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Bioactive M2 exosome hybrid nanocomposites for immune therapy of psoriasis.

Psoriasis is a chronic autoimmune skin disease characterized by persistent oxidative stress and sustained inflammation, affecting approximately 1-8% of the global population, with no curative therapy has been well-established to date. To address this, we developed a bioactive hybrid nanocomposite (Exo-Ce) by chemically conjugating M2 macrophage-derived exosomes with cerium oxide nanoparticles (CeNP), which was applied for synergistic and immunomodulatory therapy of psoriasis. This nanohybrid system effectively integrates the natural immunomodulatory properties of exosomes with the reliable ant…

Exosomes Derived from BMSCs Treated with CeONPs Ameliorate Radiation-Induced Jaw Bone Injury via miR-21-5p/STAT3 Axis-Mediated Osteogenesis and ROS Scavenging.

Background/Objectives: Radiation-induced jaw bone injury is a severe and refractory complication following radiotherapy, and the key to treatment is promoting osteogenic differentiation and alleviating oxidative stress injury in irradiated BMSCs. Cerium oxide nanoparticles (CeONPs) exhibit considerable research potential in various oxidative stress injury-related diseases due to their excellent reactive oxygen species (ROS) scavenging capacity; however, its biosafety risk makes direct application in disease treatment a matter of controversy. Methods: Recent evidence suggests that treating cell…

Ultrasensitive toltrazuril sulfone detection in eggs via a AuNPs/NH2-Ce-MOF-enhanced electrochemical immunosensor.

The widespread use of toltrazuril (TOL) as a low-toxicity anticoccidial agent in livestock production necessitates sensitive monitoring of its persistent metabolite, toltrazuril sulfone (TOS), which exhibits hepatotoxic and reproductive risks at subchronic exposure levels. Here, we proposed a novel electrochemical immunosensor for the ultrasensitive detection of TOS in eggs, utilizing a decorated amino-functionalized cerium metal-organic framework-gold nanoparticle (NH2-Ce-MOF/AuNP) nanocomposite. The NH2-Ce-MOF was synthesized via hydrothermal crystallization of (NH4)2Ce(NO3)6 and 2-aminotere…

Targeting Ischemic stroke-related oxidative stress with metal nanoparticles: Mechanisms and therapeutic advances.

BACKGROUND: Ischemic stroke is a major cause of mortality and disability, largely driven by excessive reactive oxygen species (ROS) during i … ncluded, while non-metal nanomaterials, irrelevant studies, and duplicates were excluded. RESULTS: Cerium-, manganese-, copper-, and iron-based nanoparticles exhibit enzyme-mimetic antioxidant activity by scavenging ROS and regulating oxidative stress pathways. Nanozymes and drug-loaded nanoparticles enhance neuronal survival, reduce infarction, and mod …

An Injectable ROS-Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions.

Intrauterine injury triggers a self-reinforcing cycle of inflammation, oxidative stress, and fibrosis that culminates in intrauterine adhesions (IUA), severely impairing women's reproductive health. Current treatments, including hysteroscopic adhesiolysis combined with hormonal therapy or physical barriers, show high recurrence and cannot simultaneously target these interconnected pathways. Here, we developed an injectable ROS-responsive hydrogel (GPP) loaded with cerium-tannic acid metal-phenolic nanozymes (CeTA) that exhibit superoxide dismutase (SOD)- and catalase (CAT)-mimetic activities. …

Enhancing exosomes efficacy with engineered nanozymes for a multi-targeted combination strategy in osteoarthritis treatment.

Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by multifactorial pathological mechanisms, and remains a signifi … ptosis. This platform combines dental pulp stem cells-derived exosomes (Exo) with hollow mesoporous cerium oxide nanozymes, which were first loaded with curcumin and subsequently coated with hyaluronic acid, termed HA@Cur@CeO2. In vitro, this combination reduced intracellular ROS and promoted macrophage polarization toward the anti-inflammatory M2 phenot …

Oxygen sensing using time-domain X-ray luminescence.

Oxygen tension is a critical physiological parameter in deep tissues; however, high-resolution and non-invasive measurement of oxygenation remains challenging. In this study, we developed a prototype for a lifetime measurement system based on a pulsed carbon nanotube X-ray source to evaluate X-ray-excited luminescence oxygen sensing. The X-ray irradiated a PDMS fiber containing the rapidly responding X-ray scintillator cerium-doped lutetium orthosilicate (LSO) and an oxygen sensing dye, (Pt(II) meso-Tetra(pentafluorophenyl)porphine (PtTFPP)), that is excited by the LSO X-ray luminescence and e…

CeO2-Loaded Shear-Thinning Hydrogel Combined with Dental Pulp Stem Cells Modulates the Oxidative-Inflammatory Microenvironment To Enhance Facial Nerve Regeneration.

Stem cell transplantation holds great promise for facial nerve repair, yet its efficacy is largely constrained by the excessive accumulation of reactive oxygen species (ROS) and the highly inflammatory microenvironment. Thus, developing bioactive scaffolds with robust antioxidant capacity for stem cell transplantation remains a challenge. In this study, an injectable and self-healing composite hydrogel composed of chitosan, graphene oxide, and cerium oxide nanoparticles (CeNPs) was developed to provide structural support for the neural conduit, create a favorable microenvironment for human den…

Feedback-regulated 3D-printed hydrogel micropatch for integrated therapy of fungal keratitis.

RATIONALE: Fungal keratitis remains clinically challenging due to limited drug bioavailability, frequent dosing, reactive oxygen species (ROS)-mediated stromal damage, perforation risk, and bacterial coinfection. In the study, we developed a feedback-regulated multifunctional corneal micropatch (MFCP) via 3D printing for the treatment of fungal keratitis. METHODS: The dual-network hydrogel micropatch comprises an ROS-responsive hydrogel (RRH), voriconazole-loaded F127DA micelles (VCZ-F127DA), and gatifloxacin-loaded cerium metal-organic frameworks (GAT-MOFs). We characterized its physicochemi…

The gamma and neutron shielding performance of CeO2 and Er2O3 doped Al2Si2O5(OH)4-KAlSi3O8-SiO2 ceramics.

This study investigates the effects of cerium oxide (CeO2) and erbium oxide (Er2O3) doping on conventionally produced Al2Si2O5(OH)4-KAlSi3O8-SiO2 ceramics for potential photon and neutron shielding applications. The experimental setup involved measuring photon intensities at various energies emitted by a Barium-133 radioisotope. From these measurements, key shielding properties such as the mass attenuation coefficient (μ/ρ), half-value thickness (Δ0.5), mean free path (λ), effective atomic number (Zeff), and electron density (Nel) were derived. These experimental results were then compared wit…

The associations between prenatal rare earth elements exposure and preterm birth: integrate insights from birth cohort and in vitro study.

Rare earth elements (REEs) are emerging environmental contaminants, yet their effects on preterm birth (PTB) remain poorly understood. This … ndividual and mixture of REEs exposure elevated PTB risk by 18-51 % after adjusting for covariates. Cerium (Ce), praseodymium (Pr) and gadolinium (Gd) were the primary contributors. Environmentally-relevant REEs concentrations (0.5-100 μg/L) treatment enhanced trophoblast invasion by 2.7-19.2 folds, accompanied by MMP-9 upregulation and TIMP-1 suppressio …

Synergistic Enhancement of Ethanol Oxidation on Pd/Ce2Ti2O7-TiO2 via Multiorbital (p-d-f) Interactions.

Ethanol oxidation reaction (EOR) is a key component of direct ethanol fuel cells (DEFCs). However, due to its slow kinetics, EOR remains a significant challenge, leading to an increasing search for low-cost, efficient, and stable catalysts. Herein, palladium (Pd) nanostructured catalysts supported on titanium dioxide (Pd/TiO2) and cerium titanate (Pd/Ce2Ti2O7-TiO2) were prepared for EOR. The Pd/Ce2Ti2O7-TiO2 catalyst exhibits superior electroactivity toward the EOR, demonstrating a high mass activity of 2.70 and 2.63-fold relative to Pd/TiO2 and Pd/C, respectively. The enhanced behavior was at…

Multifunctional Hydrogel with Photothermal ROS Scavenging and Antibacterial Activity Accelerates Diabetic Wound Healing.

Poor diabetic wound healing poses a critical threat to human health. Excessive oxidative stress and increased susceptibility to bacterial infection are key issues that impede diabetic wound healing. Cerium oxide nanoparticles (CeO2 NPs) have attracted increasing attention because of their unique antioxidant and antimicrobial properties. Here, this work designs a near-infrared (NIR) light-responsive gelatin methacryloyl (GelMA)/CeO2/polydopamine (PDA) hydrogel with antibacterial and antioxidant effects. The hydrogel exhibits a stable, efficient, and controllable photothermal conversion capacity…

Стратегии, основанные на нанопчасти, для преодоления кровеносного барьера в расстройствах CNS и раке мозга: точная диагностика и лечение болезни Альцгеймера, Паркинсона, множественный склероз и глиобластомы.

Технологии, основанные на нанопчасти (NP), трансформируют управление расстройствами центральной нервной системы (CNS), такими, как болезнь Альцгеймера (AD), болезнь Паркинсона (PD), множественный склероз (MS) и рак мозга (BC), глиобластома, превысив уровень мозгового барьера (BBB) и опухоли крови (BBTB). Этот обзор включает подходы к NP, включающие органические (например, липосомы, полимерные NP), неорганические (например, золото, окись железа), углеродные и гибридные системы, для преодоления барьеров, обусловленных конкретными заболеваниями. В AD суперпарамагнитные оксиды железа (SPIONs) и зо

Совпадение в аннотации оригинала
Nanoparticle (NP)-based technologies are transforming the management of central nervous system (CNS) disorders such as Alzheimer's disease ( … ection, while liposomes precisely deliver anti-amyloid drugs. For PD, dopamine-loaded liposomes and cerium oxide NPs reinstate dopaminergic function and decrease oxidative stress, with improved motor outcomes. In MS, PEGylated liposomes and PLGA NPs regulate autoimmune responses, inducing remyelination and attenuating neuroinflammation. For BC, dendrimer …

A Dual-Antioxidative Coating on Transmucosal Component of Implant to Repair Connective Tissue Barrier for Treatment of Peri-Implantitis.

Since the microgap between implant and surrounding connective tissue creates the pass for pathogen invasion, sustained pathological stimuli can accelerate macrophage-mediated inflammation, therefore affecting peri-implant tissue regeneration and aggravate peri-implantitis. As the transmucosal component of implant, the abutment therefore needs to be biofunctionalized to repair the gingival barrier. Here, a mussel-bioinspired implant abutment coating containing tannic acid (TA), cerium and minocycline (TA-Ce-Mino) is reported. TA provides pyrogallol and catechol groups to promote cell adherence.…

Electrokinetic Insights into the Triple Ionic and Electronic Conductivity of a Novel Nanocomposite Functional Material for Protonic Ceramic Fuel Cells.

Triple ionic and electronic conductivity (TIEC) in cathode materials for protonic ceramic fuel cells (PCFCs) is a desirable feature that enh … d a dominant proton-conducting phase, BaCe1-( x + y + z ) Cox Zry Fez O3- δ (H-BCCZF). The dominant cerium-rich H-BCCFZ phase enhances the material's oxygen vacancy concentration and the proton defects formation and transport with a low enthalpy of protonation of -30 ± 9 kJ mol-1 . The area-specific resistance of the BCCFZ symmetrical cell is 0.089 Ω cm2 …

Variation in the concentration and regional distribution of magnetic nanoparticles in human brains, with and without Alzheimer's disease, from the UK.

The presence of magnetic nanoparticles (MNPs) in the human brain was attributed until recently to endogenous formation; associated with a pu … , all the elderly MBB brains contain varying concentrations of non-physiological metals (e.g. lead, cerium), suggesting universal incursion of environmentally-sourced particles, likely across the geriatric blood-brain barrier (BBB). Cerebellar Manchester samples contained significantly lower (~ 9×) ferrimagnetic content compared with those from a young ( …

Enhancement of gamma-aminobutyric acid-activated chloride channel currents by lanthanides in rat dorsal root ganglion neurons.

Lanthanum was previously reported to potentiate the GABA-induced chloride currents reversibly by acting at a distinct site on the GABAA rece … +/- 0.2 > terbium (Tb3+) 9.3 +/- 0.5 > europium (Eu3+) 5.4 +/- 0.4 > neodymium (Nd3+) 4.1 +/- 0.2 > cerium (Ce3+) 3.3 +/- 0.2 > lanthanum (La3+) 2.4 +/- 0.2 (n = 10). The enhancing effect of Tb3+ was dose dependent, with an EC50 356 +/- 12 microM (n = 10), and weakly voltage dependent, increasing with hyperpolarization. The amplitudes of currents induced …

Core-shell Au@CeO2 nanozyme-mediated aptasensor for dual-mode SERS/colorimetric detection of kanamycin.

Kanamycin (KANA), a widely used aminoglycoside antibiotic, may accumulate in food products and pose potential risks to human health, calling for sensitive and reliable analytical strategies. A dual-mode detection method integrating surface-enhanced Raman spectroscopy (SERS) with colorimetric sensing was developed. This approach enabled sensitive and rapid detection of KANA. A core-shell Au@CeO2 nanozyme-mediated aptasensor was synthesized, which exhibited oxidase-like activity and enhanced SERS performance. Without KANA, adsorption of the aptamer onto the nanozyme surface inhibited the nanozym

Self-healing quaternized chitosan-phenylboronic hydrogel with ceria nanozymes and stem-cell exosomes simultaneously eradicates MRSA biofilm and regenerates diabetic wounds.

Diabetic wounds represent a major clinical challenge due to their susceptibility to bacterial biofilm infections, persistent oxidative stress, and impaired tissue regeneration. Current therapeutic approaches typically address these pathological factors individually, limiting their overall efficacy in achieving complete wound closure. There is thus an urgent need for integrated platforms capable of simultaneously targeting multiple barriers to healing. Here we show that a self-healing hydrogel composed of quaternized chitosan-phenylboronic acid (QCSP), ceria nanoparticles (CeNPs), and embryonic