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From laboratory to clinic: opportunities and challenges of functional food active ingredients in cancer therapy.

This review provides a comprehensive analysis of the potential of functional food active ingredients in cancer prevention and therapy. It outlines the multifaceted anticancer mechanisms of bioactive compounds-such as polyphenols, carotenoids, omega-3 fatty acids, phytosterols, alkaloids, isothiocyanates, polysaccharides, phenolic acids, flavonols, and amide-bearing compounds-which include antioxidant and anti-inflammatory activities, induction of apoptosis and autophagy, modulation of the tumor microenvironment, interference with cell cycle regulation and signaling pathways, and regulation of

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… Lycopene, a carotenoid found in tomatoes, is known to suppress chronic inflammatory signaling; notably, it inhibits NF-κB activation, thereby reducing pro-inflammatory cytokines and mediators such as COX-2 and iNOS in the tumor microenvironment. … Clinical studies demonstrate that circulating lycopene increases with supplementation (pooled mean difference: 0.1361; 95% CI [0.0574; 0.2148]), correlating with a 7% reduction in specific prostate cancer types. …

Oxyphenbutazone ameliorates carfilzomib induced cardiotoxicity in rats via inhibition of oxidative free radical burst and NF-κB/IκB-α pathway.

Carfilzomib (CFZ), a chemotherapeutic agent used for multiple myeloma treatments reported to cause high incidence of cardiac events either new onset and/or exacerbate formerly diagnosed heart failure with ventricular and myocardial dysfunction. Purpose: Current research designed to explore and examine the preventive effect of oxyphenbutazone in the CFZ -instigated cardiotoxicity. Methodology: Female Wistar Rats weighing 200-250 g selected randomly and grouped as follows: Group 1 designated as the Normal control and receive normal saline only. Group 2 served toxic control and exposed to CFZ (4

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… Antioxidant and anti-apoptotic potency of allicin and lycopene against methotrexate-induced cardiac injury in rats Environ. Sci. Pollut. Res. Int. 30 38 2023 88724 88733 10.1007/s11356-023-28686-4 Epub 2023 Jul 13 PMID: 37440131 37440131 Ahmad S.F. … Ameliorating effect of lycopene and N-acetylcysteine against cisplatin-induced cardiac injury in rats Pak. Vet. J. 42 1 2022 107 111 10.29261/pakvetj/2021.035 Esparís-Ogando A. Alegre A. Bortezomib is an efficient agent in plasma cell leukemias Int. J. …

Açai Berry Attenuates Cyclophosphamide-Induced Damage in Genitourinary Axis-Modulating Nrf-2/HO-1 Pathways.

Cyclophosphamide (CYP) is used to treat different malignancies and autoimmune disorders in men. This chemotherapy frequently reduces tumors, which is beneficial, but also causes infertility because of severe oxidative stress, inflammation, and apoptosis in the bladder and testes brought on by its metabolite, acrolein. The goal of this study was to assess the efficacy of a novel food, açai berry, in preventing CYP-induced damage in the bladder and testes.MethodsCYP was administered intraperitoneally once during the experiment at a dose of 200 mg/kg body weight diluted in 10 mL/kg b.w. of water.

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… Five forms of carotenoids—carotene, lycopene, astaxanthin, lutein, and zeaxanthin—are found in the pulp of açai fruit [ 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. … Lycopene protects against cyclosporine A-induced testicular toxicity in rats. Theriogenology. 2007;67:778–785. doi: 10.1016/j.theriogenology.2006.10.013. 130. Ceribasi A.O., Türk G., Sönmez M., Sakin F., Ateşşahin A. …

Терапевтическая ориентация на нейроинфламацию, вызванную ожирением, и нейродегенерацию.

Ожирение является одним из основных из изменяемых факторов риска, ведущих к нейроинфламмации и нейродегенерации. Чрезмерное содержание жира в ожирении способствует постепенному проникновению иммунных клеток в жировые ткани, что приводит к высвобождению провоспалительных факторов, таких, как цитокины и адипокины. Эти подстрекательские посредники циркулируют по кровотоку, пропагандируя воспаление как на периферии, так и в центральной нервной системе. Гут дисбиоз, который приводит к утечке кишечного барьера, усугубляет воспаление и играет важную роль в увязке ожирения с патогенезом нейроинфламмац

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… Lycopene is another dietary supplement with BBB penetrating properties that was able to decrease IL-1β, IL-6, and NF-κB levels within the hypothalamus of HFD rats ( 139 ). … Lycopene also greatly increases activities of glutathione (GSH), SOD and catalase (CAT) and decreases malondialdehyde (MDA), a by-product of peroxidation caused by ROS, and hydrogen peroxide in the cerebrum of HFD rats ( 139 ). …

The Redox Paradox of Natural Supplements in Cancer: A Narrative Review to Guide Clinical Practice.

Supplements are widely perceived as safe and beneficial; yet in oncology, this assumption is questionable. Clinical trials over the past few decades have often produced disappointing results, raising a critical question: are these agents used correctly, or could they inadvertently cause harm? This review examines supplements frequently used in cancer care-such as oral vitamin C, berberine, N-acetylcysteine, vitamin D, vitamin E, melatonin, polyphenols, alpha-lipoic acid, selenium, and coenzyme Q10-which can act as tumor suppressors or promoters depending on dose, route, and disease stage. We e

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… Antioxidants increase overall mortality. [ 139 ] | Prevention and mortality | 104,196 | Systematic review and meta-analysis | Men and women for primary cancer | Beta carotene, selenium, vitamin C (ascorbic acid), vitamin E (α-tocopherol), and lycopene alone or in combination | Beta-carotene 15–30 mg/ … , folate, iron, carotenoids, beta-carotene, selenium, pyridoxine | Vitamin A, 1500 to 8000 µg/day; vitamin C, 310 to 750 mg/day; vitamin D, 125 to 620 IU/day; vitamin E, 40 to 300 IU/day; folate 128 to 703 µg/day; beta-carotene 20 mg/day, lycopene, 837 to 11 680 µg/day; iron, <11.3 to >17.3 mg/day or …

Antioxidants in brain tumors: current therapeutic significance and future prospects.

Brain cancer is regarded among the deadliest forms of cancer worldwide. The distinct tumor microenvironment and inherent characteristics of brain tumor cells virtually render them resistant to the majority of conventional and advanced therapies. Oxidative stress (OS) is a key disruptor of normal brain homeostasis and is involved in carcinogenesis of different forms of brain cancers. Thus, antioxidants may inhibit tumorigenesis by preventing OS induced by various oncogenic factors. Antioxidants are hypothesized to inhibit cancer initiation by endorsing DNA repair and suppressing cancer progress

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… Lycopene is known to act on tumor cells by preventing DNA damage, suppressing survival, and inhibiting motility. In a preclinical assay, lycopene has shown the potential to induce apoptosis in glioblastoma cells [ 208 ]. … Lycopene supplementation potentiates the therapeutic response to standard therapy in GBM by suppressing tumor recurrence [ 209 ]. …

Hidrox® Counteracts Cyclophosphamide-Induced Male Infertility through NRF2 Pathways in a Mouse Model.

BACKGROUND: Every year, men use cyclophosphamide to treat various cancers and autoimmune diseases. On the one hand, this chemotherapy often has the beneficial effect of regressing the tumor, but on the other hand, it leads to infertility due to excessive oxidative stress and apoptosis in the testes caused by its metabolite, acrolein. METHODS: The objective of this study was to evaluate the beneficial power of a new compound called Hidrox®, containing 40-50% hydroxytyrosol, in counteracting the damage related to fertility induced by cyclophosphamide. The study was conducted using a single intr

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… Lycopene protects against cyclosporine A-induced testicular toxicity in rats Theriogenology 2007 67 778 785 10.1016/j.theriogenology.2006.10.013 17123593 119. Ceribasi A.O. Turk G. Sonmez M. Sakin F. Atessahin A. … Toxic effect of cyclophosphamide on sperm morphology, testicular histology and blood oxidant-antioxidant balance, and protective roles of lycopene and ellagic acid Basic Clin. Pharmacol. Toxicol. 2010 107 730 736 10.1111/j.1742-7843.2010.00571.x 20353483 120. Elkin E.R. Harris S.M. Loch-Caruso R. …

Research prioritization of men's health and urologic diseases.

OBJECTIVES: We sought to determine whether disease representation in the Cochrane Database of Systematic Reviews (CDSR) reflects disease burden, measured by the Global Burden of Disease (GBD) Study as disability-adjusted life-years (DALYs). MATERIALS AND METHODS: Two investigators performed independent assessment of ten men's health and urologic diseases (MHUDs) in CDSR for systematic review and protocol representation, which were compared with percentage of total 2010 DALYs for the ten conditions. Data were analyzed for correlation using Spearman rank analysis. RESULTS: Nine of ten MHUDs we

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… prostatic obstruction (P) Prostatic Diseases and Urologic Cancers Group N/A 2014 Prostate cancer 5-alpha-reductase inhibitors for prostate cancer prevention (R) Prostatic Diseases and Urologic Cancers Group 9 2008 Screening for prostate cancer (R) Prostatic Diseases and Urologic Cancers Group 5 2013 Lycopene … Prostatic Diseases and Urologic Cancers Group | N/A | 2014 Prostate cancer | 5-alpha-reductase inhibitors for prostate cancer prevention (R) | Prostatic Diseases and Urologic Cancers Group | 9 | 2008 | Screening for prostate cancer (R) | Prostatic Diseases and Urologic Cancers Group | 5 | 2013 | Lycopene …

Phytosome-Enhanced Secondary Metabolites for Improved Anticancer Efficacy: Mechanisms and Bioavailability Review.

PurposePhytosome technology, an advanced lipid-based delivery system, offers a promising solution for enhancing the bioavailability and therapeutic efficacy of secondary metabolites, particularly in cancer treatment. These metabolites, such as flavonoids, terpenoids, and alkaloids, possess significant anticancer potential but are often limited by poor solubility and low absorption. This review aims to investigate how phytosome encapsulation improves the pharmacokinetic profiles and anticancer effectiveness of these bioactive compounds.Patients and methodsThis comprehensive review is based on a

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… Terpenoids, such as lycopene and gamma-tocopherol, have important functions in preventing the growth of cancer. 96 These compounds are recognized for their ability to inhibit cell division and trigger programmed cell death (apoptosis) in cancer cells, specifically in models of prostate and breast cancer … Terpenoid Group: Lycopene and gamma-tocopherol. Polyphenol Group: Etoposide, resveratrol, curcumin, and epigallocatechin gallate (EGCG). Flavonoid Group: Apigenin, genistein, and kaempferol. …

Mutual connected IL-6, EGFR and LIN28/Let7-related mechanisms modulate PD-L1 and IGF upregulation in HNSCC using immunotherapy

The development of techniques and immunotherapies are widely applied in cancer treatment such as checkpoint inhibitors, adoptive cell therapy, and cancer vaccines apart from radiation therapy, surgery, and chemotherapy give enduring anti-tumor effects. Minority people utilize single-agent immunotherapy, and most people adopt multiple-agent immunotherapy. The difficulties are resolved by including the biomarkers to choose the non-responders’ and responders’ potentials. The possibility of the potential complications and side effects are examined to improve cancer therapy effects. The Head and Ne

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… PD-L1 overexpression was demonstrated to activate IGF-1R-mediated PI3K/Akt and RAF/MEK/ERK pathways and elevate STAT3, NF-κB, and c-Myc, which are reversible by lycopene in tongue squamous cell carcinoma ( 9 ). … Programmed death-ligand 1 signaling and expression are reversible by lycopene via PI3K/AKT and Raf/MEK/ERK pathways in tongue squamous cell carcinoma. Genes Nutr (2022) 17(1). doi: 10.1186/s12263-022-00705-y 9. Li J, Xu J, Yan X, Jin K, Li W, Zhang R. …

Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications.

Reactive oxygen species (ROS) act as critical secondary messengers in various intracellular signaling pathways that regulate cellular proliferation, differentiation, and survival under normal physiological conditions. However, dysregulation of redox signaling-driven by genetic mutations, epigenetic alterations, and posttranscriptional or posttranslational modifications-plays a central role in malignant transformation and cancer progression. Cancer cells typically exhibit elevated basal ROS levels due to increased metabolic activity, mitochondrial dysfunction, and oncogene activation. This mode

Comprehensive Review of Methodology to Detect Reactive Oxygen Species (ROS) in Mammalian Species and Establish Its Relationship with Antioxidants and Cancer.

Evidence suggests that reactive oxygen species (ROS) mediate tissue homeostasis, cellular signaling, differentiation, and survival. ROS and antioxidants exert both beneficial and harmful effects on cancer. ROS at different concentrations exhibit different functions. This creates necessity to understand the relation between ROS, antioxidants, and cancer, and methods for detection of ROS. This review highlights various sources and types of ROS, their tumorigenic and tumor prevention effects; types of antioxidants, their tumorigenic and tumor prevention effects; and abnormal ROS detoxification in

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… Among 600 types of carotenoids, β -carotene and lycopene exhibit high antioxidant properties [ 111 ]. Hepatic catabolism of β -carotene leads to vitamin retinol that may neutralize peroxyl radicals [ 112 ]. … Apart from NAC, other AOs such as lycopene were also evaluated for their ability to reduce the cisplatin toxicity. One study revealed lycopene ability to reduce the cisplatin-induced renal toxicity [ 152 ]. …

Antioxidant effects of Spirulina platensis (Arthrospira platensis) on cyclophosphamide-induced testicular injury in rats.

Cyclophosphamide (CP) is known to reduce fertility. The protective effects of Spirulina plantesis (SP) against CP-induced testicular toxicity were investigated. Male Wistar rats were categorized into eight groups (n = 7). Four groups of rats were administered CP at a dose of 5 mg in 5 mL distilled water kg-1 per day orally. Two of these groups were received SP (500 and 1000 mg kg-1 per day) orally after CP administration. One of these groups was also received vitamin E (100 mg kg-1 per day) intraperitoneally. A vehicle treated control group, two SP control groups (500 and 1000 mg kg-1 per day)

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… protects against cyclophosphamide-induced reproductive toxicity Reprod Toxicol 2007 24 3 365 370 17624719 10.1016/j.reprotox.2007.05.007 39 Ceribasi AO Turk G Sonmez M Toxic effect of cyclophosphamide on sperm morphology, testicular histology and blood oxidant-antioxidant balance, and protective roles of lycopene …

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise.

Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Multiple strategies aiming to promote healthy aging and extend the lifespan have been developed including lifestyle adjustments, medical treatments, and social programs. A multitude of antiaging medicines and remedies have also been explored. Here, we use data from the CAS Content Collect

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… A recent systematic review has also reported that vitamin D intake notably lowers the risk of acute respiratory infections. 230 Other vitamins such as B vitamins, K vitamins, and others have been examined as dietary supplements that assist healthy aging. 225 Vitamin B12 in combinations with bacopa, lycopene … effect in various animal and cell models. 368 Its antiaging efficacy has been documented in vitro , using mesenchymal stem cells, as well as in vivo , in model animals. 369 It was implied to inhibit aging by regulating the KAT7-P15 signaling axis. 369 Other carotenoids, including α- and γ-carotenes, lycopene …

Advances in Diet and Physical Activity in Breast Cancer Prevention and Treatment.

There is currently a growing interest in diets and physical activity patterns that may be beneficial in preventing and treating breast cancer (BC). Mounting evidence indicates that indeed, the so-called Mediterranean diet (MedDiet) and regular physical activity likely both help reduce the risk of developing BC. For those who have already received a BC diagnosis, these interventions may decrease the risk of tumor recurrence after treatment and improve quality of life. Studies also show the potential of other dietary interventions, including fasting or modified fasting, calorie restriction, keto

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… Lycopene, a natural antioxidant found in tomatoes, exhibits antitumor activity through its antioxidant, anti-inflammatory, and immunomodulatory properties. … Lycopene also inhibits the growth of BC cells by blocking NF-κB signaling [ 21 ]. …

The Burden of Cancer, Government Strategic Policies, and Challenges in Pakistan: A Comprehensive Review.

Cancer is a severe condition characterized by uncontrolled cell division and increasing reported mortality and diagnostic cases. In 2040, an estimated 28.4 million cancer cases are expected to happen globally. In 2020, an estimated 19.3 million new cancer cases (18.1 million excluding non-melanoma skin cancer) had been diagnosed worldwide, with around 10.0 million cancer deaths. Breast cancer cases have increased by 2.26 million, lung cancer by 2.21 million, stomach by 1.089 million, liver by 0.96 million, and colon cancer by 1.93 million. Cancer is becoming more prevalent in Pakistan, with 19

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… Cardioprotection, anti-inflammatory, Antimutagenic, and anti-carcinogenic qualities are only a few of the biological advantages of tomato lycopene ( 71 ). Lycopene-rich tomatoes and tomato products have decreased the risk of chronic diseases such as cancer and heart disease ( 71 ). …

A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health.

Curcumin is the most important active component in turmeric extracts. Curcumin, a natural monomer from plants has received a considerable attention as a dietary supplement, exhibiting evident activity in a wide range of human pathological conditions. In general, curcumin is beneficial to human health, demonstrating pharmacological activities of anti-inflammation and antioxidation, as well as antitumor and immune regulation activities. Curcumin also presents therapeutic potential in neurodegenerative, cardiovascular and cerebrovascular diseases. In this review article, we summarize the advancem

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… Lycopene can increase the antioxidant function of curcumin and effectively improve its antioxidation in mice with acute ethanol oxidative injury [ 132 ]. Glycyrrhetinic acid combined with curcumin could inhibit the proliferation of liver cancer cells and induce apoptosis more effectively [ 133 ]. … The combination of lycopene and curcumin on the acute ethanol oxidative damage in mice antioxidant effects Cap. Med. Univ. 2021 42 89 93 133. Chang M.X. Wu M.M. Li H.M. The inhibitory effect of curcumin combined with glycyrrhetinic acid on the proliferation of hepatoma HepG-2 cells Drug Eval. …

Drug repurposing: A novel strategy to target cancer stem cells and therapeutic resistance.

Chemotherapy is an effortless and frequently used approach in cancer therapy. However, in most cases, it can only prolong life expectancy and does not guarantee a complete cure. Furthermore, chemotherapy is associated with severe adverse effects, one of the major complications of effective cancer therapy. In addition, newly published research outputs show that cancer stem cells are involved in cancer disease progression, drug resistance, metastasis, and recurrence and that they are functional in the trans-differentiation capacity of cancer stem cells to cancer cells in response to treatments.

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… Phytonutrients in cancer therapy Several phytonutrients are being demonstrated as promising sources of anti-cancer agents by affecting the regulation of various signaling pathways, together with autophagy and apoptosis. 234 Sulforaphane, resveratrol, lycopene, epigallocatechin, curcumin, and berberine … are some phytochemicals that exerted their anti-cancer potential in vitro and in vivo through modulating the autophagy-apoptosis in clinical trials for different cancer types. 235 Furthermore, dietary components such as capsaicin, cucurbitacin B, isoflavones, catechins, lycopene, benzyl isothiocyanate …

Crosstalk of thioredoxin system and programmed cell death: from pathophysiology to novel therapy.

The thioredoxin (Trx) system, an integral component of cellular redox regulation, preserves protein dithiol-disulfide equilibrium through its conserved Cys-Gly-Pro-Cys active site and is involved in key cellular functions, including cell proliferation, apoptosis, and signal transduction. In cancer biology, the thioredoxin system plays dual roles: overexpression can suppress oxidative stress and promote tumor growth, whereas dysfunction can trigger programmed cell death (PCD). However, a critical area for future research is to delineate how Trx modulates the intricate networks of PCD, and to id

От ожирения до митохондриальной дисфункции в периферальных тканях и в центральной нервной системе.

Ожирение - это состояние хронического низкосортного воспаления, затрагивающего периферийные органы тела, а также центральную нервную систему. Дефункция жировой ткани, возникающая в условиях ожирения, является ключевым фактором возникновения и развития различных заболеваний, включая нейродегенеративные расстройства. Митохондрия, ключевые органеллы в производстве клеточной энергии, играет важную роль в этой дисфункции тканей. В многочисленных исследованиях подчеркивается тесная связь между ожирением и дисфункцией митохондриалов адипоцита, что приводит к чрезмерному производству ROS и воспалению

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… Lycopene (LYC) is the main carotenoid present in tomatoes and tomato products, and its anti-obesity effect has been shown in mice fed a high-fat diet, whose adiposity was reduced after supplementation. LYC could reduce body weight gain by increasing energy expenditure. …