Результаты поиска

Cyclophosphamide L2 protocol: a combination chemotherapeutic regimen for advanced non-hodgkin's lymphoma.

A group of 49 patients with advanced non-Hodgkin's lymphoma were entered in a combination-chemotherapy protocol (cyclophosphamide L2). Of 14 patients with diffuse poorly differentiated lymphocytic lymphoma (DPDL), 64% responded with two partial remissions (PR) and seven complete remissions (CR). Both PRs are stable at 17+ months while six of the CR group are free of disease at 3+-23+ months. Fifty-three percent of 30 patients with diffuse histiocyctic lymphoma (DHL) responded with 23% attaining CR status. Of the nine PR patients, six are stable at 11+-23+ months while six of the seven CR group…

Romidepsin Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone Versus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Previously Untreated Peripheral T-Cell Lymphoma: Final Analysis of the Ro-CHOP Trial.

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.The primary analysis of the Ro-CHOP phase III randomized controlled trial (ClinicalTrials.gov identifier: NCT01796002) established that romidepsin (Ro) plus cyclophosphamide, dox…

Effects of Mega-COMLA (cyclophosphamide, cytarabine, vincristine, and methotrexate followed by leucovorin and prednisone) plus CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) in the treatment of lymphoid neoplasms with very poor prognosis.

Treatment results remain very poor for some clinical and histopathologic subsets of patients with aggressive non-Hodgkin's lymphoma. We treated 21 such patients with a high-dose combination chemotherapy regimen [Mega-COMLA (cyclophosphamide, cytarabine, vincristine, and methotrexate followed by leucovorin and prednisone) + CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone)] in an attempt to improve disease-free survival. Neoplasms were classified using the Lukes-Collins system. Eight patients had T-cell lymphomas (convoluted lymphocytic lymphoma, four patients; T-cell lymphoma/l…

Полная реадмиссия плазмабластической лимфомы с Даратумумабом и мягкого режима Cyclophosphamide, Doxorubicin, Vincristine и Prednisolone (Mini-CHOP).

Плазмабластическая лимфома (PBL) — редкий и весьма агрессивный подтип диффузной большой лимфомы B-клеток, характеризующийся мрачным прогнозом. Из-за его редкости и агрессивности не существует какого-либо установленного стандарта заботы о ПБЛ. Лечение основано главным образом на крупных химиотерапиях на основе лимфомы или множественных миэломы, а результаты остаются низкими. Мы представляем 84-year-old Человек с обширной онкологической историей, который подавал PBL на правой ноге, не реагировав на последующее радиационное лечение. Мягкий режим циклофосфамида, доксорубицина, винкристина и предни

Совпадение в аннотации оригинала
Plasmablastic lymphoma (PBL) is a rare and highly aggressive subtype of diffuse large B-cell lymphoma, characterized by a dismal prognosis. … th PBL on his right foot which did not respond to subsequent radiation treatment. A mild regimen of cyclophosphamide, doxorubicin, vincristine, and prednisolone (mini-CHOP) normally utilized to treat large B-cell lymphoma was supplemented with the CD38-directed monoclonal antibody, daratumumab. This combination regimen was selected for the elderly patient due to h …

Retinoic Acid and Calcitriol Protect Mouse Primordial Follicles from Cyclophosphamide Treatment-Induced Apoptosis.

Chemotherapy causes primordial follicle apoptosis, resulting in premature ovarian insufficiency (POI) and infertility. In this study, we found that intraperitoneal injection of retinoic acid (RA) and calcitriol partially reversed the cyclophosphamide and doxorubicin treatment-induced decrease in primordial follicles in neonatal mouse ovaries. Furthermore, RA and calcitriol co-treatment reversed cyclophosphamide treatment-induced PI3K/Akt activity and FOXO3a nuclear export in the oocytes within primordial follicles, suggesting that the oocyte transcriptional activity was decreased, which in tur…

Electroacupuncture Attenuates Cyclophosphamide-Induced Bladder Pain by Restoring Autophagy in Spinal Inhibitory Interneurons.

Interstitial cystitis/bladder pain syndrome is characterized by chronic pelvic pain and urinary symptoms. Autophagy and oxidative stress are essential to neuronal homeostasis, and their dysregulation in spinal circuits may contribute to persistent pain. While electroacupuncture (EA) has been reported to alleviate cystitis-related pain, the associated cellular changes in the spinal dorsal horn remain incompletely understood. In this study, we used the cyclophosphamide (CYP)-induced cystitis rat model to investigate the cellular and molecular mechanisms underlying the analgesic effects of EA. Be…

Gonadotropin-releasing hormone agonists during cyclophosphamide for ovarian protection in systemic lupus erythematosus.

ABSTRACT: This study aimed to assess whether co-treatment with gonadotropin-releasing hormone agonists during cyclophosphamide therapy protects ovarian function and preserves fertility in women with systemic lupus erythematosus. We performed a systematic review and meta-analysis of comparative cohort studies including premenopausal women with systemic lupus erythematosus treated with intravenous cyclophosphamide with or without gonadotropin-releasing hormone agonists. The primary outcome was primary ovarian insufficiency, with pregnancy and serious adverse events as secondary outcomes. Two rev…

Yam-Active Protein Protects Against Cyclophosphamide-Induced Testicular Injury by Suppressing Inflammatory Responses.

Chemotherapy-induced gonadotoxicity severely compromises male fertility, yet effective interventions remain limited. Building on our previous finding that yam protein (YP) modulates the gut-microbiota axis, this study investigated its direct protective role against cyclophosphamide (CTX)-induced testicular injury. Spectral analysis revealed a protein fraction (L-YP) with strong intrinsic fluorescence and optimal cytoprotection against oxidative stress. Proteomic characterization revealed six dominant proteins (YP1-YP6). In vivo experiments demonstrated that L-YP upregulates the expression of t…

Chronic graft-<I>versus</i>-host disease in the era of posttransplant cyclophosphamide.

Chronic graft-versus-host disease (cGVHD) remains a leading cause of late morbidity after allogeneic hematopoietic cell transplantation (HCT), but its phenotype under modern prophylaxis with post-transplant cyclophosphamide (PTCy) is not well characterized. We conducted a prospective, single-center study of 600 consecutive adults undergoing HCT with PTCy- based prophylaxis to assess incidence, clinical manifestations, treatment response, prognostic factors, and outcomes. Donors included matched siblings (36%), matched unrelated (34%), haploidentical (24%), and mismatched unrelated (6%). The 1-…

Immunomodulatory effects of sea buckthorn leaf green tea in cyclophosphamide-induced immunosuppressed mice.

Sea buckthorn leaf green tea prepared from Hippophae rhamnoides L. leaves contains a complex mixture of bioactive phytochemicals, yet its immunoregulatory potential remains unclear. The study aimed to investigate the immunomodulatory effects and underlying mechanisms of sea buckthorn leaf green tea extract (SBGT) in cyclophosphamide-induced immunosuppressed mice. Widely targeted metabolomics revealed that green tea processing significantly increased the contents of flavonoids and polyphenols in sea buckthorn leaves. Animal experiments showed that SBGT effectively alleviated cyclophosphamide-in…

[Employment Status Breast Cancer Patients Received Dose-Dense EC (Epirubicin plus Cyclophosphamide) Therapy].

PURPOSE: To support the employment of breast cancer patients, it is important to reveal the factors that influence the side effects of chemotherapy on employment. However, there are still a few reports on the factors regarding the side effects of breast cancer chemotherapy and employment. In this study, we report on the employment status of patients with first-episode breast cancer who were treated with dd EC before surgery. SUBJECTS: Patients who underwent cancer treatment at Hospital of the University of Occupational and Environmental Health between January 2023 and December 2024 and met th

Luteolin alleviates cyclophosphamide-induced premature ovarian failure in rats by regulating RNF8/HDAC2.

ObjectiveThe study aimed to investigate the role of luteolin in alleviating POF and its underlying molecular mechanisms.MethodsPOF model was established in rats by intraperitoneal injection of 100 mg/kg cyclophosphamide. Then, rats in the treatment group received intragastric administration of with luteolin at doses of 25 mg/kg, 50 mg/kg and 100 mg/kg, respectively. Rats in POF model group were administered the same volume of saline intragastrically. The concentrations of E2, FSH, AMH, P, LH, SOD and MDA in serum were quantified using ELISA kits. H&E and TUNEL staining were employed to assess …

Shengxian decoction alleviates cyclophosphamide-induced immunosuppression via improving B cell-mediated immune responses.

BACKGROUND: Chemotherapy is a prevalent and extensively utilized cancer treatment modality. However, it can result in immunosuppression. She … mechanisms. METHODS: The immunosuppression mouse model was generated through the administration of cyclophosphamide for 3 days. After that, the mice were treated by SXD extracts at doses of 0.47 and 0.94 g/kg/day, respectively. The spleen, thymus and blood of mice were collected for evaluation of drug efficacy. The population of B and T cells was detected by flow …

Haploidentical Stem Cell Transplantation With Dual Source of Cells and Post-Transplant Cyclophosphamide.

BACKGROUND: Dual sources of cells (DSC) with peripheral blood stem cell apheresis (PBSC) and surgical bone marrow (BM) for haploidentical hematopoietic cell transplantation (Hid-HCT) are used in China and some Asian countries. The experience of the Baltimore group for haploidentical transplant with post-transplant cyclophosphamide (PT-Cy) and reduced-intensity-conditioning (RIC) regimen used BM as a source of hematopoietic stem cells. METHODS: We retrospectively analyzed 64 Hid-HCT with DSC and PT-Cy, RIC (n = 57), or myeloablative-conditioning (MAC) (n = 7), from two public health Brazilian …

Cancer immunotherapeutic targeting tropomyosin receptor kinase C (TrkC) through its conjugate and cyclophosphamide.

PURPOSE: Cancer cells often overexpressed specific receptors to support their proliferation and promote immunosuppressive tumor microenvironment. Tropomyosin receptor kinase C (TrkC) is known to be overexpressed in cancer, and implicated in promoting tumor progression and metastasis. This study investigates synergistic efficacy and immunomodulatory effect of a peptidomimetic TrkC-targeted ligand (IYIY) conjugated with dinitrophenol (DNP) hapten (IYIY-DNP), in combination with cyclophosphamide (CTX), an alkylating chemotherapeutic with immune-modulating properties. MATERIALS AND METHODS: Femal…

Danggui Buxue Decoction Combined with Borneol Improves Cyclophosphamide-Induced Myelosuppression by Inhibiting CDK2.

Objective: This study explored the effective components and molecular targets of Danggui Buxue decoction (DBD) combined with borneol (DBD&Bor) in alleviating myelosuppression. Methods: A network pharmacology strategy was used to identify the active components and key targets of DBD&Bor in the context of myelosuppression. In vivo, the effects of the DBD&Bor and its effective components on cyclophosphamide (CTX)-induced myelosuppression in rats were evaluated through immunohematological analysis, histopathological analysis, and organ index analysis. In vitro, the impact of the effective componen…

Green synthesized selenium nanoparticles mitigate cyclophosphamide-induced reproductive toxicity in male Wistar rats.

Cyclophosphamide (CP), a widely used alkylating chemotherapeutic and immunosuppressive agent, is associated with significant reproductive toxicity in male patients, primarily through oxidative stress and inflammatory damage to testicular tissue. This study investigates the protective effect of green-synthesised selenium nanoparticles (SeNPs) from Azadirachta indica leaves extract against CP-induced reproductive toxicity in male Wistar rats. SeNPs were characterised by FTIR, XRD, DLS, SEM, TEM, and EDX, confirming crystalline structure, and mean particle sizes of 70-100 nm. Male rats (n = 30) w…

Evaluating rituximab against cyclophosphamide or cyclosporine in idiopathic membranous nephropathy: a meta-analysis.

BACKGROUND: Idiopathic membranous nephropathy (IMN) is a common cause of nephrotic syndrome in adults. While cyclophosphamide and cyclosporine are established treatments, rituximab has emerged as a promising alternative. This meta-analysis aims to compare the efficacy of rituximab versus cyclophosphamide and cyclosporine in patients with IMN. METHODS: A meta-analysis was conducted in accordance with PRISMA guidelines. Databases including PubMed, EMBASE, Cochrane and Web of Science were searched for randomized controlled trials and observational studies comparing rituximab to cyclophosphamide …