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Single-cell RNA sequencing analysis of bone cancer pain model induced by Lewis lung cancer cells in male mice.

BACKGROUND: Bone cancer pain (BCP) is one of the most severe complications faced by cancer patients, with complex physiological and pathological mechanisms and unclear molecular characteristics. METHODS: The BCP model was established by inoculating Lewis lung cancer cells into the femur to induce hyperalgesia and spontaneous pain. Single-cell RNA sequencing technology was used to characterize the cell composition and molecular features of the L2-L4 spinal cord after BCP modelling. RESULTS: Our research results identified a total of 10 cell types, namely excitatory neurons, inhibitory neurons…

Hypoxia-Inducible Factor-1: A Novel Therapeutic Target for the Management of Cancer, Drug Resistance, and Cancer-Related Pain.

Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor that regulates the transcription of many genes that are responsible for the adaptation and survival of tumor cells in hypoxic environments. Over the past few decades, tremendous efforts have been made to comprehensively understand the role of HIF-1 in tumor progression. Based on the pivotal roles of HIF-1 in tumor biology, many HIF-1 inhibitors interrupting expression, stabilization, DNA binding properties, or transcriptional activity have been identified as potential therapeutic agents for various cancers, yet none of these inhi

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… In an in vivo study using a metastatic bone cancer pain model, the downregulation of annexin A3, a highly expressed protein during bone cancer pain, alleviated pain by inhibiting the HIF-1/VEGF signaling pathway [ 168 ]. … Further studies should address the role of HIF-1 in cancer pain to provide advantages for targeting HIF-1 as a novel anticancer approach. Figure 4 Proposed signaling pathways inducing peripheral neuropathic cancer pain (PNCP) through HIF-1α in hypoxic conditions. …

Frequency of and Factors Associated With Nonmedical Opioid Use Behavior Among Patients With Cancer Receiving Opioids for Cancer Pain.

IMPORTANCE: One of the main aims of research on nonmedical opioid use (NMOU) is to reduce the frequency of NMOU behaviors through interventi … o June 6, 2018. Patients were eligible for inclusion if they had cancer and were taking opioids for cancer pain for at least 1 week. Patients were excluded if they had no follow-up within 3 months of initial consultation, did not complete the appropriate questionnaire, or did not have scheduled opioid treatments. After exclusion, a total of 1554 consecutive p …

Cross-lagged longitudinal analysis of pain and fear of cancer recurrence in young female survivors of breast and gynaecological cancers.

Chronic cancer-related pain affects up to 40% of cancer survivors, yet why pain persists after cancer treatment has ended is not well-understood. The Cancer Threat Interpretation (CTI) model proposes that fear of cancer recurrence (FCR) may perpetuate pain, yet research testing the CTI model to date has been largely cross-sectional. This longitudinal study assessed pain and FCR in 111 Adolescent and Young Adult (18-39 years) survivors of breast and gynaecological cancers, a group at high risk for FCR and long-term impact of pain. Pain and FCR were measured every 2 months over 3 timepoints. We

The cortical morphology of cingulate cortex and microarchitecture of cingulum bundle correlate with cancer pain and anxiety in lung cancer patients.

The cingulate cortex (CC) and cingulum bundle (CB) are key structures involved in pain processing. Thus, we explored the correlations between cortical morphometry of the CC, white matter integrity of the CB, and pain-related assessments in lung cancer patients with cancer pain (CP+). Structural and diffusion spectrum imaging, along with emotion and pain-related assessments, were collected from 45 CP+ patients, 47 lung cancer patients without pain (CP-), and 35 healthy controls (HC). Cortical morphometry and tract-based automatic analysis evaluated the CC and CB. One-way ANOVA revealed signific…

Pain in long-term adult survivors of childhood cancers and their siblings: a report from the Childhood Cancer Survivor Study.

Little is known about pain among long-term adult survivors of childhood cancers. The study investigated pain prevalence in this population compared with sibling controls and examined pain-related risk factors. Three self-reported pain outcomes including pain conditions, prescription analgesics used, and pain attributed to cancer and treatment were assessed among 10,397 cancer survivors and 3034 sibling controls from the Childhood Cancer Survivor Study. Pain conditions (pain/abnormal sensation, migraines, and other headaches) were reported by 12.3%, 15.5%, and 20.5% of survivors, respectively;

Efficacy and safety of transdermal fentanyl and sustained-release oral morphine in patients with cancer and chronic non-cancer pain.

PURPOSE: To evaluate effectiveness and safety information of transdermal fentanyl (TDF) (Duragesic/Durogesic) and sustained-release oral morphine (SRM) in cancer pain (CP) and chronic non-cancer pain (NCP), a pooled analysis was conducted on datasets of published, open label, uncontrolled (no comparator group) and randomised controlled (with SRM as comparator) studies of TDF. PATIENTS AND METHODS: Eight trials with treatment durations of at least 28 days met the inclusion criteria. The effectiveness analysis assessed changes in average pain and pain 'right now' scores between baseline and Day…

Effectiveness of a tele-nursing system for palliative cancer pain in patients with advanced cancer: A pilot randomized controlled trial.

OBJECTIVE: This study evaluated the effectiveness of the Cancer Pain Monitoring System (CAPAMOS), a tele-nursing system for cancer pain relief. METHODS: A pilot randomized controlled trial was conducted from October 2019 to February 2023 among outpatients at Tohoku University Hospital. Participants were randomly assigned in a 1:1 ratio to either the intervention or the control group. Eligible patients reported an average pain score of ≥ 3 on the numerical rating scale over 24 hours. Pain, self-management, and quality of life (QoL) were assessed through questionnaires at enrolment (T0), and at…

The ambiguity of opioids revealed by immunology is changing the knowledge and the therapeutic approach in cancer and non-cancer pain: A narrative review.

Herein, we summarize the steps of a common scientific path taken by the two Guest Editors, an Anesthesiologist (EA) and an Immunologist (AS), and started 25 years ago at the National Cancer Institute in Rome. When in 1980 WHO codified the usage of opioids for cancer pain relief, it was matter of debate whether only disease progression rather than opioid tolerance were the driving force of opioid escalation. The selective intratumoral accumulation of morphine observed in an experimental xenograft model - the initial scenario of our scientific collaboration - revealed a surprising interaction be…

An Explainable AI-Guided Framework for Cancer Pain Phenotyping and Clinical Decision-Making.

PURPOSE: Current pain management often relies primarily on pain intensity, which may not capture patient variability or guide individualized care. Advances in machine learning (ML) and explainable artificial intelligence (XAI) offer opportunities to improve assessment by identifying clinically meaningful subgroups and enhancing model interpretability. This study aimed to identify distinct cancer pain phenotypes using explainable machine learning and to develop a phenotype-guided clinical decision framework to support individualized pain assessment and management. DESIGN: A cross-sectional stu…

Platinum-Paeonol Complexes as ERK Inhibitors To Restrain Melanoma and Relieve Cancer Pain.

Melanoma is a refractory skin cancer with a poor response to chemotherapy and immunotherapy. Activation of the ERK pathway drives cell proli … ssing the metastasis and angiogenesis of melanoma. Uncommonly, DPAP showed the potential to relieve cancer pain by inhibiting the expressions of p-ERK1/2 and COX-2 in nerve cells and inactivating microglia and astrocytes in the spinal cord of mice. Contrary to conventional ERK inhibitors, DPAP upregulated programmed cell death ligand 1 (PD-L1), creating a uni …

Financial hardship and pain among cancer survivors: a French nationwide cross-sectional analysis.

PURPOSE: The relationship between financial hardship and pain in cancer survivors remains poorly understood, with limited evidence linking financial hardship to pain outcomes. METHODS: This nationwide web-based cross-sectional study examined the relationship between pain and financial hardship in French cancer survivors. Data were collected between January 27 and March 20, 2023, through 12 cancer associations and 12 Facebook groups. Primary outcomes were financial hardship (QLQ-C30) and pain status (BPI-SF). Secondary measures included pain characteristics, socio-professional categories and c

Real-World Experience With Initiating Buprenorphine in Opioid Tolerant Patients with Cancer Pain.

CONTEXT: Full-opioid agonists are commonly used for cancer-related pain but include risks such as constipation and respiratory depression. Buprenorphine, a partial opioid agonist, may offer a safer alternative, though concerns regarding withdrawal symptoms and efficacy remain. This study evaluates the real-world success of initiating buprenorphine in opioid tolerant patients for cancer-related pain management. OBJECTIVES: Assess the success rate of initiating buprenorphine products in opioid tolerant patients with cancer-related pain and chronic pain with a history of cancer and evaluate asso

Educational Needs of Nurses in Remote Islands in Japan Regarding Cancer Pain Management.

Nurses play a crucial role in pain management for cancer patients and therefore need sufficient knowledge of pain relief. However, nurses on remote islands have few opportunities to attend training and may face difficulties in clinical practice. This study aimed to identify educational needs and gain insights into the education necessary for cancer pain management through an analysis of the learning needs of nurses on remote islands. A self-administered questionnaire survey was conducted on registered nurses working in cancer pain management on remote islands in Japan. Responses were received …

Endoscopy-assisted intrathecal morphine pump implantation for severe cancer pain: a case report.

This article presents a successful case of endoscopic-assisted intrathecal morphine pump implantation for the treatment of cancer pain associated with bone metastases. The patient was a 45-year-old female with severe cancer pain resulting from multiple bone metastases of rectal malignancy, which was poorly managed by the traditional three-step analgesic ladder. Preoperative intrathecal test puncture was attempted at multiple spinal levels but failed to access the intrathecal space. Subsequently, an endoscopic-assisted intrathecal morphine pump implantation was successfully performed at the L5-…

Co-designing opioid stewardship guidelines for cancer pain management in Nepal: study protocol.

INTRODUCTION: Cancer pain remains inadequately managed in low-resource settings such as Nepal, where regulatory barriers, stigma, limited opioid availability, and insufficient clinical training hinder effective treatment. Although opioids are essential for moderate to severe cancer pain, concerns regarding misuse and weak system-level governance restrict rational access, contributing to avoidable suffering and health inequities. The Pilot Initiative for Local Opioid Treatment (PILOT) study aims to co-design, pilot, and evaluate a contextually appropriate opioid stewardship framework to strengt…

Prelimbic cortex-basolateral amygdala glutamatergic circuit drives cancer-induced bone pain in mice.

Cancer-induced bone pain (CIBP), resulting from bone metastases, is excruciating and lacks effective treatment. Previous studies on CIBP mechanisms mainly focused on the peripheral nervous system and spinal cord, with limited attention to the brain. This study investigates the prelimbic cortex (PrL) to basolateral amygdala (BLA) circuit in regulating CIBP in female mice. CIBP models were established by injecting E0771 cells into the tibias of C57BL/6J female mice. c-Fos expression and calcium activity in BLAGlu neurons were significantly elevated in CIBP models. Optogenetic inhibition of eithe

Effective ropivacaine delivery using lipid nanoparticles enables simultaneous cancer therapy and pain control.

Cancer and its associated pain pose a serious threat to human health. Cancer therapy and pain management are two distinct medical discipline … n (DRG), spinal cord, and tumor. The accumulated LNPs/Rop in the nervous system effectively relieve cancer pain by blocking pain signal transduction and significantly extends the duration of action to at least 36 h, while it is less than 6 h for free Rop. Meanwhile, LNPs/Rop at a safe dose (3 mg/kg) show comparable anti-tumor potency to an equivalent dose of …

Pain profiles in pancreatic cancer and chronic pancreatitis: a multicenter cross-sectional analysis.

INTRODUCTION: Abnormal pain processing has been associated with impaired patient-reported outcomes (PROMs) in chronic pancreatitis (CP), but its clinical relevance in pancreatic ductal adenocarcinoma (PDAC) remains unclear. We investigated the association between P-QST-defined hyperalgesia and pain-related, psychological, and quality-of-life outcomes in patients with painful PDAC and compared these associations with CP. METHODS: This multicenter cross-sectional analysis included patients with painful CP and PDAC at five tertiary referral hospitals in Denmark, Germany and the USA. Based on the

Opioid Use in Cancer Pain Management: Navigating the Line Between Relief and Addiction.

The use of opioids for cancer-related pain is essential but poses significant challenges due to the risk of misuse and the development of opioid use disorder (OUD). This review takes a multidisciplinary perspective based on the current scientific literature to analyze the pharmacological mechanisms, classification, and therapeutic roles of opioids in oncology. Key risk factors for opioid misuse-including psychiatric comorbidities, prior substance use, and insufficient clinical monitoring-are discussed in conjunction with validated tools for pain assessment and international guidelines. The rev