curcumin produced similar overall effects in OSMF management. … Notably, both treatments improved cheek flexibility and reduced submucosal thickness, with lycopene showing a significantly higher reduction than curcumin [ 253 , 254 ]. …