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Multiple Myeloma Associated Bone Disease.

The lytic bone disease is a hallmark of multiple myeloma, being present in about 80% of patients with newly diagnosed MM, and in more during the disease course. The myeloma associated bone disease (MBD) severely affects the morbidity and quality of life of the patients. MBD defines treatment demanding MM. In recent years, knowledge of the underlying pathophysiology has increased, and novel imaging technologies, medical and non-pharmaceutical treatments have improved. In this review, we highlight the major achievements in understanding, diagnosing and treating MBD. For diagnosing MBD, low-dose

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… WBMRI is recommended over combined spinal and pelvic MRI as lesions in rib cage, shoulder girdles and long bones could otherwise be missed. The NICE-guidelines suggest considering whole-body MRI as first-line imaging when multiple myeloma is suspected [ 42 ]. …

Р

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… Paradoxical respiration or paradoxical motion of the lung usually results from traumatic injury to the thorax ( flail chest) in which several ribs are fractured in two or more places and are no longer attached by bony cartilage to the rest of the rib cage. …

Biology and Diseases of Dogs

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Bone Phenotyping Approaches in Human, Mice and Zebrafish - Expert Overview of the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork").

A synoptic overview of scientific methods applied in bone and associated research fields across species has yet to be published. Experts from the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal Traits translational Network") Working Group 2 present an overview of the routine techniques as well as clinical and research approaches employed to characterize bone phenotypes in humans and selected animal models (mice and zebrafish) of health and disease. The goal is consolidation of knowledge and a map for future research. This expert paper provides a comprehensive overview of state-of-the-art

Acromegaly complications: an update.

CONTEXT: Appropriate diagnosis and treatment of comorbidities is key to managing acromegaly given their adverse clinical impact on quality of life and survival; thus, it is important to increase overall awareness of complications and their individualized management. EVIDENCE: This review examines the current literature on pathophysiology, diagnosis, and clinical presentation of acromegaly complications, as well as impact of acromegaly therapy and current goals for treatment outcomes of these morbidities. CONCLUSION: We focus on the most relevant acromegaly comorbidities including cardiorespi

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… Increased lung volume and distensibility with decreased elasticity ( 75 ), together with altered rib cage geometry, may reduce ventilatory efficiency with inadequate ventilatory response to exercise demand, resulting in low workload capacity ( 76 ). …

Unpacking adiposity: a narrative critical appraisal of diverse obesity definitions.

BACKGROUND: Obesity is a complex, multifaceted chronic disease that poses a major global health challenge. Traditionally, population-level screening and follow-up have relied heavily on body mass index (BMI). Although BMI provides a simple, standardized measure for epidemiological studies, it does not account for individual variations in muscle mass, fat distribution, or metabolic health. Consequently, relying solely on weight-to-height ratios-even when supplemented with waist circumference, waist-to-hip ratio, or waist-to-height ratio-limits precise individual diagnosis and comprehensive heal

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… A high WHR (WHR > 1.0 in men and > 0.85 in women) indicates fat accumulation [ 1 , 27 ], but WC alone—measured at the midpoint between the lower border of the rib cage and the iliac crest—provides a useful, inexpensive, and simple correlate of abdominal fat distribution and the associated risk of adverse …

Current and future applications of ultrasound imaging in peripheral nerve disorders.

Neuromuscular ultrasound (NMUS) is a rapidly evolving technique used in neuromuscular medicine to provide complimentary information to standard electrodiagnostic studies. NMUS provides a dynamic, real time assessment of anatomy which can alter both diagnostic and management pathways in peripheral nerve disorders. This review describes the current and future techniques used in NMUS and details the applications and developments in the diagnosis and monitoring of compressive, hereditary, immune-mediated and axonal peripheral nerve disorders, and motor neuron diseases. Technological advances have

Abstracts for NAPCON 2025

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ЭПОС/ПОНСА Резюме

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Perspective Applications and Associated Challenges of Using Nanocellulose in Treating Bone-Related Diseases.

Bone serves to maintain the shape of the human body due to its hard and solid nature. A loss or weakening of bone tissues, such as in case of traumatic injury, diseases (e.g., osteosarcoma), or old age, adversely affects the individuals quality of life. Although bone has the innate ability to remodel and regenerate in case of small damage or a crack, a loss of a large volume of bone in case of a traumatic injury requires the restoration of bone function by adopting different biophysical approaches and chemotherapies as well as a surgical reconstruction. Compared to the biophysical and chemothe

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… Besides bone, nanocellulose could also be used as a substitute for the cartilage that is a smooth elastic tissue and covers the ends of long bones at the joints and nerves and is commonly present in the ear, nose, rib cage, intervertebral disks, and several other parts of the body. …

Combinatorial targeting of cancer bone metastasis using mRNA engineered stem cells.

BACKGROUND: Bone metastases are common and devastating to cancer patients. Existing treatments do not specifically target the disease sites and are therefore ineffective and systemically toxic. Here we present a new strategy to treat bone metastasis by targeting both the cancer cells ("the seed"), and their surrounding niche ("the soil"), using stem cells engineered to home to the bone metastatic niche and to maximise local delivery of multiple therapeutic factors. METHODS: We used mesenchymal stem cells engineered using mRNA to simultaneously express P-selectin glycoprotein ligand-1 (PSGL-1)

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… This model had a 90% incidence for bone metastases, and the majority of bone metastases were located in legs (femur/hip area) and spine, but we also found some metastases in the rib cage, the scapula and the mammary fad pad. …

Abstracts

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Image-Guided Percutaneous Ablation for Primary and Metastatic Tumors.

Image-guided percutaneous ablation methods have been further developed during the recent two decades and have transformed the minimally invasive and precision features of treatment options targeting primary and metastatic tumors. They work by percutaneously introducing applicators to precisely destroy a tumor and offer much lower risks than conventional methods. There are usually shorter recovery periods, less bleeding, and more preservation of organ parenchyma, expanding the treatment options of patients with cancer who may not be eligible for resection. Image-guided ablation techniques are c

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… In the case of HIFU, ablation of small liver tumors, even in patients with advanced cirrhosis, is relatively safe, but current challenges that are still being addressed are targeting tumors in difficult locations, such as the liver dome, structures near the rib cage, structures near large blood vessels …

Influence of the TGF-β Superfamily on Osteoclasts/Osteoblasts Balance in Physiological and Pathological Bone Conditions.

The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells (osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones, cytokines, and growth factors-in particular the members of the TGF-β superfamily such as the bone morphogenetic proteins-not only regulate the proliferation, differentiation, and functioning of these cells, but also coordinate the communication between them to ensure an appropriate response. Therefore, this review focuses on TGF-β superfamily and its influence on bone formation and repair, through the regulation of

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… In the same way, BMP-7-deficient mice die shortly after birth and not only have skeletal abnormalities in discrete areas such as rib cage, skull, and the hind limbs, but also eye and kidney defects [ 158 ]. 3.2. TGF-β Superfamily Signaling Pathways and Their Regulation 3.2.1. …

In Vivo Bone Tissue Engineering Strategies: Advances and Prospects.

Reconstruction of critical-sized bone defects remains a tremendous challenge for surgeons worldwide. Despite the variety of surgical techniques, current clinical strategies for bone defect repair demonstrate significant limitations and drawbacks, including donor-site morbidity, poor anatomical match, insufficient bone volume, bone graft resorption, and rejection. Bone tissue engineering (BTE) has emerged as a novel approach to guided bone tissue regeneration. BTE focuses on in vitro manipulations with seed cells, growth factors and bioactive scaffolds using bioreactors. The successful clinical

42nd International Symposium on Intensive Care & Emergency Medicine

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… Diaphragm thickening fraction (TFdi) and diaphragm excursion (EXdi) were measured under varying resistive load (none, marked, complete airway occlusion), varying postural load (semi-recumbent vs. supine) and varying thoracoabdominal motion (abdominal- vs. rib cage-predominant inspiration). … TFdi also decreased in the supine position ( p = 0.004) and with rib cage-predominant inspiration ( p < 0.001). EXdi decreased with increasing resistance ( p < 0.001) and supine position ( p = 0.013). Conclusions: Changing physiological conditions has differential effects on Pdi, TFdi, and EXdi. …

Abstracts from the 53rd European Society of Human Genetics (ESHG) Conference: e-Posters.

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&quot; Nucleolus in Human Beasons: Ribosome Biogenesis &quot; , &quot; Nucleolar Survey &quot; и &quot; Terrapeutic Opportunities &quot; .

Nucleolus превратился в динамичную и многофункциональную субядерную органилию, интегрирующую рибосомный биогенез с клеточным ростом и сигнализацией стресса. Регулирование нуклеолярной функции все чаще признается в качестве главного движителя человеческих заболеваний, связывающего изменённое рибосомное производство и нуклеолярное наблюдение с раком, рибосомопатиями, синдромами преждевременного старения, нейродегенерацией и иммунными расстройствами. В этом обзоре мы интегрируем структурные, молекулярные и болезнетворные перспективы нуклеолярной биологии для определения того, как рипосомный биоге

Proceedings to the 2020 Online Conference of the Particle Therapy Cooperative Group (PTCOG2020Online): 13-14 September 2020Organized by the Particle Therapy Cooperative Group (PTCOG), this special online meeting featured abstracts and programs that enabled the communication and cross fertilization for which PTCOG meetings are known.

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Ход работы 34th Симпозиум ESVN-ECVN 23rd-24th сентябрь 2022.

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