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Patient Preferences for Treatment Outcomes in Oncology with a Focus on the Older Patient-A Systematic Review.

For physicians, it is important to know which treatment outcomes are prioritized overall by older patients with cancer, since this will help them to tailor the amount of information and treatment recommendations. Older patients might prioritize other outcomes than younger patients. Our objective is to summarize which outcomes matter most to older patients with cancer. A systematic review was conducted, in which we searched Embase and Medline on 22 December 2020. Studies were eligible if they reported some form of prioritization of outcome categories relative to each other in patients with all

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… Measuring Patient Preferences: An Overview of Methods with a Focus on Discrete Choice Experiments Rheum. Dis. Clin. N. Am. 2018 44 337 347 10.1016/j.rdc.2018.01.009 29622300 …

Daratumumab in combination with proteasome inhibitors, rapidly decreases polyclonal immunoglobulins and increases infection risk among relapsed multiple myeloma patients: a single center retrospective study.

BackgroundDaratumumab (Dara) is generally well tolerated, but is associated with increased risk of infection.MethodsWe investigated hypogammaglobinemia occurrence in different Dara-based regimens. Multiple myeloma (MM) patients were treated with ⩾2 cycles of Dara-based therapy during 2016-2020, mainly for relapsed/refractory disease. Data on patient characteristics, treatment regimens, polyclonal IgG (poly-IgG) and uninvolved free light chain (Un-FLC) levels during treatment, as well as predictors for hypogammaglobinemia and predictors for infections, were evaluated retrospectively.ResultsA to

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… Ann Rheum Dis 2015 ; 74 : 1474 – 1478 . 25710470 10.1136/annrheumdis-2014-206016 PMC4484251 18 Van De Donk N . Predictive markers of high-grade or serious treatment-emergent infections with daratumumab-based regimens in Newly Diagnosed Multiple Myeloma (NDMM) . …

Распространяется жизнь, угрожая вирусом Нокардии отитидискавиарум у молодой женщины с недавно диагностированным системным волшебством эритематос, отчетом по делу и анализом литературы.

По сообщениям, инфекция, вызванная нокардией, наблюдается главным образом у иммунокомпромиссированных пациентов. Обычно он представляет собой легочную или распространенную болезнь с предрасположенностью к мозгу. Инфекции - это редкая этиология внутричерепной сосудистой аневризмы. В этой связи мы сообщаем о случае распространения Nocardia otitidiscaviarum (N. otitidiscaviarum) у молодой женщины, у которой недавно был диагностирован системный волчан (SLE), осложняемый развитием инфекционной внутричерепной аневризмы. Насколько нам известно, это четвертый случай внутричерепной аневризмы, связанной

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… Ann Rheum Dis. 1991;50(12):968–969. doi: 10.1136/ard.50.12.968-b. PMID: 1768177; PMCID: PMC1004599. 57. Mufti P., Jamil B. Pneumonia caused by Nocardia caviae in a healthy neonate. J Pak Med Assoc. 1995;45(10):272–273. 58. Eren E., Ulu-Kilic A., Atalay A., Demiraslan H., Parkan O., Koc N. …

Socioeconomic Burden of Cancer in Korea from 2011 to 2015.

PurposeThough the socioeconomic burden of cancer on patients is increasing in South Korea, there is little research regarding the type of cancer that incurs the highest costs. This study analyzed the socioeconomic burden on cancer patients from 2011 to 2015 according to sex and age.Materials and methodsA prevalence-based approach was applied utilizing claim data of the National Health Insurance Service in Korea to estimate the socioeconomic burden of cancer on patients. Patients who received treatment for cancer from 2011 to 2015 were the study subjects. The total socioeconomic burden of their

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… Ann Rheum Dis. 2010;69 Suppl 1:i89-91. 28. Pritchard C, Sculpher M. Productivity costs: principles and practice in economic evaluation. London: Office of Health Eco- nomics (OHE); 2000. 29. Jung YH, Ko SJ. Estimating socioeconomic costs of five major diseases. …

Treatment-related Decisional Conflict, Quality of Life, and Comorbidity in Older Adults with Cancer.

ObjectiveThe present study aims to examine the relationships between and among cancer treatment-related decisional conflict, quality of life, and comorbidity in older adults with cancer.MethodsA convenience sample of 200 older adults was recruited from outpatient medical oncology and radiation oncology practices in the northeastern United States. A cross-sectional, descriptive, correlational study design was used employing a survey method. Survey instruments included the Decisional Conflict scale (DCS) (with five subscales, including informed, values clarity, support, uncertainty, and effectiv

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… User Manual – Decisional Conflict Scale Last accessed on 2018 Jun 04 Available from: http://www.ohri.ca/decisionaid 23 Sangha O Stucki G Liang MH Fossel AH Katz JN The self-administered comorbidity questionnaire: A new method to assess comorbidity for clinical and health services research Arthritis Rheum …

Metronomic chemotherapy: changing the paradigm that more is better.

The introduction of the "maximum tolerated dose" in usual treatment protocols (and its concomitant overt toxicity) made necessary the imposition of rest periods between cycles of therapy-a practice that not only involves re-growth of tumour cells, but also growth of selected clones resistant to the therapy. To avoid the problems caused by traditional chemotherapeutic regimens, a new modality of drug administration called "metronomic chemotherapy" has been proposed. This name makes reference to the chronic, equally spaced administration of (generally) low doses of various chemotherapeutic drugs

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… Arthritis Rheum. 1989;32:1065–73. doi: 10.1002/anr.1780320903. 31. Steiner R. Angiostatic activity of anticancer agents in the chick embryo chorioallantoic membrane (che–cam) assay. EXS. 1992;61:449–542. doi: 10.1007/978-3-0348-7001-6_75. 32. Salven P, Mänpää H, Orpana A, Alitalo K, Joensuu H. …

European guidance for the diagnosis and management of osteoporosis in postmenopausal women.

Guidance is provided in a European setting on the assessment and treatment of postmenopausal women at risk from fractures due to osteoporosis.IntroductionThe International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis published guidance for the diagnosis and management of osteoporosis in 2013. This manuscript updates these in a European setting.MethodsSystematic reviews were updated.ResultsThe following areas are reviewed: the role of bone mineral density measurement for the diagnosis of osteoporosis and assessment of fracture

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basi

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… Emodin Emodin is most commonly extracted from the roots and rhizomes of, Rheum palmatum (Chinese rhubarb, family: Polygonaceae), although it is found in other plants from the same family, such as Polygonum cuspidatum (Asian knotweed) and Polygonum multiflorum (Chinese knotweed), and in plants from other …

Окисляющие молекулярные сигнатуры в неизлечимых заболеваниях: систематический обзор комплексных подходов к машинному обучению и системной биологии.

Окисляющий стресс является одним из основных факторов патогенеза иммунных заболеваний в результате его воздействия на клеточный метаболизм, митохондриальную функцию, иммунную сигнализацию и воспалительную травму тканей. Разрушение гомеостазиса способствует метаболическому перепрограммированию и постоянной активации врожденной и адаптивной иммунной реакции, что способствует прогрессированию заболеваний через многочисленные подстрекательские и аутоиммунные расстройства. Последние достижения в области высокопроизводительных молекулярных технологий привели к созданию крупномасштабных многомерных н

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Oxidative stress is a key contributor to the pathogenesis of immune-mediated diseases through its effects on cellular metabolism, mitochondr … mune-mediated diseases including multiple sclerosis, systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, Sjögren's syndrome, and inflammatory bowel disease. Across the reviewed studies, oxidative stress associated with molecular signatures were consistently linked to immune activation, mitochondrial metabolism, and inflammatory signalin …

Secondary antibody deficiencies: what's around the corner?

Secondary antibody deficiencies (SADs) are characterized by impaired humoral immunity, which can cause recurrent and severe infections. Several factors may contribute to SAD development, making it difficult to establish a clear etiological classification. This heterogeneity also leads to clinical variability, further complicating patient management and treatment strategies. Various diagnostic and therapeutic algorithms are often adapted from those used in primary antibody deficiencies, potentially resulting in under- or over-treatment. Key points include the decision to initiate Immunoglobulin

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… Semin Arthritis Rheum. (2022) 57:152099. doi: 10.1016/j.semarthrit.2022.152099, PMID: 125. Sorrell TC, Forbes IJ. Depression of immune competence by phenytoin and carbamazepine studies in vivo and in vitro . Clin Exp Immunol. (1975) 20:273–85., PMID: 126. …

The role of mesenchymal stem cells in attenuating inflammatory bowel disease through ubiquitination.

Inflammatory bowel disease (IBD), a condition of the digestive tract and one of the autoimmune diseases, is becoming a disease of significant global public health concern and substantial clinical burden. Various signaling pathways have been documented to modulate IBD, but the exact activation and regulatory mechanisms have not been fully clarified; thus, a need for constant exploration of the molecules and pathways that play key roles in the development of IBD. In recent years, several protein post-translational modification pathways, such as ubiquitination, phosphorylation, methylation, acety

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… Allogenic mesenchymal stem cells transplantation in refractory systemic lupus erythematosus: a pilot clinical study [published correction appears in Ann Rheum Dis. Ann Rheum Dis. (2010) 69:1423–9. doi: 10.1136/ard.2009.123463 63. Guo J, Yang J, Cao G, Fan H, Guo C, Ma YE, et al. …

A Review on the Molecular Mechanisms of Action of Natural Products in Preventing Bone Diseases.

The drugs used for treating bone diseases (BDs), at present, elicit hazardous side effects that include certain types of cancers and strokes, hence the ongoing quest for the discovery of alternatives with little or no side effects. Natural products (NPs), mainly of plant origin, have shown compelling promise in the treatments of BDs, with little or no side effects. However, the paucity in knowledge of the mechanisms behind their activities on bone remodeling has remained a hindrance to NPs' adoption. This review discusses the pathological development of some BDs, the NP-targeted components, an

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… Desoxyrhapontigenin ( 2 ), a stilbene derived from Rheum undulatum , was shown to prevent OCG in RANKL-exposed BMMs by halting the activation of extracellular signal-regulated kinase (ERK) and suppressing the gene expression of c-Fos and NFATc1 [ 85 ]. … Rhein from Rheum Rhabarbarum Inhibits Hydrogen-Peroxide-Induced Oxidative Stress in Intestinal Epithelial Cells Partly through PI3K/Akt-Mediated Nrf2/HO-1 Pathways J. Agric. Food Chem. 2019 67 2519 2529 10.1021/acs.jafc.9b00037 30779558 144. Kim J.H. Kim M. Hong S.Y. Kim E.Y. Lee H. Jung H.S. …

IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives.

Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways are substantial players in orchestrating the cancer microenvironment. Thus, they appear to be potential targets in anti-tumor therapy. The aim of this article is to elucidate the role of IL-6 in the tumor ecosystem and to review the possible therapeutic approaches in head and neck cancer.

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… Interleukin-6 Receptor Inhibition with Tocilizumab Reduces Disease Activity in Rheumatoid Arthritis with Inadequate Response to Disease-Modifying Antirheumatic Drugs: The Tocilizumab in Combination with Traditional Disease-Modifying Antirheumatic Drug Therapy Study Arthritis Rheum. 2008 58 2968 2980 …

Quality of patient-reported outcome reporting and related trial characteristics in randomized controlled trials of cancer pain: A systematic review based on the CONSORT-PRO extension.

ObjectiveTo systematically evaluate the reporting completeness of patient-reported outcomes (PROs) in randomized controlled trials of cancer pain and to descriptively examine how reporting completeness varied across trial characteristics.MethodsA systematic search of four Chinese literature databases (CNKI, SinoMed, VIP, Wanfang) and three international databases (PubMed, Cochrane Library, Embase) was conducted to identify relevant trials. Randomized controlled trials (RCTs) on cancer pain published from 1 January 2015 to 1 March 2026 that used PROs as either primary or secondary outcomes were

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… Rheum Dis Clin N Am 45 2 2019 211 229 10.1016/j.rdc.2019.01.006 30952394 6 Mayo N.E. ISOQOL Dictionary of Quality of Life and Health Outcomes Measurement 2015 ISOQOL 7 Lopez G. Lacey J. Christie A.J. …

Patterns of Glomerular Injury: Histopathological Classification and Clinical Correlation.

Glomerular diseases represent a diverse group of conditions that significantly contribute to chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide. Understanding the histopathological patterns of glomerular injury is essential for accurate diagnosis, prognosis, and targeted therapy. This comprehensive review explores the morphologic, immunopathologic, and clinical characteristics of major glomerular disorders, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, immunoglobulin A nephropathy, lupus nephritis, and others. Histological

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… Rheum Dis Clin North Am. 2018;44:561–569. doi: 10.1016/j.rdc.2018.06.003. 111. Membranous nephropathy: treatment outline and risk stratification. Arabi Z. Avicenna J Med. 2012;2:60–64. doi: 10.4103/2231-0770.102278. 112. …

Advances in the mechanism and therapies of achondroplasia.

Achondroplasia (ACH), is the prevailing type of genetic dwarfism in humans, caused by mutations in fibroblast growth factor receptor 3 (FGFR3) that are inherited in an autosomal dominant manner. FGFR3 is mainly expressed in condensed mesenchyme, chondrocytes, and mature osteoblasts and osteoclasts, in which it regulates the formation, development, growth, and remodeling of the skeletal system. Mutations in FGFR3 causing ACH result in enhanced FGFR3 signaling through combined mechanisms including enhancing FGF dimerization and tyrosine kinase activity and stabilizing FGF receptors. In ACH, supp

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… Ann Rheum Dis. 2020;79(1):112–122. doi: 10.1136/annrheumdis-2019-215696. 94. Zhang H., Wang H., Zeng C., et al. mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis. …

The Role of Extracellular Vesicles in Bone Regeneration and Associated Bone Diseases.

Extracellular vesicles (EVs) are nanoscale particles with a lipid bilayer membrane structure secreted by various cell types. Nearly all human cells secrete EVs, primarily mediating intercellular communication. In recent years, scientists have discovered that EVs can carry multiple biological cargos, such as DNA, non-coding RNAs (ncRNAs), proteins, cytokines, and lipids, and mediate intercellular signal transduction. Bone is a connective tissue with a nerve supply and high vascularization. The repair process after injury is highly complex, involving interactions among multiple cell types and bi

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… Rheum. Dis. 2013;72:157–161. doi: 10.1136/annrheumdis-2012-202453. 76. Bultink I.E.M., Lems W.F. Osteoarthritis and osteoporosis: What is the overlap? Curr. Rheumatol. Rep. 2013;15:328. doi: 10.1007/s11926-013-0328-0. 77. Cosenza S., Ruiz M., Toupet K., Jorgensen C., Noël D. …

Advancements in Immunology and Microbiology Research: A Comprehensive Exploration of Key Areas.

Immunology and microbiology research has witnessed remarkable growth and innovation globally, playing a pivotal role in advancing our understanding of immune mechanisms, disease pathogenesis, and therapeutic interventions. This manuscript presents a comprehensive exploration of the key areas in immunology research, spanning from the utilisation of bacterial proteins as antibody reagents to the intricate realms of clinical immunology and disease management. The utilisation of bacterial immunoglobulin-binding proteins (IBPs), including protein A (SpA), protein G (SpG), and protein L (SpL), has r

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… Rheum. Dis. 2021;80:14–25. doi: 10.1136/annrheumdis-2020-218272. 118. Kivity S., Agmon-Levin N., Zandman-Goddard G., Chapman J., Shoenfeld Y. Neuropsychiatric Lupus: A Mosaic of Clinical Presentations. BMC Med. 2015;13:43. doi: 10.1186/s12916-015-0269-8. 119. …

Bone fragility and osteoporosis in children and young adults.

Osteoporosis is a metabolic bone disorder which increases fragility fracture risk. Elderly individuals, especially postmenopausal women, are particularly susceptible to osteoporosis. Although rare, osteoporosis in children and young adults is becoming increasingly evident, highlighting the need for timely diagnosis, management and follow-up. Early-onset osteoporosis is defined as the presence of a low BMD (Z-score of ≤ -2.0 in individuals aged < 20 years; T-score of ≤ -2.5 in those aged between 20 to 50 years) accompanied by a clinically significant fracture history, or the presence of low-ene

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… Peris P, Guañabens N, Martínez de Osaba MJ, Monegal A, Alvarez L, Pons F, Ros I, Cerdá D and Muñoz-Gómez J, (2002) Clinical characteristics and etiologic factors of premenopausal osteoporosis in a group of Spanish women Semin Arthritis Rheum 32:64-70. 10.1053/sarh.2002.33725 97. …

GBA1 as a risk gene for osteoporosis in the specific populations and its role in the development of Gaucher disease.

BACKGROUND: Osteoporosis and its primary complication, fragility fractures, contribute to substantial global morbidity and mortality. Gaucher disease (GD) is caused by glucocerebrosidase (GBA1) deficiency, leading to skeletal complications. This study aimed to investigate the impact of the GBA1 gene on osteoporosis progression in GD patients and the specific populations. METHODS: We selected 8115 patients with osteoporosis (T-score ≤ - 2.5) and 55,942 healthy individuals (T-score > - 1) from a clinical database (N = 95,223). Monocytes from GD patients were evaluated in relation to endoplasmic

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… Kwak HB Ha H Kim H-N Lee J-H Kim HS Lee S Kim H-M Kim JY Kim H-H Song YW Lee ZH Reciprocal cross-talk between RANKL and interferon-gamma-inducible protein 10 is responsible for bone-erosive experimental arthritis Arthritis Rheum 2008 58 5 1332 1342 10.1002/art.23372 18438854 32. …