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Impact of COVID-19 on immunocompromised populations during the Omicron era: insights from the observational population-based INFORM study.

BackgroundImmunocompromised individuals are not optimally protected by COVID-19 vaccines and potentially require additional preventive interventions to mitigate the risk of severe COVID-19. We aimed to characterise and describe the risk of severe COVID-19 across immunocompromised groups as the pandemic began to transition to an endemic phase.MethodsCOVID-19-related hospitalisations, intensive care unit (ICU) admissions, and deaths (01/01/2022-31/12/2022) were compared among different groups of immunocompromised individuals vs the general population, using a retrospective cohort design and elec

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… Ann Rheum Dis. 2021;80(10):1322–1329. doi: 10.1136/annrheumdis-2021-220626. 20. Shoham S., Batista C., Ben Amor Y., et al. Vaccines and therapeutics for immunocompromised patients with COVID-19. eClinicalMedicine. 2023;59 doi: 10.1016/j.eclinm.2023.101965. 21. …

Developing the Breast Utility Instrument to Measure Health-Related Quality-of-Life Preferences in Patients with Breast Cancer: Selecting the Item for Each Dimension.

Introduction. Generic preference-based instruments inadequately measure breast cancer (BrC) health-related quality-of-life preferences given advances in therapy. Our overall purpose is to develop the Breast Utility Instrument (BUI), a BrC-specific preference-based instrument. This study describes the selection of the BUI items. Methods. A total of 408 patients from diverse BrC health states completed the EORTC QLQ-C30 and BR45 (breast module). For each of 10 dimensions previously assessed with confirmatory factor analysis, we evaluated data fit to the Rasch model based on global model and item

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… Arthritis Rheum . 2007 ; 57 :1358–62. DOI: 10.1002/art.23108 18050173 32 Bray N Tudor Edwards R. Preference-based measurement of mobility-related quality of life: developing the MobQoL-7D health state classification system . Disabil Rehabil . 2022 ; 44 :2915–29. …

Definition and management of very high fracture risk in women with postmenopausal osteoporosis: a position statement from the Brazilian Society of Endocrinology and Metabolism (SBEM) and the Brazilian Association of Bone Assessment and Metabolism (ABRASSO).

Several drugs are available for the treatment of osteoporosis in postmenopausal women. Over the last decades, most patients requiring pharmacological intervention were offered antiresorptive drugs as first-line therapy, while anabolic agents were considered a last resource for those with therapeutic failure. However, recent randomized trials in patients with severe osteoporosis have shown that anabolic agents reduce fractures to a greater extent than antiresorptive medications. Additionally, evidence indicates that increases in bone mineral density (BMD) are maximized when patients are treated

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… Jeune B Short time-frame from first to second hip fracture in the Funen County Hip Fracture Study Osteoporos Int 2006 17 9 1353 1357 16823545 10.1007/s00198-006-0125-y 24 van Geel TA van Helden S Geusens PP Winkens B Dinant GJ Clinical subsequent fractures cluster in time after first fractures Ann Rheum …

A review of neurotoxicities associated with immunotherapy and a framework for evaluation.

Immuno-oncology agents, including immune checkpoint inhibitors (ICIs) and chimeric antigen receptor T (CAR-T) cell therapies, are increasing in use for a growing list of oncologic indications. While harnessing the immune system against cancer cells has a potent anti-tumor effect, it can also cause widespread autoimmune toxicities that limit therapeutic potential. Neurologic toxicities have unique presentations and can progress rapidly, necessitating prompt recognition. In this article, we review the spectrum of central and peripheral neurologic immune-related adverse events (irAEs) associated

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… Semin Arthritis Rheum. 2014;43(5):638–647. 48. Safa H, Johnson DH, Trinh VA, et al. Immune checkpoint inhibitor related myasthenia gravis: single center experience and systematic review of the literature. J Immunother Cancer. 2019;7(1):319. 49. Suzuki S, Ishikawa N, Konoeda F, et al. …

Novel Treatments in Myasthenia Gravis.

Myasthenia gravis (MG) is the prototypical autoimmune disorder caused by specific autoantibodies at the neuromuscular junction. Broad-based immunotherapies, such as corticosteroids, azathioprine, mycophenolate, tacrolimus, and cyclosporine, have been effective in controlling symptoms of myasthenia. While being effective in a majority of MG patients many of these immunosuppressive agents are associated with long-term side effects, often intolerable for patients, and take several months to be effective. With advances in translational research and drug development capabilities, more directed ther

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… Arthr Rheum. ( 1998 ) 41 : 761 – 7 . 10.1002/1529-0131(199805)41:5<761::AID-ART2>3.0.CO;2-M 9588727 14. Hartung H-P . Advances in the understanding of the mechanism of action of iVIg . J Neurol. ( 2008 ) 255 : 3 – 6 . 10.1007/s00415-008-3002-0 18685919 15. Sathasivam S . …

Clinical practice guidelines and consensus statements in oncology--an assessment of their methodological quality.

BackgroundConsensus statements and clinical practice guidelines are widely available for enhancing the care of cancer patients. Despite subtle differences in their definition and purpose, these terms are often used interchangeably. We systematically assessed the methodological quality of consensus statements and clinical practice guidelines published in three commonly read, geographically diverse, cancer-specific journals. Methods Consensus statements and clinical practice guidelines published between January 2005 and September 2013 in Current Oncology, European Journal of Cancer and Journal o

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… Arthritis Rheum 59: 1625–1638. 119. Collaboration TC (2014) Understanding Searching Techniques to Inform HTA, Systematic Reviews and Guideline Development. 120. Graham R, Mancher M, Wolman DM, Greenfield S, Steinberg E (2011) Clinical Practice Guidelines We Can Trust. …

Carpal tunnel syndrome.

Carpal tunnel syndrome is one of the most common peripheral neuropathies. It affects mainly middle aged women. In the majority of patients the exact cause and pathogenesis of CTS is unclear. Although several occupations have been linked to increased incidence and prevalence of CTS the evidence is not clear. Occupational CTS is uncommon and it is essential to exclude all other causes particularly the intrinsic factors such as obesity before attributing it to occupation. The risk of CTS is high in occupations involving exposure to high pressure, high force, repetitive work, and vibrating tools.

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… syndrome Rheumatology (Oxford) 2005 44 5 647 50 15743755 10.1093/rheumatology/keh571 104 Ly-Pen D Andreu JL de Blas G Sanchez-Olaso A Millan I Surgical decompression versus local steroid injection in carpal tunnel syndrome: a one-year, prospective, randomized, open, controlled clinical trial Arthritis Rheum …

Neutrophil diversity and function in health and disease.

Neutrophils, the most abundant type of granulocyte, are widely recognized as one of the pivotal contributors to the acute inflammatory response. Initially, neutrophils were considered the mobile infantry of the innate immune system, tasked with the immediate response to invading pathogens. However, recent studies have demonstrated that neutrophils are versatile cells, capable of regulating various biological processes and impacting both human health and disease. Cytokines and other active mediators regulate the functional activity of neutrophils by activating multiple receptors on these cells,

Quantitative Magnetic Resonance Spectroscopy and T2 Mapping for Evaluating Knee Subchondral Bone and Cartilage Changes in Chronic Kidney Disease.

ObjectiveTo investigate water and lipid composition changes in knee subchondral bone marrow and cartilage in chronic kidney disease (CKD) patients compared with age- and sex-matched healthy controls using magnetic resonance spectroscopy (MRS) and T2 mapping.DesignThis IRB-approved case-control study included 20 CKD patients (12 men, 8 women) and 20 age- and sex-matched healthy controls (10 men, 10 women). MRS and T2 measurements were performed on regions of interest in the knee subchondral bone and cartilage. Water content, lipid composition, fat content, and the unsaturation index (UI) were q

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… Ann Rheum Dis. 1989;48(3):183-7. 9. Hage S, Hage V, El-Khoury N, Azar H, Chelala D, Ziadé N. Musculoskeletal disorders in hemodialysis patients: different disease clustering according to age and dialysis vintage. Clin Rheumatol. 2020;39(2):533-9. 10. …

Immunological consequences of CAR T-cell therapy: an analysis of infectious complications and immune reconstitution.

AbstractChimeric antigen receptor (CAR) T-cell therapy has demonstrated remarkable efficacy in treating relapsed and refractory (R/R) B-cell neoplasms, such as diffuse large B-cell lymphoma (DLBCL) and multiple myeloma (MM). Despite its success, the long-term effects and sequelae of CAR T cells on the immune system remain underexplored. This study presents a 1-year follow-up analysis of 52 patients (42 with R/R DLBCL and 10 with R/R MM) treated with anti-CD19- and B-cell maturation antigen-targeted CAR T cells, focusing on immune reconstitution and infectious complications. Our findings reveal

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… treated with chimeric antigen receptor T-cell therapy: ASCO guideline J Clin Oncol 39 35 2021 3978 3992 34724386 10.1200/JCO.21.01992 13 Navarro G Taroumian S Barroso N Duan L Furst D Tocilizumab in rheumatoid arthritis: a meta-analysis of efficacy and selected clinical conundrums Semin Arthritis Rheum …

Pulmonary hypertension and the potential of 'drug' repurposing: A case for African medicinal plants.

AbstractPulmonary hypertension (PH) is a haemodynamic disorder in which elevated blood pressure in the pulmonary circulation is caused by abnormal vascular tone. Despite advances in treatment, PH mortality remains high, and drug repurposing has been proposed as a mitigating approach. This article reviews the studies that have investigated drug repurposing as a viable option for PH. We provide an overview of PH and highlight pharmaceutical drugs with repurposing potential, based on limited evidence of their mechanisms of action. Moreover, studies have demonstrated the benefits of medicinal plan

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… Int J Rheum Dis. 2016;19(2):192–198. doi: 10.1111/1756-185X.12304. 30. Cheong HI, Farha S, Park MM, et al. Endothelial phenotype evoked by low dose carvedilol in pulmonary hypertension. Front Cardiovasc Med. 2018;5:180. doi: 10.3389/fcvm.2018.00180. 31. …

Supporting the gastrointestinal microenvironment during high-dose chemotherapy and stem cell transplantation by inhibiting IL-1 signaling with anakinra.

High-dose chemotherapy causes intestinal inflammation and subsequent breakdown of the mucosal barrier, permitting translocation of enteric pathogens, clinically manifesting as fever. Antibiotics are mainstay for controlling these complications, however, they are increasingly recognized for their detrimental effects, including antimicrobial resistance and dysbiosis. Here, we show that mucosal barrier injury induced by the mucotoxic chemotherapeutic agent, high-dose melphalan (HDM), is characterized by hyper-active IL-1b/CXCL1/neutrophil signaling. Inhibition of this pathway with IL-1RA, anakinr

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… Rheum. Dis. 2006;65:1006–1012. doi: 10.1136/ard.2005.048371. 30. van der Velden WJ, Herbers AH, Netea MG, Blijlevens NM. Mucosal barrier injury, fever and infection in neutropenic patients with cancer: Introducing the paradigm febrile mucositis. Br. J. …

High Mortality of HLH in ICU Regardless Etiology or Treatment.

Background: Adult hemophagocytic lymphohistiocytosis (HLH) is highly lethal in the ICU. The diagnostic and therapeutic emergency that HLH represents is compounded by its unknown pathophysiological mechanisms. Here, we report on a large cohort of adult HLH in the ICU (ICU-HLH). We analyzed prognostic factors associated with mortality to define the diagnostic and therapeutic challenges in this specific population. Methods: This retrospective study included adult patients diagnosed with HLH in four ICUs in Marseille, France between 2010 and 2020. Patients who fulfilled the HLH-2004 criteria (≥ 4/

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… Arthritis Rheum. (2012) 64:1680–8. 10.1002/art.33496 56. Girard-Guyonvarc'h C, Palomo J, Martin P, Rodriguez E, Troccaz S, et al. Unopposed IL-18 signaling leads to severe TLR9-induced macrophage activation syndrome in mice. Blood. (2018) 131:1430–41. 10.1182/blood-2017-06-789552 57. …

A Retrospective Observational Study of Risk Factors for Denosumab-Related Osteonecrosis of the Jaw in Patients with Bone Metastases from Solid Cancers.

This single-center retrospective observational study aimed to identify risk factors for developing denosumab-related osteonecrosis of the jaw (DRONJ) in stage IV solid cancer patients with bone metastases. In total, 123 consecutive patients who had received 120 mg of denosumab every 4 weeks at least twice between July 2014 and October 2018 were included. We surveyed their demographics, medical history, blood test, underlying disease, and intraoral findings. Fourteen patients (11.4%) developed DRONJ within a mean denosumab administration period of 4 months (range: 2-52 months). Univariate analy

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… Arthritis Rheum. 2014;43:542–557. doi: 10.1016/j.semarthrit.2013.07.010. 50. Ristow O., Otto S., Troeltzsch M., Hohlweg-Majert B., Pautke C. Treatment perspectives for medication-related osteonecrosis of the jaw (MRONJ) J. Craniomaxillofac. Surg. 2015;43:290–293. doi: 10.1016/j.jcms.2014.11.014. …

The PI3K inhibitor buparlisib suppresses osteoclast formation and tumour cell growth in bone metastasis of lung cancer, as evidenced by multimodality molecular imaging.

Non‑small cell lung cancer (NSCLC) metastasis commonly occurs in bone, which often results in pathological fractures. Sustained phosphoinositide‑3‑kinase (PI3K) signalling promotes the growth of PI3K‑dependent NSCLC and elevates osteoclastogenic potential. The present study investigated the effects of a PI3K inhibitor on NSCLC growth in bone and osteoclast formation, and aimed to determine whether it could control symptoms associated with bone metastasis. A bone metastasis xenograft model was established by implanting NCI‑H460‑luc2 lung cancer cells, which contain a phosphatidylinositol‑​4,5‑b

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… 10.1002/cbf.3260 28370169 40 Blüml S Friedrich M Lohmeyer T Sahin E Saferding V Brunner J Puchner A Mandl P Niederreiter B Smolen JS Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells Ann Rheum …

An update on the diagnosis and management of the polyneuropathy of POEMS syndrome.

POEMS syndrome is a rare, chronic, disabling paraneoplastic disorder characterized by peripheral neuropathy, organomegaly, endocrinopathy, monoclonal plasma cells disorder and skin changes. Diagnosis relies on the fulfillment of a set of clinical criteria of which polyneuropathy and a monoclonal plasma cell dyscrasia are early and essential features. Treatment may be either local or systemic and is aimed at the monoclonal plasma cell disorder. Our knowledge of the pathogenesis underlying the POEMS syndrome has advanced greatly over the past years, favoring an important progression in the recog

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… Arthritis Rheum. 1997;40(4):786–787. doi: 10.1002/art.1780400430. 6. Nobile-Orazio E, Terenghi F, Giannotta C, Gallia F, Nozza A. Serum VEGF levels in POEMS syndrome and in immune-mediated neuropathies. Neurology. 2009;72(11):1024–1026. doi: 10.1212/01.wnl.0000344569.13496.ff. 7. …

The Multiple Roles of Microrna-223 in Regulating Bone Metabolism.

Bone metabolism is a lifelong process for maintaining skeletal system homeostasis, which is regulated by bone-resorbing osteoclasts and bone-forming osteoblasts. Aberrant differentiation of osteoclasts and osteoblasts leads to imbalanced bone metabolism, resulting in ossification and osteolysis diseases. MicroRNAs (miRNAs) are pivotal factors in regulating bone metabolism via post-transcriptional inhibition of target genes. Recent studies have revealed that miR-223 exerts multiple effects on bone metabolism, especially in the processes of osteoclast and osteoblasts differentiation. In this rev

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… MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis Arthritis Rheum. 2009 60 1294 1304 10.1002/art.24475 19404929 22. Lee Y. Kim M. Han J. Yeom K.H. Lee S. Baek S.H. Kim V.N. …

RANK, RANKL and osteoprotegerin in bone biology and disease.

Upon the discovery of RANK, RANKL and OPG in the late 1990s, their importance in the maintenance of the skeletal structure and their dramatic role in bone disease were largely unexpected. In recent years the understanding of these proteins, in particular their regulation, has greatly increased. This review aims to bring the interested reader up to date with the latest news and views on the mechanisms controlling bone resorption in normal and pathological conditions.

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… Dore RK Lane NE Ory PA Peterfy CG Sharp JT Van der HD Zhou L Tsuji W Newmark R Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial Arthritis Rheum …

Artificial intelligence in immunotherapy: revolutionizing diagnostic and therapeutic applications in cancer and autoimmune diseases.

Artificial intelligence (AI) is increasingly advancing precision immunotherapy by integrating high-dimensional biomedical data to support di … g EHR, laboratory, imaging, and wearable data—supporting precision management in conditions such as rheumatoid arthritis and type 1 diabetes. Key challenges include data heterogeneity, model interpretability, and governance; however, explainable AI, federated learning, and digital twin frameworks offer practical routes toward trustworthy clinical transl …

Position Statement on Diagnosis and Treatment of Cardiac Amyloidosis - 2021.

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