Результаты поиска

Real world risk of infusion reactions and effectiveness of front-line obinutuzumab plus chlorambucil compared with other frontline treatments for chronic lymphocytic leukemia.

BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in North America. Previous studies have shown improved progression free survival (PFS) and response rates in unfit patients treated with obinutuzumab compared to other regimens. The aim of this study was to evaluate the obinutuzumab-chlorambucil regimen in the context of historical treatments and first-dose infusion reactions at CancerCare Manitoba (CCMB). METHODS: A retrospective chart review was conducted for patients treated with obinutuzumab from January 1, 2014 to December 31, 2017 at CCMB. A minimum data …

Factors associated with human papillomavirus infection detected by polymerase chain reaction among urban Canadian aboriginal and non-aboriginal women.

OBJECTIVES: To determine the prevalence and correlates of human papillomavirus (HPV) infection among women attending an ethnically mixed, predominantly low-income, inner-city primary care clinic. STUDY DESIGN: Cross-sectional survey (N = 1,477). Demographic, behavioral, and reproductive history data were collected by questionnaire. Cervical swabs were analyzed for gonorrhea and chlamydial infections, abnormal cytology, and HPV infection assessed by PCR followed by hybridization for types 6, 11, 16, 18, 31, 33, and 35. RESULTS: Human papillomavirus was detected in 33% of specimens, with no si

Mixed anxiety-depression in a primary-care clinic.

To determine the prevalence and clinical significance of a mixed anxiety-depressive (MAD) syndrome in primary care, a two-stage sampling design was applied to 796 consecutive clinic attendees without known psychiatric illness. Among 78 systematically interviewed subjects, 10.3% (n = 8) had a depressive disorder alone, 12.8% (n = 10) had an anxiety disorder alone, 19.2% (n = 15) had a comorbid anxiety and depressive disorder and 12.8% (n = 10) had a combination of subsyndromal anxiety and depressive features that fulfilled either ICD-10 or our own operational criteria for MAD. Patients with MAD

Thyroid screening tests in psychiatric inpatients.

This study reports on a retrospective evaluation of the current practice of screening for thyroid dysfunction in an adult psychiatric inpatient program. Sixty-four percent of 342 admissions were tested during their hospital stay. Although 13.7% of tests yielded abnormal values on one or more of the thyroid indices, only 0.9% resulted in a diagnosis of hypothyroidism. None of the other abnormal test results led to any specific action being taken. The present pattern of use of thyroid function screening as observed in this study does not appear optimal. Issues in the selection of thyroid screeni

The neurological manifestations of chronic inhalation of leaded gasoline.

Abnormal neurological signs were found in 46 of 50 children and adolescents chronically sniffing leaded gasoline. These abnormalities resolved within eight weeks in all but one case. Exaggerated deep reflexes, postural tremor and evidence of cerebellar dysfunction occurred in a highly significnat number of patients. Forty-nine had blood lead levels greater than or equal to 40ug/dl. The mean blood lead levels were significantly higher in those with (a) abnormally brisk deep reflexes and (b) with evidence of cerebellar dysfunction, than in those without these findings. Five optional treatment re

Impact of a dental/dental hygiene tobacco-use cessation curriculum on practice.

Tobacco use is the chief avoidable cause of morbidity and mortality in North America and is associated with increased risk for oral cancer and increased prevalence and severity of periodontitis and other oral conditions. By delivering two- to three-minute tobacco-use cessation counseling (TUCC), oral health professionals can achieve quit rates substantially higher than the spontaneous quit rate. However, many clinicians report lack of training and knowledge in TUCC as barriers to providing cessation counseling. The purpose of this study was to evaluate whether implementation of a comprehensive

Predicting Fracture Risk After Non-Recent High Risk Fracture: Improving accuracy with simple modifiers to FRAX.

Prior fracture is among the strongest predictors of future osteoporotic fracture. However, the Fracture Risk Assessment Tool (FRAX®) incorpo … hat captured by standard FRAX inputs. In this population-based retrospective cohort study using the Manitoba Bone Mineral Density Registry linked to comprehensive provincial administrative health data, adults ≥40 years undergoing first DXA between 1996-2018 were included (N=88,653). Individuals who had a prior recent fracture (occurring less than 2 years p …

Детские трудности и аутоиммунные заболевания: глобальный исследовательский ландшафт, < < горячие точки > > , связанные с иммунизацией, и новые тенденции, вытекающие из библиометрического анализа трех баз данных.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Детские трудности все чаще признаются в качестве важного психосоциального воздействия в раннем возрасте, которое может формировать долгосрочную иммунную функцию и способствовать аутоиммунным заболеваниям посредством хронического стресса, регулирования нейроэндокринной дистрибьюции и провокационной активации. Однако структура знаний, " горячих точек " исследований и тенденции в области развития в этой области остаются недостаточно характерными. МЕТОДЫ: С момента создания базы данных по 31 декабря 2025 года публикации, посвященные детским недугам и аутоиммунным з

Совпадение в аннотации оригинала
BACKGROUND: Childhood adversity is increasingly recognized as an important early-life psychosocial exposure that may shape long-term immune … nstitutions included the University of California System, Harvard University, and the University of Manitoba. Major publication venues included Journal of Psychosomatic Research and Psychosomatic Medicine. Keyword analysis identified childhood adversity, depression, multiple sclerosis, rheumatoid arthritis, stress, autoimmune disease, and inflammation as m …

Performance of FRAX in Men With Prostate Cancer: A Registry-Based Cohort Study.

The Fracture Risk Assessment Tool (FRAX®) was created to predict major osteoporotic fractures (MOF) and hip fractures in the general population. Whether FRAX accurately predicts fractures in men with prostate cancer is unknown. Our objective was to assess the performance of FRAX for predicting incident fractures in men with prostate cancer. Men from the Manitoba Bone Mineral Density (BMD) Registry (1996-2018) with prostate cancer diagnoses in the 3 years prior to dual-energy X-ray absorptiometry (DXA) were identified. FRAX scores with and without BMD were calculated. From population-based heal…

A population-based study of outcomes in adjuvant radiotherapy for stage II endometrial carcinoma.

OBJECTIVE: Our study aimed to analyze recurrence and survival outcomes in stage II endometrial cancer patients treated with adjuvant radiotherapy at CancerCare Manitoba, a Canadian provincial cancer program. METHODS: This retrospective population-based cohort study identified all International Federation of Gynecology and Obstetrics (FIGO) 2009 stage II endometrioid type endometrial carcinoma diagnosed between January 1995 and December 2019. All patients underwent surgery followed by vaginal vault brachytherapy alone or external beam pelvic radiotherapy plus vaginal vault brachytherapy. We us…

Polypharmacy and Potentially Inappropriate Medication Use in Older Adults With Systemic Lupus Erythematosus.

OBJECTIVE: To assess the prevalence and potential risk factors for polypharmacy and prescribing of the potentially inappropriate medications, opioids and benzodiazepines/Z-drugs, in older adults with systemic lupus erythematosus (SLE). METHODS: The study population comprised adults age ≥50 years meeting American College of Rheumatology or Systemic Lupus International Collaborating Clinics classification criteria followed at a tertiary care rheumatology clinic. Information on prescriptions filled in the 4 months preceding chart review was obtained from the Manitoba Drug Program Information Net…

Use of Benzodiazepines and Z-Drugs in Multiple Sclerosis.

OBJECTIVE: Use of benzodiazepines and Z-drugs (non-benzodiazepine sedative hypnotics) is controversial due to adverse health outcomes in the general population. However, little is known about their use in people with multiple sclerosis (MS). We estimated the incidence and prevalence of benzodiazepine and Z-drug use (jointly BZD) in the MS population as compared to an age-, sex- and geographically-matched population without MS, and examined the association of mood/anxiety disorders with the use of BZD over a twenty-year period. METHODS: Using administrative data from Manitoba, Canada, we ident…

Canine leptospirosis in Canada, test-positive proportion and risk factors (2009 to 2018): A cross-sectional study.

Over the past decade, there has been an apparent increased frequency and widened distribution of canine leptospirosis in Canada, however, th … tion over the study period were Nova Scotia (18.5%) and Ontario (9.6%), with the prairie provinces (Manitoba and Alberta combined) having the lowest proportion (1.0%); the northern territories could not be evaluated due to limited testing. In the final model, dog age, sex, breed, month, and year test performed, and location (urban/rural, province) of the p …

Off-label postpartum use of domperidone in Canada: a multidatabase cohort study.

BACKGROUND: Trends in off-label postpartum use of domperidone and the impact of safety advisories on its use remain unknown. Our objectives … administrative health databases from 5 Canadian provinces (British Columbia, Alberta, Saskatchewan, Manitoba and Ontario). We excluded patients with less than 1 year of prepregnancy database history and with approved indications for domperidone. We assessed domperidone use in the 6 months postpartum and the impact of the 2012 and 2015 Health Canada advisor …

Accuracy of FRAX® in People With Multiple Sclerosis.

People with multiple sclerosis (MS) have a higher risk of low bone mineral density (BMD), osteoporosis, and osteoporotic fractures than healthy adults. The Fracture Risk Assessment tool (FRAX® ) has been reported to underestimate fracture risk in people with MS when BMD is unknown. We tested FRAX performance for people with MS when BMD is known, and determined if MS is a risk factor for fracture independent of FRAX score. Using population-based databases in Manitoba, Canada, we identified people with MS who underwent BMD screening after MS diagnosis (n = 744) and controls matched on age, sex, …

Near-field infrared nanospectroscopy and super-resolution fluorescence microscopy enable complementary nanoscale analyses of lymphocyte nuclei.

Recent super-resolution fluorescence microscopy (3D-Structured Illumination Microscopy, 3D-SIM) studies have revealed significantly altered … 620 microscope, 15× objective, 0.62 NA and 64 × 64 array Focal Plane Array detector (University of Manitoba), or with a similar microscope equipped with both 15× and 25× (0.81 NA) objectives, 128 × 128 FPA and either thermal source or synchrotron source (single beam) infrared light at the Advanced Light Source (ALS), LBNL, Berkeley CA. Near-field IR spect …

Antiestrogen use reduces risk of cervical neoplasia in breast cancer patients: a population-based study.

We investigated the potential use and quantification of human enteric viruses in municipal wastewater samples of Winnipeg (Manitoba, Canada) as alternative indicators of contamination and evaluated the processing stages of the wastewater treatment plant. During the fall 2019 and winter 2020 seasons, samples of raw sewage, activated sludge, effluents, and biosolids (sludge cake) were collected from the North End Sewage Treatment Plant (NESTP), which is the largest wastewater treatment plant in the City of Winnipeg. DNA (Adenovirus and crAssphage) and RNA enteric viruses (Pepper mild mottle viru…

A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX.

Trabecular bone score (TBS) is a gray-level textural index of bone microarchitecture derived from lumbar spine dual-energy X-ray absorptiome … babilities were adjusted for TBS using an adjustment factor derived from an independent cohort (the Manitoba Bone Density Cohort). Overall, the GR of TBS for major osteoporotic fracture was 1.44 (95% confidence interval [CI] 1.35-1.53) when adjusted for age and time since baseline and was similar in men and women (p > 0.10). When additionally adjusted for …

Associations of Body Mass Index With Incident Fractures and Hip Structural Parameters in a Large Canadian Cohort.

CONTEXT: Fractures in obese individuals are of public health importance, but the relationship between obesity and fracture is complex and remains poorly understood. OBJECTIVE: The study examined the association of body mass index (BMI) with bone structural and strength parameters and incident fracture. DESIGN AND SETTING: We performed cross-sectional and longitudinal analyses using data from the Manitoba Bone Density Program. PARTICIPANTS: We included 51 313 women and 4689 men aged 50 years or older referred for dual-energy X-ray absorptiometry scans. For 41 919 women and 4085 men, we were …

Environmental risk from Lyme disease in central and eastern Canada: a summary of recent surveillance information.

BACKGROUND: Lyme disease is the most commonly reported vector-borne disease in the temperate world. It is emerging in central and eastern Ca … ere mapped for comparison. RESULTS: The number of confirmed Lyme disease-endemic areas in southern Manitoba, southern and eastern Ontario, southern Quebec, southern New Brunswick and in some locations in Nova Scotia increased from 10 in 2009 to 22 confirmed endemic areas in 2012. The collated field surveillance data indicated that I. scapularis tick popul …